Nishijima Aki 西島亜紀

… Alternative Names

NISHIJIMA Aki 西島亜紀

MATSUNOBU Aki 松延亜紀

Less

Researcher Number	40566105
Affiliation (Current)	2025: 藤田医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2021: 藤田医科大学, 医学部, 講師 2018 – 2019: 秋田大学, 医学系研究科, 助教 2017: 秋田大学, 医学(系)研究科(研究院), 助教 2014 – 2015: 秋田大学, 医学(系)研究科(研究院), 助教 2013: 佐賀大学, 医学部, 助教 … More 2012: 佐賀大学, 医学部, 医員 2011: 佐賀大学, 医学部付属病院, 助教 2010: 佐賀大学, 医学部, 助教 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 49030:Experimental pathology-related
Keywords	Principal Investigator 内臓脂肪組織 / NAFLD / 脂肪毒性 / 脂肪組織 / dysbiosis / 血管内皮細胞 / エンドトキシン / 肝臓学 / アディポソーム / 皮下脂肪組織 … More / エクソソーム / 細胞外小胞 / アポトーシス / 肝細胞 / 癌幹細胞ー間質細胞相互作用 / 癌幹細胞-間質細胞相互作用 / 肝癌幹細胞 … More Except Principal Investigator がんの進展 / 適応応答 / 細胞内コネキシン / パネキシン / 放射線耐性 / 小胞体ストレス応答 / 腫瘍浸潤リンパ球 / 逆行輸送 / 細胞内輸送 / ストレス応答 / ATF6α / 小胞体ストレス / がん幹細胞 / ギャップ結合 / コネキシン Less

LPS暴露腸間膜由来血管内皮細胞がNAFLD病態形成に果たす役割の解明Principal Investigator
- Principal Investigator
  
  西島亜紀
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Fujita Health University
Intracellular connexin-induced adaptive stress-response pathway – Its molecular bases
- Principal Investigator
  
  Omori Yasufumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Akita University
Mechanism of visceral/subcutaneous adipose tissue derived adiposome-induced hepatocyte lipotoxicityPrincipal Investigator
- Principal Investigator
  
  Nishijima Aki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
Roles of adipose tissue in survival, proliferation, differentiation and lipotoxicity of hepatocytesPrincipal Investigator
- Principal Investigator
  
  Nishijima Aki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
  Saga University
The regulation mechanism of adipose tissue in survival, proliferation, differentiation and migration of hepatocellular carcinoma-derived cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  NISHIJIMA Aki (MATSUNOBU Aki)
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saga University

All 2020 2019 2018 2016 2015 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Interaction between Esophageal Squamous Cell Carcinoma and Adipose Tissue in Vitro.2016
- Author(s)
  Nakayama A, Aoki S, Uchihashi K, Nishijima-Matsunobu A, Yamamoto M, Kakihara N, Iwakiri R, Fujimoto K, Toda S
- Journal Title
  
  Am J Pathol.
  
  Volume: 印刷中 Issue: 5 Pages: 1180-94
- DOI
  10.1016/j.ajpath.2016.01.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462302, KAKENHI-PROJECT-25461001, KAKENHI-PROJECT-26460941
[Journal Article] Differential effects of adipose tissue stromal cells on the apoptosis, growth and invasion of bladder urothelial carcinoma between the superficial and invasive types.2016
- Author(s)
  Kawasaki-Nanri M, Aoki S, Uchihashi K, Yamamoto M, Udo K, Nishijima-Matsunobu A, Kakihara N, Noguchi M, Uozumi J, Toda S.
- Journal Title
  
  Int J Urol.
  
  Volume: 印刷中 Issue: 6 Pages: 510-19
- DOI
  10.1111/iju.13086
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462302, KAKENHI-PROJECT-25461001, KAKENHI-PROJECT-25462485, KAKENHI-PROJECT-25462486, KAKENHI-PROJECT-26460941
[Journal Article] The Apoptotic Effect of HIF-1α Inhibition Conbined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions2015
- Author(s)
  Tanaka T, Kitajima Y, Miyake S, Yanagihara K, Hara H, Nishijima-Matsunobu A, Baba K, Shida M, Wakiyama K, Nakamura J, Noshiro H.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 9 Pages: e0137257-e0137257
- DOI
  10.1371/journal.pone.0137257
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461001
[Journal Article] Three-dimensional culture model for analyzing crosstalk between adipose tissue and hepatocytes2013
- Author(s)
  Nishijima-Matsunobu A, Uchihashi K, Aoki S, Ootani A, Node K, Toda S
- Journal Title
  
