SHINOZAKI Shohei 篠崎昇平

… Alternative Names

SHINOZAKI SHOHEI 篠崎昇平

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Researcher Number	40622626
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2020: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 2016 – 2017: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 2013 – 2014: 東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座准教授
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related Except Principal Investigator Basic Section 49010:Pathological biochemistry-related / Pathological medical chemistry / Biological pharmacy
Keywords	Principal Investigator インスリン抵抗性 / 一酸化窒素 / 慢性炎症 / S-ニトロソ化 / iNOS / 糖尿病 / メタボリックシンドローム / GSNOR / 動脈硬化 / β細胞 … More / 老化 / インスリン抵抗 / シグナル伝達 / SIRT1 / 加齢関連疾患 … More Except Principal Investigator iNOS / S-nitrosylation / GSNOR / diabetes / リバーロキサバン / beta cell / anticoagulant / inflammation / 老化 / S-ニトロソ化 / インスリン抵抗性 / 糖尿病 / 慢性炎症 / β細胞 / 2型糖尿病 / 分子生物学 / Sepsis / Macrophage / Heart / Cytokine / Nitric Oxide / マクロファージ / 心臓 / S-ニトロソ化タンパク質 / 炎症 / NO Less

A novel mechanism of type 2 diabetes through S-nitrosylation and development of new therapiesPrincipal Investigator
- Principal Investigator
  
  Shinozaki Shohei
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of the role of denitrosylation enzyme in type 2 diabetes pancreatic beta cell dysfunction and search for new therapeutic agents
- Principal Investigator
  
  Tanioka Toshihiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Showa University
2型糖尿病の膵β細胞機能不全における新たな発症メカニズムの解明と原因療法の確立
- Principal Investigator
  
  金木正夫
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical and Dental University
Elucidation of septic myocardial injury control mechanism based on denitrosation and search for therapeutic drugs
- Principal Investigator
  
  TANIOKA Toshihiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Elucidation of mechanisms for metabolic disorder and chronic inflammation by S-nitrosylation, a novel protein modification after translation.Principal Investigator
- Principal Investigator
  
  SHINOZAKI Shohei
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical and Dental University
The role of S-nitrosylation for pathological mechanisms of metabolic syndrome.Principal Investigator
- Principal Investigator
  
  SHINOZAKI SHOHEI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical and Dental University

All 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle2019
- Author(s)
  Nakazawa Harumasa、Ikeda Kazuhiro、Shinozaki Shohei、Yasuhara Shingo、Yu Yong-Ming、Martyn J.A. Jeevendra、Tompkins Ronald G.、Yorozu Tomoko、Inoue Satoshi、Kaneki Masao
- Journal Title
  
  FEBS Open Bio
  
  Volume: 9 Issue: 2 Pages: 348-363
- DOI
  10.1002/2211-5463.12580
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06952, KAKENHI-PROJECT-17K18084
[Journal Article] Beneficial effects of xanthohumol on obesity and insulin resistance in obese, diabetic (ob/ob) mice.2018
- Author(s)
  Mabuchi, S., Shinozaki, S., Soejima, Y., Tsuzuki, T., Naito, H., Sawabe, M., Kaneki, M., Shimokado, K.
- Journal Title
  
  Open Access Journal of Foood and Nutrition
  
  Volume: 1 Pages: 1-10
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19048
[Journal Article] iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53.2017
- Author(s)
  Nakazawa H, Chang K, Shinozaki S, Yasukawa T, Ishimaru K, Yasuhara S, Yu YM, Martyn JA, Tompkins RG, Shimokado K, Kaneki M
- Journal Title
  
