Ohata Hirokazu 大畑広和

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OHATA Hirokazu 大畑広和

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Researcher Number	40570057
Other IDs
Affiliation (Current)	2026: 帝京大学, 先端総合研究機構, 講師
Affiliation (based on the past Project Information) *help	2026: 帝京大学, 先端総合研究機構, 講師 2022 – 2024: 帝京大学, 先端総合研究機構, 講師 2020 – 2021: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2016 – 2017: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2012 – 2013: 独立行政法人国立がん研究センター, 研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator がん幹細胞 / 治療抵抗性 / 癌 / シングルセル遺伝子発現解析 / カリウムチャネル / 大腸がん / CD44

治療抵抗性克服に向けた休止型大腸がん幹細胞の分子基盤解明と新規治療戦略の創出Principal Investigator
- Principal Investigator
  
  大畑広和
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Teikyo University
抗がん剤抵抗性を示す休止型大腸がん幹細胞を標的にした治療戦略の構築Principal Investigator
- Principal Investigator
  
  大畑広和
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Teikyo University
Autophagy provides a quiescent state in colon cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  Ohata Hirokazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Teikyo University
  National Cancer Center Japan
Identification of functional potassium channels in colon cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  Ohata Hirokazu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  National Cancer Center Japan
Analysis of mechanism of maintaining the stemness properties in human colon cancer stem cells using innovative spheroid culture systemPrincipal Investigator
- Principal Investigator
  
  OHATA Hirokazu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  National Center of Neurology and Psychiatry

All 2024 2023 2022 2021 2020 2017 2013 2012

All Journal Article Presentation Book

[Book] 治療標的としてのがん幹細胞2020
- Author(s)
  伊藤　貴浩、大畑　広和
- Total Pages
  128
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-20K09023
[Journal Article] PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway2023
- Author(s)
  Ohata Hirokazu、Shiokawa Daisuke、Sakai Hiroaki、Kanda Yusuke、Okimoto Yoshie、Kaneko Syuzo、Hamamoto Ryuji、Nakagama Hitoshi、Okamoto Koji
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 6 Pages: 112519-112519
- DOI
  10.1016/j.celrep.2023.112519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07037, KAKENHI-PROJECT-23K07467, KAKENHI-PROJECT-21H03081, KAKENHI-PROJECT-21H03550
[Journal Article] Stemness and immune evasion conferred by TDO2-AHR pathway are associated with liver metastasis of colon cancer.2022
- Author(s)
  Miyazaki T, Chung S, Sakai H, Ohata H, Obata Y, Shiokawa D, Mizoguchi Y, Kubo T, Ichikawa H, Taniguchi H, Aoki K, Soga T, Nakagama H, *Okamoto K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 113 Issue: 1 Pages: 170-181
- DOI
  10.1111/cas.15182
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03081, KAKENHI-PROJECT-20K09023, KAKENHI-PROJECT-21K07163, KAKENHI-PROJECT-22K07037
[Journal Article] NF-κB suppression synergizes with E7386, an inhibitor of CBP/β-catenin interaction, to block proliferation of patient-derived colon cancer spheroids.2022
- Author(s)
  Kanda Y, Ohata H, Miyazaki T, Sakai H, Mori Y, Shiokawa D, Yokoi A, Owa T, Ochiai A, *Okamoto K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 586 Pages: 93-99
- DOI
  10.1016/j.bbrc.2021.11.063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03081, KAKENHI-PROJECT-20K09023, KAKENHI-PROJECT-20K16230, KAKENHI-PROJECT-22K07037
[Journal Article] Establishment of in vitro 3D spheroid cell cultivation from human gynecologic cancer tissues2021
- Author(s)
  Ueda Haruka、Mori Yutaro、Yamawaki Kaoru、Ishiguro Tatsuya、Ohata Hirokazu、Sato Ai、Sugino Kentaro、Yachida Nozomi、Yamaguchi Manako、Suda Kazuaki、Tamura Ryo、Yoshihara Kosuke、Okamoto Koji、Enomoto Takayuki
- Journal Title
  
  STAR Protocols
  
  Volume: 2 Issue: 1 Pages: 100354-100354
- DOI
  10.1016/j.xpro.2021.100354
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09023, KAKENHI-PROJECT-20K21647, KAKENHI-PROJECT-20H03821, KAKENHI-PROJECT-18K09250, KAKENHI-PROJECT-21K09490
[Journal Article] Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer2020
- Author(s)
  Shiokawa Daisuke、Sakai Hiroaki、Ohata Hirokazu、Miyazaki Toshiaki、Kanda Yusuke、Sekine Shigeki、Narushima Daichi、Hosokawa Masahito、Kato Mamoru、Suzuki Yutaka、Takeyama Haruko、Kambara Hideki、Nakagama Hitoshi、Okamoto Koji
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 20 Pages: 4451-4464
- DOI
  10.1158/0008-5472.can-20-0378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09023, KAKENHI-PROJECT-20K16230, KAKENHI-PROJECT-18K07283
[Journal Article] The induction of selected Wnt target genes by Tcf1 generates tumorigenic colon stem cells.2017
- Author(s)
  Shiokawa D, Sato A, Ohata H, Muto M, Sekine S, Kato M, Shibata T, Nakagama H, Okamoto K.
- Journal Title
  
