Kohara Hiroshi 小原洋志

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KOHARA Hiroshi 小原洋志

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Researcher Number	40528733
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2019: 東京大学, 医科学研究所, 特任講師 2014: 九州大学, 生体防御医学研究所, 研究員 2009 – 2010: Kyoto University, 医学研究科, 研究員
Review Section/Research Field	Principal Investigator Hematology / Biofunction/Bioprocess Except Principal Investigator Pediatrics
Keywords	Principal Investigator iPS細胞 / ES細胞 / 白血病 / 発生・分化 / 内科 / 先天性骨髄形成異常性貧血 / ヒトES細胞 / がん抑制遺伝子 / がん遺伝子 / 加齢変化 … More / 骨形成 / 血管新生 / 神経ペプチド / 徐放 / ゼラチンハイドロゲル / バイオマテリアル … More Except Principal Investigator ミトコンドリア / 疾患特異的iPS細胞 / オートファジー / 赤芽球分化 / iPS細胞 / 先天性溶血性貧血 / ターゲット遺伝子シーケンスパネル / 次世代シークエンサー / 新生児溶血性貧血 / フローサイトメトリー / 赤血球浸透圧脆弱性 / 赤血球酵素 / 赤血球膜タンパク質 / 先天性赤血球形成異常性貧血 / 転写因子 / 細胞周期 / 赤血球分化 / 赤血球酵素異常症 / 赤血球膜異常症 / 疾患遺伝子パネル / 次世代型シークエンサー / 無効造血 / 溶血性貧血 Less

iPS細胞を活用した先天性赤血球異常症の病態解析と新規治療標的の探索Principal Investigator
- Principal Investigator
  
  小原洋志
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Pathological analysis of congenital hemolytic anemia due to mitochondrial selective autophagy disorder
- Principal Investigator
  
  KANNO HITOSHI
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Women's Medical University
Mechanical dissection of leukemic stem cell generation by using primate ES/iPS cell-derived hematopoietic stem/progenitor cellsPrincipal Investigator
- Principal Investigator
  
  Kohara Hiroshi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
p53ノックアウト霊長類ES/iPS細胞を利用した白血病幹細胞発生機構の解明Principal Investigator
- Principal Investigator
  
  小原洋志
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
a novel approach to create and characterize bone and bone marrow by the combination of tissue engineering and hematologyPrincipal Investigator
- Principal Investigator
  
  KOHARA Hiroshi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Kyoto University

All 2019 2017 2016 2010 2009

All Journal Article Presentation

[Journal Article] KLF1 Mutation E325K Induces Cell-cycle Arrest in Erythroid Cells Differentiated from Congenital Dyserythropoietic Anemia (CDA) Patient-specific Induced Pluripotent Stem Cells.2019
- Author(s)
  Kohara H, Utsugisawa T, Sakamoto C, Hirose L, Ogawa Y, Ogura H, Sugawara A, Aoki T, Iwasaki T, Asai T, Doisaki S, Okuno Y, Muramatsu H, Abe T, Kurita R, Miyamoto S, Sakuma T, Shiba M, Yamamoto T, Ohga S, Yoshida K, Ogawa S, Ito E, Kojima S, Kanno H, Tani K.
- Journal Title
  
  Exp Hematol.
  
  Volume: 73 Pages: 25-37
- DOI
  10.1016/j.exphem.2019.03.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-17H01547, KAKENHI-PROJECT-19K16500, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-16K10041, KAKENHI-PROJECT-16K19181
[Journal Article] 遺伝性メトヘモグロビン血症Ⅰ型の兄妹例2019
- Author(s)
  羽賀洋一、高橋浩之、三井一賢、中村俊紀、松岡正樹、小嶋靖子、小倉浩美、菅野仁、服部幸夫、小原明
- Journal Title
  
  日本小児科学会雑誌
  
  Volume: 123 Pages: 861-865
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10041
[Journal Article] Angiogenesis induced by controlled release of neuropeptide substance P2010
- Author(s)
  Kohara H, Tajima S, Yamamoto M, Tabata Y.
- Journal Title
  
  31巻
  
  Pages: 8617-8625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21860051
[Journal Article] Angiogenesis induced by controlled release of neuropeptide substance P2010
- Author(s)
  Kohara H, Tajima S, Yamamoto M, Tabata Y
- Journal Title
  
