Moriya Kei 守屋圭

… Alternative Names

守屋圭モリヤケイ

MORIYA KEI 守屋圭

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Researcher Number	40526852
Other IDs
Affiliation (Current)	2025: 奈良県立医科大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 奈良県立医科大学, 医学部, 研究員 2016 – 2017: 奈良県立医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related Except Principal Investigator Medical pharmacy / Gastroenterology
Keywords	Principal Investigator 酸化ストレス / Nrf2 / ヘスペリジン / 抗酸化剤 / 原発性胆汁性胆管炎 / 抗酸化的機序 / 糖化ヘスペリジン Except Principal Investigator 肝線維化 / ウルソデオキシコール酸 / farnesoid X receptor … More / FXR / OCT1 / 肝癌 / 胆汁酸 / 血管新生 / DPPⅣ阻害剤 / DPPIV阻害剤 / 非アルコール性脂肪肝炎 / PAI-1 / DPP4阻害剤 / PAI-1阻害剤 / SGLT-2阻害剤 / DPP-Ⅳ阻害剤 / ARB / 生活習慣病 / NASH Less

抗酸化Nrf2経路賦活によるPBCの病態改善　―ヘスペリジンを用いた新治療―Principal Investigator
- Principal Investigator
  
  守屋圭
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nara Medical University
Identification of novel treatment and biomarkers based on pharmacokinetics in patients with hepatocellular carcinoma
- Principal Investigator
  
  Namisaki Tadashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nara Medical University
Establishment of new treatment targeting lifestyle diseases and coagulation fibrinolytic system related to the development of NASH
- Principal Investigator
  
  Noguchi Ryuichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nara Medical University

All 2024 2022 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Benefit of glucosyl Hesperidin in patients with primary biliary cholangitis: A multicenter, open-label, randomized control study2022
- Author(s)
  Moriya K, Asada K, Suzuki S, Enomoto M, Fujinaga Y, Tsuji Y, Namisaki T, Yoshiji H.
- Journal Title
  
  Medicine (Baltimore)
  
  Volume: 101 Issue: 48 Pages: e32127-e32127
- DOI
  10.1097/md.0000000000032127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08060
[Journal Article] Clinical significance of the Scheuer histological staging system for primary biliary cholangitis in Japanese patients.2017
- Author(s)
  Namisaki T, Moriya K, Kitade M, Kawaratani H, Takeda K, Okura Y, Takaya H, Nishimura N, Seki K, Kaji K, Sato S, Sawada Y, Yamao J, Mitoro A, Uejima M, Mashitani T, Shimozato N, Nakanishi K, Furukawa M, Saikawa S, Kubo T, Yoshiji H.
- Journal Title
  
  Eur J Gastroenterol Hepatol.
  
  Volume: 29 Pages: 23-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08077
[Journal Article] Effect of combined farnesoid X receptor agonist and angiotensin Ⅱtipe 1 receptor blocker on hepatic fibrosis.2017
- Author(s)
  Namisaki T. Moriya K, Kitade M, Takeda K, Kaji K, Okura Y, Shimozato N. Sato S, Nishimura N, Seki K, Kawaratani H, Takaya H, Sawada Y, Akahane T, Saikawa S, Nakanishi K, Kubo T, Furukawa M, Noguchi R, Asada K, Kitagawa K, Ozutsumi T, Tsuji Y, Kaya H Yoshiji
- Journal Title
  
  Hepatol commun.
  
  Volume: 1 Issue: 9 Pages: 928945-928945
- DOI
  10.1002/hep4.1104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09438, KAKENHI-PROJECT-15K08077
[Journal Article] Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis.2016
- Author(s)
  Namisaki T, Noguchi R, Moriya K, Kitade M, Aihara Y, Douhara A, Nishimura N, Takeda K, Okura Y, Kawaratani H, Takaya H, Seki K, Yoshiji H.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 51 Pages: 162-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461018
[Journal Article] Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, ameliorates the development of liver fibrosis in diabetic Otsuka Long-Evans Tokushima fatty rats.2016
- Author(s)
  Nishimura N, Kitade M, Noguchi R, Namisaki T, Moriya K, Takeda K, Okura Y, Aihara Y, Douhara A, Kawaratani H, Asada K, Yoshiji H.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461018
[Journal Article] Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis.2016
- Author(s)
  Namisaki T, Noguchi R, Moriya K, Kitade M, Aihara Y, Douhara A, Nishimura N, Takeda K, Okura Y, Kawaratani H, Takaya H, Seki K, Yoshiji H
- Journal Title
  
