TAMAI Keiichi 玉井恵一

Researcher Number	40509262
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2023: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 2016: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 上席主任研究員 2015: 地方独立法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 上席主任研究員 2014: 宮城県立がんセンター研究所, 上席主任研究員 2012 – 2014: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 研究員 … More 2012: 地方独立行政法人宮城県立がんセンター(研究所), がん先進治療開発研究部, 主任研究員 2012: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療研究部, 主任研究員 2011: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 主任研究員 2010: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), 免疫学部, 副主任研究員 2010: 宮城県立がんセンター研究所, 免疫学部, 副主任研究員 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Tumor biology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 42040:Laboratory animal science-related / Basic Section 56050:Otorhinolaryngology-related / Gastroenterology / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 55020:Digestive surgery-related / Digestive surgery … More / Urology / Respiratory surgery / Tumor biology / Carcinogenesis Less
Keywords	Principal Investigator HCV / Hrs / ESCRT / 肝臓癌 / 肝細胞癌 / がん幹細胞 / 胆道癌 / 胆管癌 / 癌幹細胞 / 小胞輸送 / exosomes … More Except Principal Investigator … More がん幹細胞 / 胆管癌 / PDX / BEX2 / 抗体医薬 / マクロファージ / 自然免疫 / Fc受容体 / ヒト化マウス / 下咽頭癌 / ncRNA / 胆管がん / 胃がん / 胃癌 / 大腸癌 / 大腸がん / IL-2R / IL2R / 扁平上皮癌 / 扁平上皮がん / 抗体 / RNA / 下咽頭がん / マラリア / 受容体 / 赤血球 / PD-1 / 腫瘍免疫 / 免疫不全 / immunocheckpoint / tumor immunology / ADCC / antibody / FcR / RBC / innate immunity / immunodeficient mice / 頭頸部癌 / 腎細胞癌 / 腎癌 / non coding RNA / Periostin / 肺癌 / 膵癌 / 胆道癌 / CD274 / プロテオーム / オートファジー / 小胞輸送 / 癌 / 増殖因子受容体 / ESCRT / 肝炎 / 免疫 / ウィルス / 肝線維化 / HCV / 肝臓学 Less

静止期癌幹細胞維持分子BEX2を標的とした新たな胃癌治療の開発
- Principal Investigator
  
  島真央
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
新規SRC制御分子FAXCによる肝内胆管癌幹細胞の維持機構
- Principal Investigator
  
  佐藤賢一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Improvement of humanized mice through elucidation of interaction between mouse innate immune system and human cells
- Principal Investigator
  
  Takahashi Takeshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Central Institute for Experimental Animals
下咽頭癌癌幹細胞に対する特異的抗体の樹立と診断・治療への応用
- Principal Investigator
  
  藤井慶太郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  University of Tsukuba
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Role of common gamma chain in colorectal cancer
- Principal Investigator
  
  Wakui Yuta
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Role of ncRNA in hypopharyngeal cancer
- Principal Investigator
  
  Saijoh Satoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Dormant cancer stme cell-targeting therapy for cholangiocarcinoma
- Principal Investigator
  
  Kayayose Yu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Development of a new therapy to target the dormant cancer stem cell in patients with hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  Tamai Keiichi
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Identifcaiton of cancer stem cells in HNSCC
- Principal Investigator
  
  Morita Shinkichi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Development of highly immunodeficient mice by regulating innate immune systems
- Principal Investigator
  
  Takahashi Takeshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Central Institute for Experimental Animals
Target therapy for cancer-associated fibroblast in pancreatic cancer
- Principal Investigator
  
  Abue Makoto
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
A new targeting therapy against periostin in lung cancer
- Principal Investigator
  
  Nakagawa Takayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Development of non-coding RNA-targeting therapy for refractory renal carcinoma
- Principal Investigator
  
  Kawamura Sadafumi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Identification of a small compound targeting cancer stem cells in cholangiocarcinoma
- Principal Investigator
  
  Yamamoto Kuniharu
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Identification of a dormant cancer stem cell-related genePrincipal Investigator
- Principal Investigator
  