  Cell Reports
  
  Volume: 19 Issue: 5 Pages: 981-994
- DOI
  10.1016/j.celrep.2017.04.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16878, KAKENHI-PUBLICLY-16H01581, KAKENHI-PROJECT-16K15436
[Journal Article] Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications.2017
- Author(s)
  Ishiguro T, Ohata H, Sato A, Yamawaki K, Enomoto T, Okamoto K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 108 Issue: 3 Pages: 283-289
- DOI
  10.1111/cas.13155
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01581, KAKENHI-PROJECT-26293073, KAKENHI-PROJECT-15K14390, KAKENHI-PROJECT-17K16878, KAKENHI-PROJECT-17H04336, KAKENHI-PROJECT-16K15436, KAKENHI-PROJECT-15K20132
[Journal Article] Induction of the stem-like cell regulator CD44 by Rho kinase inhibiition con ntributes to the mmaintenance of colon-initiating cells2012
- Author(s)
  Hirokazu Ohata, Tatsuyya Ishiguro, Yuki Aihhara, Ai Sato, Hiroaki Sakai, Shgeki Sekine, Hirokkazu Taniguchi. Takayuki Akasu, Shin Fujita, Hitoshi Nakagama, , Koji Okaamoto
- Journal Title
  
  Cancer Research
  
  Volume: vol.72 Pages: 5101-55110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790727
[Journal Article] Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells.2012
- Author(s)
  Hirokazu Ohata
- Journal Title
  
  Cancer Research
  
  Volume: 72 Issue: 19 Pages: 5101-5110
- DOI
  10.1158/0008-5472.can-11-3812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590299, KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376, KAKENHI-PROJECT-24790727, KAKENHI-PUBLICLY-23112523
[Presentation] Activation of autophagy contributes to the chemoresistance in colon cancer2024
- Author(s)
  Hirokazu Ohata, Daisuke Shiokawa, Koji Okamoto
- Organizer
  第83回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-23K07467
[Presentation] PROX1 induction by autophagy provides a persister-like state via repression of NOX1-mTORC1 pathway in colon cancer cells2022
- Author(s)
  Hirokazu Ohata, Daisuke Shiokawa, Koji Okamoto
- Organizer
  第81回日本癌学会
- Data Source
  KAKENHI-PROJECT-20K09023
[Presentation] 大腸がん幹細胞における Akt-mTOR経路を介したCD44の発現制御機構2013
- Author(s)
  大畑広和、中釜斉、岡本康司
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790727
[Presentation] 大腸がん幹細胞におけるAkt-mTOR経路を介したCD44の発現制御機構2013
- Author(s)
  大畑広和、中釜斉、岡本康司
- Organizer
  第72回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24790727
[Presentation] ROCK阻害剤は CD44の発現誘導を介して大腸がん幹細胞の増殖を促進する2012
- Author(s)
  大畑広和、石黒竜也、中釜斉、岡本康司
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790727
[Presentation] ROCK阻害剤はCD44の発現誘導を介して大腸がん幹細胞の増殖を促進する2012
- Author(s)
  大畑広和、石黒竜也、中釜斉、岡本康司
- Organizer
  第71回　日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790727

1. 岡本康司

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 塩川大介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohata Hirokazu 大畑 広和

OHATA Hirokazu 大畑 広和

Research Projects

Research Products

Co-Researchers

治療抵抗性克服に向けた休止型大腸がん幹細胞の分子基盤解明と新規治療戦略の創出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

抗がん剤抵抗性を示す休止型大腸がん幹細胞を標的にした治療戦略の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Autophagy provides a quiescent state in colon cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of functional potassium channels in colon cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of mechanism of maintaining the stemness properties in human colon cancer stem cells using innovative spheroid culture systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 治療標的としてのがん幹細胞2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stemness and immune evasion conferred by TDO2-AHR pathway are associated with liver metastasis of colon cancer.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NF-κB suppression synergizes with E7386, an inhibitor of CBP/β-catenin interaction, to block proliferation of patient-derived colon cancer spheroids.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of in vitro 3D spheroid cell cultivation from human gynecologic cancer tissues2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The induction of selected Wnt target genes by Tcf1 generates tumorigenic colon stem cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Induction of the stem-like cell regulator CD44 by Rho kinase inhibiition con ntributes to the mmaintenance of colon-initiating cells2012

Author(s)

Journal Title

Data Source

[Journal Article] Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells.2012

Ohata Hirokazu 大畑広和

OHATA Hirokazu 大畑広和