Hata Saori 羽田沙緒里

… Alternative Names

羽田沙緒里ハタサオリ

HATA Saori 羽田沙緒里

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Researcher Number	40581012
Other IDs
External Links
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Affiliation (based on the past Project Information) *help	2023: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2020: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2018 – 2019: 北海道大学, 薬学研究院, 助教 2016: 北海道大学, 薬学研究院, 助教 2015: 北海道大学, 薬学研究科(研究院), 助教 2012 – 2013: 北海道大学, 薬学研究科(研究院), 助教 2010 – 2011: 北海道大学, 大学院・薬学研究院, 助教
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator アルツハイマー病 / バイオマーカー / 診断マーカー / γセクレターゼ Except Principal Investigator 神経 / 神経軸索 / APP / 神経細胞 / 孤発性*アルツハイマー病 / 膜小胞輸送 … More / 微小管 / キネシン / キネシン－1 / 軸索輸送 / アミロイドβ / 認知症 / アルツハイマー病 Less

Revealing the functional mechanisms of neuronal protective peptides for developing a treatment for Alzheimer's disease.Principal Investigator
- Principal Investigator
  
  羽田沙緒里
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Mechanism of action of Alzheimer's disease-related peptide p3-Alc on neuronsPrincipal Investigator
- Principal Investigator
  
  Hata Saori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
  Hokkaido University
Pathogenesis of Alzheimer's disease based on vesicular transport system in neuron
- Principal Investigator
  
  SUZUKI TOSHIHARU
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hokkaido University
Alzheimer's disease-related peptides as a biomarker for diagnosis in early stage Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  HATA Saori
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Analysis of p3-Alc peptides, the novel biomarker for Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  HATA Saori
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Analysis of p3-Alc, metabolic product of AlcadeinPrincipal Investigator
- Principal Investigator
  
  HATA Saori
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University

[Book] Lipids and Cellular Membranes in Amyloid Disease2011
- Author(s)
  Saori Hata, Yuhki Saito, Toshiharu Suzuki
- Publisher
  Wiley-VCH(in press)
- Data Source
  KAKENHI-PROJECT-22890001
[Book] Lipids and Cellular Membranes in Amyloid Disease (Edited by Jelinek, R.)2011
- Author(s)
  Hata, S., Saito, Y., Suzuki, T.
- Publisher
  Wiley-VCH
- Data Source
  KAKENHI-PROJECT-22890001
[Book] Lipids and Cellular Membranes in Amyloid Disease2011
- Author(s)
  Saori Hata, Yuhki Saito, Toshiharu Suzuki
- Publisher
  Wiley-VCH
- Data Source
  KAKENHI-PROJECT-22890001
[Journal Article] アルツハイマー病と免疫 - 脳内ペプチドp3-Alcβによるミトコンドリア活性の増強と神経炎症抑制 -2023
- Author(s)
  鈴木利治、羽田沙緒里
- Journal Title
  
  炎症と免疫
  
  Volume: 31 Pages: 548-551
- Data Source
  KAKENHI-PROJECT-23K06840
[Journal Article] Brain <scp>p3‐Alcβ</scp> peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide2023
- Author(s)
  Hata S, Saito H, Kakiuchi T, Fukumoto D, Yamamoto S, Kasuga K, Kimura A, Moteki K, Abe R, Adachi S, Kinoshita S, Yoshizawa-Kumagaye K, Nishio H, Saito T, Saido TC, Yamamoto T, Nishimura M, Taru H, Sobu Y, Ohba H, Nishiyama S, Harada N, Ikeuchi T, Tsukada H, Ouchi Y, Suzuki T
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: - Issue: 5 Pages: 1-15
- DOI
  10.15252/emmm.202217052
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0143, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-20H03600, KAKENHI-PROJECT-22K06597, KAKENHI-PROJECT-23K06840, KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-22K15270, KAKENHI-PROJECT-23K26790
[Journal Article] Axonal transport of Frizzled5 by Alcadein α-containing vesicles is associated with kinesin-12023
- Author(s)
  Shiraki Yuzuha、Mitsuma Monet、Takada Ritsuko、Hata Saori、Kitamura Akira、Takada Shinji、Kinjo Masataka、Taru Hidenori、M?ller Ulrike C.、Yamamoto Tohru、Sobu Yuriko、Suzuki Toshiharu
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 34 Issue: 11
- DOI
  10.1091/mbc.e22-10-0495
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06597, KAKENHI-PROJECT-23K06840, KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-22K15270, KAKENHI-PUBLICLY-22H05642, KAKENHI-PUBLICLY-22H04826, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H02498
[Journal Article] Extracellular release of ILEI/FAM3C and amyloid-β is associated with the activation of distinct synapse subpopulations.2021
- Author(s)
  Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido C T, Murayama S, Kasuga K, Ikeuchi K, Suzuki T, Nishimura M
- Journal Title
  
  Journal of Alzheimer’s disease
  
  Volume: 80 Issue: 1 Pages: 159-174
- DOI
  10.3233/jad-201174
- NAID
  120007019774
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-20K16491, KAKENHI-PROJECT-18H02566, KAKENHI-PROJECT-18K07384, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546
[Journal Article] γ-Secretase activity is associated with Braak Senile Plaque stages2020
- Author(s)
  Kakuda Nobuto、Yamaguchi Haruyasu、Akazawa Kohei、Hata Saori、Suzuki Toshiharu、Hatsuta Hiroyuki、Murayama Shigeo、Funamoto Satoru、Ihara Yasuo
- Journal Title
  
