Nakajima Wataru 中嶋亘

… Alternative Names

中嶋亘ナカジマワタル

NAKAJIMA Wataru 中嶋亘

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Researcher Number	40557500
Other IDs
Affiliation (Current)	2025: 日本医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 日本医科大学, 医学部, 講師 2016 – 2019: 日本医科大学, 医学部, 講師 2009: 日本医科大学, 老人病研究所, 助教 2009: 老人病研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Obstetrics and gynecology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Biological Sciences
Keywords	Principal Investigator 薬剤耐性 / EGFR変異 / 耐性克服療法 / 代謝リプログラミング / 薬剤反応性 / 癌 / パクリタキセル / シスプラチン / アンスラサイクリン / 乳癌 / 微小管阻害薬 / アポトーシス … More Except Principal Investigator … More 急性骨髄性白血病 / RAD51 / DNA修復機構 / DNMT3A変異 / ミトコンドリア活性 / MCL-1 / ベネトクラクス耐性 / シタラビン耐性 / FLT3-ITD / NPM1変異 / ミトコンドリアDNAコピー数 / Hedgehogシグナル / 細胞周期制御 / Aurora-A / GLUT3 / 癌遺伝子 / 足場非依存性増殖 / β / Hedgehog signal / B / IKKα / NF-KB / Mdm2 / Hedeho sinal / Stat3 / IL-6 / 発癌 / P53 / O-GlcNAc修飾 / グルコーストランスポーター / NF-κB / グルコース代謝 / p53 / 癌抑制 / 癌化 Less

Clinical significance and development of new target treatment of activated mitochondrial function in acute myeloid leukemia
- Principal Investigator
  
  山口博樹
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nippon Medical School
DNMT3A変異陽性AMLに生じるG2/M期の遺伝子発現異常とその標的治療の開発
- Principal Investigator
  
  脇田知志
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nippon Medical School
分子標的薬耐性肺がんにおける薬剤耐性獲得機構の解明と代謝制御を利用した治療法開発Principal Investigator
- Principal Investigator
  
  中嶋亘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nippon Medical School
Identification of factors that contribute to the anti-tumor effect of the microtubule targeting agent Paclitaxelin in TNBC cellsPrincipal Investigator
- Principal Investigator
  
  Nakajima Wataru
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nippon Medical School
Analysis of the gene transcriptional network system regulated by nuclear tumor suppressive factors
- Principal Investigator
  
  TANAKA Nobuyuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nippon Medical School

All 2023 2022 2019 2018 2017 2016 2010 2009 2008 2007

All Journal Article Presentation Patent

[Journal Article] Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments2023
- Author(s)
  Torii Takeru、Sugimoto Wataru、Itoh Katsuhiko、Kinoshita Natsuki、Gessho Masaya、Goto Toshiyuki、Uehara Ikuno、Nakajima Wataru、Budirahardja Yemima、Miyoshi Daisuke、Nishikata Takahito、Tanaka Nobuyuki、Hirata Hiroaki、Kawauchi Keiko
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 11 Pages: 766-766
- DOI
  10.1038/s41419-023-06310-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08293, KAKENHI-PLANNED-21H05127, KAKENHI-PROJECT-21H02062
[Journal Article] The iron chelator deferriferrichrysin induces paraptosis via extracellular signal‐related kinase activation in cancer cells2023
- Author(s)
  Kinoshita Natsuki、Gessho Masaya、Torii Takeru、Ashida Yukako、Akamatsu Minori、Guo Alvin Kunyao、Lee Sunmin、Katsuno Tatsuya、Nakajima Wataru、Budirahardja Yemima、Miyoshi Daisuke、Todokoro Takehiko、Ishida Hiroki、Nishikata Takahito、Kawauchi Keiko
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 9 Pages: 653-662
- DOI
  10.1111/gtc.13053
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09629, KAKENHI-PROJECT-22K08293, KAKENHI-PROJECT-21H02062
[Journal Article] DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death2019
- Author(s)
  Itoh Katsuhiko、Ebata Takahiro、Hirata Hiroaki、Torii Takeru、Sugimoto Wataru、Onodera Keigo、Nakajima Wataru、Uehara Ikuno、Okuzaki Daisuke、Yamauchi Shota、Budirahardja Yemima、Nishikata Takahito、Tanaka Nobuyuki、Kawauchi Keiko
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 17 Pages: 3175-3175
- DOI
  10.3390/molecules24173175
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04054, KAKENHI-PROJECT-19J21096, KAKENHI-PROJECT-16K11161, KAKENHI-PROJECT-18K06231
[Journal Article] p53-independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells2018
- Author(s)
  Sharma Kanika、Vu Thien-Trang、Cook Wade、Naseri Mitra、Zhan Kevin、Nakajima Wataru、Harada Hisashi
- Journal Title
  
  Molecular Oncology
  
  Volume: 12 Issue: 6 Pages: 788-798
- DOI
  10.1002/1878-0261.12172
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11161
[Journal Article] The anti-apoptotic protein MCL1, a novel target of lung cancer therapy2018
- Author(s)
  Wataru Nakajima、Nobuyuki Tanaka
- Journal Title
  
