Kobayashi Minoru 小林稔

… Alternative Names

KOBAYASHI minoru 小林稔

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Researcher Number	40644894
Other IDs
Affiliation (Current)	2025: 京都大学, 生命科学研究科, 特定助教
Affiliation (based on the past Project Information) *help	2018 – 2025: 京都大学, 生命科学研究科, 特定助教 2019: 京都大学, 放射線生物研究センター, 特定研究員 2018: 京都大学, 生命科学研究科, 特定研究員 2016 – 2017: 京都大学, 放射線生物研究センター, 特定研究員 2016: 京都大学, 放射線生物研究センター, 研究員 … More 2013 – 2016: 京都大学, 医学(系)研究科(研究院), 研究員 2015: 京都大学, 大学院医学研究科, 研究員 2014: 京都大学, 医学(系)研究科(研究院), 特定研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Radiation science / Medium-sized Section 50:Oncology and related fields / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator 放射線抵抗性 / 低酸素 / 腫瘍内微小環境 / In vivo imaging / DNA損傷修復 / 遺伝子スクリーニング / 概日リズム Except Principal Investigator がん / 低酸素 / 放射線治療 … More / 微小環境 / HIF-1 / 放射線抵抗性 / 放射線 / 増感 / マーカー / 浸潤 / 浸潤・転移関連遺伝子 / 低酸素応答 / 放射線治療抵抗性 / 治療抵抗性 / クローン進化 / 腫瘍不均一性 / DNA損傷 / ストローマ細胞 / バイオマーカー / が / 抵抗性 / 再発 / Sima / p53 / がん抑制遺伝子 / 血中マーカー / 抗酸化能 / 新規責任遺伝子 / 放射線抵抗壊死 / 細胞動態 / 腫瘍内低酸素 / 分割照射 / エネルギー代謝 / 酸素恒常性 Less

腫瘍微小環境内で放射線抵抗性を担うHIF活性化間質細胞の同定Principal Investigator
- Principal Investigator
  
  小林稔
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyoto University
Analysis of the effect of hypoxic environment on DNA damage repair mechanism: Toward understanding of tumor heterogeneity
- Principal Investigator
  
  原田浩
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Kyoto University
放射線抵抗性の腫瘍内低酸素分画をモニターする血中バイオマーカーの開発
- Principal Investigator
  
  原田浩
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyoto University
Identification of stromal subcellular population which exhiites active HIF signaling and is responsible for radioresistance of cancer
- Principal Investigator
  
  原田浩
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kyoto University
Construct of realtime DNA damage-repair responce detention system and analysis of intratumor DNA damage-repair responcePrincipal Investigator
- Principal Investigator
  
  Kobayashi Minoru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyoto University
Genome-wide screening of blood markers for hypoxic cancer cells within malignant solid tumors
- Principal Investigator
  
  Harada Hiroshi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kyoto University
TR research toward the establishment of personalized cancer radiation therapy
- Principal Investigator
  
  Harada Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kyoto University
A novel invasion-related gene involved in tumor recurrence after radiation therapy
- Principal Investigator
  
  Harada Hiroshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kyoto University
Development of novel therapies targeting the dynamics of tumor microenvironment and HIF-1Principal Investigator
- Principal Investigator
  
  Kobayashi Minoru
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyoto University
Mechanism of Action and Function of a novel HIF-1 activator in p53-deficient cancers
- Principal Investigator
  
  Harada Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kyoto University
Novel gene network responsible for hypoxic response and radioresistance of cancer cells
- Principal Investigator
  
  Morinibu Akiyo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Interplay between the molecular mechanism for hypoxia response and that for antioxidant capacity
- Principal Investigator
  
  Harada Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Search for factors inducing radioresistance using lentivirus librariesPrincipal Investigator
- Principal Investigator
  
  Kobayashi Minoru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Molecular Mechanisms behind Cancer Cells-specific Oxygen Homeostasis and Their Influence on Tumor Radioresistance
- Principal Investigator
  
  Harada Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Spatiotemporal analyses of the dynamics of hypoxic tumor cells for the optimization of fractionated radiation therapy for cancers
- Principal Investigator
  
  Harada Hiroshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Elucidation of mechanisms for tumor malignancy and radioresistance by crosstalk between Hypoxia, circadian rhythm and metabolic regulationPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI minoru
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book Patent

[Book] 実験医学2020年6月号「酸素環境感知の基本メカニズムとがん」2020
- Author(s)
  小林　稔、原田　浩
- Total Pages
  7
- Publisher
  羊土社
- ISBN
  9784758125321
- Data Source
  KAKENHI-PROJECT-18K15589
[Journal Article] Hypoxia- and Postirradiation Reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner2024
- Author(s)
  Peter W.T. LEE; Tatsuya SUWA; Minoru KOBAYASHI; Hui YANG; Lina R. KOSEKI; Satoshi TAKEUCHI; Christalle C.T. CHOW; Takaaki YASUHARA; Hiroshi HARADA
- Journal Title
  
  British Journal of Cancer
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18274
[Journal Article] Reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent2024
- Author(s)
  Nogita K; Sugahara T; Miki K; Mu H; Kobayashi M; Harada H; Ohe K
- Journal Title
  