  The American Journal of Pathology
  
  Volume: － Issue: 6 Pages: 1323-1331
- DOI
  10.1016/j.ajpath.2020.02.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07384, KAKENHI-PUBLICLY-18H04851, KAKENHI-PROJECT-18H02566
[Journal Article] Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α-deficient mice2020
- Author(s)
  Gotoh N、Saito Yi、Hata S、Saito H、Ojima D、Murayama Ci、Shigeta M、Abe T、Konno D、Matsuzaki F、Suzuki T、Yamamoto T
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 28 Pages: 9650-9662
- DOI
  10.1074/jbc.ra119.012386
- NAID
  120007116485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07065, KAKENHI-PUBLICLY-19H04791, KAKENHI-PROJECT-18H02566, KAKENHI-PROJECT-18K07384, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H04003
[Journal Article] Enhanced amyloid-β generation by γ-secretase complex in detergent-resistant membrane microdomains with reduced cholesterol levels2020
- Author(s)
  Hata S, Hu A, Piao Y, Nakaya T, Taru H, Morishima-Kawashima M, Murayama S, Nishimura M, Suzuki T.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 29 Issue: 3 Pages: 382-393
- DOI
  10.1093/hmg/ddz297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PUBLICLY-18H04851, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18H02566, KAKENHI-PROJECT-18K07384
[Journal Article] Decrease in p3‐Alcβ37 and p3‐Alcβ40, products of Alcadein β generated by γ‐secretase cleavages, in aged monkeys and patients with Alzheimer's disease2019
- Author(s)
  Hata S、Omori C、Kimura A、Saito H、Kimura N、Gupta V、Pedrini S、Hone E、Chatterjee P、Taddei K、Kasuga K、Ikeuchi T、Waragai M、Nishimura M、Hu A、Nakaya T、Meijer L、Maeda M、Yamamoto T、Masters CL、Rowe CC、Ames D、Yamamoto K、Martins RN、Gandy S、Suzuki T
- Journal Title
  
  Alzheimer's & Dementia: Translational Research & Clinical Interventions
  
  Volume: 5 Issue: 1 Pages: 740-750
- DOI
  10.1016/j.trci.2019.09.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07384, KAKENHI-PROJECT-19K07065, KAKENHI-PROJECT-19K21585, KAKENHI-PUBLICLY-18H04851, KAKENHI-PROJECT-17H03574, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-16K08237, KAKENHI-PROJECT-18H02566
[Journal Article] X11 and X11-like proteins regulate the level of extrasynaptic glutamate receptors2018
- Author(s)
  Motodate Rika、Saito Haruka、Sobu Yuriko、Hata Saori、Saito Yuhki、Nakaya Tadashi、Suzuki Toshiharu
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 148 Issue: 4 Pages: 480-498
- DOI
  10.1111/jnc.14623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07384, KAKENHI-PUBLICLY-18H04851, KAKENHI-PROJECT-18H02566
[Journal Article] Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides2018
- Author(s)
  Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, Barnych B, Hammock BD, Bohl B, Koch P, Omori C, Yamamoto K, Hata S, Suzuki T, Karg F, Gizzi P, Haber VE, Bencetic Mihaljevic V, Tavcar B, Portelius E, Pannee J, Blennow K, Zetterberg H, Garbis SD, Auvray P, Gerber H, Fraering J, Fraering PC, Meijer L.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 62 Issue: 4 Pages: 1663-1681
- DOI
  10.3233/jad-170875
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J06504, KAKENHI-PROJECT-16K14690, KAKENHI-PROJECT-18K07384
[Journal Article] The cytoplasmic region of the amyloid β‐protein precursor (APP) is necessary and sufficient for the enhanced fast velocity of APP transport by kinesin‐12018
- Author(s)
  Maoko Tsukamoto Kyoko Chiba Yuriko Sobu Yuzuha Shiraki Yuka Okumura Saori Hata Akira Kitamura Tadashi Nakaya Seiichi Uchida Masataka Kinjo Hidenori Taru Toshiharu Suzuki
- Journal Title
  
  FEBS Letters
  
  Volume: 592 Issue: 16 Pages: 2716-2724
- DOI
  10.1002/1873-3468.13204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06201, KAKENHI-PROJECT-18K07384, KAKENHI-PUBLICLY-18H04851, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-18H02566
[Journal Article] Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease2017
- Author(s)
  Chiori Omori, Rika Motodate, Yuzuha Shiraki, Kyoko Chiba, Yuriko Sobu, Ayano Kimura, Tadashi Nakaya, Hikaru Kondo, Satoshi Kurumiya, Toru Tanaka, Kazuo Yamamoto, Motowo Nakajima, Toshiharu Suzuki and Saori Hata
- Journal Title
  
  Nutritional neuroscience
  
  Volume: 印刷中 Issue: 9 Pages: 538-546
- DOI
  10.1080/1028415x.2016.1199114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15J02220, KAKENHI-PROJECT-15K18854, KAKENHI-PROJECT-17J06504, KAKENHI-PROJECT-16K14690, KAKENHI-PROJECT-26293010
[Journal Article] Alternative Selection of BACE1 Cleavage Sites in APP Harboring Protective And Pathogenic Mutations Within the Aβ Sequence2016
- Author(s)
  Kimura, A., Hata, S., Suzuki, T
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 46 Pages: 24041-24053
- DOI
  10.1074/jbc.m116.744722
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18854, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-16K14690
[Journal Article] Specific triazine herbicides induce amyloidβ42 production.2016
- Author(s)
  Portlius E, Durieu E, Bodin M, Cam M, Pannee J, Leuxe C, Mabondzo A, Oumata N, Galons H, Lee J-Y, Chang Y-T, Stuber K, Koch P, Fontanine G, Potier M, Manouspoulou A, Garbis S, Covaci A, VanDam D, De Deyn P, Karg F, Flajolet M, Omori C, Hata S, Suzuki T, Blennow K, Zetteberg H, and Meijer L
- Journal Title
  
  J. Alzheimer Dis
  
  Volume: 54 Issue: 4 Pages: 1593-1605
- DOI
  10.3233/jad-160310
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-16K14690
[Journal Article] Expression and localization of X11 family proteins in neurons2016
- Author(s)
  Motodate, R., Saito, Y., Hata, S., Suzuki, T.
- Journal Title
  
  Brain Res
  
  Volume: 1646 Pages: 227-234
- DOI
  10.1016/j.brainres.2016.05.054
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18854, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-16K14690
[Journal Article] Cytoplasmic Fragment of Alcadein α Generated by Regulated Intramembrane Proteolysis Enhances Amyloid β-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage2015
- Author(s)
  Norio Takei, Yuriko Sobu, Ayano Kimura, Satomi Urano, Yi Piao, Yoichi Araki, Hidenori Taru, Tohru Yamamoto, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 290 Issue: 2 Pages: 987-995
- DOI
  10.1074/jbc.m114.599852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460058, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-26870464, KAKENHI-PROJECT-15K18854, KAKENHI-PROJECT-25460059
[Journal Article] Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E2015
- Author(s)
  Kimura, A., Hata, S., Suzuki, T.
- Journal Title
  