  Cell Tissue Res
  
  Volume: 352 Pages: 611-612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] Three-dimensional culture model for analyzing crosstalk between adipose tissue and hepatocytes2013
- Author(s)
  Nishijima-Matsunobu A, Aoki S, Uchihashi K, Fujimoto K, Toda S
- Journal Title
  
  Cell Tissue Res
  
  Volume: 352 Issue: 3 Pages: 611-621
- DOI
  10.1007/s00441-013-1588-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591050, KAKENHI-PROJECT-24791553, KAKENHI-PROJECT-25461001
[Journal Article] Osteoblast migration into type I collagen gel and differentiation osteocyte-like cells within a self-produced mineralized matrix: A novel system for analyzing differentiation from osteoblast to osteocyte2013
- Author(s)
  Uchihashi K, Aoki S, Matsunobu A, Ootani A, Node K, Toda S
- Journal Title
  
  Bone
  
  Volume: 52 (1) Pages: 102-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] Three-Dimensional Culture Model for Analyzing Adipose Tissue–Hepatocyte Crosstalk2013
- Author(s)
  Aki Nishijima-Matsunobu, Shigehisa Aoki, Kazuyoshi Uchihashi, Kazuma Fujimoto, and Shuji Toda
- Journal Title
  
  Cell and Tissue Research
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] Adipose tissue behavior is distinctly regulated by neighboring cells and fluid flow stress: a possible role of adipose tissue in peritoneal fibrosis2013
- Author(s)
  Aoki S, Udo K, Morimoto H, Ikeda S, Takezawa T, Uchihashi K,, Nishijima-Matsunobu A, Noguchi M, Toda S
- Journal Title
  
  Journal of Artifical Organs
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] Interaction between adipose tissue stromal cells and gastric cancer cells in vitro2011
- Author(s)
  Nomoto-Kojima N, Aoki S, Uchihashi K, Matsunobu A, Koike E, et. al.
- Journal Title
  
  Cell Tissue Res
  
  Volume: 344 Pages: 287-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] 脂肪組織を基盤とした生体恒常性・メタボリックシンドローム病態解析モデル2011
- Author(s)
  松延亜紀, 藤本一眞, 戸田修二
- Journal Title
  
  臨床検査
  
  Volume: 55 Pages: 581-586
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] 脂肪組織を基盤とした生体恒常性・メタボリックシンドローム病態解析モデル2011
- Author(s)
  松延亜紀、藤本一眞、戸田修二
- Journal Title
  
  臨床検査
  
  Volume: 55 (6) Pages: 533-538
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] 脂肪組織と脂肪細胞の基礎形態学2011
- Author(s)
  戸田修二、松延亜紀、内橋和芳、山本美保子、薬師寺舞、他4名
- Journal Title
  
  臨床検査
  
  Volume: 55 (6) Pages: 581-586
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] 脂肪組織と脂肪細胞の基礎形態学2011
- Author(s)
  戸田修二, 松延亜紀, 内橋和芳, 山本美保子, 薬師寺舞, 山崎文朗, 小池英介, 青木茂久, 杉原甫
- Journal Title
  
  臨床検査
  
  Volume: 55 Pages: 533-538
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] A promising culture model for analying the interaction between adipose tissue and cardiomyocytes2011
- Author(s)
  Anan M, Uchihashi K, Aoki S, Matsunobu A, Ootani A, Node K, Toda S
- Journal Title
  
  Endocrinology
  
  Volume: 152 (4) Pages: 1599-1605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] Epidermal regeneration by keratinocyte-alien mesenchymal cell interactions2010
- Author(s)
  Aoki S, Kitajima Y, Takezawa T, UchihashiK, Matsunobu A, et. al.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 30 (5) Pages: 428-433
- NAID
  10027651753
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] The air liquid-interface, a skin microenvironment, promotes growth of melanoma cells, but not their apoptosis and invasion, through activation of mitogen-activated protein kinase2010
- Author(s)
  Yee CH, Aoki S, Uchihashi K, Matsunobu A,Yamasaki F, et.al.
- Journal Title
  
