TSUTSUMI KOICHIRO 堤康一郎

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TSUTSUMI Koichiro 堤康一郎

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Researcher Number	40610910
Other IDs
Affiliation (Current)	2025: 岡山大学, 医療開発領域, 助教
Affiliation (based on the past Project Information) *help	2025: 岡山大学, 医療開発領域, 助教 2019 – 2023: 岡山大学, 大学病院, 助教 2018: 岡山大学, 医学部, 客員研究員 2012 – 2017: 岡山大学, 大学病院, 助教 2014: 岡山大学, 岡山大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / 0903:Organ-based internal medicine and related fields Except Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator IPMN / プロテオーム / 細胞外小胞 / FFPE / 診断マーカー / 膵癌 / 膵癌診断 / 膵オルガノイドモデル / 治療効果予測 / 膵癌オルガノイド … More / 癌 / 良悪性鑑別 / プロテオーム解析 / 良悪性診断 / 膵液診断マーカー / プロテオミクス / 膵液 / 血漿 / エクソソーム / 間葉系幹細胞 / 膵がん幹細胞 / 特異的タンパク質 / 癌特異的タンパク質 / SPECT / PET / 分子イメージング / 膵臓癌 / イメージング / 膵がん … More Except Principal Investigator 膵癌 / オルガノイド / REIC遺伝子 / 遺伝子治療 / 消化管腫瘍 / 次世代内視鏡診療 / ctDNA / 炎症性腸疾患関連腫瘍 / リキッドバイオプシー / 人工知能 / 間質 / 膵がん / シングルセル解析 / メチル化 / ADM / 膵腺房 / NNMT / エクソソーム / 細胞外小胞 / プロテオミクス / 診断マーカー / miR-34a-5p / 治療標的 / microRNA / 胆道癌 / 肝臓癌 / 腫瘍免疫 / DKK3 / REIC / 癌遺伝子治療 / 消化器癌 / 癌抑制遺伝子 / 膵臓癌 / REIC/Dkk-3 Less

IPMN併存膵癌の発生メカニズムの解明：IPMN由来の細胞外小胞に着目した研究Principal Investigator
- Principal Investigator
  
  堤康一郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
Next-generation endoscopic system using liquid biopsy and multimodality artificial intelligence
- Principal Investigator
  
  衣笠秀明
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
膵オルガノイドモデル構築による高精度膵癌診断と治療法の開発Principal Investigator
- Principal Investigator
  
  堤康一郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
膵がんメチオームマーカーとしてのNNMT代謝物の有効性
- Principal Investigator
  
  千々松良太
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Development of high-precision early diagnosis methods for cholangiocarcinoma using normal and tumor organoid models.
- Principal Investigator
  
  Kato Hironari
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
A novel diagnostic method for malignant IPMN based on the results of proteomicsPrincipal Investigator
- Principal Investigator
  
  Tsutsumi Koichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
エクソソーム中のmicroRNA解析によるIPMN良悪性診断マーカーの探索Principal Investigator
- Principal Investigator
  
  堤康一郎
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0903:Organ-based internal medicine and related fields
- Research Institution
  Okayama University
網羅的プロテオーム解析を用いたIPMNの新規良悪性診断法の開発Principal Investigator
- Principal Investigator
  
  堤康一郎
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Okayama University
The analysis of the function and the clinical application of REIC/ Dkk-3 gene in digestive organ cancer
- Principal Investigator
  
  Kato Hironari
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Okayama University
Development of molecular imaging of pancreatic cancer by targeting cancer stem cell, mesenchymal stem cell or cancer-specific proteinsPrincipal Investigator
- Principal Investigator
  
  TSUTSUMI KOICHIRO
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Okayama University
The analysis of the function and the clinical application of REIC/Dkk-3 gene in digestive organ cancer
- Principal Investigator
  
  KATO Hironari
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Okayama University

All 2024 2023 2017 2013

All Journal Article Presentation

[Journal Article] MicroRNA-34a-5p: A pivotal therapeutic target in gallbladder cancer2024
- Author(s)
  Oda Takashi、Tsutsumi Koichiro、Obata Taisuke、Ueta Eijiro、Kikuchi Tatsuya、Ako Soichiro、Fujii Yuki、Yamazaki Tatsuhiro、Uchida Daisuke、Matsumoto Kazuyuki、Horiguchi Shigeru、Kato Hironari、Okada Hiroyuki、Chijimatsu Ryota、Otsuka Motoyuki
- Journal Title
  
  Molecular Therapy: Oncology
  
  Volume: 32 Issue: 1 Pages: 200765-200765
- DOI
  10.1016/j.omton.2024.200765
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08773, KAKENHI-PROJECT-23K07813, KAKENHI-PROJECT-21K07962
[Journal Article] Methylation analysis of DCC gene in saliva samples is an efficient method for non-invasive detection of superficial hypopharyngeal cancer2024
- Author(s)
  Hirai R, Kinugasa H, Yamamoto S, Ako S, Tsutsumi K, Abe M, Miyahara K, Nakagawa M, Otsuka M
- Journal Title
  