  FEBS Lett
  
  Volume: 589 Issue: 18 Pages: 2394-2400
- DOI
  10.1016/j.febslet.2015.07.017
- NAID
  120005828463
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18854, KAKENHI-PROJECT-26293010
[Journal Article] Increased levels of plasma p3-Alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease2014
- Author(s)
  Omori C, Kaneko M, Nakajima E, Akatsu H, Waragai M, Maeda M, Moroshima-Kawashima M, Saito Y, Nakaya T, Taru H, Yamamoto T, Asada T, Hata S, Suzuki T. for J-ADNI
- Journal Title
  
  J. Alzheimers Dis
  
  Volume: 39 Issue: 4 Pages: 861-870
- DOI
  10.3233/jad-131610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-24500433, KAKENHI-PROJECT-24591695, KAKENHI-PROJECT-24790062, KAKENHI-PROJECT-25460058, KAKENHI-PROJECT-25460059, KAKENHI-PROJECT-26293010
[Journal Article] Increased levels of plasma p3-Alcα35, a major fragment of Alcadeinαbyγ-secretase cleavage, in Alzheimer's disease2014
- Author(s)
  Omori, C., Kaneko, M., Nakajima, E., Akatsu, H., Waragai, M., Maeda, M., Morishima-Kawashima, M., Saito, Y., Nakaya, N., Taru, H., Yamamoto, T., Asada, T., Hata S., Suzuki T., J-ADNI
- Journal Title
  
  J. Alzheimer Dis
  
  Volume: 39 Pages: 861-870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790062
[Journal Article] Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice2014
- Author(s)
  Waragai, M., Hata, S., Suzuki, T., Ishii, R., Fujii, C.,Tokuda, T., Arai, A., Ohrui, T., Higuchi, S., Yoshida, M., Igarashi, K., Moriya, M., Iwai, N., Uemura, K.
- Journal Title
  
  Jounal of Alzheimer's Disease
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790062
[Journal Article] Mechanism of intramembrane cleavage of Alcadeins by γ-secretase2013
- Author(s)
  Piao, Y., Kimura, A., Urano, S., Saito, Y., Taru, H., Yamamoto, T., Hata, S. and Suzuki, T
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 4 Pages: e62431-e62431
- DOI
  10.1371/journal.pone.0062431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23790070, KAKENHI-PROJECT-24790062, KAKENHI-PROJECT-25460058, KAKENHI-PROJECT-25460059
[Journal Article] Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.2012
- Author(s)
  Hata S
- Journal Title
  
  Mol Neurodegener.
  
  Volume: 16 Issue: 1 Pages: 16-16
- DOI
  10.1186/1750-1326-7-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590933, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23790990, KAKENHI-PROJECT-24790062, KAKENHI-PUBLICLY-23113701
[Journal Article] Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue2012
- Author(s)
  Matsushima T
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 23 Pages: 19715-19724
- DOI
  10.1074/jbc.m111.334847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240039, KAKENHI-PROJECT-22590055, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23500445, KAKENHI-PROJECT-23790069, KAKENHI-PROJECT-24790062, KAKENHI-PUBLICLY-23113701
[Journal Article] Constitutive Cleavage of the Single-pass Transmembrane Protein Alcadeinα Prevents Aberrant Peripheral Retention of Kinesin-1.2012
- Author(s)
  Chiaki Maruta
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 8 Pages: e43058-e43058
- DOI
  10.1371/journal.pone.0043058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23790069, KAKENHI-PROJECT-24790062
[Journal Article] Potential utility of soluble p3-alcadeinα plasma levels as a biomarker for sporadic Alzheimer's disease2012
- Author(s)
  Kamogawa K, Kohara K, Tabara Y, Takita R, Miki T, Konno T, Hata S, Suzuki T
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 31 Issue: 2 Pages: 421-8
- DOI
  10.3233/jad-2012-120601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390185, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23390188, KAKENHI-PROJECT-24790062, KAKENHI-PUBLICLY-23113701
[Journal Article] Coordinated increase ofγ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients : quantitative analysis of p3-Alcαwith a new ELISA system2011
- Author(s)
  Konno T, Hata S., 他11名
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 6 Pages: 76-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890001
[Journal Article] Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease : evidence for γ-secretase dysfunction2011
- Author(s)
  Hata S
- Journal Title
  
  Ann.Neurol.
  
  Volume: 69 Issue: 6 Pages: 1026-1031
- DOI
  10.1002/ana.22343
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590055, KAKENHI-PROJECT-22659011, KAKENHI-PROJECT-22890001, KAKENHI-PUBLICLY-23113701, KAKENHI-PROJECT-23300155, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23500445
[Journal Article] Coordinated increase of y-secretase products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alca with a new ELISA system2011
- Author(s)
  Konno, et al.
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 6 Issue: 1 Pages: 76-76
- DOI
  10.1186/1750-1326-6-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200041, KAKENHI-PROJECT-22590055, KAKENHI-PROJECT-22659011, KAKENHI-PROJECT-22890001, KAKENHI-PUBLICLY-23113701, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23790069
[Journal Article] 新しいバイオマーカー;アルカデイン2010
- Author(s)
  羽田沙緒里、今野禎子、鈴木利治
- Journal Title
  
  Pharma Medica
  
  Volume: 28 Pages: 15-19
- Data Source
  KAKENHI-PROJECT-22890001
[Journal Article] 新しいバイオマーカー;アルカデイン2010
- Author(s)
  羽田沙緒里、今野禎子、鈴木利治
- Journal Title
  
  Pharma Medica.
  
