Nagai Kojiro 長井幸二郎

… Alternative Names

NAGAI Kojiro 長井幸二郎

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Researcher Number	40542048
Other IDs
Affiliation (Current)	2025: 地方独立行政法人静岡県立病院機構静岡県立総合病院(救急診療部、循環器病診療部、がん診療部、臨床診療部, 臨床診療部, センター長
Affiliation (based on the past Project Information) *help	2016 – 2022: 徳島大学, 病院, 講師 2012 – 2014: 徳島大学, 大学病院, 講師 2010 – 2012: The University of Tokushima, 病院, 講師 2009: The University of Tokushima, 医学部・歯学部附属病院, 講師
Review Section/Research Field	Principal Investigator Kidney internal medicine / Basic Section 53040:Nephrology-related Except Principal Investigator Kidney internal medicine / Basic Section 53040:Nephrology-related / Social dentistry
Keywords	Principal Investigator メサンギウム細胞 / 慢性腎臓病 / 糸球体硬化 / 細胞老化 / ループス腎炎 / 糖尿病性腎臓病 / オートファジー / シグナル伝達 / 糖尿病 / 発生・分化 … More / 内科 / 糖尿病性腎症 / 細胞内シグナル伝達 / smad1 / mTOR経路 / 細胞伝達経路 / 多発性嚢胞腎 / EGF受容体 / PTEN … More Except Principal Investigator 糖尿病性腎症 / BMP4 / 糖尿病 / 慢性腎臓病 / PACE4 / ポドサイト障害 / サイトカイン / 高血圧 / 動脈硬化 / 糖尿病性腎臓病(DKD) / Estrogen / ERR / DKD / 腎硬化症 / 予防プログラム / 口腔 / 歯周病 / メタボリックシンドローム / 特定健診 / 食事習慣 / 歯科保健 / 口腔保健行動 / コホート研究 / 食習慣 / 保健指導 / 糖尿病外来患者 / 口腔健康状態 / 臨床指標 / 重症化予防 / 肥満 / 歯科保健行動 / 歯科保健指導 / 尿細管間質 / 腎臓病 / 腎線維化 / DNA障害 / 虚血再灌流 / DNA損傷 / 臓器老化 / 線維化 / 急性腎障害 / DNA損傷応答 / 分子標的治療 / ALK3/6 / BMP / 抗体医療 / バイオマーカー / Sox9 / Smad1 Less

Elucidation of the molecular mechanisms responsible for the recent increase in DKD
- Principal Investigator
  
  TOMINAGA Tatsuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  The University of Tokushima
The role of autophagy in mesangial cells in the development of chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  長井幸二郎
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  The University of Tokushima
Elucidation of oral environmental factors involved in prevention of diabetic nephropathy and development of oral version prevention program
- Principal Investigator
  
  Yoshioka Masami
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Tokushima Bunri University
  The University of Tokushima
Development of new CKD therapeutic agent targeting cytokine processing enzyme
- Principal Investigator
  
  TOMINAGA Tatsuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
The role of mesangial cells in glomeruli formation and the development of diabetic kidney diseasePrincipal Investigator
- Principal Investigator
  
  NAGAI Kojiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
A novel treatment method focusing on DNA damage response
- Principal Investigator
  
  KISHI Seiji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
Role of cell signaling pathway in mesangial cells in the progression of chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  NAGAI Kojiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
Development of Specific Biomarker and Molecular Targeting Therapy for Diabetic Nephropathy by RAS-independent Pathway
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
The new mechanism in the development of polycystic kidney～the role of PTEN and EGF receptor in the proximal tubule～Principal Investigator
- Principal Investigator
  