  Br J Cancer
  
  Volume: - Issue: 10 Pages: 1725-1731
- DOI
  10.1038/s41416-024-02654-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07462, KAKENHI-PROJECT-20K17051
[Journal Article] MicroRNA-451a inhibits gemcitabine-refractory biliary tract cancer progression by suppressing the MIF-mediated PI3K/AKT pathway2023
- Author(s)
  Obata Taisuke、Tsutsumi Koichiro、Ueta Eijiro、Oda Takashi、Kikuchi Tatsuya、Ako Soichiro、Fujii Yuki、Yamazaki Tatsuhiro、Uchida Daisuke、Matsumoto Kazuyuki、Horiguchi Shigeru、Kato Hironari、Okada Hiroyuki、Otsuka Motoyuki
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: 34 Pages: 102054-102054
- DOI
  10.1016/j.omtn.2023.102054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07962, KAKENHI-PROJECT-23K24090
[Journal Article] Promising therapeutic efficacy of a novel REIC/Dkk-3 expressing adenoviral vector for hepatocellular carcinoma.2017
- Author(s)
  Sawahara H, Shiraha H, Uchida D, Kato H, Kato R, Oyama A, Nagahara T, Iwamuro M, Horiguchi S, Tsutsumi K, Mandai M, Mimura T, Wada N, Takeuchi Y, Kuwaki K, Onishi H, Nakamura S, Watanabe M, Sakaguchi M, et al.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: - Issue: 10 Pages: 1769-1777
- DOI
  10.1111/jgh.13757
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290039, KAKENHI-PROJECT-26293352, KAKENHI-PROJECT-15K14382, KAKENHI-PROJECT-25220206, KAKENHI-PROJECT-15H04974, KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-15K08999, KAKENHI-PROJECT-15K09001
[Presentation] DCC salivary methylation analysis is extremely useful for screening patients with superficial hypopharyngeal cancer2023
- Author(s)
  R. Hirai, H. Kinugasa, S. Ako, K. Tsutsumi, M. Abe, K. Miyahara, M. Nakagawa, and M. Otsuka
- Organizer
  UEGW
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07462
[Presentation] 胆嚢オルガノイドを用いた発癌モデルより同定したmiR-34a-5p補充による胆嚢癌治療の開発2023
- Author(s)
  織田崇志、堤康一郎
- Organizer
  日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07962
[Presentation] REIC/Dkk-3遺伝子導入による膵癌治療の検討2013
- Author(s)
  内田大輔、白羽英則、加藤博也、永原照也、片岡淳郎、岩室雅也、堀口繁、堤　康一郎、渡部昌実、那須保友、公文裕巳、山本和秀
- Organizer
  第44回　日本膵臓学会大会
- Place of Presentation
  仙台国際センター(仙台市)
- Data Source
  KAKENHI-PROJECT-24590977
[Presentation] REIC/Dkk-3遺伝子導入による膵癌治療の検討2013
- Author(s)
  内田大輔、白羽英則、加藤博也、永原照也、片岡淳郎、岩室雅也、堀口繁、堤　康一郎、渡部昌実、那須保友、公文裕巳、山本和秀
- Organizer
  日本すい臓学会大会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-24590977

1. KATO Hironari (60619039)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. SHIRAHA Hidenori (40379748)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. NASU Yasutomo (20237572)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. UCHIDA Daisuke (50749215)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. YAMAMOTO Kazuhide (90140491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. UEDA Masashi (40381967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松下浩志 (20786107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 岩室雅也 (30645403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 赤穂宗一郎 (00882854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 千々松良太 (60803210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 石井秀始 (10280736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 衣笠秀明 (70774800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. WATANABE Masami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 阪口政清

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUTSUMI KOICHIRO 堤 康一郎

TSUTSUMI Koichiro 堤 康一郎

Research Projects

Research Products

Co-Researchers

IPMN併存膵癌の発生メカニズムの解明：IPMN由来の細胞外小胞に着目した研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Next-generation endoscopic system using liquid biopsy and multimodality artificial intelligence

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵オルガノイドモデル構築による高精度膵癌診断と治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵がんメチオームマーカーとしてのNNMT代謝物の有効性

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of high-precision early diagnosis methods for cholangiocarcinoma using normal and tumor organoid models.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel diagnostic method for malignant IPMN based on the results of proteomicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エクソソーム中のmicroRNA解析によるIPMN良悪性診断マーカーの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

網羅的プロテオーム解析を用いたIPMNの新規良悪性診断法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of the function and the clinical application of REIC/ Dkk-3 gene in digestive organ cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of molecular imaging of pancreatic cancer by targeting cancer stem cell, mesenchymal stem cell or cancer-specific proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of the function and the clinical application of REIC/Dkk-3 gene in digestive organ cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] MicroRNA-34a-5p: A pivotal therapeutic target in gallbladder cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methylation analysis of DCC gene in saliva samples is an efficient method for non-invasive detection of superficial hypopharyngeal cancer2024

Author(s)

Journal Title

DOI

TSUTSUMI KOICHIRO 堤康一郎

TSUTSUMI Koichiro 堤康一郎