  Tamai Keiichi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Role of CD274 in cancer stem cell of cholangicarcinoma
- Principal Investigator
  
  SHIINA Masaaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Role of Hrs in life cycle of hepatitis C virusPrincipal Investigator
- Principal Investigator
  
  TAMAI Keiichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Roles of ESCRT in Oncogenesis
- Principal Investigator
  
  TANAKA NOBUYUKI
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Analysis of immunological reaction in liver using JFH-1 and establishment of novel therapy
- Principal Investigator
  
  SHIINA Masaaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Miyagi Cancer Center Research Institute
  Tohoku University
Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathwayPrincipal Investigator
- Principal Investigator
  
  TAMAI Keiichi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Miyagi Cancer Center Research Institute

All 2023 2021 2020 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] BEX2 is poor prognostic factor and required for cancer stemness in gastric cancer2023
- Author(s)
  Yasumoto Akihiro、Fujimori Haruna、Mochizuki Mai、Shibuya-Takahashi Rie、Nakamura-Shima Mao、Shindo Norihisa、Yamaguchi Kazunori、Fukushi Daisuke、Wakui Yuta、Sugai Takahiro、Iwai Wataru、Abue Makoto、Sato Ikuro、Satoh Kennichi、Katayose Yu、Yasuda Jun、Shibata Chikashi、Tamai Keiichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 655 Pages: 59-67
- DOI
  10.1016/j.bbrc.2023.03.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03756, KAKENHI-PROJECT-20K17767, KAKENHI-PROJECT-21K07111, KAKENHI-PROJECT-21K07137, KAKENHI-PROJECT-22K07313, KAKENHI-PROJECT-20K17068
[Journal Article] Multi-gene Liquid Biopsy to Detect Resistance to First-line Osimertinib in Patients With<i>EGFR</i>-mutated Lung Adenocarcinoma2023
- Author(s)
  ITO SHIN、TSURUMI KYOJI、SHINDO NORIHISA、SOMA SATOSHI、YAMAGUCHI KAZUNORI、TAMAI KEIICHI、MOCHIZUKI MAI、FUJIMORI HARUNA、MORITA MAMI、WATANABE KANA、SUZUKI AYA、FUKUHARA TATSURO、YASUDA JUN
- Journal Title
  
  Anticancer Research
  
  Volume: 43 Issue: 11 Pages: 5031-5040
- DOI
  10.21873/anticanres.16702
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07111, KAKENHI-PROJECT-20K09701
[Journal Article] Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein2021
- Author(s)
  Saijoh S, Nakamura-Shima M, Shibuya-Takahashi R, Ito R, Sugawara A, Yamazaki T, Imai T, Asada Y, Matsuura K, Iwai W, Wakui Y, Abue M, Kawamura S, Katayose Y, Fujimori H, Mochizuki M, Yasuda J, Yamaguchi K, Sugamura K,Satoh K, Katori Y, Tamai K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 537 Pages: 132-139
- DOI
  10.1016/j.bbrc.2020.11.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03795, KAKENHI-PROJECT-20H03756, KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-19K22793, KAKENHI-PROJECT-21K09665, KAKENHI-PROJECT-19K17952
[Journal Article] Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD2712020
- Author(s)
  Morita Shinkichi、Mochizuki Mai、Shibuya-Takahashi Rie、Nakamura-Shima Mao、Yamazaki Tomoko、Imai Takayuki、Asada Yukinori、Matsuura Kazuto、Kawamura Sadafumi、Yamaguchi Kazunori、Yasuda Jun、Sugamura Kazuo、Katori Yukio、Satoh Kennichi、Tamai Keiichi
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 39 Issue: 1 Pages: 6-11
- DOI
  10.1089/mab.2019.0040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09334, KAKENHI-PROJECT-18K09363, KAKENHI-PROJECT-18K16432, KAKENHI-PROJECT-19K16816, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-17K11166, KAKENHI-PROJECT-17K11414, KAKENHI-PROJECT-19K08430, KAKENHI-PROJECT-19K09295, KAKENHI-PROJECT-19K09903
[Journal Article] CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells2020
- Author(s)
  Hatsuzawa Yuuri、Yamaguchi Kazunori、Takanashi Tomoka、Sato Ikuro、Tamai Keiichi、Mochizuki Mai、Iwai Wataru、Wakui Yuta、Abue Makoto、Yamamoto Kuniharu、Yasuda Jun、Mizuma Masamichi、Unno Michiaki、Sugamura Kazuo
- Journal Title
  