  長井幸二郎
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima

All 2021 2020 2019 2018 2017 2016 2013 2012 2011 2010 2008

All Journal Article Presentation

[Journal Article] TGF-β1 is involved in senescence-related pathways in glomerular endothelial cells via p16 translocation and p21 induction2021
- Author(s)
  Ueda Sayo、Tominaga Tatsuya、Ochi Arisa、Sakurai Akiko、Nishimura Kenji、Shibata Eriko、Wakino Shu、Tamaki Masanori、Nagai Kojiro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41598-021-01150-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08593, KAKENHI-PROJECT-21K07367, KAKENHI-PROJECT-21K15663
[Journal Article] Dual disruption of eNOS and ApoE gene accelerates kidney fibrosis and senescence after injury2021
- Author(s)
  Kenji Nishimura、Kensei Taguchi、Seiji Kishi、 Craig R Brooks、Arisa Ochi、Hiroyuki Kadoya、Yasumasa Ikeda、Masashi Miyoshi、Masanori Tamaki、Hideharu Abe、Ken-Ichi Aihara、Naoki Kashihara、Kojiro Nagai
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 556 Pages: 142-148
- DOI
  10.1016/j.bbrc.2021.03.111
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08705, KAKENHI-PROJECT-21K07914, KAKENHI-PROJECT-19K17745, KAKENHI-PROJECT-21K15663
[Journal Article] Association between diabetes-related clinical indicators and oral health behavior among patients with type 2 diabetes2021
- Author(s)
  Masami Yoshioka, Yuichiro Kawashima, Yoshihiko Noma, Makoto Fukui, Shizuko Yanagisawa, Yasuhiko Shirayama, Kojiro Nagai, and Daisuke Hinode
- Journal Title
  
  The Journal of Medical Investigation
  
  Volume: 68 Pages: 140-147
- NAID
  130008038410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K12009
[Journal Article] Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men2020
- Author(s)
  Yoshioka Masami、Okamoto Yoshifumi、Murata Masahiro、Fukui Makoto、Yanagisawa Shizuko、Shirayama Yasuhiko、Nagai Kojiro、Hinode Daisuke
- Journal Title
  
  Journal of Diabetes Research
  
  Volume: － Pages: 1-5
- DOI
  10.1155/2020/4042129
- NAID
  120006999401
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09943, KAKENHI-PROJECT-19K10227, KAKENHI-PROJECT-17K12009
[Journal Article] All-trans retinoic acid suppresses bone morphogenetic protein 4 in mouse diabetic nephropathy through a unique retinoic acid response element2019
- Author(s)
  Tamaki Masanori、Tominaga Tatsuya、Fujita Yui、Koezuka Yasuhiko、Ichien Go、Murakami Taichi、Kishi Seiji、Yamamoto Keiichi、Abe Hideharu、Nagai Kojiro、Doi Toshio
- Journal Title
  
  American Journal of Physiology-Endocrinology and Metabolism
  
  Volume: 316 Issue: 3 Pages: E418-E431
- DOI
  10.1152/ajpendo.00218.2018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09619, KAKENHI-PROJECT-16K19490
[Journal Article] An adjustment in BMP4 function represents a treatment for diabetic nephropathy and podocyte injury2018
- Author(s)
  Fujita Yui、Tominaga Tatsuya、Abe Hideharu、Kangawa Yumi、Fukushima Naoshi、Ueda Otoya、Jishage Kou-ichi、Kishi Seiji、Murakami Taichi、Saga Yumiko、Kanwar Yashpal S.、Nagai Kojiro、Doi Toshio
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 13011-13011
- DOI
  10.1038/s41598-018-31464-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08245, KAKENHI-PROJECT-16K09619
[Journal Article] Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy2018
- Author(s)
  Ono Hiroyuki、Abe Hideharu、Sakurai Akiko、Ochi Arisa、Tominaga Tatsuya、Tamaki Masanori、Kishi Seiji、Murakami Taichi、Nagai Kojiro、Kohashi Masayuki、Doi Toshio
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 10548-10548
- DOI
  10.1038/s41598-018-28439-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07415, KAKENHI-PROJECT-18K08245, KAKENHI-PROJECT-16K09619
[Journal Article] Urinary Exosomal mRNA of WT1 as Diagnostic and Prognostic Biomarker for Diabetic Nephropathy2018
- Author(s)
  Abe Hideharu、Sakurai Akiko、Ono Hiroyuki、Hayashi Sanae、Yoshimoto Sakiya、Ochi Arisa、Ueda Sayo、Nishimura Kenji、Shibata Eriko、Tamaki Masanori、Kishi Fumi、Kishi Seiji、Murakami Taichi、Nagai Kojiro、Doi Toshio
- Journal Title
  
  J. Med. Invest.
  
  Volume: 65 Issue: 3.4 Pages: 208-215
- DOI
  10.2152/jmi.65.208
- NAID
  130007495809
- ISSN
  1343-1420, 1349-6867
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07415, KAKENHI-PROJECT-16K09619
[Journal Article] Urinary IgG4 and Smad1 are Specific Biomarkers for Renal Structural and Functional Changes in Early Stage of Diabetic Nephropathy.2018
- Author(s)
  Doi T, Moriya T, Fujita Y, Minagawa N, Usami M, Sasaki T, Abe H, Kishi S, Murakami T, Ouchi M, Ichien G, Yamamoto K, Ikeda H, Koezuka Y, Takamatsu N, Shima K, Mauer M, Nagai K, Tominaga T.
- Journal Title
  