  Biomaterials
  
  Volume: 31 Pages: 8617-8625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21860051
[Presentation] Functional Analysis of Congenital Dyserythropoietic Anemia (CDA) Patient-Specific Induced Pluripotent Stem Cells2017
- Author(s)
  Hiroshi Kohara, Hiromi Ogura, Takako Aoki, Yoshie Ogawa, Chika Sakamoto, Shohei Miyamoto, Hitoshi Kanno, Kenzaburo Tani
- Organizer
  第8回日本血液学会国際シンポジウム
- Place of Presentation
  宮崎シーガイア
- Year and Date
  2017-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16183
[Presentation] Functional analysis of congenital dyserythropoietic anemia (CDA) -specific iPS cells2017
- Author(s)
  Hiroshi Kohara, Yoshie Ogawa, Taiju Utsugisawa, Chika Sakamoto, Shohei Miyamoto, Hitoshi Kanno, Kenzaburo Tani
- Organizer
  第79回日本血液学会学術集会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2017-10-20
- Data Source
  KAKENHI-PROJECT-17K16183
[Presentation] Inducible KLF1 Gene Expression Successfully Ameliorates Hemoglobin Switching in Erythroid Cells Derived from Congenital Dyserythropoietic Anemia (CDA) Patient Specific iPS Cells2017
- Author(s)
  Hiroshi Kohara, Yoshie Ogawa, Shohei Miyamoto, Hiromi Ogura, Taiju Utsugisawa, Hitoshi Kanno, Kenzaburo Tani
- Organizer
  第20回米国遺伝子細胞治療学会年会
- Place of Presentation
  The Marriott Wardman Park Hotel, ワシントンDC, 米国
- Year and Date
  2017-05-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16183
[Presentation] Inducible KLF1 Gene Expression Ameliorates Hemoglobin Switching in Erythroid Cells Derived from Congenital Dyserythropoietic Anemia (CDA) Patient Specific iPS Cells2017
- Author(s)
  Hiroshi Kohara, Yoshie Ogawa, Shohei Miyamoto, Hiromi Ogura, Taiju Utsugisawa, Hitoshi Kanno, Kenzaburo Tani
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2017-07-20
- Data Source
  KAKENHI-PROJECT-17K16183
[Presentation] Generation and Fanctional Analysis of Congenital Dyserythropoietic Anemia(CDA) Patient-Specific Induced Pluripotent Stem Cells2016
- Author(s)
  Hiroshi Kohara, Hiromi Ogura, Takako Aoki, Chika Sakamoto, Yoshie Ogawa, Shohei Miyamoto, Hitoshi Kanno, Kenzaburo Tani
- Organizer
  American Society of Hematology, 58th Annual Meeting ＆Exposition
- Place of Presentation
  San Diego（America)
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10041
[Presentation] Role of P53 on T lymphopoisis from Human Embryonic Stem Cells2016
- Author(s)
  小原　洋志
- Organizer
  American Society of Gene & Cell Therapy 19th Annual Meeting
- Place of Presentation
  ワシントンDC, 米国
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19552
[Presentation] ゼラチンハイドロゲルを用いた神経ペプチド徐放システムによる血管新生誘導2010
- Author(s)
  小原洋志、田畑泰彦
- Organizer
  第39回医用高分子シンポジウム
- Place of Presentation
  東京大学(東京都)
- Data Source
  KAKENHI-PROJECT-21860051
[Presentation] The controlled release of neuropeptide induces angiogenesis2010
- Author(s)
  Kohara H., Yamamoto, M., Tabata Y
- Organizer
  Biomedical Engineering Society 2010 Annual Meeting
- Place of Presentation
  Austin Convention Center (米国テキサス州)
- Data Source
  KAKENHI-PROJECT-21860051
[Presentation] 徐放化神経ペプチドによる血管新生の誘導2010
- Author(s)
  小原洋志、田畑泰彦
- Organizer
  第31回日本炎症・再生医学会
- Place of Presentation
  京王プラザホテル(東京都)
- Data Source
  KAKENHI-PROJECT-21860051
[Presentation] The controlled release of neuropeptide induces angiogenesis.2010
- Author(s)
  Kohara, H., Yamamoto, M., Tabata, Y.
- Organizer
  Biomedical Engineering Society 2010 Annual Meeting.
- Place of Presentation
  Austin Convention Center (米国)
- Data Source
  KAKENHI-PROJECT-21860051
[Presentation] ゼラチンハイドロゲルを用いた神経ペプチドの徐放による血管新生誘導2009
- Author(s)
  小原洋志
- Organizer
  第31回日本バイオマテリアル学会
- Place of Presentation
  京都テルサ (京都府)
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21860051
[Presentation] ゼラチンハイドロゲルを用いた神経ペプチドの徐放による血管新生誘導2009
- Author(s)
  小原洋志
- Organizer
  第31回日本バイオマテリアル学会
- Place of Presentation
  京都テルサ(京都府)
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21860051

1. KANNO HITOSHI (70221207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kohara Hiroshi 小原 洋志

KOHARA Hiroshi 小原 洋志

Research Projects

Research Products

Co-Researchers

iPS細胞を活用した先天性赤血球異常症の病態解析と新規治療標的の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathological analysis of congenital hemolytic anemia due to mitochondrial selective autophagy disorder

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanical dissection of leukemic stem cell generation by using primate ES/iPS cell-derived hematopoietic stem/progenitor cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

p53ノックアウト霊長類ES/iPS細胞を利用した白血病幹細胞発生機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

a novel approach to create and characterize bone and bone marrow by the combination of tissue engineering and hematologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] KLF1 Mutation E325K Induces Cell-cycle Arrest in Erythroid Cells Differentiated from Congenital Dyserythropoietic Anemia (CDA) Patient-specific Induced Pluripotent Stem Cells.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 遺伝性メトヘモグロビン血症Ⅰ型の兄妹例2019

Author(s)

Journal Title

Data Source

[Journal Article] Angiogenesis induced by controlled release of neuropeptide substance P2010

Author(s)

Journal Title

Data Source

[Journal Article] Angiogenesis induced by controlled release of neuropeptide substance P2010

Author(s)

Journal Title

Data Source

[Presentation] Functional Analysis of Congenital Dyserythropoietic Anemia (CDA) Patient-Specific Induced Pluripotent Stem Cells2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Functional analysis of congenital dyserythropoietic anemia (CDA) -specific iPS cells2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Inducible KLF1 Gene Expression Successfully Ameliorates Hemoglobin Switching in Erythroid Cells Derived from Congenital Dyserythropoietic Anemia (CDA) Patient Specific iPS Cells2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Inducible KLF1 Gene Expression Ameliorates Hemoglobin Switching in Erythroid Cells Derived from Congenital Dyserythropoietic Anemia (CDA) Patient Specific iPS Cells2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Generation and Fanctional Analysis of Congenital Dyserythropoietic Anemia(CDA) Patient-Specific Induced Pluripotent Stem Cells2016

Author(s)

Organizer

Place of Presentation

Kohara Hiroshi 小原洋志

KOHARA Hiroshi 小原洋志