  Volume: 28 Pages: 15-19
- Data Source
  KAKENHI-PROJECT-22890001
[Journal Article] Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain2010
- Author(s)
  Kondo, M., Shiono, M., Itoh, G., Takei, N., Matsushima, T., Maeda, M., Taru, H., Hata, S., 他3名
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 5 Pages: 35-35
- NAID
  120005158908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890001
[Journal Article] Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice
- Author(s)
  Waragai, M., Hata, S., Suzuki, T., Ishii, R., Fujii, C., Tokuda, T., Arai, A., Ohrui, T., Higuchi, S., Yoshida, M., Igarashi, K., Moriya, M., Iwai, N., Uemura, K
- Journal Title
  
  J. Alzheimer Dis
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790062
[Patent] パーキンソン病の診断指標2019
- Inventor(s)
  伴（羽田）沙緒里、山本融、正木勉、出口一志、鎌田正紀、ほか7名
- Industrial Property Rights Holder
  伴（羽田）沙緒里、山本融、正木勉、出口一志、鎌田正紀、ほか7名
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K07384
[Patent] アルカデインペプチド切断物による認知症またはアルツハイマー病診断方法または予後予測方法2011
- Inventor(s)
  鈴木利治、伴(羽田)沙緒里、清藤勉、柏原昌次
- Industrial Property Rights Holder
  国立大学法人北海道大学、株式会社免疫生物研究所
- Industrial Property Number
  2011-082975
- Filing Date
  2011-04-04
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] アルツハイマー病による神経障害を抑制する脳内ペプチドの解析と治療法開発への応用2023
- Author(s)
  羽田沙緒里、齋藤遥、尾内康臣、鈴木利治
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06840
[Presentation] アルツハイマー病の有効な治療法開発に向けて2023
- Author(s)
  羽田沙緒里
- Organizer
  第60回日本生化学会北海道支部例会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06840
[Presentation] 神経機能ペプチドp3-Alcβの前駆体Alcadeinβの発現制御機構2023
- Author(s)
  木下祥一、羽田沙緒里、鈴木利治
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06840
[Presentation] p3-Alcβ製剤(ALC919)を用いた経皮吸収アルツハイマー病治療薬開発2023
- Author(s)
  鈴木利治, 尾内康臣, 安達博敏, 羽田沙緒里
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06840
[Presentation] Brain derived p3-Alcβ peptide enhance the mitochondrial activity and protect neurons against Aβ toxicity2023
- Author(s)
  Saori Hata
- Organizer
  Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06840
[Presentation] 脳内在性ペプチドp3-AlcβはAβオリゴマーによる神経細胞内へのCa2+流入効果を抑制する2023
- Author(s)
  茂手木広一, 齋藤遥, 木下祥一, 羽田沙緒里, 鈴木利治
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06840
[Presentation] p3-Alcβ のAβ オリゴマー神経傷害性に対する機能解明2023
- Author(s)
  羽田沙緒里、齋藤遥、茂手木広一、鈴木利治
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06840
[Presentation] P3-Alcβ機能部位遺伝子変異の評価2020
- Author(s)
  林　理沙、羽田沙緒里、斎藤貴志、春日健作、西道隆臣、池内　健、鈴木利治
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] アルツハイマー病新規治療法開発を目指した脳内在性ペプチドの解析2020
- Author(s)
  羽田沙緒里、齋藤遥、木下祥一、鈴木利治
- Organizer
  第９３回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] アルツハイマー病脳におけるラフトの資質変化とγセクレターゼの局在・機能変化2020
- Author(s)
  羽田沙緒里、Hu Anqi、村山繁雄、森島真帆、西村正樹、鈴木利治
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] アルツハイマー脳におけるラフトの脂質変化とγセクレターゼの局在・機能変化2020
- Author(s)
  羽田沙緒里、胡安琪、村山繁雄、森島真帆、西村正樹、鈴木利治
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] 神経保護ペプチドp3-Alcβの前駆体Alcadeinβ遺伝子のプロモーター解析2020
- Author(s)
  鈴木利治、白石昂也、中矢正、羽田沙緒里
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Enhanced β- and β’-cleavages of APP in Alcadeinα knockout mouse brain.2019
- Author(s)
  Toshiharu Suzuki, Naoya Goto, Haruka Saito, Saori Hata, Tohru Yamamoto
- Organizer
  Alzheimer's Association International Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Alcadein α欠損マウスにおけるAPPのアミロイド生成的代謝の促進機構2019
- Author(s)
  鈴木利治、後藤直也、林　理沙、羽田沙緒里、山本　融
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] 新規AD治療薬候補p3-Alcβの作用メカニズム解明2019
- Author(s)
  羽田沙緒里、齋藤遥、木村彩乃、鈴木利治
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] Enhanced β- and β’-cleavages of APP in Alcadeina knockout mouse brain.2019
- Author(s)
  Toshiharu Suzuki, Naoya Goto, Haruka Saito, Saori Hata, Tohru Yamamoto
- Organizer
  Alzheimer's Association International Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] 新規AD治療薬候補p3-Alcβの作用メカニズム解明2019
- Author(s)
  羽田沙緒里、齋藤遥、木村彩乃、鈴木利治
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] アルツハイマー病マウスモデルへのp3-Alcβペプチド投与と脳内Aβ変化の解析2019
- Author(s)
  木下祥一，齊藤　遥、齊藤貴志、西道隆臣、鈴木利治、羽田沙緒里
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] AlcαとAPPがFrizzledの神経終末への局在を制御する2019
- Author(s)
  満間百音、白木柚葉、齊藤　遥、羽田沙緒里、鈴木利治
- Organizer
  第56回日本生化学会北海道支部例会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Altered levels of p3-Alcβ peptides in the CSF of aged monkeys and Alzheimer’s disease patients.2019
- Author(s)
  Saori Hata, Ayano Kimura, Haruka Saito, Masaaki Waragai, Takeshi Ikeuchi, Ralph Martins, Nobuyuki Kimura, Masaki Nishimura, Toshiharu Suzuki
- Organizer
  Alzheimer's Association International Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] キネシン-1によるFrizzledの軸索輸送が神経終末のWntシグナルを制御する2019
- Author(s)
  満間百音、白木柚葉、齊藤　遥、高田律子、山本　融、高田慎治、羽田沙緒里、鈴木利治
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Prevention of neurons from toxicity induced by Aβ42 by p3-Alcβ peptides and their pharmacokinetics in ice.2019
- Author(s)
  Haruka Saito, Saori Hata, Toshiharu Suzuki
- Organizer
  Alzheimer's Association International Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] Mirochondria as a therapeutic target of Alzheimer’s disease.2019
- Author(s)
  Toshiharu Suzuki, Saori Hata
- Organizer
  The 7th International ALA and Prophyrin Symposium (IAPS7)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] Altered levels of p3-Alcβ peptides in the CSF of aged monkeys and Alzheimer’s disease patients.2019
- Author(s)
  Saori Hata, Ayano Kimura, Haruka Saito, Masaaki Waragai, Takeshi Ikeuchi, Ralph Martins, Nobuyuki Kimura, Masaki Nishimura, Toshiharu Suzuki
- Organizer
  Alzheimer's Association International Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Prevention of neurons from toxicity induced by Aβ42 by p3-Alcα peptides and their pharmacokinetics in mice.2019
- Author(s)
  Haruka Saito, Saori Hata, Toshiharu Suzuki
- Organizer
  Alzheimer's Association International Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] p3-Alcβ37機能コアペプチドp3-Alcβ[9-19]測定法の開発2018
- Author(s)
  林理沙、齋藤遥、羽田沙緒里、鈴木利治
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] γ-セクレターゼ切断産物p3-Alcβペプチドの加齢およびAD発症による産生変化2018
- Author(s)
  羽田沙緒里、木村彩乃、木村展之、池内健、春日健作、藁谷正明、西村正樹、鈴木利治
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] Phosphorylation within an acidic region of Alcadeinα regulates interaction with kinesin-12018
- Author(s)
  Anqi Hu, Yuriko Sobu, Saori Hata, Toshiharu Suzuki
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Aβ42 oligomer誘導性の神経毒性を緩和するp3-Alcβペプチドの体内動態解析2018
- Author(s)
  木下祥一、齋藤遥、木村彩乃、大森智織、羽田沙緒里、鈴木利治
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Aβ毒性から神経を保護するp3-Alcβを用いたアルツハイマー病治療戦略2018
- Author(s)
  鈴木利治、齋藤　遥、木村彩乃、大森智織、羽田沙緒里
- Organizer