  Journal of Cancer Treatment and Diagnosis
  
  Volume: 2 Pages: 54-58
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11161
[Journal Article] Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL12017
- Author(s)
  Junya Suzuki, Wataru Nakajima, Hidenori Suzuki, Yumi Asano, Nobuyuki Tanaka
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 482 Issue: 4 Pages: 1334-1340
- DOI
  10.1016/j.bbrc.2016.12.037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11161, KAKENHI-PROJECT-17H04054
[Journal Article] BH3 mimetics: Their action and efficacy in cancer chemotherapy.2016
- Author(s)
  Nakajima W, Tanaka N.
- Journal Title
  
  Integrative Cancer Science and Therapeutics
  
  Volume: 3 Issue: 3 Pages: 437-441
- DOI
  10.15761/icst.1000184
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670164, KAKENHI-PROJECT-16K11161
[Journal Article] Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells.2016
- Author(s)
  Matsumoto M, Nakajima W, Seike M, Gemma A, Tanaka N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 473(2) Issue: 2 Pages: 490-6
- DOI
  10.1016/j.bbrc.2016.03.053
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-26670164, KAKENHI-PROJECT-16K11161
[Journal Article] Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase2and6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase-3.2010
- Author(s)
  Ando, M., Uehara, I., Kogure, K., Asano, Y., Nakajima, W., Abe, Y., Kawauchi, K., Tanaka, N.
- Journal Title
  
  J Nippon Med Sch 77
  
  Pages: 97-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054039
[Journal Article] 5-Aza-2'-deoxycytidine restores proapoptotic function of p53 in cancer cells resistant to p53-induced apoptosis.2008
- Author(s)
  Yagi, S., Oda-Sato, E., Uehara, I., Asano, Y., Nakajima, W., Takeshita, T., Tanaka, N.
- Journal Title
  
  Cancer Invest 26
  
  Pages: 680-688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054039
[Journal Article] Synergistic induction of apoptosis by p53-inducible Bcl-2 family proteins Noxa and Puma.2007
- Author(s)
  Wataru Nakajima
- Journal Title
  
  J. Nippon Med. Sch. 74
  
  Pages: 148-175
- NAID
  130004146900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054039
[Journal Article] Synergistic induction of apoptosis by p53-inducible Bcl-2 family proteins Noxa and Puma.2007
- Author(s)
  Nakajima, W., Tanaka, N.
- Journal Title
  
