shiimura yuki 椎村祐樹

… Alternative Names

Shiimura Yuki 椎村祐樹

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Researcher Number	40551297
Other IDs	https://orcid.org/0000-0002-9752-7399
Affiliation (Current)	2026: 久留米大学, 付置研究所, 講師 2026: 京都大学, 医学研究科, 客員研究員
Affiliation (based on the past Project Information) *help	2018 – 2024: 久留米大学, 付置研究所, 助教 2017: 京都大学, 医学研究科, 客員研究員 2016: 京都大学, 医学研究科, 特定研究員
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Basic Section 43020:Structural biochemistry-related / Functional biochemistry Except Principal Investigator Basic Section 43020:Structural biochemistry-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator 構造生物学 / GPCR / グレリン受容体 / 立体構造 / 立体構造認識抗体 / グレリン / 構造解析 / アシルトランスフェラーゼ / グレリンOアシルトランスフェラーゼ / グレリンO-アシルトランスフェラーゼ … More / Cryo-EM / 結晶構造解析 / GHSR / 抗体 / X線結晶構造解析 … More Except Principal Investigator クライオ電子顕微鏡 / グレリン受容体 / アレスチン / Gタンパク質 / ケモカイン / クラスA GPCR / バイスシグナリング / 単粒子解析 / バイアスシグナリング / Gタンパク質共役受容体 / 脂肪酸修飾 / 構造解析 / ペプチドホルモン / フェニルアラニン・クラスター / X線結晶構造解析 / オクタン酸 / 脂肪酸 / ギャップ構造 / がん悪液質 / アナモレリン / 結晶構造解析 / 立体構造 / GPCR / グレリン Less

Structural study of the initial transducer engagement by GPCR
- Principal Investigator
  
  堤尚孝
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Science Tokyo
膜結合型酵素によるグレリン活性化機構の解明Principal Investigator
- Principal Investigator
  
  椎村祐樹
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Kurume University
グレリン受容体のシグナル伝達選択機構の構造基盤
- Principal Investigator
  
  浅田秀基
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyoto University
Cryo-EM structure of the ghrelin receptor coupled to an engineered heterotrimeric G proteinPrincipal Investigator
- Principal Investigator
  
  Shiimura Yuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kurume University
Why is the acyl-modification of ghrelin necessary for activity?
- Principal Investigator
  
  Masayasu Kojima
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Kurume University
Crystal Structure Analysis of Ghrelin ReceptorPrincipal Investigator
- Principal Investigator
  
  Shiimura Yuki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kurume University
Establishment of anti-ghrelin receptor antibodies for crystallizationPrincipal Investigator
- Principal Investigator
  
  Shiimura Yuki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyoto University

All 2025 2024 2023 2022 2021 2020 2019 2018 2016

All Journal Article Presentation Book

[Book] 循環器内科2022
- Author(s)
  佐藤貴弘、井田隆徳、椎村祐樹、児島将康
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20KK0359
[Journal Article] How the ghrelin receptor recognizes the acyl-modified orexigenic hormone2025
- Author(s)
  Shiimura Yuki、Kojima Masayasu、Sato Takahiro
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 18 Pages: 1549366-1549366
- DOI
  10.3389/fnmol.2025.1549366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06117, KAKENHI-PROJECT-24K14640, KAKENHI-PROJECT-23K18292
[Journal Article] Ghrelin-LEAP2 interactions along the stomach-liver axis2025
- Author(s)
  Sakai Katsuya、Nakazato Yuki、Shiimura Yuki、Zhang Weidong、Nakazato Masamitsu
- Journal Title
  
  Endocrine Journal
  
  Volume: 72 Issue: 4 Pages: 341-353
- DOI
  10.1507/endocrj.ej24-0543
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06004, KAKENHI-PROJECT-22K06117, KAKENHI-PROJECT-24K18646
[Journal Article] The structure and function of the ghrelin receptor coding for drug actions2025
- Author(s)
  Yuki Shiimura, Dohyun Im, Ryosuke Tany, Hidetsugu Asada, Ryoji Kise, Eon Kurumiya, Hideko Wakasugi-Masuho, Satoshi Yasuda, Kazuma Matsui, Jun-ichi Kishikawa, Takayuki Kato, Takeshi Murata, Masayasu Kojima, So Iwata, Ikuo Masuho
- Journal Title
  
