UCHIBORI Ken 内堀健

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Uchibori Ken 内堀健

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Researcher Number	40633053
Affiliation (Current)	2026: 公益財団法人がん研究会, 有明病院呼吸器内科, 医長
Affiliation (based on the past Project Information) *help	2022 – 2024: 公益財団法人がん研究会, 有明病院呼吸器内科, 医長 2019 – 2020: 公益財団法人がん研究会, 有明病院呼吸器内科, 医長 2018: 公益財団法人がん研究会, 有明病院呼吸器内科, 副医長
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator EGFR-TKI / EGFR遺伝子変異 / EGFR遺伝子変異陽性肺癌 / 免疫チェックポイント阻害剤 / EGFR陽性肺癌 / SCLC転化 / 分子標的薬 / 小細胞癌転化 / チロシンキナーゼ阻害剤 / 耐性 … More / EGFR遺伝子 / 血漿cfDNA / C797S / EGFR / 薬剤耐性 / C797S変異 / Osimertinib / EGFR阻害剤 Less

Molecular profiling and elucidation of the mechanism regarding small cell carcinoma transformation in EGFR-positive lung cancerPrincipal Investigator
- Principal Investigator
  
  Uchibori Ken
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Japanese Foundation for Cancer Research
Research for detecting and overcoming multidrug resistance caused by EGFR-C797S/T790M mutationPrincipal Investigator
- Principal Investigator
  
  UCHIBORI Ken
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Japanese Foundation for Cancer Research

All 2025 2024 2023 2021 2020 2019

All Journal Article Presentation

[Journal Article] AXL‐Mediated Drug Resistance in ALK‐Rearranged NSCLC Enhanced by GAS6 From Macrophages and MMP11 Positive Fibroblasts2025
- Author(s)
  Utsumi Takahiro、Mizuta Hayato、Seto Yosuke、Uchibori Ken、Nishio Makoto、Okamoto Isamu、Katayama Ryohei
- Journal Title
  
  Cancer Science
  
  Volume: 116 Issue: 4 Pages: 1034-1047
- DOI
  10.1111/cas.70006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07199, KAKENHI-PROJECT-22K16205, KAKENHI-PROJECT-24K02333, KAKENHI-PROJECT-22K18383
[Journal Article] A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer2024
- Author(s)
  Suzuki Mai、Uchibori Ken、Oh-hara Tomoko、Nomura Yumi、Suzuki Ryusei、Takemoto Ai、Araki Mitsugu、Matsumoto Shigeyuki、Sagae Yukari、Kukimoto-Niino Mutsuko、Kawase Yusuke、Shirouzu Mikako、Okuno Yasushi、Nishio Makoto、Fujita Naoya、Katayama Ryohei
- Journal Title
  
  npj Precision Oncology
  
  Volume: 8 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41698-024-00542-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16205, KAKENHI-PROJECT-21K06510, KAKENHI-PROJECT-22K18383
[Journal Article] Monitoring epidermal growth factor receptor C797S mutation in Japanese non?small cell lung cancer patients with serial cell‐free DNA evaluation using digital droplet PCR2021
- Author(s)
  Ariyasu Ryo、Uchibori Ken、Sasaki Takaaki、Tsukahara Mika、Kiyotani Kazuma、Yoshida Ryohei、Ono Yusuke、Kitazono Satoru、Ninomiya Hironori、Ishikawa Yuichi、Mizukami Yusuke、Yanagitani Noriko、Fujita Naoya、Nishio Makoto、Katayama Ryohei
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 6 Pages: 2371-2380
- DOI
  10.1111/cas.14879
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03446, KAKENHI-PROJECT-18K15936, KAKENHI-PROJECT-20K21554, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03522, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-20K07671
[Journal Article] Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity2021
- Author(s)
  Yoshizawa Takahiro、Uchibori Ken、Araki Mitsugu、Matsumoto Shigeyuki、Ma Biao、Kanada Ryo、Seto Yosuke、Oh-hara Tomoko、Koike Sumie、Ariyasu Ryo、Kitazono Satoru、Ninomiya Hironori、Takeuchi Kengo、Yanagitani Noriko、Takagi Satoshi、Kishi Kazuma、Fujita Naoya、Okuno Yasushi、Nishio Makoto、Katayama Ryohei
- Journal Title
  
