FUJIKI Ryoji 藤木亮次

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Ryoji Fujiki 藤木亮次

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Researcher Number	40534516
Other IDs
Affiliation (Current)	2025: 千葉大学, 医学部附属病院, 特任助教
Affiliation (based on the past Project Information) *help	2024: 千葉大学, 医学部附属病院, 特任助教 2019 – 2023: 公益財団法人かずさDNA研究所, ゲノム事業推進部, 特任研究員 2021 – 2022: 千葉大学, 医学部附属病院, 特任助教 2010 – 2012: 東京大学, 分子細胞生物学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Complex systems / Molecular biology Except Principal Investigator Basic Section 53020:Cardiology-related / Biological Sciences
Keywords	Principal Investigator クロマチン / がん / 糖修飾 / 転写制御 / 転写 / AI / 胃がん / エピジェネティクス / クロマチンリモデリング / ARID1A … More Except Principal Investigator … More 大動脈 / 病態解析 / 遺伝性疾患 / 循環器 / 病因遺伝子 / DNAメチル化修飾 / ヒストンアセチル化修飾 / 性ホルモン受容体 / クロマチン高次構造 / Zfpタンパク / Y染色体 / エピジェネティクス / 性差 / クロマチン / エピゲノム / 核内受容体 / 性ホルモン Less

AI技術によるARID1A欠損胃がんクロマチン構造異常の検出Principal Investigator
- Principal Investigator
  
  藤木亮次
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Chiba University
Impacts of ARID1A driver mutation in gastric cancer developmentPrincipal Investigator
- Principal Investigator
  
  Ryoji Fujiki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Chiba University
Pathophysiological Study on Aortopathy towards Prevention
- Principal Investigator
  
  MORISAKI TAKAYUKI
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
性差構築におけるエピゲノムコードの解明
- Principal Investigator
  
  武山健一
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
核内糖修飾シグナルを制御する過渡的複合体の同定の試みPrincipal Investigator
- Principal Investigator
  
  藤木亮次
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
転写を制御する核内糖修飾シグナルの試験管内解析Principal Investigator
- Principal Investigator
  
  藤木亮次
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
The identification and molecular function of nuclear glycosyl transferase complexPrincipal Investigator
- Principal Investigator
  
  FUJIKI Ryoji
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo

All 2022 2012 2011 2010

All Journal Article Presentation Patent

[Journal Article] ARID1A loss-of-function induces CpG island methylator phenotype2022
- Author(s)
  Yamada Harumi、Takeshima Hideyuki、Fujiki Ryoji、Yamashita Satoshi、Sekine Shigeki、Ando Takayuki、Hattori Naoko、Okabe Atsushi、Yoshikawa Takaki、Obama Kazutaka、Katai Hitoshi、Kaneda Atsushi、Ushijima Toshikazu
- Journal Title
  
  Cancer Letters
  
  Volume: 532 Pages: 215587-215587
- DOI
  10.1016/j.canlet.2022.215587
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08456, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-21K15525
[Journal Article] GlcNAcylation of histone H2B facilitates its monoubiquitination2011
- Author(s)
  Fujiki R., Hashiba W., Sekine H., Yokoyama A., Chikanishi T., Ito S., Imai Y., Kim J., He HH., Igarashi K., Kanno J., Ohtake F., Kitagawa H., Roeder RG., Brown M., Kato S.
- Journal Title
  
  Nature
  
  Volume: 480 Pages: 557-560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Nuclear receptor coregulators merge transcriptional coregulation with epigenetic regulation2011
- Author(s)
  Kato S., Yokoyama A., Fujiki R.
- Journal Title
  
  Trends Biochem Sci
  
  Volume: 36 Pages: 272-281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Transcriptional controls by nuclear fat-soluble vitamin receptors through chromatin reorganization2011
- Author(s)
  Kato S., Fujiki R.
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 75 Pages: 410-413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] GlcNAcylation of histone H2B facilitates its monoubiquitination2011
- Author(s)
  Fujiki R, Hashiba W, Sekine H, Yokoyama A, Chikanishi T, Ito S, Imai Y, Kim J, He HH, Igarashi K, Kanno J, Ohtake F, Kitagawa H, Roeder RG, Brown M, Kato S
- Journal Title
  