  Nature Structural and Molecular Biology
  
  Volume: 32 Issue: 3 Pages: 531-542
- DOI
  10.1038/s41594-024-01481-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01965, KAKENHI-PROJECT-24K01984, KAKENHI-PROJECT-22K06117, KAKENHI-PROJECT-23K06357, KAKENHI-PROJECT-23K18292, KAKENHI-PROJECT-24K21945, KAKENHI-PROJECT-22KK0099
[Journal Article] Acyl modifications in bovine, porcine, and equine ghrelins2024
- Author(s)
  Ida Takanori、Tominaga Hatsumi、Iwamoto Eri、Kurogi Akito、Okura Ayaka、Shimada Kengo、Kato Johji、Kuwano Atsutoshi、Ode Hirotaka、Nagata Sayaka、Kitamura Kazuo、Yazawa Takashi、Sato-Hashimoto Miho、Yasuda Masahiro、Miyazato Mikiya、Shiimura Yuki、Sato Takahiro、Kojima Masayasu
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 15 Pages: 1411483-1411483
- DOI
  10.3389/fendo.2024.1411483
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05958, KAKENHI-PROJECT-22K06117, KAKENHI-PROJECT-23K07581, KAKENHI-PROJECT-24K14640, KAKENHI-PROJECT-23K18292
[Journal Article] Neurotransmitter recognition by human vesicular monoamine transporter 22024
- Author(s)
  Im Dohyun、Jormakka Mika、Juge Narinobu、Kishikawa Jun-ichi、Kato Takayuki、Sugita Yukihiko、Noda Takeshi、Uemura Tomoko、Shiimura Yuki、Miyaji Takaaki、Asada Hidetsugu、Iwata So
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 7661-7661
- DOI
  10.1038/s41467-024-51960-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24791, KAKENHI-PROJECT-23K06357, KAKENHI-PROJECT-24K09796, KAKENHI-PROJECT-24K21945, KAKENHI-PROJECT-22KK0099
[Journal Article] Insights Into the Regulation of Offspring Growth by Maternally Derived Ghrelin.2022
- Author(s)
  Sato T, Ida T, Shiimura Y, Matsui K, Oishi K, Kojima M.
- Journal Title
  
  Front Endocrinol (Lausanne)
  
  Volume: 13 Pages: 852636-852636
- DOI
  10.3389/fendo.2022.852636
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06531, KAKENHI-PROJECT-20K08898, KAKENHI-PROJECT-21K05958, KAKENHI-PROJECT-20KK0359
[Journal Article] Expression of the ghrelin/growth hormone secretagogue receptor axis and its functional role in promoting tumor growth in primary central nervous system lymphomas2020
- Author(s)
  Muta Hiroko、Sugita Yasuo、Furuta Takuya、Shiimura Yuki、Ohshima Koichi、Nakashima Kazutaka、Sato Kensaku、Morioka Motohiro、Abe Hideyuki、Nozawa Takanori、Fujii Yukihiko、Kakita Akiyoshi
- Journal Title
  
  Neuropathology
  
  Volume: - Issue: 3 Pages: 232-239
- DOI
  10.1111/neup.12634
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16217, KAKENHI-PROJECT-17K10888, KAKENHI-PROJECT-18K08955
[Journal Article] The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone2020
- Author(s)
  Asada Hidetsugu、Inoue Asuka、Ngako Kadji Francois Marie、Hirata Kunio、Shiimura Yuki、Im Dohyun、Shimamura Tatsuro、Nomura Norimichi、Iwanari Hiroko、Hamakubo Takao、Kusano-Arai Osamu、Hisano Hiromi、Uemura Tomoko、Suno Chiyo、Aoki Junken、Iwata So
- Journal Title
  
