Ogiwara Hideaki 荻原秀明

… Alternative Names

OGIWARA Hideaki 荻原秀明

Less

Researcher Number	40568953
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, 分野長
Affiliation (based on the past Project Information) *help	2019 – 2024: 国立研究開発法人国立がん研究センター, 研究所, 分野長 2018: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2016 – 2017: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2015: 国立研究開発法人国立がん研究センター, 研究所ゲノム生物学研究分野, 研究員 2014: 国立がん研究センター, 研究所, 研究員 2011 – 2014: 独立行政法人国立がん研究センター, 研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 50:Oncology and related fields / Tumor therapeutics / Clinical oncology Except Principal Investigator Obstetrics and gynecology / Biological Sciences
Keywords	Principal Investigator 合成致死性 / 合成致死 / クロマチン制御因子 / 分子標的薬 / パラログ / がんゲノム医療 / 分子標的治療 / クロマチンリモデリング / がん抑制遺伝子 / SWI/SNFクロマチンリモデリング複合体 … More / 創薬標的探索 / 個別化がん治療 / 遺伝学的相補機構 / ARID1A/ARID1B / BRG1/BRM / CBP/p300 / 個別化がん医療 / 個別化がん治療法 / 阻害薬 / がん治療 / 標的探索 / エピジェネティクス / 個別化医療 / 若年性がん / 小児がん / SMARCB1 / 個別化治療法 / BAP1 / SETD2 / 最適化がん治療 / PBRM1 / 腎臓がん / Molecular Target Therapy / Synthetic Lethal / Chromatin Remodeling / Epigenetics / ARID1A / ヒストンアセチル化 / ヒストン修飾 / アセチル化酵素 / CBP / BRG1 / SWI/SNF … More Except Principal Investigator クロマチンリモデリング / 合成致死 / PDX / OCCC / 分子標的治療 / BSO / APR-246 / 最適化がん治療 / 患者由来細胞株 / グルタチオン / SLC7A11 / 精密医療 / ARID1A / 卵巣がん / 婦人科腫瘍 / 卵巣明細胞がん / クロマチン修飾 / SWI/SNF複合体 / CBP/p300蛋白質 / 非相同末端結合 / ヒストン修飾 / 発がん / DNA切断修復 / ヒストンアセチル化 / がん / 遺伝子融合 / がん治療 / クロマチン制御 Less

次世代型”合成致死標的探索法”を用いたSWI/SNF欠損がんに有望な新規治療標的の探索Principal Investigator
- Principal Investigator
  
  荻原秀明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Development of a rational synthetic lethal treatment to eliminate paralog-deficient cancerPrincipal Investigator
- Principal Investigator
  
  Ogiwara Hideaki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Cancer Center Japan
Development of new therapeutic target search methods by simultaneous inhibition of multiple factorsPrincipal Investigator
- Principal Investigator
  
  Ogiwara Hideaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Development of synthetic lethal therapy based on gene mutations in renal cancerPrincipal Investigator
- Principal Investigator
  
  Ogiwara Hideaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Efficacy of molecular targeting therapy and establishment of patient derived model in ARID1A-deficient ovarian clear cell carcinoma
- Principal Investigator
  
  Tomoyasu Katoh
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Cancer Center Japan
Development of cancer therapy for chromatin remodeling deficient cancerPrincipal Investigator
- Principal Investigator
  
  Ogiwara Hideaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  National Cancer Center Japan
Identification of anti-cancer targets based on synthetic lethality between paralogous genesPrincipal Investigator
- Principal Investigator
  
  OGIWARA Hideaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical oncology
- Research Institution
  National Center of Neurology and Psychiatry
Chromatin remodeling regulation involved in carcinogenesis and cancer therapy
- Principal Investigator
  
  KOHNO Takashi
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Japan

All 2024 2019 2018 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book Patent

[Book] Frontiers in Radiation Oncology2013
- Author(s)
  Oike T, Ogiwara H, Nakano T, Kohno T
- Publisher
  InTech
- Data Source
  KAKENHI-PLANNED-22131006
[Journal Article] Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers.2019
- Author(s)
  Ogiwara H, Takahashi K, Sasaki M, Kuroda T, Yoshida H, Watanabe R, Maruyama A, Makinoshima H, Chiwaki F, Sasaki H, Kato T, Okamoto A, Kohno T.
- Journal Title
  
  Cancer Cell
  
  Volume: 35 Issue: 2 Pages: 177-190
- DOI
  10.1016/j.ccell.2018.12.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11310, KAKENHI-PROJECT-17H04298, KAKENHI-PROJECT-19K22892, KAKENHI-PROJECT-18H03330
[Journal Article] Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression.2016
- Author(s)
  Ogiwara H, Sasaki M, Mitachi T, Oike T, Higuchi S, Tominaga Y, Kohno T.
- Journal Title
  
  Cancer Discov.
  
