YABE SHIGEHARU 矢部茂治

… Alternative Names

Yabe Shigeharu 矢部茂治

YABE Shigeharu 矢部茂治

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Researcher Number	40533716
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療研究所, 上級研究員
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人国立国際医療研究センター, 研究所, 細胞組織再生医学研究部上級研究員 2021 – 2022: 国立研究開発法人国立国際医療研究センター, 研究所, 細胞組織再生医学研究部上級研究員 2020: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員(移行) 2017: 国立国際医療研究センター, 細胞組織再生医学研究部, 上級研究員 2015: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員 2014: 独立行政法人国立国際医療研究センター, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Experimental pathology Except Principal Investigator Dermatology
Keywords	Principal Investigator ヒトiPS細胞 / 膵α細胞 / 膵β細胞 / 糖尿病 / インスリン / アセチルコリン / iPS-膵島 / 高血糖 / アルギン酸fiber / hPSCs … More / アルギン酸ファイバー / グルカゴン / MODY / 疾患iPS / iPS細胞 … More Except Principal Investigator 毛包誘導能 / 毛包再構築実験 / Bmi1遺伝子 / 不死化 / BMI1遺伝子 / TERT遺伝子 / 毛包再生 / 毛乳頭細胞 Less

Analysis of acetylcholine secretion and interaction between pancreatic beta and alpha cells by human iPSCs-derived pancreatic alpha cells.Principal Investigator
- Principal Investigator
  
  矢部茂治
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Center for Global Health and Medicine
Differentiation method of human pluripotent stem cells-derived pancratic alpha cellsPrincipal Investigator
- Principal Investigator
  
  Yabe Shigeharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Center for Global Health and Medicine
Establishment of Immortal Dermal papilla cells and Hair follicle regeneration technology
- Principal Investigator
  
  Kiso Masahiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  National Center for Global Health and Medicine
Pathologic analysis of MODY using pancreatic beta cells derived from MODY-iPS cells.Principal Investigator
- Principal Investigator
  
  Yabe Shigeharu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  National Center for Global Health and Medicine

All 2023 2022 2021 2018 2016 2015 2014

All Journal Article Presentation Book Patent

[Book] 膵島の再生医療-膵β細胞の発生と再生をめぐる新展開-第２章５　疾患iPS技術を利用した遺伝性糖尿病の解明と再生2015
- Author(s)
  矢部茂治、大河内仁志
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-26860272
[Book] 膵島の再生医療ー膵β細胞の発生と再生をめぐる新展開ー第2章5 疾患iPS技術を利用した遺伝子性糖の解明と再生2015
- Author(s)
  矢部茂治、大河内仁志
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-26860272
[Journal Article] Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug Evaluation2022
- Author(s)
  Higashi-Kuwata Nobuyo、Yabe Shigeharu G.、Fukuda Satsuki、Nishida Junko、Tamura-Nakano Miwa、Hattori Shin-ichiro、Okochi Hitoshi、Mitsuya Hiroaki
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 10 Issue: 6 Pages: 1-5
- DOI
  10.1128/spectrum.03490-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08321
[Journal Article] TERT/BMI1-transgenic human dermal papilla cells enhance murine hair follicle formation in vivo2022
- Author(s)
  Ikeda Mayumi、Yabe Shigeharu、Kiso Masahiro、Ishiguro Naoko、Tsunemi Yuichiro、Okochi Hitoshi
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 106 Issue: 2 Pages: 78-85
- DOI
  10.1016/j.jdermsci.2022.03.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08321
[Journal Article] Efficient induction of pancreatic alpha cells from human induced pluripotent stem cells by controlling the timing for BMP antagonism and activation of retinoic acid signaling2021
- Author(s)
  Yabe Shigeharu G.、Fukuda Satsuki、Nishida Junko、Takeda Fujie、Nashiro Kiyoko、Okochi Hitoshi
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 1 Pages: e0245204-e0245204
- DOI
  10.1371/journal.pone.0245204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08321
[Journal Article] Lotus-root-shaped cell-encapsulated construct as a retrieval graft for long-term transplantation of human iPSC-derived β-cells2021
- Author(s)
  Fumisato Ozawa, Shogo Nagata, Haruka Oda, Shigeharu G Yabe , Hitoshi Okochi , Shoji Takeuchi
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 4 Pages: 102309-102309
- DOI
  10.1016/j.isci.2021.102309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20664, KAKENHI-PROJECT-16H06329, KAKENHI-PROJECT-20K08321
[Journal Article] Introduction of the TERT and BMI1 genes into murine dermal papilla cells ameliorates hair inductive activity2018
- Author(s)
  Kiso Masahiro、Yabe Shigeharu、Itoh Munenari、Nakagawa Hidemi、Okochi Hitoshi
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 90 Issue: 2 Pages: 218-221
- DOI
  10.1016/j.jdermsci.2018.02.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19740
[Journal Article] Efficient Generation of Functional Pancreatic β Cells from Human iPS Cells2016
- Author(s)
  Yabe SG, Fukuda S, Takeda F, Nashiro K and Okochi H.
- Journal Title
  
  Journal of Diabetes
  
  Volume: in press Issue: 2 Pages: 168-179
- DOI
  10.1111/1753-0407.12400
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860272
[Journal Article] Safety assessment of bone marrow derived MSC grown in platelet-rich plasma2015
- Author(s)
  Fukuda S, Hagiwara S, Fukuda S, Yakabe R, Suzuki H, Yabe SG et al.
- Journal Title
  