  Diabetes
  
  Volume: 67 Issue: 5 Pages: 986-993
- DOI
  10.2337/db17-1043
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09265, KAKENHI-PROJECT-16K09619
[Journal Article] Mesangial cell mTORC1 activation results in mesangial expansion2017
- Author(s)
  Kojiro Nagai, Tatsuya Tominaga, Sayo Ueda, Eriko Shibata, Masanori Tamaki, Motokazu Matsuura, Seiji Kishi, Taichi Murakami, Tatsumi Moriya, Hideharu Abe, Toshio Doi
- Journal Title
  
  Journal of American Society of Nephrology
  
  Volume: 28 Issue: 10 Pages: 2879-2885
- DOI
  10.1681/asn.2016111196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09619
[Journal Article] Polymorphism in the human matrix Gla protein gene is associated with the progression of vascular calcification in maintenance hemodialysis patients2013
- Author(s)
  Yoshikawa K, Abe H, Tominaga T, Nakamura M, Kishi S, Matsuura M, Nagai K, Tsuchida K, Minakuchi J, Doi T
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: 17 Issue: 6 Pages: 882-889
- DOI
  10.1007/s10157-013-0785-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390169
[Journal Article] Scleraxis modulates bone morphogenetic protein 4 (BMP4)-Smad1-smooth muscle α actin(SMA) signal transduction in diabetic nephropathy2012
- Author(s)
  Abe H, Tominaga T, Matsubara T, Abe N, Kishi S, Nagai K, Murakami T, Araoka T, Doi T.
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 24 Pages: 20430-20442
- DOI
  10.1074/jbc.m111.275610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591033, KAKENHI-PROJECT-22390169, KAKENHI-PROJECT-23659445, KAKENHI-PROJECT-24591201, KAKENHI-PROJECT-24659279
[Journal Article] Acute Glomerulonephritis in an Immunocompetent Elderly Woman after Contact with a Child who Had Been Diagnosed as Erythema Infectiosum2012
- Author(s)
  Kishi S, Yamada S, Kishi F, Shibata E, Matsuura M, Nagai K, Mima A, Abe H, Doi T.
- Journal Title
  
  Intern. Med.
  
  Volume: 51 Issue: 16 Pages: 2197-2201
- DOI
  10.2169/internalmedicine.51.7919
- NAID
  130002062315
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390169
[Journal Article] MPO-ANCA-positive anti-glomerular basement membrane antibody disease successfully treated byplasma exchange and immunosuppressive therapy.2011
- Author(s)
  Murakami T, Nagai K, Matsuura M, Kondo N, Kishi S, Araoka T, Kishi F, Sakiyama T, Mima A, Bando Y, Abe H, Doi T.
- Journal Title
  
  Ren Fail
  
  Volume: 33 Issue: 6 Pages: 626-631
- DOI
  10.3109/0886022x.2011.581401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390169
[Journal Article] Sox9 induces a chondrogenic phenotype of mesangial cells and contributes to advanced diabetic nephropathy2011
- Author(s)
  Kishi S, Abe H, Akiyama H, Tominaga T, Murakami T, Mima A, Nagai K, Kishi F, Matsuura M, Matsubara T, Iehara N, Ueda O, Fukushima N, Jishage KI, Doi T.
- Journal Title
  
  J Biol Chem
  
  Volume: 286(37) Issue: 37 Pages: 32162-9
- DOI
  10.1074/jbc.m111.244541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591032, KAKENHI-PROJECT-21591033, KAKENHI-PROJECT-21790808, KAKENHI-PROJECT-22390169
[Journal Article] Activation of Src mediates PDGF-induced Smad1 phosphorylation and contributes to the progression of glomerulosclerosis in glomerulonephritis2011
- Author(s)
  Mima A, Abe H, Nagai K, Arai H, Matsubara T, Araki M, Torikoshi K, Tominaga T, Iehara N, Fukatsu A, Kita T, Doi T
- Journal Title
  
  PLoS One.
  
  Volume: 6(3) Issue: 3 Pages: e17929-e17929
- DOI
  10.1371/journal.pone.0017929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790808, KAKENHI-PROJECT-22390169
[Journal Article] An autopsy case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with intestinal bleeding in chronic renal failure2011
- Author(s)
  Mima A, Shiota F, Matsubara T, Iehara N, Akagi T, Abe H, Nagai K, Matsuura M, Murakami T, Kishi S, Araoka T, Kishi F, Kondo N, Shigeta R, Yoshikawa K, Kita T, Doi T, Fukatsu A
- Journal Title
  
  Ren Fail.
  