  Ｊｏｕｎａｌ　ｏｆ　Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ
  
  Volume: ５１ Issue: 2 Pages: 162-72
- DOI
  10.1007/s00535-015-1104-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08077, KAKENHI-PROJECT-26461017
[Journal Article] DNA methylation of angiotensin II receptor gene in nonalcoholic steatohepatitis-related liver fibrosis.2016
- Author(s)
  Asada K, Aihara Y, Takaya H, Noguchi R, Namisaki T, Moriya K, Uejima M, Kitade M, Mashitani T, Takeda K, Kawaratani H, Okura Y, Kaji K, Douhara A, Sawada Y, Nishimura N, Seki K, Mitoro A, Yamao J, Yoshiji H.
- Journal Title
  
  World J Hepatol.
  
  Volume: 8 Issue: 28 Pages: 1194-1194
- DOI
  10.4254/wjh.v8.i28.1194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461018
[Journal Article] Efficacy of alogliptin in preventing non-alcoholic fatty liver disease progression in patients with type 2 diabetes.2016
- Author(s)
  Mashitani T, Noguchi R, Okura Y, Namisaki T, Mitoro A, Ishii H, Nakatani T, Kikuchi E, Moriyasu H, Matsumoto M, Sato S, An T, Morita H, Aizawa S, Tokuoka Y, Ishikawa M, Matsumura Y, Ohira H, Kogure A, Noguchi K, Yoshiji H.
- Journal Title
  
  Biomed Rep.
  
  Volume: 4 Pages: 183-187
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461018
[Journal Article] Combined treatment with dipeptidyl peptidase-4 inhibitor (sitagliptin) and angiotensin-II type 1 receptor blocker (losartan) suppresses progression in a non-diabetic rat model of steatohepatitis.2016
- Author(s)
  Okura Y,Yoshiji H.
- Journal Title
  
  Hepatol Res
  
  Volume: Dec28 Issue: 12 Pages: 1317-1328
- DOI
  10.1111/hepr.12860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461017, KAKENHI-PROJECT-26461018, KAKENHI-PROJECT-15K08077
[Journal Article] Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model.2015
- Author(s)
  Douhara A, Moriya K, Yoshiji H, Noguchi R, Namisaki T, Kitade M, Kaji K, Aihara Y, Nishimura N, Takeda K, Okura Y, Kawaratani H, Fukui H.
- Journal Title
  
  Mol Med Rep.
  
  Volume: 11 Pages: 1693-1700
- NAID
  40020982272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461018
[Presentation] A NEW APPROACH TO IMPROVE THE PATHOPHYSIOLOGY OF PRIMARY BILIARY CHOLANGITIS BY ACTIVATING THE NRF2/KEAP1 PATHWAY2024
- Author(s)
  Kei Moriya, Yusuke Komeda, Yuya Matsuo, Daisuke Kaya, Shinsaku Nagamatsu, Masakazu Uejima, Hideki Matsuo
- Organizer
  DDW2024（米国消化器病学会週間）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08060
[Presentation] Biochemical response to ursodeoxycholic acid predicts histologic primary ciliary cholangitis progression2018
- Author(s)
  Namisaki T, Fujinaga Y, Moriya K, Kitade M, Kaji K, Kawaratani H, Seki K, Takaya H, Sato S, Sawada Y, Akahane T, Yoshji H
- Organizer
  EASL
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08077
[Presentation] Biochemical response to ursodeoxycholic acid predicts histologic primary biliary cholangitis progression2018
- Author(s)
  Fujinaga Y, Namisaki T, Moriya K, Kitade M, Kawaratani H, Kaji K, Okura Y, Seki K, Takaya H, Sawada Y, Akahane T, Nishimura N, Sato S, Shimozato N, Saikawa S, Nakanishi K, Kubo T, Furukawa M, Yoshiji H
- Organizer
  AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08077
[Presentation] Beneficial effects of combined farnesoid X receptor agonist(INT747) and dipeptidyl peptidase-4 inhibitor(sitagliptin) on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis2017
- Author(s)
  Shimozato N, Namisaki T, Moriya K, Kitade M, Takeda K, Kawaratani H, Kaji K, Okura Y, Takaya H, Sawada Y, Nishimura N, Sato S, Saikawa S, Seki K, Furukawa M, Nakanishi K, Kubo T, Yoshiji H
- Organizer
  AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08077
[Presentation] Combination treatment of dipeptidyl peptidase IV inhibitor and angiotensin-II type 1 receptor blocker attenuates progression of nonalcoholic steatohepatitis in rats2016
- Author(s)
  Shinya Sato, Tadashi Namisaki, Kosuke Kaji, Norihisa Nishimura, Yasushi Okura, Ryuichi Noguchi, Kosuke Takeda, Kei Moriya, Mitsuteru Kitade, Kenichiro Seki, Hiroaki Takaya, Hideto Kawaratani, Yasuhiko Sawada, Naotaka Shimozato, Keisuke Nakanishi, Hitoshi Yoshiji
- Organizer
  アメリカ肝臓学会
- Place of Presentation
  ボストン　US
- Year and Date
  2016-11-11
- Data Source
  KAKENHI-PROJECT-15K08077
[Presentation] Antifibrotic effects of combined treatment with Farnesoid X receptor agonist and angiotensin-II type1 receptor blocker on hepatic fibrogenesis in the rat model of nonalcoholic steatohepatitis2016
- Author(s)
  Tadashi Namisaki, Yasushi Okura, Shinya Sato, Ryuichi Noguchi, Kei Moriya, Mitsuteru Kitade, Kosuke Takeda, Yosuke Aihara, Norihisa Nishimura, Yasuhiko Sawada, Kenichiro Seki, Hideto Kawaratani, Kosuke Kaji, Hitoshi Yoshiji.
- Organizer
  ヨーロッパ肝臓学会
- Place of Presentation
  バルセロナ　スペイン
- Year and Date
  2016-04-13
- Data Source
  KAKENHI-PROJECT-15K08077
[Presentation] DPP4阻害薬及びアンギオテンシンII受容体拮抗薬併用による肝病態進展抑制効2016
- Author(s)
  大倉康志、浪崎正、野口隆一、守屋圭、北出光輝、竹田幸祐、瓦谷英人、相原洋祐、西村典久、佐藤慎哉、澤田保彦、関建一郎、増谷剛、鍛冶孝佑、吉治仁志
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2016-04-22
- Data Source
  KAKENHI-PROJECT-26461018