  Volume: 6 Pages: 430-445
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26830122
[Journal Article] The EGFR mutation status affects the relative biological effectiveness of carbon-ion beams in non-small cell lung carcinoma cells.2015
- Author(s)
  Amornwichet N, Oike T, Shibata A, Nirodi CS, Ogiwara H, Makino H, Kimura Y, Hirota Y, Isono M, Yoshida Y, Ohno T, Kohno T, Nakano T.
- Journal Title
  
  Sci Rep.
  
  Volume: 11 Issue: 1 Pages: 11305-11305
- DOI
  10.1038/srep11305
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09988, KAKENHI-PROJECT-15K15449, KAKENHI-PROJECT-26670549, KAKENHI-PROJECT-26830122, KAKENHI-PROJECT-25861066, KAKENHI-PROJECT-24390288, KAKENHI-PROJECT-26701005
[Journal Article] SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells2015
- Author(s)
  Meryem Alagoz, Yoko Katsuki, Hideaki Ogiwara, Tomoo Ogi, Atsushi Shibata, Andreas Kakarougkas, and Penny Jeggo
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 43(16) Issue: 16 Pages: 7931-7944
- DOI
  10.1093/nar/gkv722
- NAID
  120006986903
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670549, KAKENHI-PROJECT-26830122, KAKENHI-PROJECT-26291005, KAKENHI-PROJECT-26701005, KAKENHI-PROJECT-15H02654
[Journal Article] Carbon-Ion Beam Irradiation Kills X-Ray-Resistant p53-Null Cancer Cells by Inducing Mitotic Catastrophe2014
- Author(s)
  Amornwichet N, Oike T, Shibata A, Ogiwara H, Tsuchiya N, Yamauchi M, Saitoh Y, Sekine R, Isono M, Yoshida Y, Ohno T, Kohno T, Nakano T
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 12 Pages: e115121-e115121
- DOI
  10.1371/journal.pone.0115121
- NAID
  120006986291
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-24791275, KAKENHI-PROJECT-25861066, KAKENHI-PROJECT-25893030, KAKENHI-PROJECT-26670549, KAKENHI-PROJECT-26701005, KAKENHI-PROJECT-26830122
[Journal Article] Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice2014
- Author(s)
  Kato K, Nakajima K, Ui A, Muto-Terao Y, Ogiwara H, Nakada S
- Journal Title
  
  Mol Cell
  
  Volume: 53(4) Issue: 4 Pages: 617-30
- DOI
  10.1016/j.molcel.2014.01.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300358, KAKENHI-PROJECT-23310040, KAKENHI-PROJECT-24710057, KAKENHI-PUBLICLY-25131708, KAKENHI-PROJECT-26830122
[Journal Article] Proposal for a synthetic lethality therapy using the paralog dependence of cancer cells-response2014
- Author(s)
  Oike T, Ogiwara H, Nakano T, Kohno T
- Journal Title
  
  Cancer Res
  
  Volume: 74 Issue: 17 Pages: 4948-4949
- DOI
  10.1158/0008-5472.can-14-0674
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-26830122
[Journal Article] Chromatin-regulating proteins as targets for cancer therapy.2014
- Author(s)
  Oike T, Ogiwara H, Amornwichet N, Nakano T, Kohno T.
- Journal Title
  
  J Radiat Res.
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe.2014
- Author(s)
  Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, Kubo N, Nakano T, Kohno T
- Journal Title
  
  Radiother Oncol
  
  Volume: 111 Issue: 2 Pages: 222-227
- DOI
  10.1016/j.radonc.2014.03.015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-26830122
[Journal Article] Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice2014
- Author(s)
  Kato K, Nakajima K, Ui A, Muto-Terao Y, Ogiwara H, Nakada S
- Journal Title
  
  Mol Cell.
  