  Volume: 33 Issue: 6 Pages: 622-625
- DOI
  10.3109/0886022x.2011.585730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390169
[Journal Article] Activation of bone morphogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy2011
- Author(s)
  Tominaga T, Abe H, Ueda O, Goto C, Nakahara K, Murakami T, Mima A, Nagai K, Araoka T, Kishi S, Fukushima N, Jishage KI, Doi T
- Journal Title
  
  J Biol Chem
  
  Volume: 286(22) Issue: 22 Pages: 20109-16
- DOI
  10.1074/jbc.m110.179382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590628, KAKENHI-PROJECT-21591033, KAKENHI-PROJECT-21790808, KAKENHI-PROJECT-22390169
[Journal Article] Transcription factor 7-like 2(TCF7L2) regulates activin receptor-like kinase 1(ALK1)/ Smad1 pathway for development of diabetic nephropathy2010
- Author(s)
  Araoka T, Abe H, Tominaga T, Mima A, Matsubara T, Murakami T, Kishi S, Nagai K, Doi T
- Journal Title
  
  Mol Cells
  
  Volume: 30(3) Issue: 3 Pages: 209-218
- DOI
  10.1007/s10059-010-0109-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591033, KAKENHI-PROJECT-21790808, KAKENHI-PROJECT-22390169
[Journal Article] Trophoblast glycoprotein : possible candidate mediating podocyte injuries in glomerulonephritis2010
- Author(s)
  Murakami T, Abe H, Nagai K, Tominaga T, Takamatsu N, Matsubara T, Araoka T, Kishi S, Takahashi T, Mima A, Takai Y, Kopp JB, Doi T.
- Journal Title
  
  Am J Nephrol
  
  Volume: 32(6) Issue: 6 Pages: 505-521
- DOI
  10.1159/000321366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591032, KAKENHI-PROJECT-21591033, KAKENHI-PROJECT-22390169
[Presentation] メサンギウム細胞と腎障害2021
- Author(s)
  長井幸二郎
- Organizer
  第51回日本腎臓学会西部学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08705
[Presentation] P16は糸球体内皮細胞においてTGF-b刺激により核内移行する2021
- Author(s)
  上田紗代、長井幸二郎、冨永辰也、越智ありさ、西村賢二、柴田恵理子、田蒔昌憲、安部秀斉
- Organizer
  第64回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08705
[Presentation] Association between Periodontal Status and Renal Function2019
- Author(s)
  Masami Yoshioka, Yoshifumi Okamoto, Daisuke Hinode, Shizuko Yanagisawa, Yasuhiko Shirayama, Kojiro Nagai
- Organizer
  2019 IADR/AADR/CADR General Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K12009
[Presentation] 成体腎疾患におけるメサンギウム細胞のin vivoでの機能解析2019
- Author(s)
  長井　幸二郎
- Organizer
  第52回日本臨床腎移植学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09619
[Presentation] メサンギウム細胞の機能解析によるCKD病態解明2018
- Author(s)
  長井　幸二郎
- Organizer
  第48回日本腎臓学会西部学術大会
- Data Source
  KAKENHI-PROJECT-16K09619
[Presentation] Mesangial Matrix Expansion Attenuated by All-Trans Retinoic Acid Through Direct Suppression of Bone Morphogenetic Protein 4 in Mouse Diabetic Nephropathy2018
- Author(s)
  Masanori Tamaki、Tatsuya Tominaga、Yui Fujita、Seiji Kishi、Taichi Murakami、Kojiro Nagai、Hideharu Abe、Toshio Doi
- Organizer
  KIDNEY WEEK 2018 American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09619
[Presentation] Palovarotene, selective retinoic receptor-γ agonist, inhibited both BMP4 and TGF-β signaling pathways in diabetic nephropathy2017
- Author(s)
  Yui Fujita, Tatsuya Tominaga, Masanori Tamaki, Taichi Murakami, Seiji Kishi, Kojiro Nagai, Hideharu Abe, Toshio Do1
- Organizer
  The American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09700
[Presentation] Palovarotene, Selective Retinoic Receptor-γ Agonist, Inhibited Both BMP4 and TGF-β Signaling Pathways in Diabetic Nephropathy2017
- Author(s)
  Yui Fujita, Tatsuya Tominaga, Masanori Tamaki, Taichi Murakami, Seiji Kishi, Kojiro Nagai, Hideharu Abe, Toshio Doi
- Organizer
  KIDNEY WEEK 2017 American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09619
[Presentation] The role of BMP4 signal pathway on the glomerulosclerosis.2017
- Author(s)
  Tatsuya Tominaga, Yui Fujita, Taichi Murakami, Seiji Kishi, Kojiro Nagai, Hideharu Abe, Toshio Doi
- Organizer
  Keystone symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09700
[Presentation] Glomerulosclerosis Attenuated by Retinoic Acid through Bone Morphogenetic Protein 4 Suppression in Mice with Streptozotocin-Induced Diabetes2017
- Author(s)
  Masanori Tamaki, Tatsuya Tominaga, Yui Fujita, Seiji Kishi, Taichi Murakami, Kojiro Nagai, Hideharu Abe, Toshio Doi
- Organizer
  KIDNEY WEEK 2017 American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09619
[Presentation] レチノイン酸による糖尿病性糸球体硬化分子BMP4制御機構の検討2017
- Author(s)
  田蒔昌憲、冨永辰也、藤田結衣、松浦元一、岸誠司、村上太一、長井幸二郎、安部秀斉、土井俊夫
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09619
[Presentation] In vivo evidence of mTORC1-S6 kinase pathway involvement in the development of glomerulosclerosis in　human IgA nephropathy2016
- Author(s)
  Kojiro Nagai, Tatsuya Tominaga, Taichi Murakami, Eriko Shibata, Seiji Kishi, Motokazu Matsuura, Hideharu Abe, Toshio Doi
- Organizer
  KIDNEY WEEK 2016 American Society of Nephrology
- Place of Presentation
  Chicago, USA
- Year and Date
  2016-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09619
[Presentation] メサンギウム細胞のin vivoでの機能解析～mTOR経路の活性化は糸球体硬化を誘導する～2016
- Author(s)
  長井　幸二郎、冨永　辰也、村上　太一、柴田　恵理子、岸　誠司、松浦　元一、安部　秀斉、土井　俊夫
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K09619
[Presentation] Multiple cyst formation in PTEN conditional knockout mice in kidney.2008
- Author(s)
  長井幸二郎
- Organizer
  41^<st> Annunal meeting, American Society of Nephrology
- Place of Presentation
  Philadelphia, U.S.A.
- Year and Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-21890170