  npj Precision Oncology
  
  Volume: 5 Issue: 1 Pages: 32-32
- DOI
  10.1038/s41698-021-00170-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22572, KAKENHI-PROJECT-18K15936, KAKENHI-PROJECT-18K06594, KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K16370, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524
[Presentation] 小細胞癌への形質転換とL718V二次変異を来したEGFR L858R陽性非小細胞肺癌の解析2024
- Author(s)
  角藤　翔、内堀　健、西尾　誠人、宮内　栄作、杉浦　久敏、片山　量平
- Organizer
  第65回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16205
[Presentation] EGFR遺伝子変異陽性非小細胞肺がんの小細胞癌転化後のサブタイプ解析2024
- Author(s)
  藤嶋　駿介、網野　喜彬,丹生谷　究二郎,磯　博和,伊藤　雅弘,菅井　万優,次富　亮輔,有安　亮,内堀　健,北園　聡,柳谷　典子, 二宮　浩範,片山　量平,西尾　誠人
- Organizer
  第65回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16205
[Presentation] EGFR-T790M+C797S変異に対する分子標的治療に耐性を示す多重変異とその克服2023
- Author(s)
  内堀健
- Organizer
  第64回　日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16205
[Presentation] 初回Osimertinib開始前の血漿中TP53変異はnegative biomarkerの可能性がある2020
- Author(s)
  内堀健、小楠真典、次富亮輔、眞鍋亮、坂本博昭、戸塚猛大、吉田寛、網野喜彬、有安亮、北園聡、栁谷典子、宝来威、片山量平、林理絵、Siew-Kee Low、西尾誠人
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15936
[Presentation] EGFR変異陽性肺癌における血中EGFR変異の経時的変化2019
- Author(s)
  内堀　健
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15936
[Presentation] 初回Osimertinib治療中におけるNGSを用いた血漿cell free DNAの経時的解析2019
- Author(s)
  内堀　健
- Organizer
  第60回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15936

1. SETO Yosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 石川雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 高木聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

UCHIBORI Ken 内堀 健

Uchibori Ken 内堀 健

Research Projects

Research Products

Co-Researchers

Molecular profiling and elucidation of the mechanism regarding small cell carcinoma transformation in EGFR-positive lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for detecting and overcoming multidrug resistance caused by EGFR-C797S/T790M mutationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] AXL‐Mediated Drug Resistance in ALK‐Rearranged NSCLC Enhanced by GAS6 From Macrophages and MMP11 Positive Fibroblasts2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Monitoring epidermal growth factor receptor C797S mutation in Japanese non?small cell lung cancer patients with serial cell‐free DNA evaluation using digital droplet PCR2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 小細胞癌への形質転換とL718V二次変異を来したEGFR L858R陽性非小細胞肺癌の解析2024

Author(s)

Organizer

Data Source

[Presentation] EGFR遺伝子変異陽性非小細胞肺がんの小細胞癌転化後のサブタイプ解析2024

Author(s)

Organizer

Data Source

[Presentation] EGFR-T790M+C797S変異に対する分子標的治療に耐性を示す多重変異とその克服2023

Author(s)

Organizer

Data Source

[Presentation] 初回Osimertinib開始前の血漿中TP53変異はnegative biomarkerの可能性がある2020

Author(s)

Organizer

Data Source

[Presentation] EGFR変異陽性肺癌における血中EGFR変異の経時的変化2019

Author(s)

Organizer

Data Source

[Presentation] 初回Osimertinib治療中におけるNGSを用いた血漿cell free DNAの経時的解析2019

Author(s)

Organizer

Data Source

UCHIBORI Ken 内堀健

Uchibori Ken 内堀健