NAKAHARA Osamu 中原修

Researcher Number	40583042
Other IDs
Affiliation (based on the past Project Information) *help	2012 – 2017: 熊本大学, 医学部附属病院, 非常勤診療医師 2011: 熊本大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Digestive surgery Except Principal Investigator Digestive surgery
Keywords	Principal Investigator 転移 / 浸潤 / 肝星細胞 / 癌間質細胞 / 補体C5a / 肝細胞癌 / ヒト肝星細胞 / C5a受容体 / Long non-coding RNA / 膵臓癌 … More / HOTAIR導入 / 転移性肝癌 / HOTAIR / 転移性肝腫瘍 / 膵癌 … More Except Principal Investigator 浸潤、転移 / C5aR / 肝転移 / 浸潤 / 補体 / 胃癌 / 胃癌浸潤・転移 / C5a受容体 / 補体C5a / carcinogenesis / miR-101 / p27Kip1 / Ki67 / EZH2 / エピジェネティクス / IPMN Less

Analysis of tumor-stromal interaction via complement C5a receptor in cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  NAKAHARA Osamu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Analysis for the effect of C5a receptor on cancer cell and development for targeted therapeutic strategy to C5a receptor
- Principal Investigator
  
  NITTA Hidetoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Analysis of function of long non-coding RNA associated with liver metastasis from pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  NAKAHARA osamu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Investigation into epigenetic regulatory mechanism by microRNA in carcinogenesis
- Principal Investigator
  
  TAKAMORI Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University

All 2016 2014 2012 2011

All Journal Article Presentation

[Journal Article] Degenerative hepatic hemangioma mimicking biliary cystadenocarcinoma.2016
- Author(s)
  Kaida T, Higashi T, Kitano Y, Yamamura K, Arima K, Taki K, Imai K, Nitta H, Hashimoto D, Chikamoto A, Namimoto T, Nakahara O, Beppu T, Baba H
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 31(8) Issue: 8 Pages: 1385-1385
- DOI
  10.1111/jgh.13325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10171, KAKENHI-PROJECT-16K10503
[Journal Article] EZH2 Is Associated with Malignant Behavior in Pancreatic IPMN via p27Kip1 Downregulation2014
- Author(s)
  Kuroki H, Hayashi H, Okabe H, Hashimoto D, Takamori H, Nakahara O, Nakagawa S, Fukushima Y, Chikamoto A, Beppu T, Hirota M, Iyama K, Baba H
- Journal Title
  
  PLOS ONE
  
  Volume: 9(8) Issue: 8 Pages: e100904-e100904
- DOI
  10.1371/journal.pone.0100904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592033, KAKENHI-PROJECT-24592034, KAKENHI-PROJECT-26462047
[Journal Article] NO donor and MEK inhibitor synergistically inhibit proliferation and invasion of cancer cells2012
- Author(s)
  Furuhashi S, Sugita H, Takamori H, Horino K, Nakahara O, Okabe H, Miyake K, Tanaka H, Beppu T, Baba H
- Journal Title
  
  Int J Oncol
  
  Volume: 40(3) Pages: 807-15
- DOI
  10.3892/ijo.2011.1243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591898, KAKENHI-PROJECT-23592015, KAKENHI-PROJECT-23592016
[Journal Article] Carcinogenesis of intraductal papillary mucinous neoplasm of the pancreas : loss of microrna-101 promotes overexpression of histone methyltransferase EZH22012
- Author(s)
  Nakahara O
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: (印刷中) Issue: S3 Pages: 565-71
- DOI
  10.1245/s10434-011-2068-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390247, KAKENHI-PROJECT-22591525, KAKENHI-PROJECT-23591898, KAKENHI-PROJECT-23591940, KAKENHI-PROJECT-24591949, KAKENHI-PROJECT-24592034
[Journal Article] 【ERASに基づく術前・術中・術後管理】合併症別慢性肝疾患2011
- Author(s)
  増田稔郎、別府透、近本亮、美馬浩介、岡部弘尚、古橋聡、阿部真也、中原修、田中洋、堀野敬、石河隆敏、高森啓史、馬場秀夫
- Journal Title
  
  消化器外科
  
  Volume: 34(4) Pages: 487-491
- URL
  http://www.herusu-shuppan.co.jp/shokaki/gs201104.html
- Data Source
  KAKENHI-PROJECT-23592015
[Journal Article] 胆管癌との鑑別に難渋した胆管断端神経腫の1例2011
- Author(s)
  清住雄希、高森啓史、堀野敬、生田義明、中原修、近本亮、別府透、猪山賢一、馬場秀夫
- Journal Title
  