  Nature
  
  Volume: 480(7378) Issue: 7378 Pages: 557-560
- DOI
  10.1038/nature10656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04044, KAKENHI-PUBLICLY-22121502, KAKENHI-PROJECT-22780086, KAKENHI-PROJECT-23659712, KAKENHI-PROJECT-23689066
[Journal Article] Williams syndrome is an epigenome-regulator disease2011
- Author(s)
  Kitagawa H., Fujiki R., Yoshimura K., Oya H., Kato S.
- Journal Title
  
  Endocr J
  
  Volume: 58 Pages: 77-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Multiple post-translational modifications in hepatocyte nuclear factor 4alpha2011
- Author(s)
  Yokoyama A., Katsura S., Ito R., Hashiba W., Sekine H., Fujiki R., Kato S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 410 Pages: 749-753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Nuclear receptor coregulators merge transcriptional coregulation with epigenetic regulation.2011
- Author(s)
  Kato S, Yokoyama A, Fujiki R.
- Journal Title
  
  Trends Biochem.Sci.
  
  Volume: (In press)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Regulated histone methyltransferase and demethylase complexes in the control of genes by nuclear receptor2011
- Author(s)
  Yokoyama A., Fujiki R., Ohtake F., Kato S.
- Journal Title
  
  Cold Spring Harb SympQuant Biol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Nuclear receptor coregulators merge transcriptional coregulation with epigenetic regulation.2011
- Author(s)
  Kato S, Yokoyama A, Fujiki R.
- Journal Title
  
  Trends Biochem.Sci.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121502
[Journal Article] KIAA1718 is a histone demethylase that erases repressive histone methyl marks2010
- Author(s)
  Yokoyama A, Okuno Y, Chikanishi T, Hashiba W, Sekine H. Fujiki R. Kato S.
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 867-873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Glucose-induced expression of MIP1-genes requires O-GlcNAc transferase in monocytes2010
- Author(s)
  Chikanishi T., Fujiki R., Hashiba W., Sekine H., Yokoyama A., Kato S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 394 Pages: 865-870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Glucose-induced expression of MIP-1 genes requires O-GlcNAc transferase in monocytes2010
- Author(s)
  Chikanishi T, Fujiki R, Hashiba W, Sekine H, Yokoyama A, Kato S.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 394 Pages: 865-870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor2010
- Author(s)
  Sawatsubashi S., Murata T., Lim J., Fujiki R., Ito S., Suzuki E., Tanabe M., Zhao Y., Kimura S., Fujiyama S., Ueda T., Umetsu D., Ito T., Takeyama K., Kato S.
- Journal Title
  
  Genes Dev
  
  Volume: 24 Pages: 159-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Hormonal gene regulation through DNA methylation and demethylation2010
- Author(s)
  Kouzmenko A., Ohtake F., Fujiki R., Kato S.
- Journal Title
  
  Epigenomics
  
  Volume: 2 Pages: 765-774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Double PHD fingers protein DPF2 recognizes acetylated histones and suppress the function of estrogen-related receptor alpha through histone deacetylase 12010
- Author(s)
  Matsuyama R, Takada I, Yokoyama A, Fujiyama-Nakamura S, Tsuji N, Kitagawa H, Fujiki R., Kim M, Kouzu-Fujita M, Yano T, Kato S.
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 18166-18176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Role of nuclear O-Glycosylation in epigenetic regulation2010
- Author(s)
  Fujiki R., Chikanishi T., Hashiba W., Kato S.
- Journal Title
  
  Tanpakushitsu Kakusan Koso(Japanese)
  