  Pancreatology
  
  Volume: 20 Issue: 3 Pages: 493-500
- DOI
  10.1016/j.pan.2020.01.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05410, KAKENHI-PROJECT-19K17416, KAKENHI-PROJECT-20K17068, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-17K09469, KAKENHI-PROJECT-17K10716, KAKENHI-PROJECT-19K08430, KAKENHI-PROJECT-18K15799
[Journal Article] BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma2020
- Author(s)
  Tamai Keiichi、Nakamura-Shima Mao、Shibuya-Takahashi Rie、Kanno Shin-Ichiro、Yasui Akira、Mochizuki Mai、Iwai Wataru、Wakui Yuta、Abue Makoto、Yamamoto Kuniharu、Miura Koh、Mizuma Masamichi、Unno Michiaki、Kawamura Sadafumi、Sato Ikuro、Yasuda Jun、Yamaguchi Kazunori、Sugamura Kazuo、Satoh Kennichi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 21592-21592
- DOI
  10.1038/s41598-020-78539-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16432, KAKENHI-PROJECT-20K17068, KAKENHI-PROJECT-19H03795, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-17K09469, KAKENHI-PROJECT-17K10716, KAKENHI-PROJECT-17K11166, KAKENHI-PROJECT-19K08430, KAKENHI-PROJECT-18K15799
[Journal Article] Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species2018
- Author(s)
  Yokoyama Misa、Tanuma Nobuhiro、Shibuya Rie、Shiroki Takeharu、Abue Makoto、Yamamoto Kuniharu、Miura Koh、Yamaguchi Kazunori、Sato Ikuro、Tamai Keiichi、Satoh Kennichi
- Journal Title
  
  International Journal of Oncology
  
  Volume: 52 Pages: 881-891
- DOI
  10.3892/ijo.2018.4258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19356, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-15K09055, KAKENHI-PROJECT-17K10716
[Journal Article] Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor?binding protein 2 in renal cell carcinoma2017
- Author(s)
  Katayama Hiromichi、Tamai Keiichi、Shibuya Rie、Nakamura Mao、Mochizuki Mai、Yamaguchi Kazunori、Kawamura Sadafumi、Tochigi Tatsuo、Sato Ikuro、Okanishi Takamasa、Sakurai Kunie、Fujibuchi Wataru、Arai Yoichi、Satoh Kennichi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 12016-12016
- DOI
  10.1038/s41598-017-12191-z
- NAID
  120006364089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06848, KAKENHI-PLANNED-17H06396, KAKENHI-PROJECT-16K07132, KAKENHI-PROJECT-16K20290, KAKENHI-PROJECT-16K07187
[Journal Article] Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells.2017
- Author(s)
  Nasu K, Yamaguchi K, Takanashi T, Tamai K, Sato I, Ine S, Sasaki O, Satoh K, Tanaka N, Tanaka Y, Fukushima T, Harigae H, Sugamura K.
- Journal Title
  