  Volume: 53 Pages: 617-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe2014
- Author(s)
  Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, Kubo N, Nakano T, Kohno T
- Journal Title
  
  Radiother Oncol.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma2014
- Author(s)
  Nakaoku T, Tsuta K, Ichikawa H, Shiraishi K, Sakamoto H, Enari M, Furuta K, Shimada Y, Ogiwara H, Watanabe SI, Nokihara H, Yasuda K, Hiramoto M, Nammo T, Ishigame T, Schetter AJ, Okayama H, Harris CC, Kim YH, Mishima M, Yokota J, Yoshida T, Kohno T
- Journal Title
  
  Clin Cancer Res.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] Possible involvement of LKB1-AMPK signaling in non-homologous end joining.2014
- Author(s)
  Ui A, Ogiwara H, Nakajima S, Kanno S-I, Watanabe R, Harata M, Okayama H, Harris CC, Yokota J, Yasui A and Kohno T
- Journal Title
  
  Oncogene
  
  Volume: 33 Issue: 13 Pages: 1640-1648
- DOI
  10.1038/onc.2013.125
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22131005, KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-23510059, KAKENHI-PROJECT-23658281, KAKENHI-PROJECT-23701110, KAKENHI-PROJECT-24380183, KAKENHI-PROJECT-24710057, KAKENHI-PLANNED-25116009, KAKENHI-PUBLICLY-25118503, KAKENHI-PUBLICLY-25125703, KAKENHI-PROJECT-25660286, KAKENHI-PROJECT-26830122
[Journal Article] SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability2014
- Author(s)
  Watanabe R, Ui A, Kanno S-I, Ogiwara H, Nagase T, Kohno T, and Yasui A.
- Journal Title
  
  Cancer Res.
  
  Volume: 74 Issue: 9 Pages: 2465-2475
- DOI
  10.1158/0008-5472.can-13-3608
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22131005, KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-26340020, KAKENHI-PROJECT-26830122
[Journal Article] Possible involvement of LKB1-AMPK signaling in non-homologous end joining2014
- Author(s)
  Ui A, Ogiwara H, Nakajima S, Kanno S, Watanabe R, Harata M, Okayama H, Harris CC, Yokota J, Yasui A, Kohno T
- Journal Title
  
  Oncogene.
  
  Volume: 33 Pages: 1640-1648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] Molecular mechanisms underlying oncogenic RET fusion in lung adenocarcinoma2014
- Author(s)
  Mizukami T, Shiraishi K, Shimada Y, Ogiwara H, Tsuta K, Ichikawa H, Sakamoto H, Kato M, Shibata T, Nakano T, Kohno T
- Journal Title
  
  J Thoracic Oncol
  
  Volume: 9 Issue: 5 Pages: 622-630
- DOI
  10.1097/jto.0000000000000135
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-26830122
[Journal Article] Chromatin-regulating proteins as targets for cancer therapy.2014
- Author(s)
  Oike T, Ogiwara H, Amornwichet N, Nakano T, Kohno T.
- Journal Title
  
  J Radiat Res
  
  Volume: 55 Issue: 4 Pages: 613-628
- DOI
  10.1093/jrr/rrt227
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-25861066, KAKENHI-PROJECT-26830122
[Journal Article] SWI/SNF Factors Required for Cellular Resistance to DNA Damage Include ARID1A and ARID1B and Show Interdependent Protein Stability2014
- Author(s)
  Watanabe R, Ui A, Kanno S, Ogiwara H, Nagase T, Kohno T, Yasui A
- Journal Title
  
  Cancer Res.
  
  Volume: 74 Pages: 2465-2475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] Molecular Mechanisms Underlying Oncogenic RET Fusion in Lung Adenocarcinoma2014
- Author(s)
  Mizukami T, Shiraishi K, Shimada Y, Ogiwara H, Tsuta K, Ichikawa H, Sakamoto H, Kato M, Shibata T, Nakano T, Kohno T
- Journal Title
  
  J Thorac Oncol.
  