  胆道
  
  Volume: 25 Pages: 774-778
- NAID
  10031122817
- URL
  https://www.jstage.jst.go.jp/article/tando/25/5/25_5_774/_article/-char/ja/
- Data Source
  KAKENHI-PROJECT-23592015
[Journal Article] 【がん患者の周術期管理のすべて】術後のがん化学療法の実際膵癌術後化学療法の実際(解説/特集)2011
- Author(s)
  阿部真也、高森啓史、田中洋、中原修、古橋聡、美馬浩介、堀野敬、増田稔郎、近本亮、石河隆敏、別府透、馬場秀夫
- Journal Title
  
  外科治療
  
  Volume: 104増刊号 Pages: 855-860
- URL
  http://search.jamas.or.jp/link/ui/2011236076
- Data Source
  KAKENHI-PROJECT-23592015
[Journal Article] 進行肝細胞癌集学治療の一環としてのSorafenibの可能性2011
- Author(s)
  石河隆敏、別府透、近本亮、田中洋、増田稔郎、岡部弘尚、美馬浩介、堀野敬、高森啓史、中原修、馬場秀夫
- Journal Title
  
  癌と化学療法
  
  Volume: 38(12) Pages: 2499-2501
- URL
  http://www.pieronline.jp/content/article/0385-0684/38120/2499
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 膵癌の病態解明と新規バイオマーカーとしてのmiR-101の意義2012
- Author(s)
  中原　修
- Organizer
  2012年度日本消化器関連学会週間（JDDW 2012）
- Place of Presentation
  神戸国際展示場
- Data Source
  KAKENHI-PROJECT-24592034
[Presentation] 膵切除前後の膵外分泌機能の変化と術後肝臓脂肪沈着への影響2011
- Author(s)
  中原　修
- Organizer
  第42回日本膵臓学会大会
- Place of Presentation
  青森　ホテルニューキャッスル
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 肝切除後肝内胆管閉塞に対する超音波内視鏡を用いた経肝的内瘻化の工夫2011
- Author(s)
  中原修
- Organizer
  第23回日本肝胆膵外科学会学術集会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] Carcinogenesis of intraductal papillary mucinous neoplasm of the pancreas : Loss of microRNA-101 promotes overexpression of histone methyltransferase EZH2.2011
- Author(s)
  Nakahara O.
- Organizer
  American association for cancer research
- Place of Presentation
  アメリカ合衆国フロリダ州オーランド
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 超音波内視鏡下穿刺吸引生検を用いた粘膜下腫瘍の診断能と悪性度評価の検討2011
- Author(s)
  中原　修
- Organizer
  第49回日本癌治療学会学術集会
- Place of Presentation
  名古屋　名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 膵腫瘍に対する超音波内視鏡下穿刺吸引生検(EUS-FNA)の有用性 -質的診断能におけるFDG-PET CTとの比較-2011
- Author(s)
  中原　修
- Organizer
  第66回日本消化器外科学会総会
- Place of Presentation
  名古屋　名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] Use of the round ligament and omental flap to prevent pancreatic fistula, sequential delayed intra-abdominal hemorrhage after pancreaticoduodenectomy-double wrapping method2011
- Author(s)
  中原　修
- Organizer
  INTERNATIONAL SURGICAL WEEK 2011　第44回万国外科学会
- Place of Presentation
  横浜　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 膵PMN癌化におけるEZH2とmicroRNA101の関与2011
- Author(s)
  中原　修
- Organizer
  第20回　日本癌病態治療研究会
- Place of Presentation
  東京　東京大学医学部教育研究棟
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] IPMNにおける癌化の機序解明―miR-101とEZH2の発現の観点から― / Loss of microRNA-101 leads to carcinogenesis of pancreatic intraductal papillary mucinous neoplasms（IPMN）through overexpression of histon methyltaransferase EZH22011
- Author(s)
  中原　修
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  紙上発表
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 膵腫瘍に対する超音波内視鏡下穿刺吸引生検(EUS-FNA)の有用性-質的診断能におけるFDG-PET CTとの比較-2011
- Author(s)
  中原修
- Organizer
  第66回日本消化器外科学会総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-07-14
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 超音波内視鏡下穿刺吸引生検を用いた粘膜下腫瘍の診断能と悪性度評価の検討2011
- Author(s)
  中原修
- Organizer
  第49回日本癌治療学会学術集会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-29
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] Use of the round ligament and omental flap to prevent pancreatic fistula, sequential delayed intraabdominal hemorrhage after pancreaticoduodenectomy-double wrapping method2011
- Author(s)
  中原修
- Organizer
  INTERNATIONAL SURGICAL WEEK 2011第44回万国外科学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-08-28
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] Carcinogenesis of intraductal papillary mucinous neoplasm of the pancreas: Loss of microRNA-101 promotes overexpression of histone methyltransferase EZH22011
- Author(s)
  Nakahara O
- Organizer
  American association for cancer research
- Place of Presentation
  アメリカ合衆国　フロリダ州　オーランド
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 単孔式腹腔鏡下胆嚢摘出術の導入の経験：従来法と比較して2011
- Author(s)
  中原　修
- Organizer
  第21回九州内視鏡外科手術研究会
- Place of Presentation
  福岡　九州大学医学部百年講堂
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 切除不能膵癌におけるバイオマーカーとしてのmicroRNA-21発現の意義2011
- Author(s)
  中原修
- Organizer
  JDDW2011
- Place of Presentation
  マリンメッセ福岡
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 膵切除前後の膵外分泌機能の変化と術後肝臓脂肪沈着への影響2011
- Author(s)
  中原修
- Organizer
  第42回日本膵臓学会大会
- Place of Presentation
  ホテルニューキャッスル(青森県)
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 膵IPN癌化におけるEZH2とmicroRNA101の関与2011
- Author(s)
  中原修
- Organizer
  第20回日本癌病態治療研究会
- Place of Presentation
  東京大学医学部教育研究棟
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 切除不能膵癌におけるバイオマーカーとしてのmicroRNA-21発現の意義2011
- Author(s)
  中原　修
- Organizer
  JDDW2011
- Place of Presentation
  福岡　マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 肝切除後肝内胆管閉塞に対する超音波内視鏡を用いた経肝的内瘻化の工夫2011
- Author(s)
  中原　修
- Organizer
  第 23 回日本肝胆膵外科学会・学術集会
- Place of Presentation
  東京　京王プラザホテル
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] IPMNにおける癌化の機序解明―miR-101とEZH2の発現の観点から―/ Loss of microRNA-101 leads to carcinogenesis of pancreatic intraductal papillary mucinous neoplasms(IPMN)through overexpression of histon methyltaransferase EZH2.2011
- Author(s)
  中原修
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  紙上
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-23592015
[Presentation] 単孔式腹腔鏡下胆嚢摘出術の導入の経験:従来法と比較して2011
- Author(s)
  中原修
- Organizer
  第21回九州内視鏡外科手術研究会
- Place of Presentation
  九州大学医学部百年講堂(福岡県)
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-23592015