  第37回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Phosphorylation of Alcadeina is required for kinesin-1 association.2018
- Author(s)
  Anqi Hu, Yuriko Sobu, Saori Hata, Toshiharu Suzuki
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Aβオリゴマーによる神経毒性を緩和するp3-Alcβペプチドのin vitroにおける機能解析2018
- Author(s)
  齋藤遥, 羽田沙緒里, 木村彩乃, 鈴木利治
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] Alcadeinβ代謝産物p3-AlcβはAβ及びNMDA誘導性神経毒性を緩和する2018
- Author(s)
  齋藤遥、羽田沙緒里、木村彩乃、大森智織、山本一夫、鈴木利治
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] γ-セクレターゼ切断産物p3-Alcβペプチドの加齢およびAD発症による産生変化2018
- Author(s)
  羽田沙緒里、木村彩乃、木村展之、池内健、春日健作、藁谷正明、西村正樹、鈴木利治
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Alcadein代謝ペプチドをシードとしたアルツハイマー病新規治療法の開発2018
- Author(s)
  羽田沙緒里、齋藤遥、木村彩乃、鈴木利治
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] lcadeinβ代謝産物p3-AlcβはAβ及びNMDA誘導性神経毒性を緩和する2018
- Author(s)
  齋藤遥、　羽田沙緒里、木村彩乃、大森智織、山本一夫、鈴木利治
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Functional analysis of p3-Alcβ peptides preventing neurons from the Aβ oligomer-induced toxicity2018
- Author(s)
  Haruka Saito, Saori Hata, Ayano Kimura, Toshiharu Suzuki
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H02566
[Presentation] Aβ毒性から神経を保護するp3-Alcβを用いたアルツハイマー病治療戦略2018
- Author(s)
  鈴木利治、齋藤　遥、木村彩乃、大森智織、羽田沙緒里
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07384
[Presentation] Level of p3-Alcβ Peptides Alter in CSF of AD Patients2017
- Author(s)
  Hata, S., Kimura, A., Waragai, M., Ikeuchi, T., Martins, RN., Kimura, N.,Nishimura, M., Suzuki,T.
- Organizer
  Alzheimer's Association International Conference 2017
- Place of Presentation
  ロンドン（イギリス）
- Year and Date
  2017-07-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Increase of p3-Alcα38 to p3-Alcα35, products by γ-secretase cleavage, in CSF of AD patients2016
- Author(s)
  Omori, C., Hata, S., Waragai, M., Yamamoto, K., Suzuki, T.
- Organizer
  Alzheimer's Association International Conference 2016
- Place of Presentation
  トロント（カナダ）
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Altered cellular cholesterol levels cause aberrant γ-secretase cleavages ofAPP and Alcadeinα2016
- Author(s)
  Hu, A., Piao, Y., Hata, S., Suzuki, T.
- Organizer
  Alzheimer's Association International Conference 2016
- Place of Presentation
  トロント（カナダ）
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Multiple phosphorylations of Alcadeinα regulates interaction with kinesin-1.2016
- Author(s)
  Sobu, Y, Hata, S., Suzuki, T.
- Organizer
  The American Society for Cell Biology, Annual Meeting
- Place of Presentation
  サンフランシスコ（アメリカ）
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Mechanism that BACE1 alternates the cleaving sites of human APP2016
- Author(s)
  Suzuki, T., Kimura, A., Hata, S.
- Organizer
  Society for Neuroscience annual meeting, Neuroscience 2016
- Place of Presentation
  サンディエゴ（アメリカ）
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Different cargo receptors, APP and Alcα, transport the same cargos cooperatively through the identical vesicular transport pathway2016
- Author(s)
  Shiraki, Y., Chiba, K., Hata, S., Suzuki T.
- Organizer
  The American Society for Cell Biology, Annual Meeting
- Place of Presentation
  サンフランシスコ（アメリカ）
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Alteration of membrane microlocalization and γ-secretase cleavages in sporadic Alzheimer's disease.2016
- Author(s)
  Hata, S., Piao, Y., Hu, A., Nishimura, M., Suzuki, T.
- Organizer
  The 4th International Conference on Molucular Neurodegeneration
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2016-05-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Alternative cleavage mechanism of human BACE12016
- Author(s)
  Suzuki, T., Kimura A., Hata, S.
- Organizer
  Alzheimer's Association International Conference 2016
- Place of Presentation
  トロント（カナダ）
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] 膜脂質組成の変化によるAPPとAlcadeinの膜内切断機構の解析2015
- Author(s)
  胡安琪、朴懿、羽田沙緒里、鈴木利治
- Organizer
  第52回日本生化学会北海道支部例会
- Place of Presentation
  北海道大学フロンティア応用科学研究棟、北海道札幌市
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] p3-Alcの検出によるγセクレターゼ切断解析2015
- Author(s)
  羽田沙緒里、大森智織、藁谷正明、鈴木利治
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森、青森県青森市
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] 孤発性アルツハイマー病における膜マイクロドメインのγセクレターゼ活性変化2015
- Author(s)
  羽田沙緒里、朴懿、西村正樹、鈴木利治
- Organizer
  第5回日本認知症予防学会　学術集会
- Place of Presentation
  神戸国際会議場、兵庫県神戸市
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Association of Alcadeinα with kinesin light chain is regulated by phosphorylations at cytoplasmic　acidic region2015
- Author(s)
  Sobu,Y.,Hata,S.,Suzuki,T
- Organizer
  Society for Neuroscience annual meeting, Neuroscience 2015
- Place of Presentation
  McCormick Place, Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] γセクレターゼの基質切断解析による孤発性アルツハイマー病発症機構の解明2015
- Author(s)
  羽田沙緒里、鈴木利治
- Organizer
  第52回日本生化学会北海道支部例会
- Place of Presentation
  北海道大学フロンティア応用科学研究棟、北海道札幌市
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Membrane lipid composition and γ-secretase cleavage of Alzheimer’s disease-related proteins2015
- Author(s)
  羽田沙緒里、朴懿、西村正樹、鈴木利治
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド、兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] AlcadeinとX11LによるAPP代謝制御2015
- Author(s)
  川原聡史、後藤直也、羽田沙緒里、山本　融、鈴木利治
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森、青森県青森市
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Functional and regulation of APP and Alcadeinα cargos transported by kinesin-1 in neuron2015
- Author(s)
  Shiraki, Y., Chiba, K., Hata, S., Suzuki, T.
- Organizer
  Society for Neuroscience annual meeting, Neuroscience 2015
- Place of Presentation
  McCormick Place, Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] p3-Alcα分子種のアルツハイマー病バイオマーカー有用性の検証2015
- Author(s)
  大森智織、羽田沙緒里、藁谷正明、前田雅弘、立花太郎、Laurent Meijer、山本一夫、鈴木利治
- Organizer
  第5回日本認知症予防学会　学術集会
- Place of Presentation
  神戸国際会議場、兵庫県神戸市
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Kinesine-1 cargo receptor APP and Alcadeinα transport different type of vesicular cargo to the axonal　terminal2015
- Author(s)
  Shiraki, Y., Chiba, K., Hata, S., Suzuki, T
- Organizer
  25th Meeting of the International Society for Neurochemistry
- Place of Presentation
  Cairns Convention Center, Cairns, Australia
- Year and Date
  2015-08-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Regulation of axonal transport of APP cargos by kinesin-12015
- Author(s)
  Suzuki, T., Chiba, K., Hata, S
- Organizer
  25th Meeting of the International Society for Neurochemistry
- Place of Presentation
  Cairns Convention Center, Cairns, Australia
- Year and Date