  Structure
  
  Volume: 28 Issue: 4 Pages: 418-425.e4
- DOI
  10.1016/j.str.2019.12.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05334, KAKENHI-PROJECT-18K16217, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-17K08264, KAKENHI-PROJECT-17K19349, KAKENHI-PROJECT-20K21392, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-18H02388
[Journal Article] Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode2020
- Author(s)
  Shiimura Yuki、Horita Shoichiro、Hamamoto Akie、Asada Hidetsugu、Hirata Kunio、Tanaka Misuzu、Mori Kenji、Uemura Tomoko、Kobayashi Takuya、Iwata So、Kojima Masayasu
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1-9
- DOI
  10.1038/s41467-020-17554-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06531, KAKENHI-PROJECT-18K16217, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-18K08497, KAKENHI-PROJECT-19K20143, KAKENHI-PLANNED-19H05777
[Presentation] 立体構造から探るグレリン受容体の分子認識機構と活性化機構2025
- Author(s)
  椎村祐樹
- Organizer
  第54回日本心脈管作動物質学会年会
- Data Source
  KAKENHI-PROJECT-24K01965
[Presentation] 成長ホルモン分泌促進因子受容体のリガンド認識機構とその活性化機構2025
- Author(s)
  椎村祐樹, 林到炫, 谷猪遼介, 浅田秀基, 木瀬亮二, 松井一真, 岩田想, 増保生郎, 児島将康
- Organizer
  第28回日本心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-22K06117
[Presentation] グレリン受容体のStructure-Based Drug Designに向けた取り組み2025
- Author(s)
  椎村祐樹
- Organizer
  24th MPRC seminar
- Invited
- Data Source
  KAKENHI-PROJECT-22K06117
[Presentation] 立体構造から探るグレリン受容体の分子認識機構と活性化機構2025
- Author(s)
  椎村祐樹
- Organizer
  第54回日本心脈管作動物質学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06117
[Presentation] DNA-encoded libraryを用いたグレリン受容体作動薬の創製2024
- Author(s)
  椎村祐樹
- Organizer
  第146回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] 成長ホルモン分泌促進因子受容体のリガンド認識機構とその活性化機構2024
- Author(s)
  椎村祐樹
- Organizer
  第28回日本心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] グレリン受容体のリガンド認識機構および活性化機構の構造学的洞察.2024
- Author(s)
  椎村祐樹、林到炫、浅田秀基、松井一真、岩田想、児島将康.
- Organizer
  日本薬学会第144年会.
- Data Source
  KAKENHI-PROJECT-20KK0359
[Presentation] Novel small-molecule GPCR drug discovery utilizing DNA-encoded library2024
- Author(s)
  椎村祐樹
- Organizer
  APPW2025
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] 構造情報に立脚したグレリン受容体アゴニストの薬理プロファイル解析2024
- Author(s)
  椎村祐樹
- Organizer
  第42回内分泌代謝学サマーセミナー
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] 立体構造から探るグレリン受容体の分子認識機構と活性化機構2024
- Author(s)
  椎村祐樹
- Organizer
  第57回日本心脈管作動物質学会
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] グレリン受容体のStructure-drug based designに向けた取り組み2024
- Author(s)
  椎村祐樹
- Organizer
  第24回千葉大学MPRCセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] 構造情報に立脚したグレリン受容体アゴニストの薬理プロファイル解析.2024
- Author(s)
  椎村祐樹, イムドヒョン, 谷猪遼介, 浅田秀基, 松井一真, 岩田想, 増保生郎, 児島将康
- Organizer
  第42回内分泌代謝学サマーセミナー
- Data Source
  KAKENHI-PROJECT-22K06117
[Presentation] Insights into the structure of the agonist-bound ghrelin receptor.2023
- Author(s)
  Yuki Shiimura, Dohyun Im, Ryosuke Tany, Ryoji Kise, Hidetsugu Asada, So Iwata, Masuho Ikuo, Masayasu Kojima.
- Organizer
  第96回日本内分泌学会学術総会.
- Data Source
  KAKENHI-PROJECT-20KK0359
[Presentation] グレリン受容体のリガンド認識機構の構造基盤.2023
- Author(s)
  椎村祐樹.
- Organizer
  第27回日本心血管内分泌代謝学会学術総会.
- Data Source
  KAKENHI-PROJECT-20KK0359
[Presentation] 構造情報に基づいたグレリン受容体アゴニストのシグナル活性の比較.2023
- Author(s)
  椎村祐樹、林到炫、谷猪遼介、浅田秀基、増保生郎、松井一真、岩田想、児島将康.
- Organizer
  第49回神経内分泌学会.
- Data Source
  KAKENHI-PROJECT-20KK0359
[Presentation] The structural feature of ghrelin receptor.2023
- Author(s)
  Yuki Shiimura, Dohyun Im, Ryosuke Tany, Hidetsugu Asada, Kazuma Matsui, Masuho Ikuo, So Iwata, Masayasu Kojima.
- Organizer
  第44回日本肥満学会・第41回日本肥満症治療学会学術集会. 日韓台合同シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0359
[Presentation] Structure of an antagonist-bound ghrelin receptor2022
- Author(s)
  Y. Shiimura, S. Horita, A. Hamamoto, H. Asada, K. Hirata, K. Mori, T. Kobayashi, S. Iwata and M. Kojima
- Organizer
  Keystone symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0359
[Presentation] The cryo-EM structure of an agonist bound ghrelin receptor2022
- Author(s)
  椎村祐樹、林到炫、朝田秀基、岩田想、児島将康
- Organizer
  心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-20KK0359
[Presentation] Structure of an antagonist-bound ghrelin receptor2022
- Author(s)
  Shiimura Yuki, Horita Shoichiro, Hamamoto Akie, Asada Hidetsugu, Hirata Kunio, Mori Kenji, Kobayashi Takuya, Iwata So, Kojima Masayasu
- Organizer
  Keystone Symposia 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16217
[Presentation] グレリン受容体の立体構造解析2021
- Author(s)
  椎村祐樹、浅田秀基、岩田想、児島将康
- Organizer
  心血管内分泌学会
- Data Source
  KAKENHI-PROJECT-18K16217
[Presentation] グレリン受容体のX線結晶構造解析2019
- Author(s)
  椎村祐樹, 堀田彰一朗, 浅田秀基, 濱本明恵, 田中みすず, 平田邦生, 小林拓也, 岩田想, 児島将康.
- Organizer
  第15回GPCR研究会
- Data Source
  KAKENHI-PROJECT-18K16217
[Presentation] X線結晶構造解析を基盤とした活性型グレリン認識機構の解明2019
- Author(s)
  椎村祐樹, 堀田彰一朗, 浅田秀基, 平田邦生, 小林拓也, 児島将康, 岩田想
- Organizer
  日本薬学会第126回年会
- Data Source
  KAKENHI-PROJECT-18K16217
[Presentation] Establishment of anti-ghrelin receptor antibodies for crystallization2018
- Author(s)
  Y. Shiimura, S. Horita, H. Asada, T. Kobayashi, S. Iwata, and M. Kojima
- Organizer
  Keystone symposia on molecular and cellular biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18515
[Presentation] グレリン受容体の結晶構造解析による活性型グレリン認識機構の解明2018
- Author(s)
  椎村祐樹, 堀田彰一朗, 浅田秀基, 平田邦生, 小林拓也, 児島将康, 岩田想
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K16217
[Presentation] GHSR結晶化にむけた安定化変異体の作製2016
- Author(s)
  椎村祐樹、小林拓也、児島将康、岩田想
- Organizer
  第7回ペプチド・ホルモン研究会
- Place of Presentation
  久留米
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16K18515