  PLoS One
  
  Volume: 12(1) Issue: 1 Pages: e0170391-e0170391
- DOI
  10.1371/journal.pone.0170391
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15409, KAKENHI-PROJECT-16K19048
[Journal Article] Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation2017
- Author(s)
  Nakazawa Harumasa、Ikeda Kazuhiro、Shinozaki Shohei、Kobayashi Masayuki、Ikegami Yuichi、Fu Ming、Nakamura Tomoyuki、Yasuhara Shingo、Yu Yong-Ming、Martyn J. A. Jeevendra、Tompkins Ronald G.、Shimokado Kentaro、Yorozu Tomoko、Ito Hideki、Inoue Satoshi、Kaneki Masao
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 6618-6618
- DOI
  10.1038/s41598-017-07011-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18084, KAKENHI-PROJECT-16K19048
[Journal Article] Inflammatory stimuli induce inhibitory S-nitrosylation ofthe deacetylase SIRT1 to increase acetylation and activation of p53 and p65.2014
- Author(s)
  Shinozaki S, Chang K, Sakai M, Shimizu N, Yamada M, Tanaka T, Nakazawa H,Ichinose F, Yamada Y, Ishigami A, Ito H, Ouchi Y, Starr ME, Saito H, Shimokado K,Stamler JS, Kaneki M
- Journal Title
  
  Sci Signal
  
  Volume: 7 Issue: 351
- DOI
  10.1126/scisignal.2005375
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-25860231, KAKENHI-PROJECT-26893290
[Journal Article] A deficiency of Herp, an endoplasmic reticulum stress protein, suppresses atherosclerosis in apoE knockout mice by attenuating inflammatory responses2013
- Author(s)
  Shohei Shinozaki, Tsuyoshi Chiba, Koichi Kokame, Toshiyuki Miyata, Eiji Kaneko, and Kentaro Shimokado
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 10 Pages: e75249-e75249
- DOI
  10.1371/journal.pone.0075249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-25860231
[Journal Article] Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression.2013
- Author(s)
  Sips PY, Irie T, Zou L, Shinozaki S, Sakai M, Shimizu N, Nguyen R, Stamler JS, Chao W, Kaneki M, Ichinose F.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 304(8)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860231
[Presentation] Oral intake of sulforaphane (broccoli sprouts) on androgen in middle aged male: a randomized, placebo-controlled, pilot trial2018
- Author(s)
  Shohei Shinozaki
- Organizer
  Japan Society for Biomedical Gerontology
- Invited
- Data Source
  KAKENHI-PROJECT-18K06952
[Presentation] マクロファージにおけるS-nitrosoglutathione reductase (GSNOR)の機能2018
- Author(s)
  谷岡　利裕、篠崎　昇平、鈴木　結貴、出町　侑希子、奥田　貴久、長谷場　健、原　俊太郎
- Organizer
  第138回　日本薬学会
- Data Source
  KAKENHI-PROJECT-16K15120
[Presentation] Role of S-nitrosoglutathione reductase (GSNOR) on inflammation.2017
- Author(s)
  Tanioka T, Shinozaki S, Matsuda R, Naruo M, Okuda T, Haseba T, Hara S.
- Organizer
  第90回　日本生化学会／第40回　分子生物学会　(ConBio2017)
- Data Source
  KAKENHI-PROJECT-16K15120
[Presentation] Role of S-nitrosoglutathione reductase (GSNOR) on inflammation.2017
- Author(s)
  Tanioka T, Shinozaki S, Matsuda R, Naruo M, Okuda T, Haseba T, Hara S.
- Organizer
  13th World Congress on Inflammation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15120
[Presentation] S-nitrosylation of SIRT1 as a hub of and inflammatory spiral.2016
- Author(s)
  Shohei Shinozaki
- Organizer
  The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide.
- Place of Presentation
  宮城県仙台市　仙台国際センター
- Year and Date
  2016-05-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19048
[Presentation] 糖尿病と慢性炎症2016
- Author(s)
  篠崎昇平
- Organizer
  第58回日本老年医学会学術集会
- Place of Presentation
  石川県金沢市　石川県立音楽堂
- Year and Date
  2016-06-09
- Invited
- Data Source
  KAKENHI-PROJECT-16K19048
[Presentation] Single molecular switch may contribute to majoraging-related diseases2015
- Author(s)
  Shohei Shinozaki
- Organizer
  The 3rd Ochanomizu Atherosclerosis Forum
- Place of Presentation
  庭のホテル（東京都千代田区）
- Year and Date
  2015-02-28
- Invited
- Data Source
  KAKENHI-PROJECT-25860231
[Presentation] Inflammatory stimuli induce inhibitory S-nitrosylation of SIRT1 to increase acetylation and activation of p53 and p65.
- Author(s)
  篠崎昇平
- Organizer
  日本基礎老化学会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2015-06-12 – 2015-06-13
- Data Source
  KAKENHI-PROJECT-25860231
[Presentation] S-ニトロソ化を介したメタボリックシンドローム発症メカニズムの解明
- Author(s)
  篠崎昇平
- Organizer
  日本動脈硬化学会
- Place of Presentation
  仙台国際センター（仙台市青葉区）
- Year and Date
  2015-07-09 – 2015-07-10
- Data Source
  KAKENHI-PROJECT-25860231
[Presentation] SIRT1のS-ニトロソ化と慢性炎症・老化
- Author(s)
  篠崎昇平
- Organizer
  日本食品免疫学会
- Place of Presentation
  伊藤謝恩ホール（東京大学構内）（東京都文京区）
- Year and Date
  2015-10-15 – 2015-10-16
- Invited
- Data Source
  KAKENHI-PROJECT-25860231
[Presentation] iNOS-dependent inhibitory S-nitrosylation of the CXXC motifs in SIRT1 function as a pro-inflammatory switch leading to sustained activation of p53 and p65 NF-κB in age-related muscle wasting.
- Author(s)
  Shohei Shinozaki
- Organizer
  International Conference on Frailty & Sarcopenia Research
- Place of Presentation
  Revere Hotel Boston Common (ボストン、アメリカ合衆国）
- Year and Date
  2015-04-23 – 2015-04-25
- Data Source
  KAKENHI-PROJECT-25860231