  Volume: 9 Pages: 622-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] Druggable oncogene fusions in invasive mucinous lung adenocarcinoma.2014
- Author(s)
  Nakaoku T, Tsuta K, Ichikawa H, Shiraishi K, Sakamoto H, Enari M, Furuta K, Shimada Y, Ogiwara H, Watanabe S, Nokihara H, Yasuda K, Hiramoto M, Nammo T, Ishigame T, Schetter AJ, Okayama H, Harris CC, Kim YH, Mishima M, Yokota J, Yoshida T, Kohno T
- Journal Title
  
  Clin Cancer Res
  
  Volume: 20 Issue: 12 Pages: 3087-3093
- DOI
  10.1158/1078-0432.ccr-14-0107
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293200, KAKENHI-PROJECT-26461352, KAKENHI-PROJECT-26830122
[Journal Article] Chromatin-regulating proteins as targets for cancer therapy2014
- Author(s)
  Oike T, Ogiwara H, Amornwichet N, Nakano T, Kohno T
- Journal Title
  
  J Radiat Res.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor2013
- Author(s)
  Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T
- Journal Title
  
  Carcinogenesis.
  
  Volume: 34 Pages: 2486-2497
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG12013
- Author(s)
  Oike T, Ogiwara H, Tominaga Y, Ito K, Ando O, Tsuta K, Mizukami T, Shimada Y, Isomura H, Komachi M, Furuta K, Watanabe S, Nakano T, Yokota J, Kohno T
- Journal Title
  
  Cancer Res.
  
  Volume: 73 Pages: 5508-5518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] Inactivating mutations in SWI/SNF chromatin remodeling genes in human cancer2013
- Author(s)
  Oike T, Ogiwara H, Nakano T, Yokota J, Kohno T
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: 43 Pages: 849-855
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] Inactivating mutations in SWI/SNF chromatin remodeling genes in human cancer.2013
- Author(s)
  Oike T, Ogiwara H, Nakano T, Kohno T
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 43 Issue: 9 Pages: 849-855
- DOI
  10.1093/jjco/hyt101
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-23701110, KAKENHI-PROJECT-25861066
[Journal Article] Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor.2013
- Author(s)
  Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T
- Journal Title
  
  Carcinogenesis
  
  Volume: 34 Issue: 11 Pages: 2486-2497
- DOI
  10.1093/carcin/bgt240
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-23701110, KAKENHI-PROJECT-24310037, KAKENHI-PROJECT-24710057, KAKENHI-PROJECT-25701005
[Journal Article] A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.2013
- Author(s)
  Oike T, Ogiwara H, Tominaga Y, Ito K, Ando O, Tsuta K, Mizukami T, Shimada Y, Isomura H, Komachi M, Furuta K, Watanabe SI, Nakano T, Yokota J, Kohno T
- Journal Title
  
  Cancer Res
  
  Volume: 73 Issue: 17 Pages: 5508-5518
- DOI
  10.1158/0008-5472.can-12-4593
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-23701110
[Journal Article] CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes2012
- Author(s)
  Ogiwara H
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 12 Pages: e52810-e52810
- DOI
  10.1371/journal.pone.0052810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110, KAKENHI-PLANNED-22131006
[Journal Article] Histone acetylation by CBP and p300 at double strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors.2011
- Author(s)
  Ogiwara, H.
- Journal Title
  
  Oncogene
  
  Volume: 30 Pages: 2135-2146
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131006
[Journal Article] Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors.2011
- Author(s)
  Ogiwara H et al
- Journal Title
  
  Oncogene
  
  Volume: 30 Issue: 18 Pages: 2135-2146
- DOI
  10.1038/onc.2010.592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701110
[Journal Article] Essential factors for incompatible DNA end joining at chromosomal DNA double strand breaks in vivo2011
- Author(s)
  Ogiwara H
- Journal Title
  