1. NITTA Hidetoshi (90555749)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. TAKAMORI Hiroshi (90363514)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. OHMURAYA Masaki (60398229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SAKAMOTO Yasuo (00452897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HORINO Kei (60452900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. CHIKAMOTO Akira (10419640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. IMAI Katsunori (60555746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HAYASHI Hiromitsu (80625773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. BABA Hideo (20240905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. BEPPU Toru (70301372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 岡部弘尚 (40573621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 橋本大輔 (80508507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. KAIDA Takayoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAHARA Osamu 中原 修

Research Projects

Research Products

Co-Researchers

Analysis of tumor-stromal interaction via complement C5a receptor in cancer microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis for the effect of C5a receptor on cancer cell and development for targeted therapeutic strategy to C5a receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of function of long non-coding RNA associated with liver metastasis from pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation into epigenetic regulatory mechanism by microRNA in carcinogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Degenerative hepatic hemangioma mimicking biliary cystadenocarcinoma.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EZH2 Is Associated with Malignant Behavior in Pancreatic IPMN via p27Kip1 Downregulation2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NO donor and MEK inhibitor synergistically inhibit proliferation and invasion of cancer cells2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Carcinogenesis of intraductal papillary mucinous neoplasm of the pancreas : loss of microrna-101 promotes overexpression of histone methyltransferase EZH22012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 【ERASに基づく術前・術中・術後管理】合併症別慢性肝疾患2011

Author(s)

Journal Title

URL

Data Source

[Journal Article] 胆管癌との鑑別に難渋した胆管断端神経腫の1例2011

Author(s)

Journal Title

NAID

URL

Data Source

[Journal Article] 【がん患者の周術期管理のすべて】術後のがん化学療法の実際膵癌術後化学療法の実際(解説/特集)2011

Author(s)

Journal Title

URL

Data Source

[Journal Article] 進行肝細胞癌集学治療の一環としてのSorafenibの可能性2011

Author(s)

Journal Title

URL

Data Source

[Presentation] 膵癌の病態解明と新規バイオマーカーとしてのmiR-101の意義2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 膵切除前後の膵外分泌機能の変化と術後肝臓脂肪沈着への影響2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 肝切除後肝内胆管閉塞に対する超音波内視鏡を用いた経肝的内瘻化の工夫2011

NAKAHARA Osamu 中原修