  2015-08-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Regulation of Alcadeinα association with kinesin-1 by phosphorylation of the cytoplasmic region2015
- Author(s)
  Sobu,Y.,Hata,S.,Suzuki,T.
- Organizer
  25th Meeting of the International Society for Neurochemistry
- Place of Presentation
  Cairns Convention Center, Cairns, Australia
- Year and Date
  2015-08-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] 膜コレステロール含量に依存したγセクレターゼによる基質切断変化2015
- Author(s)
  胡安琪、朴懿、羽田沙緒里、西村正樹、鈴木利治
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森、青森県青森市
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K18854
[Presentation] Quantification of plasma p3-Alcα35 with C-terminal end- specific sELISA system2013
- Author(s)
  Kaneko,M., Omori, C., Maeda, M., Akatsu, H., Waragai, M., Nakajima, E., Asada, T., Hata, S., Suzuki, T.
- Organizer
  Alzheimer's Association International Conference 2013
- Place of Presentation
  Boston Convention and Exhibition Center (USA)
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Function of Alcadein and its metabolite, p3-Alc2013
- Author(s)
  羽田沙緒里、鈴木利治
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜　(神奈川）
- Invited
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Phosphorylation of APP is not involved in the regulation of APP anterograde transport by kinesin-1.2013
- Author(s)
  Shiraki, Y., Hata, S., Suzuki, T.
- Organizer
  Society for Neuroscience annual meeting, Neuroscience 2013
- Place of Presentation
  San Diego Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Expression of novel function of Alcadein intracellular domain.2013
- Author(s)
  Sobu, U., Takei, N., Hata, S., Suzuki, T.
- Organizer
  y for Neuroscience annual meeting, Neuroscience 2013
- Place of Presentation
  San Diego Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Quantitative alteration of p3-Alc peptides in CSF of Alzheimer’s disease patients2013
- Author(s)
  Hata, S., Omori, C., Kaneko, M., Waragai, M., Urakami, K., Taniguchi, M., Ikeuchi, T., Akatsu, H., Suzuki, T.
- Organizer
  Alzheimer's Association International Conference 2013
- Place of Presentation
  Boston Convention and Exhibition Center (USA)
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] アルツハイマー病患者における血中ｐ３－Ａｌｃα解析2013
- Author(s)
  金子窓香、大森智織、前田雅弘、赤津裕康、藁谷正明、中島悦子、朝田隆、羽田沙緒里、鈴木利治
- Organizer
  第3回　日本認知症予防学会　学術集会
- Place of Presentation
  朱鷺メッセ　（新潟）
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Quantitative alteration of p3-Alc peptides in CSF of Alzheimer's disease patients2013
- Author(s)
  Hata, S
- Organizer
  Alzheimer's Association International Conference 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Neuron-specific phosphorylation of APP: The roles in APP metabolism and function2013
- Author(s)
  Suzuki, T., Matsushima, T., Saito, Y., Taru, H., Hata, S.
- Organizer
  Alzheimer's Association International Conference 2013
- Place of Presentation
  Boston Convention and Exhibition Center (USA)
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] APPとAlcadein代謝におけるApolipoprotein Eの効果2013
- Author(s)
  木村彩乃、羽田沙緒里、道川誠、鈴木利治
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター (大阪）
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Function of Alcadein and its metabolite, p3-Alc2013
- Author(s)
  羽田沙緒里
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] p3-Alc peptide in the CSF and plasma of sporadic Alzheimer's disease patients2013
- Author(s)
  Hata, S
- Organizer
  Society for Neuroscience annual meeting Neuroscience 2013
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] p3-Alc peptide in the CSF and plasma of sporadic Alzheimer’s disease patients.2013
- Author(s)
  Hata, S., Konno, T., Urakami, K., Ikeuchi, T., Akatsu, H., Suzuki, T.
- Organizer
  Society for Neuroscience annual meeting, Neuroscience 2013
- Place of Presentation
  San Diego Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] ヒト型Apolipoprotein EノックインマウスにおけるAlcadein代謝の解析2012
- Author(s)
  木村彩乃、羽田沙緒里、道川誠、鈴木利治
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡（福岡）
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Transplocation of APP cytoplasmic fragment regulated by phosphorylation of Thr668 residue. 　　　　NANOSYMPOSIUM “Alzheimer’s disease and other dementia: Abeta Metabolism2012
- Author(s)
  Suzuki, T., Matsushima, T., Hata, S., Yamamoto, T., Saito, Y.
- Organizer
  Society for Neuroscience annual meeting, Neuroscience 2012
- Place of Presentation
  Ernest N. Morial Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] 血中p3-Alcαの定量によるアルツハイマー病のγセクレターゼ切断変化解析2012
- Author(s)
  大森智織、池内健、松原悦朗、朝田隆、羽田沙緒里、鈴木利治
- Organizer
  第17回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  オークラアクトシティホテル浜松 (静岡）
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] gamma-secretaseによるAlcadeinの膜内切断と孤発性アルツハイマー病の発症機構の解明2012
- Author(s)
  Yi Piao、羽田沙緒里、鈴木利治
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡（福岡）
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Mechanism of intramembrane cleavage of neural Alcadein proteins by γ-secretase.2012
- Author(s)
  Piao, Y., Hata, S., Suzuki, T.
- Organizer
  Society for Neuroscience annual meeting, Neuroscience 2012
- Place of Presentation
  Ernest N. Morial Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Alcadeinのリン酸化2012
- Author(s)
  蘇武佑里子、古郡慶子、森島真帆、羽田沙緒里、鈴木利治
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡（福岡）
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] 脳脊髄液・血液診断マーカーとしてのp3-Alcの解析2012
- Author(s)
  羽田沙緒里
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] γセクレターゼによるAlcadeinの膜内切断は、膜脂質組成によって変化する　-孤発性アルツハイマー病の発症機構と予防への分子機構-2012
- Author(s)
  朴懿、羽田沙緒里、鈴木利治
- Organizer
  第2回　日本認知症予防学会　学術集会
- Place of Presentation
  北九州国際会議場　（福岡）
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Membrane microdomain localization of APP C-terminal fragments regulated by the phosphorylation at cytoplasmic Thr668 residue.2012
- Author(s)
  Matsushima, T., Saito, Y., Nishimura, M., Kimura, N., Hata, S., Suzuki, T.
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancourver Convention Center (Canada)
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] 脳脊髄液・血液診断マーカーとしてのp3-Alcの解析2012
- Author(s)
  羽田沙緒里、大森智織、浦上克哉、池内健、赤津裕康、朝田隆、鈴木利治
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場　（茨城）
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Increased p3-Alc peptides in the CSF and plasma of sporadic Alzheimer's disease patients.2012
- Author(s)
  Hata, S., Konno, T., Urakami, K., Ikeuchi, T., Akatsu, H., Suzuki, T.
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancourver Convention Center (Canada)
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Alcadein代謝産物による機能発現2012
- Author(s)
  江波綾佳、朴懿、森島真帆、羽田沙緒里、鈴木利治