  PLoS One
  
  Volume: 6 Issue: 12 Pages: e28756-e28756
- DOI
  10.1371/journal.pone.0028756
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-23701110
[Patent] P300を阻害する化合物によるがんの治療への応答性を予測する方法2014
- Inventor(s)
  河野隆志、荻原秀明
- Industrial Property Rights Holder
  河野隆志、荻原秀明
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-032928
- Filing Date
  2014-02-24
- Data Source
  KAKENHI-PLANNED-22131006
[Patent] P300を阻害する化合物によるがんの治療への応答性を予測する方法2014
- Inventor(s)
  河野隆志・荻原秀明
- Industrial Property Rights Holder
  河野隆志・荻原秀明
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-032928
- Filing Date
  2014-02-24
- Data Source
  KAKENHI-PROJECT-23701110
[Presentation] SMARCB1欠損がんにおける複数因子同時阻害法を用いた合成致死標的の同定2024
- Author(s)
  佐々木麻里子、荻原秀明
- Organizer
  第28回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02796
[Presentation] Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Ovarian Clear Cell Carcinoma2019
- Author(s)
  Kazuaki Takahashi1,2, Hideaki Ogiwara1, Mariko Sasaki1, Takafumi Kuroda1,2, Hiroshi Yoshida3, Reiko Watanabe3, Ami Maruyama4,5, Hideki Makinoshima4, Fumiko Chiwaki6, Hiroki Sasaki6, Tomoyasu Kato7, Aikou Okamoto2 and Takashi Kohno1
- Organizer
  The 4th Asia-Pacific Ovarian Cancer Laparotomic and Laparoscopic Operation (APOLLO)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11310
[Presentation] クロマチン制御遺伝子変異型腎臓がんにおける合成致死標的の探索2019
- Author(s)
  佐々木麻里子1、河野隆志、荻原秀明
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07312
[Presentation] クロマチンリモデリング複合体欠損がんにおける合成致死治療法の開発2018
- Author(s)
  荻原秀明、佐々木麻里子、河野隆志
- Organizer
  2018年第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K11310
[Presentation] SWI/SNFクロマチンリモデリング欠損がんにおける合成致死標的の探索2018
- Author(s)
  Hideaki Ogiwara, Mariko Sasaki, Kazuaki Takahashi, Takafumi Kuroda, Takashi Kohno
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K11310
[Presentation] Identification of Synthetic Lethal Targets in ARID1A-Deficient Ovarian Cancers2018
- Author(s)
  Kazuaki Takahashi, Hideaki Ogiwara, Mariko Sasaki, Takafumi Kuroda, Reiko Watanabe, Hiroshi Yoshida, Tomoyasu Kato, Aikou Okamoto and Takashi Kohno
- Organizer
  IGCS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11310
[Presentation] CBP欠失がんにおけるp300依存性を標的とした合成致死治療法2015
- Author(s)
  荻原秀明、佐々木麻里子、尾池貴洋、河野隆志
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26830122
[Presentation] Development of Novel Cancer Therapeutics using Synthetic Lethality2015
- Author(s)
  Takashi Kohno, Hideaki Ogiwara, Motonobu Saito
- Organizer
  第53回日本癌治療学会学術集会
- Place of Presentation
  京都府国立京都国際会館
- Year and Date
  2015-10-29
- Invited
- Data Source
  KAKENHI-PROJECT-26830122
[Presentation] HER2/HER3シグナル阻害によるNRG1遺伝子融合陽性肺がんの治療2015
- Author(s)
  中奥敬史, 蔦幸治、村山貴彦、中田飛鳥, 白石航也、荻原秀明、金永学、三嶋理晃、後藤典子, 河野隆志
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26830122
[Presentation] Druggable oncogene fusions in invasive mucinous lung adenocarcinoma2015
- Author(s)
  Takashi Nakaoku, Koji Tsuta, Hitoshi Ichikawa, Kouya Shiraishi, Hiromi Sakamoto, Masato Enari, Koh Furuta, Yoko Shimada, Hideaki Ogiwara, Shun-ichi Watanabe, Hiroshi Nokihara, Kazuki Yasuda, Masaki Hiramoto, Takao Nammo, Young Hak Kim, Michiaki Mishima, Jun Yokota, Teruhiko Yoshida, and Takashi Kohno
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Pennsylvania Convenetion Center Philadelphia, Pennsylvania, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830122
[Presentation] がん遺伝子融合とクロマチン制御異常を標的とした肺がん個別化治療2015
- Author(s)
  河野隆志、荻原秀明、齋藤元伸
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋国際会議場
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-26830122
[Presentation] SNF5/SMARCB1変異がんにおける合成致死遺伝子の探索2015
- Author(s)
  三田地隆史、板垣宏、河野隆志、荻原秀明
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  兵庫県神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26830122
[Presentation] Personalized medicine of lung cancer using RET oncogene fusion and SWI/SNF deficiency2014
- Author(s)
  Takashi Kohno,Hideaki Ogiwara,
- Organizer
  International Conference 2014: Replication, repair and transcription
- Place of Presentation
  Kyoto Univ, Kyoto
- Invited
- Data Source
  KAKENHI-PLANNED-22131006
[Presentation] DNA切断修復と発がん・がん治療2013
- Author(s)
  河野隆志、荻原秀明、尾池貴洋、水上達治、白石航也
- Organizer
  日本放射線影響学会第56回大会
- Year and Date
  2013-10-19
- Data Source
  KAKENHI-PROJECT-23701110
[Presentation] Curcumin suppresses multiple DNA damage response pathways and has potency as sensitizer to PARP inhibitor2013
- Author(s)
  Hideaki Ogiwara1, Ayako Ui2, Bunsho Shiotani3, Lee Zou3, Akira Yasui2, Takashi Kohno1
- Organizer
  The 72nd Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23701110
[Presentation] Personalized Medicine of Lung Adenocarcinoma Based on Genetic Alterations2013
- Author(s)
  Takashi Kohno Ph D, Hideaki Ogiwara Ph D, Tatsuji Mizukami MD
- Organizer
  原研・国際キックオフシンポジウム
- Year and Date
  2013-11-28
- Data Source
  KAKENHI-PROJECT-23701110
[Presentation] Curcumin suppresses multiple DNA damage response pathways and has potency as sensitizer to PARP inhibitor2013
- Author(s)
  Hideaki Ogiwara, Ayako Ui, Bunsho Shiotani, Lee Zou, Akira Yasui, Takashi Kohno
- Organizer
  第72回日本癌学会学術総会
- Year and Date
  2013-10-05
- Data Source
  KAKENHI-PROJECT-23701110