  Cancer Sci
  
  Volume: 108 Issue: 3 Pages: 435-443
- DOI
  10.1111/cas.13163
- NAID
  120006844097
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06848, KAKENHI-PROJECT-16K07187, KAKENHI-PROJECT-16K07132
[Journal Article] Enhanced expression of PKM2 is involved in the gastric cancer development via regulating cancer specific metabolism.2017
- Author(s)
  Shiroki T, Yokoyama M, Tanuma N, Maejima R, Tamai K, Yamaguchi K, Oikawa T, Noguchi T, Miura K, Fujiya T, Shima H, Sato I, Kamiya N, Hatakeyama M, Iijima K, Shimosegawa T and Satoh K.
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中 Issue: 5 Pages: 931-940
- DOI
  10.1111/cas.13211
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-26461967, KAKENHI-PROJECT-26462077, KAKENHI-PROJECT-15K19080, KAKENHI-PROJECT-16K08773, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-16K15273, KAKENHI-PROJECT-16K07132
[Journal Article] ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways2016
- Author(s)
  Oshima R, Hasegawa T, Tamai K, Sugeno N, Yoshida S, Kobayashi J, Kikuchi A, Baba T, Futatsugi A, Sato I, Satoh K, Takeda A, Aoki M and Tanaka N
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 24997-24997
- DOI
  10.1038/srep24997
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461263, KAKENHI-PUBLICLY-15H01550, KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-15K14414, KAKENHI-PROJECT-26461303
[Journal Article] Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling.2014
- Author(s)
  Watanuki, Z.Kosai, H., Osanai, N., Ogama, N., Mochizuki, M., Tamai, K., Yamaguchi, K., Satoh, K., Fukuhara, T., Maemondo, M., Ichinose, M., Nukiwa, T., Tanaka, N.
- Journal Title
  
  Biochem Biophy Res Commun
  
  Volume: 455 Issue: 3-4 Pages: 269-276
- DOI
  10.1016/j.bbrc.2014.11.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24591184, KAKENHI-PROJECT-24592613
[Journal Article] Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer.2014
- Author(s)
  Abue, M., Yokoyama, M., Shibuya, R., Tamai, K., Yamaguchi, K., Sato, I., Tanaka, N., Hamada, S., Shimosegawa, T., Sugamura, K., Satoh, K.
- Journal Title
  
  Int J Oncol
  
  Volume: 10 Issue: 2 Pages: 1-9
- DOI
  10.3892/ijo.2014.2743
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24591022, KAKENHI-PROJECT-25290047, KAKENHI-PROJECT-25670591, KAKENHI-PROJECT-25430163
[Journal Article] Hepatocyte Growth Factor Regulated Tyrosine Kinase Substrate in the peripheral development and function of B-cells2014
- Author(s)
  Nagata T, Murata K, Murata R, Sun S-L, Saito Y, Yamaga S, Tanaka N, Tamai K, Moriya K, Kasai N, Sugamura K, and Ishii N.
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 443 Issue: 2 Pages: 351-356
- DOI
  10.1016/j.bbrc.2013.11.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06848, KAKENHI-PROJECT-23592521, KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24592613, KAKENHI-PROJECT-24659487
[Journal Article] Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma2014
- Author(s)
  Keiichi Tamai, Mao Nakamura, Masamichi Mizuma, Mai Mochizuki, Misa Yokoyama, Hiroyuki Endo, Kazunori Yamaguchi, Takayuki Nakagawa, Masaaki Shiina, Michiaki Unno, Koji Muramoto, Ikuro Sato, Kennichi Satoh, Kazuo Sugamura, and Nobuyuki Tanaka
- Journal Title
  
  Cancer Science
  
  Volume: 105 Issue: 6 Pages: 667-674
- DOI
  10.1111/cas.12406
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-25290047, KAKENHI-PROJECT-25640073, KAKENHI-PROJECT-25860572, KAKENHI-PROJECT-26861427
[Journal Article] Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer2014
- Author(s)
  Nakagawa T, Endo H, Yokoyama M, Abe J, Tamai K, Tanaka N, Sato I, Takahashi S, Kondo T, Satoh K.
- Journal Title
  
  Biochem Biophy Res Commun
  
  Volume: 436 Issue: 2 Pages: 319-324
- DOI
  10.1016/j.bbrc.2013.05.101
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24791480, KAKENHI-PROJECT-25670611, KAKENHI-PROJECT-25860572
[Journal Article] Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer.2013
- Author(s)
  Endo H, Shiroki T, Nakagawa T, Yokoyama M, Tamai K, Yamanami H, Fujiya T, Sato I, Yamaguchi K, Tanaka N, Iijima K, Shimosegawa T, Sugamura K, Satoh K.
- Journal Title
  