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡　（福岡）
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Increased p3-Alc peptides in the CSF and plasma of sporadic Alzheimer's disease patients2012
- Author(s)
  Hata, S
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Role of Apolipoprotein E on Alcadeins metabolism.2012
- Author(s)
  Kimura, A., Hata, S., Suzuki, T.
- Organizer
  Society for Neuroscience annual meeting, Neuroscience 2012
- Place of Presentation
  Ernest N. Morial Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] p3-Alcのアルツハイマー病早期診断マーカーとしての有用性の検証2012
- Author(s)
  金子窓香、羽田沙緒里、鈴木利治
- Organizer
  第17回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  オークラアクトシティホテル浜松　（静岡）
- Data Source
  KAKENHI-PROJECT-24790062
[Presentation] Quantification of plasma P3-Alc level with sELISA systems2011
- Author(s)
  Fang, J., Konno, T., Horikoshi-Sakuraba, Y., Hata, S, 他4名
- Organizer
  Alzheimer's Association International Conference 2011
- Place of Presentation
  Porte de Versailles (France)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] アポリポタンパク質EによるAlcadein代謝への影響2011
- Author(s)
  木村彩乃、羽田沙緒里、鈴木利治
- Organizer
  第84回日本生化学大会
- Place of Presentation
  国立京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] Alcadein epsilon-cleavage followed by gamma-cleavage2011
- Author(s)
  Piao, Y., Hata, S., Suzuki, T.
- Organizer
  Alzheimer's Association International Conference 2011
- Place of Presentation
  Porte de Versailles (France)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] Alternative γ-secretase processing in sporadic Alzheimer's disease suggested by p3-Alc peptide, metabolic product of Alcadein2011
- Author(s)
  Hata, S, 他5名
- Organizer
  Alzheimer's Association International Conference 2011
- Place of Presentation
  Porte de Versailles (France)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] Alcadeinのγセクレターゼによる膜内切断機構の解明2011
- Author(s)
  朴懿、羽田沙緒里、鈴木利治
- Organizer
  第84回日本生化学大会
- Place of Presentation
  国立京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] Altered processing og gamma-secretase substrates and clearance of peptide products (Abeta and p3-Alc) as a pathogenesis of sporadic Alzheimer's disease2011
- Author(s)
  Suzuki, T., Hata, S
- Organizer
  9th Asia/Oceania Regional Congress Of Gerontology And Geriatrics 2011
- Place of Presentation
  Melbourne Convention Centre (Australia)(招待講演)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] アルツハイマー病の新たな生化学的マーカー2011
- Author(s)
  羽田沙緒里浦上克哉、谷口美也子、池内健、鈴木利治
- Organizer
  第1回認知症予防学会学術大会
- Place of Presentation
  米子コンベンションセンター(鳥取)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] Alcadeinαの欠失によりAPPのアミロイド産生的代謝は亢進する2011
- Author(s)
  山本融、後藤直也、齊藤有紀、羽田沙緒里、松崎文雄、鈴木利治
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] アルツハイマー病の新たな生化学的マーカー2011
- Author(s)
  羽田沙緒里, 他4名
- Organizer
  第1回認知症予防学会学術大会
- Place of Presentation
  米子コンベンションセンター(鳥取)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] Alternativeγ-secretase processing in sporadic Alzheimer's disease suggested by p3-Alc peptide, metabolic product of Alcadein2011
- Author(s)
  Hata, S. Urakami, K., Taniguchi, M., Akatsu, H., Gandy, S., Suzuki, T
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Porte de Versailles(France)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] p3-Alcのアルツハイマー病発症サロゲートマーカーおよび診断バイオマーカーとしての応用2011
- Author(s)
  羽田沙緒里
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] p3-Alcのアルツハイマー病発症サロゲートマーカーおよび診断バイオマーカーとしての応用2011
- Author(s)
  羽田沙緒里
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡(静岡)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] Enhanced amyloidogenic processing of APP in Alcadeinα-deficient mice2011
- Author(s)
  Yamamoto, T., Gotoh, N., Saito, Y., Hata, S., Suzuki, T.
- Organizer
  Society for Neuroscience annual meeting, Neuroscience 2011
- Place of Presentation
  Walter E.Washington Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] Enhanced amyloidogenic processing of APP in Alcadein-deficient mice2011
- Author(s)
  Gotoh, N., Saito, Y., Hata, S., Yamamoto, T., Suzuki, T
- Organizer
  Alzheimer's Association International Conference 2011
- Place of Presentation
  Porte de Versailles (France)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] p3-Alc Peptides Are Generated by alpha-and gamma-Secretase Cleavage of Alcadein and Indiate Alzheimer's Disease-Related gamma-secretase Dysfunction2010
- Author(s)
  Hata.S., Suzuki, T.
- Organizer
  The American Society for Cell Biology, Annual Meeting
- Place of Presentation
  Philadelphia USA
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] AlcadeinのYセクレターゼ代謝産物p3-Alcの血中からの抽出と定量2010
- Author(s)
  今野禎子、羽田沙緒里, 他6名
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] YセクレターゼによるAlcadein切断機構2010
- Author(s)
  朴懿、浦野里美、羽田沙緒里、鈴木利治
- Organizer
  第15回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] Expression and localization of Alcadein along with X11L and APP in mouse brain2010
- Author(s)
  Piao,Y., Gotoh, N., Kondo, M., Saito, Y., Hata, S., 他3名
- Organizer
  Alzheimer's Association ICAD2010
- Place of Presentation
  Honolulu USA
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] p3-Alc Peptides Are Generated byα-andγ-secretase Cleavage of Alcadein and Indiate Alzheimer's Disease-Relatedγ-secretase Dysfunction2010
- Author(s)
  Saori Hata
- Organizer
  The American Society for Cell Biology, Annual Meeting
- Place of Presentation
  Pennsylvania Convention Center(USA)
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] YセクレターゼによるAlcadein代謝産物p3-Alcの血中測定2010
- Author(s)
  今野禎子、羽田沙緒里, 他5名
- Organizer
  第15回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] Increased p3-Alca, a Y-secretase reaction product of Alcadein, in plasma of sporadic Alzheimer's disease subjects2010
- Author(s)
  Konno, T., Hata, S., 他8名
- Organizer
  Alzheimer's Association ICAD2010
- Place of Presentation
  Honolulu USA
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] Y-secretase dysfunction in sporadic Alzheimer's disease suggested by p3-Alc peptide, metabolic product of Alcadein2010
- Author(s)
  Hata., S., 他13名
- Organizer
  Alzheimer's Association ICAD2010
- Place of Presentation
  Honolulu USA
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] YセクレターゼによるAlcadein切断機構2010
- Author(s)
  朴懿、浦野里美、羽田沙緒里、鈴木利治
- Organizer
  第15回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22890001
[Presentation] γ-secretase dysfunction in sporadic Alzheimer's disease suggested by p3-Alc peptide2010
- Author(s)
  Saori Hata
- Organizer
  metabolic product of Alcadein、Alzheimer's Association ICAD2010
- Place of Presentation
  Hawai' i Convention center(USA)
- Data Source
  KAKENHI-PROJECT-22890001

