NIHIRA NAOE 仁平直江

… Alternative Names

仁平直江ニヒラナオエ

平直江タイラナオエ

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Researcher Number	40589470
Other IDs	https://orcid.org/0000-0001-5618-7538
Affiliation (Current)	2026: 聖マリアンナ医科大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2026: 聖マリアンナ医科大学, 医学研究科, 講師 2022 – 2024: 聖マリアンナ医科大学, 医学研究科, 講師 2021: 聖マリアンナ医科大学, 医学研究科, 特別研究員(RPD) 2018 – 2019: 東北大学, 歯学研究科, 大学院非常勤講師 2014: 東京慈恵会医科大学, 医学部, 助教 2011: Tokyo Medical and Dental University, 難治疾患研究所, その他 2010: 東京医科歯科大学, 難治疾患研究所, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 50010:Tumor biology-related / 0901:Oncology and related fields / Tumor biology / Tumor biology
Keywords	Principal Investigator PD-L1 / DNA損傷 / 免疫チェックポイント / cGAS-STING / 炎症 / DNA損傷応答 / 乳癌幹細胞 / 細胞周期制御

DNA損傷による炎症の誘発機構と癌免疫療法への応用Principal Investigator
- Principal Investigator
  
  仁平直江
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  St. Marianna University School of Medicine
Functional analysis of cellular PD-L1 and the clinical applicationPrincipal Investigator
- Principal Investigator
  
  仁平直江
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  St. Marianna University School of Medicine
Clarification of PD-L1 functions under genotixic stressPrincipal Investigator
- Principal Investigator
  
  仁平直江
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  St. Marianna University School of Medicine
  Tokyo Medical and Dental University
Elucidation of PD-L1 functions under genotoxic conditionPrincipal Investigator
- Principal Investigator
  
  NIHIRA NAOE
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Tohoku University
乳癌幹細胞の発生制御機構の解明Principal Investigator
- Principal Investigator
  
  平直江
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Jikei University School of Medicine
細胞周期G1/S期進行におけるc-Jun・c-Mycの発現制御機構の解明Principal Investigator
- Principal Investigator
  
  平直江
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Medical and Dental University

All 2025 2024 2023 2022 2021 2015 2010 Other

All Journal Article Presentation

[Journal Article] Nuclear PD-L1 triggers tumour-associated inflammation upon DNA damage2025
- Author(s)
  Nihira Naoe T、Wu Wenwen、Hosoi Mitsue、Togashi Yukiko、Sunada Shigeaki、Miyoshi Yasuo、Miki Yoshio、Ohta Tomohiko
- Journal Title
  
  EMBO Reports
  
  Volume: 26 Issue: 3 Pages: 635-655
- DOI
  10.1038/s44319-024-00354-9
- URL
  https://marianna-u.repo.nii.ac.jp/records/2000968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27668, KAKENHI-PROJECT-23K06681
[Journal Article] Inflammation and tumor immune escape in response to DNA damage2025
- Author(s)
  Nihira Naoe Taira、Kudo Rei、Ohta Tomohiko
- Journal Title
  
  Seminars in Cancer Biology
  
  Volume: 110 Pages: 36-45
- DOI
  10.1016/j.semcancer.2025.02.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27668, KAKENHI-PROJECT-23K06681
[Journal Article] Editorial: Community series in post-translational modifications of proteins in cancer immunity and immunotherapy, volume III2024
- Author(s)
  Zhao Xuejing、Nihira Naoe Taira、Dai Xiangpeng、Liu Zichuan
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 15 Pages: 01-03
- DOI
  10.3389/fimmu.2024.1533926
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06681
[Journal Article] The Potential Impact of BI-D1870, a Ribosomal S6 Kinase Inhibitor, on PD-L1 Expression Control2024
- Author(s)
  Nihira Naoe Taira、Takeyama Tomohiro、Wu Wenwen、Ohta Tomohiko
- Journal Title
  
  Journal of St. Marianna University
  
  Volume: 15 Issue: 2 Pages: 45-52
- DOI
  10.17264/stmarieng.15.45
- ISSN
  2185-1336, 2189-0277
- URL
  https://marianna-u.repo.nii.ac.jp/records/2000151
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27668, KAKENHI-PROJECT-23K06681
[Journal Article] Ribosomal S6 kinase (RSK) plays a critical role in DNA damage response via the phosphorylation of histone lysine demethylase KDM4B2024
- Author(s)
  Wu Wenwen、Zhu Jing、Nihira Naoe Taira、Togashi Yukiko、Goda Atsushi、Koike Junki、Yamaguchi Kiyoshi、Furukawa Yoichi、Tomita Takuya、Saeki Yasushi、Johmura Yoshikazu、Nakanishi Makoto、Miyoshi Yasuo、Ohta Tomohiko
- Journal Title
  
  Breast Cancer Research
  
  Volume: 26 Issue: 1 Pages: 146
- DOI
  10.1186/s13058-024-01901-x
- URL
  https://marianna-u.repo.nii.ac.jp/records/2001162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23H04921, KAKENHI-PROJECT-23H05479, KAKENHI-PROJECT-23K27668, KAKENHI-PROJECT-23K06681
[Journal Article] Editorial: Community series in post-translational modifications of proteins in cancer immunity and immunotherapy, volume II2023
- Author(s)
  Nihira Naoe Taira、Ohta Tomohiko、Liu Zichuan、Dai Xiangpeng
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 01-03
- DOI
  10.3389/fimmu.2023.1289016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06681, KAKENHI-PROJECT-23K27668
[Journal Article] Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance2022
- Author(s)
  Zhu Jing、Wu Wenwen、Togashi Yukiko、Taira Nihira Naoe、Johmura Yoshikazu、Zhu Dajiang、Nakanishi Makoto、Miyoshi Yasuo、Ohta Tomohiko
- Journal Title
  
