Kurabayashi Nobuhiro 倉林伸博

… Alternative Names

KURABAYASHI Nobuhiro 倉林伸博

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Researcher Number	40581658
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 主席研究員 2025: 公益財団法人東京都医学総合研究所, 先端基礎医科学研究分野, 主席研究員
Affiliation (based on the past Project Information) *help	2024: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 主席研究員 2016 – 2021: 東京大学, 大学院理学系研究科(理学部), 助教 2019 – 2020: 富山大学, 学術研究部医学系, 講師 2012 – 2015: 東京大学, 理学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 46010:Neuroscience-general-related / Neurophysiology / General neuroscience / Neuroscience in general Except Principal Investigator Complex Systems Disease Theory
Keywords	Principal Investigator 神経発生 / 大脳新皮質 / 神経前駆細胞 / ダウン症 / マウス / ストレス / 脳神経回路 / インターニューロン / 錐体細胞 / 発生期脳 … More / 神経細胞 / 中間前駆細胞 / STAT / DYRK1A / アストロサイト / ALS / 神経保護 / 筋萎縮性側索硬化症（ALS） / Nfil3 / 筋萎縮性側索硬化症 / 神経変性 … More Except Principal Investigator 造血幹細胞老化 / 異数性 / クロマチン相互作用 / ダウン症モデル / 行動実験 / 脳神経と血管の相互作用 / Hi-C 解析 / 新規モデルマウス構築 / 染色体構造と機能 / 血管病 / がん微小環境 / クロマチン動態 / 脳神経と血管相互作用 / ダウン症モデルマウス / 複合疾病 / 血管病変 / SREBP2 / NAFLD / iPS 細胞 / 肝細胞 / non-canonical PRC1 / PTIP / bivalent / ヒストン制御 / エピゲノム / 動脈硬化 / NFAT / DSCR-1 / 角膜混濁 / 血管新生 / コレステロール代謝 / 血管内皮細胞 / ダウン症 Less

ストレス暴露による神経回路変容の分子解剖Principal Investigator
- Principal Investigator
  
  倉林伸博
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
multi-pathogenesis aging research based on the Down syndrome aneuploidy model
- Principal Investigator
  
  MINAMI Takashi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  Kumamoto University
Studies on molecular mechanisms underlying abnormal neurogenesis in a mouse model of Down syndromePrincipal Investigator
- Principal Investigator
  
  Kurabayashi Nobuhiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  University of Toyama
  The University of Tokyo
Studies on molecular mechanisms underlying abnormal differentiation of neural progenitors in a mouse model of Down syndromePrincipal Investigator
- Principal Investigator
  
  Kurabayashi Nobuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  The University of Tokyo
Analysis of the mechanism of Nfil3-mediated suppression of neurodegenerationPrincipal Investigator
- Principal Investigator
  
  KURABAYASHI Nobuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The University of Tokyo

All 2020 2019 2018 2017 2016 2015 2013 2012 Other

All Journal Article Presentation

[Journal Article] In vivo single cell genotyping of mouse cortical neurons transfected with CRISPR/Cas9.2019
- Author(s)
  Andre Steinecke, Nobuhiro Kurabayashi, Yasufumi Hayano, Yugo Ishino, and Hiroki Taniguchi
- Journal Title
  
  Cell Reports
  
  Volume: 28 Issue: 2 Pages: 325-331
- DOI
  10.1016/j.celrep.2019.06.038
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06458
[Journal Article] Triple play of DYRK1A kinase in cortical progenitor cells of Trisomy 21.2019
- Author(s)
  Kurabayashi N, Nguyen MD, Sanada K
- Journal Title
  
  Neurosci Res.
  
  Volume: 138 Pages: 19-25
- DOI
  10.1016/j.neures.2018.09.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06458, KAKENHI-PUBLICLY-17H05759, KAKENHI-PUBLICLY-19H04769, KAKENHI-PROJECT-17K07045
[Journal Article] The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons.2018
- Author(s)
  Kurabayashi N, Tanaka A, Nguyen MD, Sanada K
- Journal Title
  
  Development
  
  Volume: 145 Issue: 17
- DOI
  10.1242/dev.162529
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06458, KAKENHI-PUBLICLY-17H05759, KAKENHI-PROJECT-17K07045
[Journal Article] Molecular Mechanism Underlying Abnormal Differentiation of Neural Progenitor Cells in the Developing Down Syndrome Brain2017
- Author(s)
  Kurabayashi N and Sanada K
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 7 Pages: 795-800
- DOI
  10.1248/yakushi.16-00236-1
- NAID
  130007287822
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-07-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06697
[Journal Article] The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP3 pathway.2016
- Author(s)
  Takeo Y, Kurabayashi N, Nguyen MD, Sanada K.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 25180-25180
- DOI
  10.1038/srep25180
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06697
[Journal Article] DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model.2015
- Author(s)
  Kurabayashi Nobuhiro et al.
- Journal Title
  
  EMBO Reports
  
  Volume: 16 Issue: 11 Pages: 1548-1562
- DOI
  10.15252/embr.201540374
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06697, KAKENHI-PROJECT-26640005
[Journal Article] Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells2013
- Author(s)
  Kurabayashi Nobuhiro
- Journal Title
  