  J Nippon Med Sch 74
  
  Pages: 148-157
- NAID
  130004146900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054039
[Patent] 内耳疾患治療剤2016
- Inventor(s)
  田中信之、林裕史、上原郁野、中嶋亘、鈴木英紀
- Industrial Property Rights Holder
  田中信之、林裕史、上原郁野、中嶋亘、鈴木英紀
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-232704
- Filing Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K11161
[Presentation] EGFR変異非小細胞肺がんにおける免疫チェックポイント阻害剤治療耐性因子の同定と解析2023
- Author(s)
  中嶋亘, 石野孔祐, 宮崎海, 大橋隆治, 山本林
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K08293
[Presentation] EGFR変異陽性肺がんにおける薬剤耐性獲得機構の解明と代謝制御を利用した治療法開発2023
- Author(s)
  中嶋亘, 石野孔祐, 中道真仁, 松本優, 大橋隆治, 山本林
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K08293
[Presentation] EGFR変異陽性肺がんにおける酸化的リン酸化を利用した薬剤耐性獲得機構の解明と治療法開発2022
- Author(s)
  中嶋　亘
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K08293
[Presentation] トリプルネガティブ乳がんにおける化学療法抵抗性分子機構の解析2019
- Author(s)
  中嶋亘, 浅野　由ミ, 田中信之
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K11161
[Presentation] トリプルネガティブ乳癌における微小管阻害薬パクリタキセルに対する細胞死誘導機構の解析2019
- Author(s)
  中嶋亘, 栗田智子, 阪口正洋, 坂谷貴司, 内藤善弥, 武井寛幸, 田中信之
- Organizer
  日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16K11161
[Presentation] Analysis of Paclitaxel-induced apoptosis in triple-negative breast cancer2018
- Author(s)
  Nakajima Wataru, Kurita Tomoko, Naito Zenya, Takei Hiroyuki, Tanaka Nobuyuki
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K11161
[Presentation] BRCAness乳癌細胞株の微小管阻害薬パクリタキセルに対する抵抗性機構の解析2018
- Author(s)
  中嶋亘、栗田智子、浅野由ミ、武井寛幸、田中信之
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K11161
[Presentation] 乳癌細胞株の微小管阻害薬パクリタキセルに対する分子機構の解析2017
- Author(s)
  中嶋　亘、浅野　由ミ、武井寛幸、田中　信之
- Organizer
  ２０１７年度生命科学系学会合同年次大会(ConBio2017)
- Data Source
  KAKENHI-PROJECT-16K11161
[Presentation] オートファジーによるアポトーシスの抑制機構の解析2016
- Author(s)
  鈴木　淳也、中嶋　亘、田中　信之
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K11161
[Presentation] BRCAness乳癌細胞株の微小管阻害薬パクリタキセルに対する抵抗性機構の解析2016
- Author(s)
  中嶋　亘、浅野　由ミ、武井　寛幸、田中　信之
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K11161
[Presentation] 新規p53標的遺伝子によるアクチン細胞骨格の調節を介したアポトーシス誘導機構2016
- Author(s)
  江畑　貴弘、上原　郁野、平田　宏聡、小野寺　啓吾、町山　祐亮、藤田　英明、三井　靖雅、奥崎　大介、中嶋　亘、田中　信之、川内　啓子
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K11161
[Presentation] Mechanism of Bax activation by Noxa and other BH3-only proteins2009
- Author(s)
  Wataru Nakajima
- Organizer
  Cold Spring Harbor Laboratory Cell Death meeting 2009
- Place of Presentation
  Cold Spring Harbor Laboratory, The Meedngs & Courses Office(NY,USA)
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-17054039
[Presentation] Mechanism of Bax activation by Noxa and other BH3-only proteins.2009
- Author(s)
  Nakajima, W., Yumi, Asano., Tanaka, N.
- Organizer
  Cold Spring Harbor Laboratory Cell Death meeting 2009, Cold Spring Harbor Laboratory
- Place of Presentation
  NY, USA
- Data Source
  KAKENHI-PROJECT-17054039
[Presentation] Apoptosis誘導因子baxの活性化機構の解析.2009
- Author(s)
  中嶋亘、浅野由ミ、田中信之
- Organizer
  第32会日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17054039
[Presentation] Apoptosis誘導因子Baxの活性化機構の解析2009
- Author(s)
  中嶋亘
- Organizer
  第32会日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-17054039
[Presentation] BH3-only因子Noxaによるアポトーシス誘導機構の解析2008
- Author(s)
  中嶋亘
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17054039
[Presentation] BH3-only因子Noxaによるアポトーシス誘導機構の解析第31回日本分子生物学会年会2008
- Author(s)
  中嶋亘、田中信之
- Organizer
  第81回日本生化学会大会合同年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17054039
[Presentation] Sequential activation of Bax is separately regulated by Bcl-2 family proteins.2007
- Author(s)
  Nakajima, W., Tanaka, N.
- Organizer
  2007 Cold Spring Harbor Laboratory Meeting "Cell Death"
- Place of Presentation
  Cold Spring Harbor, New York, US
- Data Source
  KAKENHI-PROJECT-17054039
[Presentation] Sequential activation of Bax is separatery regulated by Bcl-2 family proteins.2007
- Author(s)
  Wataru Nakajima
- Organizer
  2007 Cold Spring Harbor Laboratory Meeting "Cell Death"
- Place of Presentation
  Cold Spring Harbor, New York, USA
- Data Source
  KAKENHI-PROJECT-17054039
[Presentation] Analysis of apoptosis induced via BH3-only family of proteins Noxa, Bim and Puma.2007
- Author(s)
  中嶋亘
- Organizer
  第30回分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17054039

1. TANAKA Nobuyuki (80222115)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
2. 山口博樹 (90297937)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 脇田知志 (70465350)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ABE Yoshinori (00386153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. UEHARA Ikuno (50434139)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. SATO Eri (90339440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KAWAUTI Keiko (40434138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. TOBIUME Kei (40350037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中道真仁 (10837446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. GENMA Akihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. KATSUNO Tatsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 清家正博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakajima Wataru 中嶋 亘

中嶋 亘 ナカジマ ワタル

NAKAJIMA Wataru 中嶋 亘

Research Projects

Research Products

Co-Researchers

Clinical significance and development of new target treatment of activated mitochondrial function in acute myeloid leukemia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNMT3A変異陽性AMLに生じるG2/M期の遺伝子発現異常とその標的治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

分子標的薬耐性肺がんにおける薬剤耐性獲得機構の解明と代謝制御を利用した治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of factors that contribute to the anti-tumor effect of the microtubule targeting agent Paclitaxelin in TNBC cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the gene transcriptional network system regulated by nuclear tumor suppressive factors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The iron chelator deferriferrichrysin induces paraptosis via extracellular signal‐related kinase activation in cancer cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] p53-independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The anti-apoptotic protein MCL1, a novel target of lung cancer therapy2018

Author(s)

Journal Title

Data Source

[Journal Article] Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL12017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BH3 mimetics: Their action and efficacy in cancer chemotherapy.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase2and6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase-3.2010

Author(s)

Journal Title

Data Source

[Journal Article] 5-Aza-2'-deoxycytidine restores proapoptotic function of p53 in cancer cells resistant to p53-induced apoptosis.2008

Nakajima Wataru 中嶋亘

中嶋亘ナカジマワタル

NAKAJIMA Wataru 中嶋亘