1. TOMINAGA Tatsuya (80425446)

# of Collaborated Projects: 6 results

# of Collaborated Products: 18 results
2. ABE Hideharu (60399342)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. KISHI Seiji (10519507)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
4. DOI Toshio (60183498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. MIMA Akira (00432401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. MATSUURA Motokazu (10403734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Yoshioka Masami (90243708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 柳沢志津子 (10350927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 白山靖彦 (40434542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 日野出大輔 (70189801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 池田康将 (60432754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 田蒔昌憲 (90528902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 藤田結衣 (30837266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MATSUBARA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 櫻井明子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 村上太一

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
17. 荒井秀典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 家原典之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagai Kojiro 長井 幸二郎

NAGAI Kojiro 長井 幸二郎

Research Projects

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Elucidation of the molecular mechanisms responsible for the recent increase in DKD

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The role of autophagy in mesangial cells in the development of chronic kidney diseasePrincipal Investigator

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Elucidation of oral environmental factors involved in prevention of diabetic nephropathy and development of oral version prevention program

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Development of new CKD therapeutic agent targeting cytokine processing enzyme

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The role of mesangial cells in glomeruli formation and the development of diabetic kidney diseasePrincipal Investigator

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A novel treatment method focusing on DNA damage response

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Role of cell signaling pathway in mesangial cells in the progression of chronic kidney diseasePrincipal Investigator

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Development of Specific Biomarker and Molecular Targeting Therapy for Diabetic Nephropathy by RAS-independent Pathway

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The new mechanism in the development of polycystic kidney～the role of PTEN and EGF receptor in the proximal tubule～Principal Investigator

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[Journal Article] TGF-β1 is involved in senescence-related pathways in glomerular endothelial cells via p16 translocation and p21 induction2021

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[Journal Article] Dual disruption of eNOS and ApoE gene accelerates kidney fibrosis and senescence after injury2021

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[Journal Article] Association between diabetes-related clinical indicators and oral health behavior among patients with type 2 diabetes2021

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NAID

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[Journal Article] Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men2020

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Nagai Kojiro 長井幸二郎

NAGAI Kojiro 長井幸二郎