  PlosONE
  
  Volume: 8 Issue: 10 Pages: e77070-e77070
- DOI
  10.1371/journal.pone.0077070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592521, KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24570142, KAKENHI-PROJECT-24591022, KAKENHI-PROJECT-24592613, KAKENHI-PROJECT-24791480, KAKENHI-PROJECT-25290047, KAKENHI-PROJECT-25860572
[Journal Article] CD271 Defines a Stem Cell-Like Population in Hypopharyngeal Cancer2013
- Author(s)
  Imai T
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 4 Pages: e62002-e62002
- DOI
  10.1371/journal.pone.0062002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-23592521, KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24570142, KAKENHI-PROJECT-24592613, KAKENHI-PROJECT-25860572, KAKENHI-PROJECT-25861603
[Journal Article] Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway2012
- Author(s)
  Tamai K, Shiina M, Tanaka N, Nakano T, Yamamoto A, Kondo Y, Kakazu E, Inoue J, Fukushima K, Sano K, Ueno Y, Shimosegawa T, Sugamura K.
- Journal Title
  
  Virology
  
  Volume: 22(2) Issue: 2 Pages: 377-85
- DOI
  10.1016/j.virol.2011.11.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22790630, KAKENHI-PROJECT-23790762, KAKENHI-PROJECT-24300326
[Journal Article] AMSH is required to degrade ubiquitinated proteins in the central nervous system2011
- Author(s)
  Suzuki, S.; Tamai, K.; Watanabe, M., et al
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 408(2) Issue: 4 Pages: 582-588
- DOI
  10.1016/j.bbrc.2011.04.065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100005, KAKENHI-PROJECT-21590517, KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22591925, KAKENHI-PROJECT-22790630
[Journal Article] AMSH is required to degrade ubiquitinated proteins in the central nervous system.2011
- Author(s)
  Suzuki S, Tamai K, et al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790630
[Journal Article] Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+circulating monocytes in patients with advanced cirrhosis2011
- Author(s)
  E. Kakazu, Y. Ueno, Y. Kondo, J. Inoue, M. Ninomiya, O. Kimura, Y. Wakui, K. Fukushima, K. Tamai, T. Shimosegawa
- Journal Title
  
  PLoS One
  
  Volume: 6 Issue: 8 Pages: 23402-23402
- DOI
  10.1371/journal.pone.0023402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790630, KAKENHI-PROJECT-23790761, KAKENHI-PROJECT-23790762
[Journal Article] Lymphotropic HCV strain can infect human primary naive CD4(+) cells and affect their proliferation and IFN-gamma secretion activity.2011
- Author(s)
  Kondo Y, Ueno Y, Tamai K(6/10), et al.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 46(2) Pages: 232-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790630
[Journal Article] Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients : influence of hepatitis B virus genotype and resistance mutation pattern.2011
- Author(s)
  Inoue J, Ueno Y, Tamai K(10/13), et al.
- Journal Title
  
  Journal of Viral Hepatitis
  
  Volume: 18 Pages: 206-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790630
[Journal Article] Powered, The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting ofα-Synuclein2011
- Author(s)
  Takafumi Hasegawa, M. Konno, T. Baba, N. Sugeno, A. Kikuchi, M. Kobayashi, E. Miura, N. Tanaka, K. Tamai, K. Furukawa, H. Arai, F. Mori, K. Wakabayashi, M. Aoki, Y. Itoyama, A. Takeda
- Journal Title
  
  PLoS One
- Data Source
  KAKENHI-PROJECT-22790630
[Journal Article] Lymphotropic HCV strain can infect human primary naive CD4+ cells and affect their proliferation and IFN-γ secretion activity2011
- Author(s)
  Kondo Y, Ueno Y, Kakazu E, Kobayashi K, Shiina M, Tamai K, Machida K, Inoue J, Wakui Y, Fukushima K, Obara N, Kimura O, Shimosegawa T
- Journal Title
  