  Acta Histochem Cytochem
  
  Volume: 43 Pages: 1-7
- NAID
  130000158695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] Adipose tissue explants and MDCK cells reciprocally regulate their morphogenesis in coculture2010
- Author(s)
  Udo K, Aoki S, Uchihashi K, Kawasaki M, Matsunobu A, Tokuda Y, Ootani A, Toda S, Uozumi J.
- Journal Title
  
  Kidney Int
  
  Volume: 78 Pages: 60-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590740
[Journal Article] メタボリック症候群における脂肪組織の病理形態と病態解析培養モデル2010
- Author(s)
  戸田修二、青木茂久、内橋和芳、松延亜紀, 他5名
- Journal Title
  
  病理と臨床
  
  Volume: 28 (9) Pages: 959-965
- Data Source
  KAKENHI-PROJECT-22590740
[Presentation] Curcumin analog GO-Y030 diminishes cancer stem cell population by inhibiting interaction of HSP70 with its substrates2020
- Author(s)
  Suzuki M, Yamamoto Y, Nishijima A, Shibata H, Omori Y
- Organizer
  Annual Meeting 2020 of The American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07497
[Presentation] クルクミン類縁体GO-Y030はHSP70と基質との結合を阻害することでがん幹細胞画分を減少させる2020
- Author(s)
  鈴木麻弥, 山本洋平, 西島亜紀, 大森泰文
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K07497
[Presentation] クルクミン類縁体によるがん幹細胞画分の減少はHSP70/40の機能阻害を介している2019
- Author(s)
  鈴木麻弥，山本洋平，西島亜紀，大森泰文
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K07497
[Presentation] 肝細胞脂肪毒性の解明2018
- Author(s)
  西島亜紀，山本洋平，鈴木麻弥，田口歩美，大森泰文
- Organizer
  日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K09402
[Presentation] 肝細胞脂肪毒性の解明2018
- Author(s)
  西島亜紀、山本洋平、鈴木麻弥、田口歩美、大森康文
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-17K09402
[Presentation] 肥大した成熟脂肪細胞径は肝の脂肪沈着と相関する2015
- Author(s)
  西島亜紀、山本美保子、内橋和芳、青木茂久、大森泰文、杉原甫、戸田修二
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2015-05-02
- Data Source
  KAKENHI-PROJECT-25461001
[Presentation] 慢性肝疾患患者による脂肪組織と肝組織の病理学的検討2015
- Author(s)
  西島亜紀、高橋宏和、戸田修二、江口雄一郎
- Organizer
  第2回肝臓と糖尿病・代謝研究会
- Place of Presentation
  山口県下関市
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-25461001
[Presentation] 脂肪組織‐肝細胞相互作用解析モデルの確立2012
- Author(s)
  松延亜紀
- Organizer
  日本内分泌病理学会学術総会
- Place of Presentation
  仙台艮陵会館
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PROJECT-22590740
[Presentation] 脂肪組織ー肝細胞相互作用解析モデルの確立2012
- Author(s)
  松延亜紀、薬師寺舞、山本美保子、内橋和芳、青木茂久、米満伸久、戸田修二
- Organizer
  日本内分泌病理学会学術総会
- Place of Presentation
  艮陵会館(宮城県仙台市)
- Data Source
  KAKENHI-PROJECT-22590740
[Presentation] 脂肪組織由来間質細胞は胃癌の直接促進因子であり、分子標的療法の阻害因子である2012
- Author(s)
  松延亜紀
- Organizer
  日本消化管学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2012-02-10
- Data Source
  KAKENHI-PROJECT-22590740
[Presentation] 脂肪組織が、肝細胞の生存・増殖・分化に及ぼす影響とその制御機構2012
- Author(s)
  松延亜紀、薬師寺舞、山本美保子、内橋和芳、青木茂久、米満伸久、戸田修二
- Organizer
  日本内分泌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-22590740
[Presentation] 内臓脂肪組織は肝細胞に脂肪毒性を誘導する2012
- Author(s)
  松延亜紀、内橋和芳、青木茂久、山本美保子、薬師寺舞、山﨑文朗、米満伸久、戸田修二
- Organizer
  日本病理学会総会
- Place of Presentation
  京王プラザホテル
- Data Source
  KAKENHI-PROJECT-22590740
[Presentation] 脂肪組織が、肝細胞の生存・増殖・分化に及ぼす影響とその制御機構の解明2012
- Author(s)
  松延亜紀
- Organizer
  日本内分泌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-04-21
- Data Source
  KAKENHI-PROJECT-22590740
[Presentation] 内臓脂肪組織は肝細胞に脂肪毒性を誘導する2012
- Author(s)
  松延亜紀
- Organizer
  内臓脂肪組織は肝細胞に脂肪毒性を誘導する
- Place of Presentation
  京王プラザホテル
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-22590740
[Presentation] A novel model for analyzing the interaction between adipose tissue and hepatocytes2011
- Author(s)
  Matsunobu A, Uchihashi K, Aoki S, Toda S.
- Organizer
  4thInternational Congress on PREDIABATES and the METABOLIC SYNDROME
- Place of Presentation
  Spain, Madrid
- Year and Date
  2011-04-09
- Data Source
  KAKENHI-PROJECT-22590740
[Presentation] A Novel Model for Analyzing the Interaction between Adipose Tissue and Hepatocyte2011
- Author(s)
  松延亜紀
- Organizer
  4^<th> International Congress on Prediabetes and the Metabolic Syndrome
- Place of Presentation
  スペイン、マドリッド
- Year and Date
  2011-04-09
- Data Source
  KAKENHI-PROJECT-22590740
[Presentation] 脂肪組織―肝細胞相互作用解析モデルの確立
- Author(s)
  西島亜紀、青木茂久、内橋和芳、藤本一眞、戸田修二
- Organizer
  第18回アディポサイエンス・シンポジウム
- Place of Presentation
  大阪千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-25461001
[Presentation] 肝細胞―脂肪組織相互作用解析モデルの確立
- Author(s)
  西島　亜紀、青木　茂久、内橋　和芳、山本　美保子、戸田　修二
- Organizer
  第21回肝細胞研究会
- Place of Presentation
  東京医科歯科大学
- Year and Date
  2014-06-27 – 2014-06-28
- Data Source
  KAKENHI-PROJECT-25461001

