ICHIMIYA Harumi 一宮治美

… Alternative Names

YOKOTA Takashi 横田隆

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Researcher Number	40553251
Affiliation (based on the past Project Information) *help	2016: 日本医科大学, 先端医学研究所, その他 2013: 日本医科大学, 老人病研究所生化学部門, アシスタントサポートスタッフ
Review Section/Research Field	Except Principal Investigator Applied health science / Risk sciences of radiation/Chemicals / Applied health science
Keywords	Except Principal Investigator 水素 / 酸化ストレス / ミトコンドリア / 生活習慣病 / 脂質メディエーター / 酸化脂質 / 情報伝達機構 / 遺伝子発現制御 / 分子状水素 / 抗酸化物質 … More / 水素分子 / 損傷 / エネルギー代謝 / 水素吸蔵金属 Less

Mechanism to exert multi-functions of molecular hydrogen for health-care and the prevention of diseases
- Principal Investigator
  
  Ohta Shigeo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Nippon Medical School
Protective effects of hydrogen against irradiation
- Principal Investigator
  
  OHTA Shigeo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nippon Medical School
Preventive effects of geriatric and life-style related diseases by oral administration of a novel hydrogen-producing material
- Principal Investigator
  
  OHTA Shigeo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Nippon Medical School

All 2016 2015 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators.2016
- Author(s)
  Iuchi K, Imoto A, Kamimura N, Nishimaki K, Ichimiya H, Yokota T, Ohta S.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 18971-18971
- DOI
  10.1038/srep18971
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26350129, KAKENHI-PROJECT-15K16524, KAKENHI-PROJECT-25350907, KAKENHI-PROJECT-26282198
[Journal Article] Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism.2016
- Author(s)
  Kamimura N, Ichimiya H, Iuchi K, Ohta S.
- Journal Title
  
  npj Aging and Mechanisms of Disease
  
  Volume: 2 Pages: 16008-16008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26282198
[Journal Article] Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease.2015
- Author(s)
  Kanamaru T, Kamimura N, Yokota T, Iuchi K, Nishimaki K, Takami S, Akashiba H, Shitaka Y, Katsura K, Kimura K, Ohta S.
- Journal Title
  
  Neurosci Lett.
  
  Volume: 587 Pages: 126-131
- DOI
  10.1016/j.neulet.2014.12.033
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26282198, KAKENHI-PROJECT-25350907
[Journal Article] Response to Letter Regarding Article, "Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management".2015
- Author(s)
  Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Ohta S, Fukuda K, Hori S.
- Journal Title
  
  Circulation
  
  Volume: 132 Issue: 11
- DOI
  10.1161/circulationaha.115.016785
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350129, KAKENHI-PROJECT-26282198
[Journal Article] Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer's disease.2015
- Author(s)
  Kanamaru T, Kamimura N, Yokota T, Nishimaki K, Iuchi K, Lee H, Takami S, Akashiba H, Shitaka Y, Ueda M, Katsura K, Kimura K, Ohta S.
- Journal Title
  
  Brain Res.
  
  Volume: 1605 Pages: 49-58
- DOI
  10.1016/j.brainres.2015.02.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350129, KAKENHI-PROJECT-25350907, KAKENHI-PROJECT-26282198
[Journal Article] Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina2015
- Author(s)
  Yokota T, Kamimura N, Igarashi T, Takahashi H, Ohta S, Oharazawa H.
- Journal Title
  
  Clin Experiment Ophthalmol.
  
  Volume: ー Issue: 6 Pages: 568-577
- DOI
  10.1111/ceo.12525
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26282198, KAKENHI-PROJECT-26350129
[Journal Article] Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.2014
- Author(s)
  Yokoyama M, Okada S, Nakagomi A, Moriya J, Shimizu I, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, Minamino T.
- Journal Title
  
  Cell Rep
  
  Volume: 7 Issue: 5 Pages: 1691-1703
- DOI
  10.1016/j.celrep.2014.04.046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390195, KAKENHI-PUBLICLY-25126706, KAKENHI-PROJECT-25670382, KAKENHI-PLANNED-26115008, KAKENHI-PROJECT-26282198, KAKENHI-PROJECT-26350129
[Journal Article] Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management2014
- Author(s)
  Kei Hayashida, Motoaki Sano, Naomi Kamimura, Takashi Yokota, Masaru Suzuki, Shigeo Ohta, Keiichi Fukuda, Shingo Hori
- Journal Title
  
  Circulation
  
  Volume: 130 Issue: 24 Pages: 2173-80
- DOI
  10.1161/circulationaha.114.011848
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390405, KAKENHI-PROJECT-26282198, KAKENHI-PROJECT-26350129, KAKENHI-PROJECT-26670792
[Journal Article] Haploinsufficiency of akt1 prolongs the lifespan of mice2013
- Author(s)
  Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii N, Minamino T
- Journal Title
  
  PLoS One
  
  Volume: 8(7) Issue: 7 Pages: e69178-e69178
- DOI
  10.1371/journal.pone.0069178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300257, KAKENHI-PROJECT-23500971, KAKENHI-PROJECT-24390195, KAKENHI-PROJECT-24651055, KAKENHI-PUBLICLY-25126706, KAKENHI-PROJECT-25670382
[Journal Article] Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS.2012
- Author(s)
  Rikimaru M, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishimatsu S-i, Ohta S, Sunada Y.
- Journal Title
  
  Intern. Med.
  
  Volume: 51 Pages: 3351-3357
- NAID
  130003308162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24651055
[Journal Article] Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS2012
- Author(s)
  Rikimaru M, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishimatsu S, Ohta S, Sunada Y
- Journal Title
  
  Intern. Med.
  