1. Noguchi Ryuichi (30423908)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. NAMISAKI TADASHI (20526850)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. KITADE MITSUTERU (40526795)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. 吉治仁志 (40336855)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
5. NISHIMURA NORIHISA

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
6. MATSUMOTO MASANORI (60316081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. MASHITANI TSUYOSHI (20401929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 鍛治孝祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Moriya Kei 守屋 圭

守屋 圭 モリヤ ケイ

MORIYA KEI 守屋 圭

Research Projects

Research Products

Co-Researchers

抗酸化Nrf2経路賦活によるPBCの病態改善 ―ヘスペリジンを用いた新治療―Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel treatment and biomarkers based on pharmacokinetics in patients with hepatocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of new treatment targeting lifestyle diseases and coagulation fibrinolytic system related to the development of NASH

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Benefit of glucosyl Hesperidin in patients with primary biliary cholangitis: A multicenter, open-label, randomized control study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of the Scheuer histological staging system for primary biliary cholangitis in Japanese patients.2017

Author(s)

Journal Title

Data Source

[Journal Article] Effect of combined farnesoid X receptor agonist and angiotensin Ⅱtipe 1 receptor blocker on hepatic fibrosis.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis.2016

Author(s)

Journal Title

Data Source

[Journal Article] Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, ameliorates the development of liver fibrosis in diabetic Otsuka Long-Evans Tokushima fatty rats.2016

Author(s)

Journal Title

Data Source

[Journal Article] Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA methylation of angiotensin II receptor gene in nonalcoholic steatohepatitis-related liver fibrosis.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of alogliptin in preventing non-alcoholic fatty liver disease progression in patients with type 2 diabetes.2016

Author(s)

Journal Title

Data Source

[Journal Article] Combined treatment with dipeptidyl peptidase-4 inhibitor (sitagliptin) and angiotensin-II type 1 receptor blocker (losartan) suppresses progression in a non-diabetic rat model of steatohepatitis.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model.2015

Author(s)

Journal Title

NAID

Data Source

[Presentation] A NEW APPROACH TO IMPROVE THE PATHOPHYSIOLOGY OF PRIMARY BILIARY CHOLANGITIS BY ACTIVATING THE NRF2/KEAP1 PATHWAY2024

Author(s)

Organizer

Data Source

[Presentation] Biochemical response to ursodeoxycholic acid predicts histologic primary ciliary cholangitis progression2018

Author(s)

Organizer

Data Source

[Presentation] Biochemical response to ursodeoxycholic acid predicts histologic primary biliary cholangitis progression2018

Author(s)

Moriya Kei 守屋圭

守屋圭モリヤケイ

MORIYA KEI 守屋圭

抗酸化Nrf2経路賦活によるPBCの病態改善　―ヘスペリジンを用いた新治療―Principal Investigator