1. 堤尚孝 (70963495)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Masayasu Kojima (20202062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 浅田秀基 (20399041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 林到ヒョン (50721883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 野村紀通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 中里祐毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 中里雅光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 張維東

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 井田隆徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 宮地孝明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

shiimura yuki 椎村 祐樹

Shiimura Yuki 椎村 祐樹

Research Projects

Research Products

Co-Researchers

Structural study of the initial transducer engagement by GPCR

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膜結合型酵素によるグレリン活性化機構の解明Principal Investigator

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グレリン受容体のシグナル伝達選択機構の構造基盤

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Cryo-EM structure of the ghrelin receptor coupled to an engineered heterotrimeric G proteinPrincipal Investigator

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Research Institution

Why is the acyl-modification of ghrelin necessary for activity?

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Crystal Structure Analysis of Ghrelin ReceptorPrincipal Investigator

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Establishment of anti-ghrelin receptor antibodies for crystallizationPrincipal Investigator

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Research Institution

[Book] 循環器内科2022

Author(s)

Total Pages

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Data Source

[Journal Article] How the ghrelin receptor recognizes the acyl-modified orexigenic hormone2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ghrelin-LEAP2 interactions along the stomach-liver axis2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The structure and function of the ghrelin receptor coding for drug actions2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acyl modifications in bovine, porcine, and equine ghrelins2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neurotransmitter recognition by human vesicular monoamine transporter 22024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insights Into the Regulation of Offspring Growth by Maternally Derived Ghrelin.2022

Author(s)

Journal Title

shiimura yuki 椎村祐樹

Shiimura Yuki 椎村祐樹