  Regenerative Therapy
  
  Volume: 1 Pages: 72-79
- DOI
  10.1016/j.reth.2015.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860272
[Journal Article] Establishment of Maturity Onset Diabetes of the Young (MODY)-iPS cells from Japanese patient2015
- Author(s)
  Yabe SG, Iwasaki N, Yasuda K, Hamazaki TS, Konno M et al.
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: in press Issue: 5 Pages: 543-547
- DOI
  10.1111/jdi.12334
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860272, KAKENHI-PROJECT-26670604
[Journal Article] Murine Insulinoma Cell-Conditioned Medium with BETA2/Neurod1 Transduction Efficiently Induces the Differentiation of Adipose-Drived Mesenchymal Stem Cells into β-Like Cells both In Vitro and In Vivo2014
- Author(s)
  Kawamoto K, Yabe S, Konno M et al.
- Journal Title
  
  Journal of Stem Cell Research & Therapy
  
  Volume: 4 Pages: 221-230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26860272
[Patent] 膵臓α細胞への分化誘導法2021
- Inventor(s)
  矢部茂治、木村圭一、伊吹将人、大河内仁志
- Industrial Property Rights Holder
  矢部茂治、木村圭一、伊吹将人、大河内仁志
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20K08321
[Patent] 膵臓α細胞への分化誘導方法2021
- Inventor(s)
  矢部茂治、木村圭一、伊吹将人、大河内仁志
- Industrial Property Rights Holder
  矢部茂治、木村圭一、伊吹将人、大河内仁志
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20K08321
[Presentation] 3次元浮遊培養法によるヒトiPS細胞由来2型肺胞上皮細胞の分化誘導2023
- Author(s)
  矢部茂治、福田沙月、西田淳子、武田冨志枝、大河内仁志
- Organizer
  第22回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-20K08321
[Presentation] ヒトiPS細胞由来SARS-CoV-2の宿主細胞の分化誘導2022
- Author(s)
  矢部茂治、福田沙月、西田淳子、武田冨志枝、大河内仁志
- Organizer
  第21回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-20K08321
[Presentation] ヒトiPS細胞由来膵α細胞の分化誘導2021
- Author(s)
  矢部茂治、福田沙月、西田淳子、武田冨志枝、名城淨子、大河内仁志
- Organizer
  第20回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-20K08321
[Presentation] ヒトiPS細胞由来膵α細胞の分化誘導2021
- Author(s)
  矢部茂治、福田沙月、西田淳子、武田冨志枝、名城淨子、大河内仁志
- Organizer
  第20回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-20K08321
[Presentation] ヒトiPS細胞から機能的膵β細胞(iPS-beta)の分化誘導2016
- Author(s)
  矢部茂治、福田沙月、霜田雅之、大河内仁志
- Organizer
  第15回日本再生医療学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-26860272
[Presentation] 遺伝性糖尿病 (MODY)患者由来iPS細胞の膵β細胞分化過程におけるNMDによるMODY変異mRNAの分解2015
- Author(s)
  矢部茂治・岩崎直子・安田和基・浜崎辰夫・福田沙月・大河内仁志
- Organizer
  第12回日本再生医療学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-26860272

1. Kiso Masahiro (20769517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. Okochi Hitoshi (30185235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. ITOH Munenari (20408371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. NAKAGAWA Hidemi (20114580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 小沢文智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YABE SHIGEHARU 矢部 茂治

Yabe Shigeharu 矢部 茂治

YABE Shigeharu 矢部 茂治

Research Projects

Research Products

Co-Researchers

Analysis of acetylcholine secretion and interaction between pancreatic beta and alpha cells by human iPSCs-derived pancreatic alpha cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Differentiation method of human pluripotent stem cells-derived pancratic alpha cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of Immortal Dermal papilla cells and Hair follicle regeneration technology

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathologic analysis of MODY using pancreatic beta cells derived from MODY-iPS cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 膵島の再生医療-膵β細胞の発生と再生をめぐる新展開-第２章５ 疾患iPS技術を利用した遺伝性糖尿病の解明と再生2015

Author(s)

Publisher

Data Source

[Book] 膵島の再生医療ー膵β細胞の発生と再生をめぐる新展開ー第2章5 疾患iPS技術を利用した遺伝子性糖の解明と再生2015

Author(s)

Publisher

Data Source

[Journal Article] Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug Evaluation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TERT/BMI1-transgenic human dermal papilla cells enhance murine hair follicle formation in vivo2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient induction of pancreatic alpha cells from human induced pluripotent stem cells by controlling the timing for BMP antagonism and activation of retinoic acid signaling2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lotus-root-shaped cell-encapsulated construct as a retrieval graft for long-term transplantation of human iPSC-derived β-cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Introduction of the TERT and BMI1 genes into murine dermal papilla cells ameliorates hair inductive activity2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient Generation of Functional Pancreatic β Cells from Human iPS Cells2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Safety assessment of bone marrow derived MSC grown in platelet-rich plasma2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of Maturity Onset Diabetes of the Young (MODY)-iPS cells from Japanese patient2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Murine Insulinoma Cell-Conditioned Medium with BETA2/Neurod1 Transduction Efficiently Induces the Differentiation of Adipose-Drived Mesenchymal Stem Cells into β-Like Cells both In Vitro and In Vivo2014

Author(s)

YABE SHIGEHARU 矢部茂治

Yabe Shigeharu 矢部茂治

YABE Shigeharu 矢部茂治

[Book] 膵島の再生医療-膵β細胞の発生と再生をめぐる新展開-第２章５　疾患iPS技術を利用した遺伝性糖尿病の解明と再生2015