  Volume: 51(24) Pages: 3351-3357
- NAID
  130003308162
- URL
  https://www.jstage.jst.go.jp/article/internalmedicine/51/24/51_51.7529/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24651055
[Journal Article] Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS2012
- Author(s)
  Rikimaru M, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishimatsu S, Ohta S, Sunada Y
- Journal Title
  
  Intern. Med
  
  Volume: 51(24) Pages: 3351-3357
- NAID
  130003308162
- URL
  https://www.jstage.jst.go.jp/article/internalmedicine/51/24/51_51.7529/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300257
[Journal Article] H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia2012
- Author(s)
  Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, Kawamura A, Abe T, Ohta S, Fukuda K, Hori S
- Journal Title
  
  J. Am. Heart Assoc
  
  Volume: 1(5) Issue: 5
- DOI
  10.1161/jaha.112.003459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300257, KAKENHI-PROJECT-23500971, KAKENHI-PROJECT-24500871, KAKENHI-PROJECT-24651055
[Journal Article] Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide2011
- Author(s)
  Hanaoka T, Kamimura N, Yokota T, Takai S, Ohta S
- Journal Title
  
  Med. Gas Res
  
  Volume: 1(1) Issue: 1 Pages: 18-18
- DOI
  10.1186/2045-9912-1-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300257, KAKENHI-PROJECT-23500971, KAKENHI-PROJECT-24651055
[Presentation] 糖尿病モデルマウスにおける分子状水素の効果と遺伝子発現誘導の網羅的解析2013
- Author(s)
  上村尚美、一宮治美、太田成男
- Organizer
  第3回分子状水素医学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24651055
[Presentation] Hydrogen Molecule Improves Learning and Memory Function in Mitochondrial Oxidative Stress-induced Alzheimer Model Mice2013
- Author(s)
  Takashi Yokota et al.
- Organizer
  The 11th International Conference AD/PD 2013
- Place of Presentation
  Italy
- Data Source
  KAKENHI-PROJECT-23300257
[Presentation] Hydrogen Molecule Improves Learning and Memory Function in Mitochondrial Oxidative Stress-induced Alzheimer Model Mice2013
- Author(s)
  Yokota T, Nishimaki K, Ohsawa I, Ohta S.
- Organizer
  The 11th International Conference AD/PD 2013
- Place of Presentation
  Italy
- Data Source
  KAKENHI-PROJECT-24651055
[Presentation] ラット心停止モデルを用いた水素吸入療法と低体温療法の予後改善効果の検討2013
- Author(s)
  林田敬、佐野元昭、上村尚美、横田隆、太田成男、福田恵一、堀進吾
- Organizer
  第3回分子状水素医学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24651055
[Presentation] APP transgenic mice with oxidative stress.2013
- Author(s)
  Kamimura N, Kanamaru T, Yokota T, Iuchi K, Nishimaki K, Takami S, Akashiba H, Shitaka Y, Katsura K-I, Katayama Y, Ohta S.
- Organizer
  The 11th International Conference AD/PD 2013
- Place of Presentation
  Italy
- Data Source
  KAKENHI-PROJECT-24651055
[Presentation] ミトコンドリアアルデヒド脱水素酵素２活性欠損マウス(DAL101 マウス)に対する骨髄単核球移植の認知機能改善効果2012
- Author(s)
  金丸拓也、上村尚美、井内勝哉、西槙貴代美、横田隆、高見新也、赤芝洋紀、志鷹義嗣、桂研一郎、片山泰朗、太田成男
- Organizer
  第12回日本ミトコンドリア学会年会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-24651055
[Presentation] ヒト変異APP高発現マウスと酸化ストレス亢進マウスとの掛け合わせマウスの解析2012
- Author(s)
  上村尚美、金丸拓也、横田隆、井内勝哉、西槙貴代美、高見新也、赤芝洋紀、志鷹義嗣、桂研一郎、片山泰朗、太田成男
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24651055
[Presentation] 水素発生素材の利用とその安全性の検討2012
- Author(s)
  一宮治美　他
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23300257
[Presentation] 水素発生素材の利用とその安全性の検討2012
- Author(s)
  一宮治美、上村尚美、太田成男
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24651055
[Presentation] アルツハイマーモデルマウスに対する他家骨髄単核球投与の認知機能改善効果2012
- Author(s)
  金丸拓也、上村尚美、井内勝哉、西槙貴代美、横田隆、高見新也、赤芝洋紀、志鷹義嗣、桂研一郎、片山泰朗、太田成男
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24651055

1. OHTA Shigeo (00125832)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
2. KAMIMURA Naomi (60283800)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. WOLF Alexander (20434136)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. NISHIMAKI Kiyomi (00465345)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
5. YOKOTA Takashi (30445829)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. IUCHI Katsuya (40553847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. HAYASHIDA Kei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中島尚美

# of Collaborated Projects: 0 results

# of Collaborated Products: 19 results
9. ALEXANDER M. Wol

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 南野徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 鈴木昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 佐野元昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 堀進悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ICHIMIYA Harumi 一宮 治美

YOKOTA Takashi 横田 隆

Research Projects

Research Products

Co-Researchers

Mechanism to exert multi-functions of molecular hydrogen for health-care and the prevention of diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Protective effects of hydrogen against irradiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Preventive effects of geriatric and life-style related diseases by oral administration of a novel hydrogen-producing material

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism.2016

Author(s)

Journal Title

Data Source

[Journal Article] Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Response to Letter Regarding Article, "Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management".2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer's disease.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Haploinsufficiency of akt1 prolongs the lifespan of mice2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS.2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS2012

Author(s)

Journal Title

NAID

URL

Data Source

[Journal Article] Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS2012

Author(s)

ICHIMIYA Harumi 一宮治美

YOKOTA Takashi 横田隆