[Presentation] Personalized Medicine of Lung Adenocarcinoma Based on Genetic Alterations2013
- Author(s)
  Takashi Kohno,Hideaki Ogiwara, Tatsuji Mizukami
- Organizer
  The International Kick-Off Symposium for Atomic Bomb Disease Institute at Nagasaki University
- Place of Presentation
  Nagasaki Univ, Nagasaki
- Invited
- Data Source
  KAKENHI-PLANNED-22131006
[Presentation] Personalized Medicine of Lung Adenocarcinoma Based on Genetic Alterations2013
- Author(s)
  Takashi Kohno Ph D1,2, Hideaki Ogiwara Ph D1, Tatsuji Mizukami MD1
- Organizer
  原研・国際キックオフシンポジウム
- Place of Presentation
  長崎大学医学部良順会館ボードインホール
- Invited
- Data Source
  KAKENHI-PROJECT-23701110
[Presentation] ヒストンアセチル化酵素CBP/p300は、相同組換え修復遺伝子BRCA1およびRAD51の転写活性化を制御する2012
- Author(s)
  荻原　秀明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23701110
[Presentation] CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes2012
- Author(s)
  荻原秀明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PLANNED-22131006
[Presentation] Curcumin, a novel sensitizer for PARP inhibitor-based cancer therapy, working by suppression of homologous recombination and DNA damage checkpoint through inhibition of the ATR-CHK1 pathway2011
- Author(s)
  Ogiwara H. et al
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-23701110
[Presentation] Curcumin enhances the sensitivity to PARP inhibitors by suppression of homologous recombination and DNA damage checkpoint through inhibition of ATR-CHK1 pathway2011
- Author(s)
  Ogiwara H. et al
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23701110
[Presentation] Curcumin, a novel inhibitor of ATR-CHK1 pathway, suppresses homologousrecombination and DNA damage checkpoint and enhances sensitivity to PARP inhibitors2011
- Author(s)
  Ogiwara H., et al
- Organizer
  AACR-NCI-EORTC International Conference Molecular targets and cancer Therapeutics
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PLANNED-22131006
[Presentation] Curcumin, a novel inhibitor of ATR-CHK1 pathway, suppresses homologous recombination and DNA damage checkpoint and enhances sensitivity to PARP inhibitors2011
- Author(s)
  Ogiwara H. et al
- Organizer
  AACR-NCI-EORTC International Conference Molecular targets and cancer Therapeutics
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23701110
[Presentation] Curcumin, a novel sensitizer for PARP inhibitor-based cancer therapy, working by suppression of homologous recombination and DNA damage checkpoint through inhibition of the ATR-CHK1 pathway2011
- Author(s)
  Ogiwara H., et al
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PLANNED-22131006
[Presentation] Curcumin enhances the sensitivity to PARP inhibitors by suppression of homologous recombination and DNA damage checkpoint through inhibition of ATR-CHK1 pathway2011
- Author(s)
  Ogiwara H., et al
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PLANNED-22131006
[Presentation] ヒトがん細胞に対する放射線・抗がん剤治療の効果を増強する標的としてのCBP/p300蛋白質2010
- Author(s)
  荻原秀明
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PLANNED-22131006
[Presentation] 非相同末端結合に関わるヒストンアセチル化酵素CBP/p300は、がんの放射線・抗がん剤治療における増感標的である2010
- Author(s)
  荻原秀明
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PLANNED-22131006
[Presentation] Synthetic lethality-based therapy targeting paralogous genes in cancer with chromatin regulating gene deficiencies
- Author(s)
  Hideaki Ogiwara, Takahiro Oike, Takashi Kohno
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26830122
[Presentation] Synthetically lethality-based therapy targeting a paralogous gene in cancer cells with chromatin regulating gene deficiencies
- Author(s)
  Ogiwara H, Oike T, Kohno T
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2015-09-25 – 2015-09-27
- Data Source
  KAKENHI-PLANNED-22131006
[Presentation] Synthetic lethality-based treatment strategy for cancers deficient in chromatin remodeling factor BRG1
- Author(s)
  Takahiro Oike, Hideaki Ogiwara, Yuichi Tominaga, Kentaro Ito, Koji Tsuta, Tatsuji Mizukami, Yoko Shimada, Hisanori Isomura, Mayumi Komachi, Koh Furuta, Shun-ichi Watanabe, Takashi Nakano, JunYokota, Takashi Kohno
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2015-09-25 – 2015-09-27
- Data Source
  KAKENHI-PLANNED-22131006
[Presentation] Synthetic lethality-based treatment strategy for cancers deficient in chromatin remodeling factor BRG1
- Author(s)
  Takahiro Oike, Hideaki Ogiwara, Yuichi Tominaga, Kentaro Ito, Koji Tsuta, Tatsuji Mizukami, Yoko Shimada, Hisanori Isomura, Mayumi Komachi, Koh Furuta, Shun-ichi Watanabe, Takashi Nakano, JunYokota, Takashi Kohno
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26830122
[Presentation] Personalized medicine of lung cancer using RET oncogene fusion and SWI/SNF chromatin remodeling deficiency
- Author(s)
  Ogiwara H, Kohno T
- Organizer
  第５回日米修復会議
- Place of Presentation
  徳島
- Year and Date
  2014-10-28 – 2014-10-31
- Invited
- Data Source
  KAKENHI-PLANNED-22131006
[Presentation] Personalized medicine of lung cancer using RET oncogene fusion and SWI/SNF chromatin remodeling deficiency
- Author(s)
  Ogiwara H, Oike T, Mizukami T, Saito M, Shiraishi K, Kohno T
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2015-09-25 – 2015-09-27
- Invited
- Data Source
  KAKENHI-PLANNED-22131006