  J Gastroenterol
  
  Volume: 46(2) Issue: 2 Pages: 232-41
- DOI
  10.1007/s00535-010-0297-2
- NAID
  10029027386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22790630
[Journal Article] Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients : influence of hepatitis B virus genotype and resistance mutation pattern2011
- Author(s)
  J. Inoue, Y. Ueno, Y. Wakui, H. Niitsuma, K. Fukushima, Y. Yamagiwa, M. Shiina, Y. Kondo, E. Kakazu, K. Tamai, N. Obara, T. Iwasaki, T. Shimosegawa
- Journal Title
  
  J Viral Hepat
  
  Volume: 18 Issue: 3 Pages: 206-215
- DOI
  10.1111/j.1365-2893.2010.01301.x
- Data Source
  KAKENHI-PROJECT-22790630
[Journal Article] Hepatitis B Virus Replication Could Enhance Regulatory T Cell Activity by Producing Soluble Heat Shock Protein 60 From Hepatocytes.2010
- Author(s)
  Kondo Y, Ueno Y, Tamai K(7/17), et al.
- Journal Title
  
  J Infect Dis.
  
  Volume: 15;202(2) Pages: 202-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790630
[Journal Article] Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes2010
- Author(s)
  Kondo Y, Ueno Y, Kobayashi K, Kakazu E, Shiina M, Inoue J, Tamai K, Wakui Y, Tanaka Y, Ninomiya M, Obara N, Fukushima K, Ishii M, Kobayashi T, Niitsuma H, Kon S, Shimosegawa T
- Journal Title
  
  J Infect Dis.
  
  Volume: 202(2) Issue: 2 Pages: 202-13
- DOI
  10.1086/653496
- Data Source
  KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22790630
[Journal Article] Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein.2010
- Author(s)
  Tamai K, Tanaka N, et al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 27;399(3) Pages: 384-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790630
[Journal Article] Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice2010
- Author(s)
  N. Obara, K. Fukushima, Y. Ueno, Y. Wakui, O. Kimura, K. Tamai, E. Kakazu, J. Inoue, Y. Kondo, N. Ogawa, K. Sato, T. Tsuduki, K. Ishida, T. Shimosegawa
- Journal Title
  