  Volume: 55 Pages: 61-68
- NAID
  40016985465
- Data Source
  KAKENHI-PROJECT-22770165
[Journal Article] Glucose-induced expression of MIP-1 genes requires O-GlcNAc transferase in monocytes2010
- Author(s)
  Chikanishi T, Fujiki R, Hashiba W, Sekine H, Yokoyama A, Kato S.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 394 Pages: 865-870
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121502
[Patent] ヒストンタンパク質のグリコシル化を検出するための方法、ならびに当該方法に用いられる抗体2010
- Inventor(s)
  藤木亮次, 加藤茂明
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2010-229477
- Filing Date
  2010-10-12
- Data Source
  KAKENHI-PUBLICLY-22121502
[Patent] ヒストンタンパク質のグリコシル化を検出するための方法、並びに当該方法に用いられる抗体2010
- Inventor(s)
  加藤茂明、藤木亮次
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2010-10-12
- Data Source
  KAKENHI-PROJECT-22770165
[Patent] ヒストンタンパク質のグリコシル化を検出するための方法、ならびに当該方法に用いられる抗体2010
- Inventor(s)
  藤木亮次, 加藤茂明
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2010-229477
- Filing Date
  2010-10-12
- Data Source
  KAKENHI-PROJECT-22770165
[Presentation] ARID1Aドライバー変異によるDNAメチル化の異常蓄積とがん分子サブタイプの病態に与える影響2022
- Author(s)
  藤木亮次
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15525
[Presentation] ARID1Aドライバー変異によるDNAメチル化の異常蓄積ががん分子サブタイプの病態に与える影響2022
- Author(s)
  藤木亮次
- Organizer
  第15回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-21K15525
[Presentation] GlcNAcylation of histone H2B in transcriptional regulation2012
- Author(s)
  藤木亮次
- Organizer
  Keystone symposium
- Place of Presentation
  Keystone, CO, USA
- Data Source
  KAKENHI-PROJECT-22770165
[Presentation] GlcNAcylation of histone H2B in transcriptional regulation2012
- Author(s)
  藤木亮次
- Organizer
  Keystone symposium
- Place of Presentation
  Keystone, CO, USA
- Data Source
  KAKENHI-PUBLICLY-22121502
[Presentation] Roeder, Shigeaki Kato, GlcNActylation of a histone methyltransferase in regtinoic acid-induced granulopoiesis2011
- Author(s)
  Ryoji Fujiki, Toshihiro Chikanishi, Waka Hashiba, Robert G.
- Organizer
  Keystone Symposia : Histone Code : Fact or Fiction?
- Place of Presentation
  Utah, USA
- Data Source
  KAKENHI-PROJECT-22770165
[Presentation] 核内糖修飾を介するエピジェネティクスの制御機構2010
- Author(s)
  藤木亮次,加藤茂明
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22770165
[Presentation] 核内O-GlcNAc修飾を介するエピゲノム制御機構の新たな作用点の探索2010
- Author(s)
  藤木亮次
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PUBLICLY-22121502
[Presentation] 核内O-GlcNAc修飾を介するエピゲノム制御機構の新たな作用点の探索2010
- Author(s)
  藤木亮次,近西俊洋,橋場和華,関根弘樹,横山敦,加藤茂明
- Organizer
  第33回日本分子生物学会年会,第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22770165
[Presentation] 核内O-GlcNAc修飾を介するエピゲノム制御機構の新たな作用点の探索2010
- Author(s)
  藤木亮次
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22770165

1. MORISAKI TAKAYUKI (30174410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 武山健一 (30323570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 今井祐記 (10423873)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 岡田麻衣子 (00572330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 森崎裕子 (40311451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小原收 (20370926)

# of Collaborated Projects: 1 results

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7. 山田晴美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUJIKI Ryoji 藤木 亮次

Ryoji Fujiki 藤木 亮次

Research Projects

Research Products

Co-Researchers

AI技術によるARID1A欠損胃がんクロマチン構造異常の検出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impacts of ARID1A driver mutation in gastric cancer developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological Study on Aortopathy towards Prevention

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

性差構築におけるエピゲノムコードの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

核内糖修飾シグナルを制御する過渡的複合体の同定の試みPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

転写を制御する核内糖修飾シグナルの試験管内解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The identification and molecular function of nuclear glycosyl transferase complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ARID1A loss-of-function induces CpG island methylator phenotype2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GlcNAcylation of histone H2B facilitates its monoubiquitination2011

Author(s)

Journal Title

Data Source

[Journal Article] Nuclear receptor coregulators merge transcriptional coregulation with epigenetic regulation2011

Author(s)

Journal Title

Data Source

[Journal Article] Transcriptional controls by nuclear fat-soluble vitamin receptors through chromatin reorganization2011

Author(s)

Journal Title

Data Source

[Journal Article] GlcNAcylation of histone H2B facilitates its monoubiquitination2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Williams syndrome is an epigenome-regulator disease2011

Author(s)

Journal Title

Data Source

[Journal Article] Multiple post-translational modifications in hepatocyte nuclear factor 4alpha2011

Author(s)

Journal Title

Data Source

[Journal Article] Nuclear receptor coregulators merge transcriptional coregulation with epigenetic regulation.2011

Author(s)

Journal Title

FUJIKI Ryoji 藤木亮次

Ryoji Fujiki 藤木亮次