1. KOHNO Takashi (80280783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
2. Tomoyasu Katoh (50224522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. YOSHIDA Yukari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. NAKADA Shinichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 安井明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 柴田淳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ogiwara Hideaki 荻原 秀明

OGIWARA Hideaki 荻原 秀明

Research Projects

Research Products

Co-Researchers

次世代型”合成致死標的探索法”を用いたSWI/SNF欠損がんに有望な新規治療標的の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a rational synthetic lethal treatment to eliminate paralog-deficient cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new therapeutic target search methods by simultaneous inhibition of multiple factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of synthetic lethal therapy based on gene mutations in renal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Efficacy of molecular targeting therapy and establishment of patient derived model in ARID1A-deficient ovarian clear cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of cancer therapy for chromatin remodeling deficient cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of anti-cancer targets based on synthetic lethality between paralogous genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chromatin remodeling regulation involved in carcinogenesis and cancer therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Frontiers in Radiation Oncology2013

Author(s)

Publisher

Data Source

[Journal Article] Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression.2016

Author(s)

Journal Title

Data Source

[Journal Article] The EGFR mutation status affects the relative biological effectiveness of carbon-ion beams in non-small cell lung carcinoma cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Carbon-Ion Beam Irradiation Kills X-Ray-Resistant p53-Null Cancer Cells by Inducing Mitotic Catastrophe2014

Author(s)

Journal Title

Ogiwara Hideaki 荻原秀明

OGIWARA Hideaki 荻原秀明