  Genes and Development
  
  Volume: 27 Issue: 24 Pages: 2708-2721
- DOI
  10.1101/gad.226381.113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700314
[Journal Article] The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex.2013
- Author(s)
  Nobuhiro Kurabayashi
- Journal Title
  
  Development
  
  Volume: 140 Issue: 21 Pages: 4335-4346
- DOI
  10.1242/dev.099754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650161, KAKENHI-PROJECT-24700314
[Presentation] 大脳新皮質における神経細胞の発生メカニズム～ダウン症モデル動物を用いた解析～2020
- Author(s)
  倉林伸博
- Organizer
  北陸実験動物研究会　第60回研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06458
[Presentation] ダウン症モデルマウスの大脳新皮質において発生異常が引き起こされる分子メカニズム2020
- Author(s)
  倉林伸博　高雄啓三
- Organizer
  第43回　日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06458
[Presentation] Analysis of the mechanism underlying neurodevelopmental anomaly in the neocortex of a Down syndrome mouse model2019
- Author(s)
  Kurabayashi N, Tanaka A, Takao K, Sanada K
- Organizer
  Toyama Forum for Academic Summit on“Dynamic Brain”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06458
[Presentation] 大脳新皮質における神経細胞の形態変化・移動を制御するリゾフォスファチジン酸-LPA4シグナリング2018
- Author(s)
  倉林伸博　眞田佳門
- Organizer
  次世代脳　2018年度冬のシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06458
[Presentation] リゾフォスファチジン酸とその受容体LPA4による神経細胞の形態変化・移動の制御2018
- Author(s)
  倉林伸博　眞田佳門
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06458
[Presentation] Extracellular LPA-mediated regulation of neocortical neuronal migration2018
- Author(s)
  Aiki Tanaka, Nobuhiro Kurabayashi and Kamon Sanada
- Organizer
  International Young Scientists Workshop on Neural Development & Stem Cells 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06697
[Presentation] ダウン症モデルマウスの大脳新皮質における神経発生異常のメカニズムの解析2018
- Author(s)
  田中合紀　倉林伸博　眞田佳門
- Organizer
  次世代脳　2018年度冬のシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06458
[Presentation] DYRK1A overexpression contributes to enhanced astrogliogenesis in a Down syndrome mouse model.2017
- Author(s)
  Nobuhiro Kurabayashi and Kamon Sanada
- Organizer
  Dyrk Conference
- Place of Presentation
  Saint-Malo (France)
- Year and Date
  2017-03-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06697
[Presentation] リゾフォスファチジン酸を介したシグナリングは発生期の大脳新皮質における神経細胞の形態変化および移動に必要である2017
- Author(s)
  倉林伸博、田中合紀、眞田佳門
- Organizer
  次世代脳プロジェクト　冬のシンポジウム2017
- Data Source
  KAKENHI-PROJECT-15K06697
[Presentation] ダウン症関連因子DYRK1Aの過剰発現による神経前駆細胞のアストロサイト分化異常2016
- Author(s)
  倉林伸博、眞田佳門
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K06697
[Presentation] ダウン症脳における神経幹細胞のニューロン分化異常を引き起こす分子基盤2016
- Author(s)
  倉林伸博
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K06697
[Presentation] Increased dosage of DYRK1A enhances STAT activity and astrocytic differentiation of neocortical progenitors in a mouse model of Down’s syndrome2015
- Author(s)
  Nobuhiro Kurabayashi
- Organizer
  Neuroscience 2015
- Place of Presentation
  Chicago (USA)
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06697
[Presentation] 筋萎縮性側索硬化症モデルにおけるNfil3の神経保護作用2012
- Author(s)
  倉林伸博
- Organizer
  第８５回　日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24700314
[Presentation] ダウン症関連因子DYRK1AとDSCR1の過剰発現による神経幹細胞の神経分化抑制
- Author(s)
  倉林伸博
- Organizer
  第37回日本分子生物学会年回
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24700314

1. MINAMI Takashi (00345141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 大里元美 (90314286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kurabayashi Nobuhiro 倉林 伸博

KURABAYASHI Nobuhiro 倉林 伸博

Research Projects

Research Products

Co-Researchers

ストレス暴露による神経回路変容の分子解剖Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

multi-pathogenesis aging research based on the Down syndrome aneuploidy model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on molecular mechanisms underlying abnormal neurogenesis in a mouse model of Down syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on molecular mechanisms underlying abnormal differentiation of neural progenitors in a mouse model of Down syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanism of Nfil3-mediated suppression of neurodegenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] In vivo single cell genotyping of mouse cortical neurons transfected with CRISPR/Cas9.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Triple play of DYRK1A kinase in cortical progenitor cells of Trisomy 21.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Mechanism Underlying Abnormal Differentiation of Neural Progenitor Cells in the Developing Down Syndrome Brain2017

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP3 pathway.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] 大脳新皮質における神経細胞の発生メカニズム～ダウン症モデル動物を用いた解析～2020

Kurabayashi Nobuhiro 倉林伸博

KURABAYASHI Nobuhiro 倉林伸博