1. TANIOKA Toshihiro (80360585)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 金木正夫 (10769615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. CHANG Kyungho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 石丸和宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 清水伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 小亀浩市

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 中澤春政

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHINOZAKI Shohei 篠崎 昇平

SHINOZAKI SHOHEI 篠崎 昇平

Research Projects

Research Products

Co-Researchers

A novel mechanism of type 2 diabetes through S-nitrosylation and development of new therapiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of denitrosylation enzyme in type 2 diabetes pancreatic beta cell dysfunction and search for new therapeutic agents

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

2型糖尿病の膵β細胞機能不全における新たな発症メカニズムの解明と原因療法の確立

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of septic myocardial injury control mechanism based on denitrosation and search for therapeutic drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of mechanisms for metabolic disorder and chronic inflammation by S-nitrosylation, a novel protein modification after translation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of S-nitrosylation for pathological mechanisms of metabolic syndrome.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Beneficial effects of xanthohumol on obesity and insulin resistance in obese, diabetic (ob/ob) mice.2018

Author(s)

Journal Title

Data Source

[Journal Article] iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inflammatory stimuli induce inhibitory S-nitrosylation ofthe deacetylase SIRT1 to increase acetylation and activation of p53 and p65.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A deficiency of Herp, an endoplasmic reticulum stress protein, suppresses atherosclerosis in apoE knockout mice by attenuating inflammatory responses2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression.2013

Author(s)

Journal Title

Data Source

[Presentation] Oral intake of sulforaphane (broccoli sprouts) on androgen in middle aged male: a randomized, placebo-controlled, pilot trial2018

Author(s)

Organizer

Data Source

[Presentation] マクロファージにおけるS-nitrosoglutathione reductase (GSNOR)の機能2018

Author(s)

SHINOZAKI Shohei 篠崎昇平

SHINOZAKI SHOHEI 篠崎昇平