1. TODA Shuji (80188755)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
2. Omori Yasufumi (90323138)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. 山本洋平 (70400512)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. UCHIHASHI Kazuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Nishijima Aki 西島 亜紀

NISHIJIMA Aki 西島 亜紀

MATSUNOBU Aki 松延 亜紀

Research Projects

Research Products

Co-Researchers

LPS暴露腸間膜由来血管内皮細胞がNAFLD病態形成に果たす役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intracellular connexin-induced adaptive stress-response pathway &#8211; Its molecular bases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of visceral/subcutaneous adipose tissue derived adiposome-induced hepatocyte lipotoxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of adipose tissue in survival, proliferation, differentiation and lipotoxicity of hepatocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The regulation mechanism of adipose tissue in survival, proliferation, differentiation and migration of hepatocellular carcinoma-derived cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Interaction between Esophageal Squamous Cell Carcinoma and Adipose Tissue in Vitro.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential effects of adipose tissue stromal cells on the apoptosis, growth and invasion of bladder urothelial carcinoma between the superficial and invasive types.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Apoptotic Effect of HIF-1α Inhibition Conbined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three-dimensional culture model for analyzing crosstalk between adipose tissue and hepatocytes2013

Author(s)

Journal Title

Data Source

[Journal Article] Three-dimensional culture model for analyzing crosstalk between adipose tissue and hepatocytes2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Osteoblast migration into type I collagen gel and differentiation osteocyte-like cells within a self-produced mineralized matrix: A novel system for analyzing differentiation from osteoblast to osteocyte2013

Author(s)

Journal Title

Data Source

[Journal Article] Three-Dimensional Culture Model for Analyzing Adipose Tissue–Hepatocyte Crosstalk2013

Author(s)

Journal Title

Data Source

[Journal Article] Adipose tissue behavior is distinctly regulated by neighboring cells and fluid flow stress: a possible role of adipose tissue in peritoneal fibrosis2013

Author(s)

Journal Title

Data Source

[Journal Article] Interaction between adipose tissue stromal cells and gastric cancer cells in vitro2011

Author(s)

Journal Title

Data Source

[Journal Article] 脂肪組織を基盤とした生体恒常性・メタボリックシンドローム病態解析モデル2011

Author(s)

Journal Title

Data Source

Nishijima Aki 西島亜紀

NISHIJIMA Aki 西島亜紀

MATSUNOBU Aki 松延亜紀

Intracellular connexin-induced adaptive stress-response pathway – Its molecular bases