  Breast Cancer
  
  Volume: 29 Issue: 6 Pages: 1076-1087
- DOI
  10.1007/s12282-022-01389-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03431, KAKENHI-PROJECT-20H03748, KAKENHI-PROJECT-20J40010
[Journal Article] Regulation of Intrinsic Functions of PD-L1 by Post-Translational Modification in Tumors.2022
- Author(s)
  Nihira NT, Miki Y.
- Journal Title
  
  Front Oncol.
  
  Volume: 12 Pages: 825284-825284
- DOI
  10.3389/fonc.2022.825284
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03497, KAKENHI-PROJECT-20J40010
[Journal Article] Engagement of DYRK2 in proper control for cell division.2015
- Author(s)
  Nihira NT, Yoshida K.
- Journal Title
  
  Cell Cycle
  
  Volume: 14 Issue: 6 Pages: 802-7
- DOI
  10.1080/15384101.2015.1007751
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25640080, KAKENHI-PROJECT-26290041, KAKENHI-PROJECT-26830083
[Presentation] PD-L1によるcGAS-STING経路の活性化と炎症誘導2025
- Author(s)
  仁平直江、太田智彦
- Organizer
  がん関連三学会Rising Starネットワーキング2025
- Data Source
  KAKENHI-PROJECT-23K06681
[Presentation] Nuclear PD-L1 facilitates inflammation mediated by the cGAS-STING pathway in response to DNA damage2025
- Author(s)
  Naoe T Nihira, Wenwen Wu, Mitsue Hosoi, Yukiko Togashi, Tomohiko Ohta
- Organizer
  13TH AACR-JCA JOINT CONFERENCE: FROM CANCER DISCOVERY SCIENCE TO THERAPEUTIC INNOVATION
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06681
[Presentation] 免疫チェックポイント分子PD-L1によるcGAS-STING経路の活性化と炎症の誘導2024
- Author(s)
  仁平直江、太田智彦
- Organizer
  第47回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06681
[Presentation] DNA損傷応答と免疫チェックポイント：研究の最前線2024
- Author(s)
  仁平直江、太田智彦
- Organizer
  第4回日本遺伝性乳癌卵巣癌総合診療制度機構（JOHBOC）学術総会
- Data Source
  KAKENHI-PROJECT-23K06681
[Presentation] 免疫チェックポイント分子PD-L1を標的とした新規治療法の確立2023
- Author(s)
  仁平　直江
- Organizer
  第46回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06681
[Presentation] D-L1 の核内移行制御に対する分子標的薬は抗PD-1抗体による癌免疫治療の効果を向上させる2021
- Author(s)
  仁平　直江、三木義男、Wenyi Wei、Peter Sicinski、Gordon J. Freeman
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20J40010
[Presentation] PD-L1 の核内移行制御に対する分子標的薬は抗PD-1抗体による癌免疫治療の効果を向上させる2021
- Author(s)
  仁平直江
- Organizer
  第94回日本生化学会年会
- Data Source
  KAKENHI-PROJECT-20J40010
[Presentation] DYRK2は転写因子c-Jun/c-Mycへのリン酸化を介して細胞周期G1/S期の進行を制御する2010
- Author(s)
  平直江
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場・リーガロイヤルホテル大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22800017
[Presentation] 新規p53関連遺伝子AREGはDNA損傷下でのmicroRNA代謝制御に関わる
- Author(s)
  仁平（平）　直江、尾野　雅哉、吉田　清嗣
- Organizer
  第73回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26830083

1. 吉田清嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 城村由和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 太田智彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 三木義男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NIHIRA NAOE 仁平 直江

仁平 直江 ニヒラ ナオエ

平 直江 タイラ ナオエ

Research Projects

Research Products

Co-Researchers

DNA損傷による炎症の誘発機構と癌免疫療法への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of cellular PD-L1 and the clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of PD-L1 functions under genotixic stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of PD-L1 functions under genotoxic conditionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

乳癌幹細胞の発生制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞周期G1/S期進行におけるc-Jun・c-Mycの発現制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nuclear PD-L1 triggers tumour-associated inflammation upon DNA damage2025

Author(s)

Journal Title

DOI

URL

Data Source

[Journal Article] Inflammation and tumor immune escape in response to DNA damage2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Editorial: Community series in post-translational modifications of proteins in cancer immunity and immunotherapy, volume III2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Potential Impact of BI-D1870, a Ribosomal S6 Kinase Inhibitor, on PD-L1 Expression Control2024

Author(s)

Journal Title

DOI

ISSN

URL

Language

Data Source

[Journal Article] Ribosomal S6 kinase (RSK) plays a critical role in DNA damage response via the phosphorylation of histone lysine demethylase KDM4B2024

Author(s)

Journal Title

DOI

URL

Data Source

[Journal Article] Editorial: Community series in post-translational modifications of proteins in cancer immunity and immunotherapy, volume II2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance2022

Author(s)

Journal Title

NIHIRA NAOE 仁平直江

仁平直江ニヒラナオエ

平直江タイラナオエ