1. SUZUKI TOSHIHARU (80179233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
2. TARU Hidenori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. OUCHI Yasuomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. KITAMURA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 中野将希

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山本融

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 西村正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 小原克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 田原康玄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 三木哲郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hata Saori 羽田 沙緒里

羽田 沙緒里 ハタ サオリ

HATA Saori 羽田 沙緒里

Research Projects

Research Products

Co-Researchers

Revealing the functional mechanisms of neuronal protective peptides for developing a treatment for Alzheimer's disease.Principal Investigator

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Mechanism of action of Alzheimer's disease-related peptide p3-Alc on neuronsPrincipal Investigator

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Pathogenesis of Alzheimer's disease based on vesicular transport system in neuron

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Alzheimer's disease-related peptides as a biomarker for diagnosis in early stage Alzheimer's diseasePrincipal Investigator

Principal Investigator

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Analysis of p3-Alc peptides, the novel biomarker for Alzheimer's diseasePrincipal Investigator

Principal Investigator

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Analysis of p3-Alc, metabolic product of AlcadeinPrincipal Investigator

Principal Investigator

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Research Institution

[Book] Lipids and Cellular Membranes in Amyloid Disease2011

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[Book] Lipids and Cellular Membranes in Amyloid Disease (Edited by Jelinek, R.)2011

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[Book] Lipids and Cellular Membranes in Amyloid Disease2011

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[Journal Article] アルツハイマー病と免疫 - 脳内ペプチドp3-Alcβによるミトコンドリア活性の増強と神経炎症抑制 -2023

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[Journal Article] Brain <scp>p3‐Alcβ</scp> peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide2023

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[Journal Article] Axonal transport of Frizzled5 by Alcadein α-containing vesicles is associated with kinesin-12023

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[Journal Article] Extracellular release of ILEI/FAM3C and amyloid-β is associated with the activation of distinct synapse subpopulations.2021

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NAID

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[Journal Article] γ-Secretase activity is associated with Braak Senile Plaque stages2020

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[Journal Article] Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α-deficient mice2020

Hata Saori 羽田沙緒里

羽田沙緒里ハタサオリ

HATA Saori 羽田沙緒里