  J Hepatol
  
  Volume: 53 Issue: 2 Pages: 326-334
- DOI
  10.1016/j.jhep.2010.02.029
- Data Source
  KAKENHI-PROJECT-22790630
[Journal Article] Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein2010
- Author(s)
  Tamai K, Tanaka N, Nakano T, Kakazu E, Kondo Y, Inoue J, Shiina M, Fukushima K, Hoshino T, Sano K, Ueno Y, Shimosegawa T, Sugamura K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 399(3) Issue: 3 Pages: 384-90
- DOI
  10.1016/j.bbrc.2010.07.083
- Data Source
  KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22790630
[Presentation] BEX2は肝臓癌における静止期癌幹細胞維持分子である2020
- Author(s)
  福士大介、玉井恵一、小暮高之、片寄友、佐藤賢一
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20H03756
[Presentation] CD271 defines a cancer initiating cell population in hypopharyngeal cancer2015
- Author(s)
  Nobuyuki Tanaka, Takayuki Imai, Mai Mochizuki, Sayuri Sugawara, Keiichi Tamai, Kazunori Yamaguchi, Kennichi Satoh and Kazuo Sugamura
- Organizer
  AACR2015
- Place of Presentation
  米国ペンシルバニア州フィラデルフィア
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24300326
[Presentation] 下咽頭癌における新規がん幹細胞表面マーカー”CD271”の同定2013
- Author(s)
  今井隆之、玉井恵一、山口壱範、佐藤郁郎、佐藤賢一、松浦一登、西條茂、菅村和夫、田中伸幸
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24300326
[Presentation] BEX2は胆管癌細胞株においてがん幹細胞様の性質を制御する2013
- Author(s)
  玉井恵一、中村真央、望月麻衣、小鎌直子、山口壱範、横山美沙、佐藤賢一、菅村和夫、田中伸幸
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24300326
[Presentation] Hrs依存性エクソゾーム経路によるHCV放出制御2010
- Author(s)
  玉井恵一, 田中伸幸, 上野義之, 下瀬川徹, 菅村和夫
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590713
[Presentation] HCV感染における小胞輸送タンパクHrsの役割2010
- Author(s)
  玉井恵一、田中伸幸、上野義之、下瀬川徹、菅村和夫
- Organizer
  第64回日本細菌学会東北支部総会
- Place of Presentation
  仙台
- Year and Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-22790630
[Presentation] HCV感染における小胞輸送タンパクHrsの役割2010
- Author(s)
  玉井恵一、田中伸幸、上野義之、下瀬川徹、菅村和夫
- Organizer
  第64回日本細菌学会東北支部総会
- Place of Presentation
  仙台
- Year and Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-22590713
[Presentation] Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway2010
- Author(s)
  Tamai K, Shiina M, Kondo Y, Kakazu E, Inoue J, Fukushima K, Ueno Y, Tanaka N, Shimosegawa T, Sugamura K
- Organizer
  17th International Meeting on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-22590713
[Presentation] Hrs依存性エクソゾーム経路によるHCV放出制御2010
- Author(s)
  玉井恵一, 田中伸幸, 上野義之, 下瀬川徹, 菅村和夫
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22790630
[Presentation] 非代償性肝硬変のアミノ酸imbalanceは樹状細胞の成熟化を抑制し、分岐鎖アミノ酸(BCAA)により改善する2010
- Author(s)
  嘉数英二, 上野義之, 福島耕治, 近藤泰輝, 椎名正明, 井上淳, 玉井恵一, 小原範之, 木村修, 涌井祐太, 下瀬川徹
- Organizer
  静脈経腸栄養
- Place of Presentation
  東京
- Year and Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-22590713
[Presentation] 下咽頭がん幹細胞マーカーCD271の同定
- Author(s)
  望月麻衣, 今井隆之, 玉井恵一, 佐藤郁郎, 山口壹範, 佐藤賢一, 菅村和夫, 田中伸幸
- Organizer
  日本細菌学会東北支部会
- Place of Presentation
  仙台市
- Year and Date
  2014-08-22 – 2014-08-23
- Data Source
  KAKENHI-PROJECT-24300326
[Presentation] CD271 plays critical roles in invading cancer cells in hypopharyngeal carcinoma
- Author(s)
  Mochizuki, M. Tamai, K., Tanaka, N.
- Organizer
  第73回日本癌学会総会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24300326
[Presentation] BEX2 plays critical roles for maintaining dormant cancer stem cells
- Author(s)
  Tamai, K. Mochizuki, M. Tanaka, N.
- Organizer
  第73回日本癌学会総会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24300326

1. 佐藤賢一 (10282055)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. SHIINA Masaaki (50455820)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. Yamaguchi Kazunori (80373215)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. Yamamoto Kuniharu (00375073)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Takahashi Takeshi (80335215)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 藤盛春奈 (80882935)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KOBAYASHI Koju (30250781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. TANAKA NOBUYUKI (60280872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
9. OGAMA Naoko (30390892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. SUGAMURA Kazuo (20117360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Abue Makoto (50599967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. Nakagawa Takayuki (10626261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Kawamura Sadafumi (40292213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Morita Shinkichi (10773955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. Saijoh Satoshi (00583642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Kayayose Yu (20302151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. Wakui Yuta (50756939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 三浦康 (40282074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 高見一弘 (30823728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 藤井慶太郎 (30839379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 島真央 (50726304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SUGENO Naoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. Nasu Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. Takanashi Tomoka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 渡辺雅彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 長谷川隆文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 安田純

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. 海野倫明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 伊藤信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 高橋莉恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 佐藤郁郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 島礼

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAMAI Keiichi 玉井 恵一

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Development of a new therapy to target the dormant cancer stem cell in patients with hepatocellular carcinomaPrincipal Investigator

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Identification of a dormant cancer stem cell-related genePrincipal Investigator

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TAMAI Keiichi 玉井恵一