  Chemical Communications
  
  Volume: 60 Issue: 11 Pages: 1472-1475
- DOI
  10.1039/d3cc05628g
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18274, KAKENHI-PROJECT-21K07727, KAKENHI-PROJECT-22K20530, KAKENHI-PROJECT-21KK0144, KAKENHI-PROJECT-23K27546
[Journal Article] DDX5 enhances HIF‐1 activity by promoting the interaction of HIF‐1α with HIF‐1β and recruiting the resulting heterodimer to its target gene loci2024
- Author(s)
  Yukari SHIRAI; Tatsuya SUWA; Minoru KOBAYASHI; Sho KOYASU; Hiroshi HARADA
- Journal Title
  
  Biology of the Cell
  
  Volume: 116 Issue: 2
- DOI
  10.1111/boc.202300077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18274, KAKENHI-PROJECT-22K15879, KAKENHI-PROJECT-21K07727, KAKENHI-PROJECT-21KK0144, KAKENHI-PROJECT-23K27546
[Journal Article] Hypoxia- and Postirradiation Reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner2024
- Author(s)
  Peter W.T. LEE; Tatsuya SUWA; Minoru KOBAYASHI; Hui YANG; Lina R. KOSEKI; Satoshi TAKEUCHI; Christalle C.T. CHOW; Takaaki YASUHARA; Hiroshi HARADA
- Journal Title
  
  British Journal of Cancer
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27546
[Journal Article] Whole-Body and Whole-Organ 3D Imaging of Hypoxia Using an Activatable Covalent Fluorescent Probe Compatible with Tissue Clearing2024
- Author(s)
  Daichi M. Sakamoto; Iori Tamura; Bo Yi; Sho Hasegawa; Yutaro Saito; Naoki Yamada; Yoichi Takakusagi; Shimpei I. Kubota; Minoru Kobayashi; Hiroshi Harada; Kenjiro Hanaoka; Masayasu Taki; Masaomi Nangaku; Kazuki Tainaka; Shinsuke Sando
- Journal Title
  
  ACS Nano
  
  Volume: 18 Issue: 6 Pages: 5176-5179
- DOI
  10.1021/acsnano.3c12716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18274, KAKENHI-PROJECT-21K16159, KAKENHI-PROJECT-22K15435, KAKENHI-PROJECT-21K07727, KAKENHI-PROJECT-21KK0144, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05262, KAKENHI-PROJECT-23K24198, KAKENHI-PROJECT-23K27304, KAKENHI-PROJECT-23K27546
[Journal Article] Hypoxia- and Postirradiation Reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner2024
- Author(s)
  Peter W.T. LEE; Tatsuya SUWA; Minoru KOBAYASHI; Hui YANG; Lina R. KOSEKI; Satoshi TAKEUCHI; Christalle C.T. CHOW; Takaaki YASUHARA; Hiroshi HARADA
- Journal Title
  
  British Journal of Cancer
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21KK0144
[Journal Article] ZBTB2 is recruited to a specific subset of HIF-1 target loci to facilitate full gene expression under hypoxia2023
- Author(s)
  Chow CCT; Kobayashi M; Kambe G; *Harada H
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 435 Issue: 15 Pages: 168162-168162
- DOI
  10.1016/j.jmb.2023.168162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18274, KAKENHI-PROJECT-21K07727, KAKENHI-PROJECT-21KK0144, KAKENHI-PROJECT-23K27546
[Journal Article] Inhibition of transforming growth factor‐β signals suppresses tumor formation by regulation of tumor microenvironment networks2023
- Author(s)
  Tokizaki Shiori、Podyma‐Inoue Katarzyna A.、Matsumoto Takehisa、Takahashi Kazuki、Kobayashi Miho、Ibi Haruka、Uchida Shizuka、Iwabuchi Sadahiro、Harada Hiroyuki、Hashimoto Shinichi、Miyazono Kohei、Shirouzu Mikako、Watabe Tetsuro
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 1 Pages: 211-226
- DOI
  10.1111/cas.16006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07727, KAKENHI-PROJECT-20H00513, KAKENHI-PROJECT-23H05486
[Journal Article] 放射線による細胞死と組織障害2022
- Author(s)
  百海享洲、武内智史、王美惠、宮長真広、嶋貫悠、小林稔、原田浩
- Journal Title
  
  医学のあゆみ
  
  Volume: 283 Pages: 23445-23450
- Data Source
  KAKENHI-PROJECT-21KK0144
[Journal Article] Proteolysis of a histone acetyl reader, ATAD2, induces chemoresistance of cancer cells under severe hypoxia by inhibiting cell cycle progression in S phase2022
- Author(s)
  Haitani Takao、Kobayashi Minoru、Koyasu Sho、Akamatsu Shusuke、Suwa Tatsuya、Onodera Yasuhito、Nam Jin-Min、Nguyen Phuong Thi Lien、Menju Toshi、Date Hiroshi、Ogawa Osamu、Harada Hiroshi
- Journal Title
  
  Cancer Letters
  
  Volume: 528 Pages: 76-84
- DOI
  10.1016/j.canlet.2021.12.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17164, KAKENHI-PUBLICLY-20H05033, KAKENHI-PROJECT-20H03621, KAKENHI-PROJECT-21K07727, KAKENHI-PROJECT-21K19445, KAKENHI-PROJECT-21KK0144
[Journal Article] ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness2022
- Author(s)
  Koyasu Sho、Horita Shoichiro、Saito Keisuke、Kobayashi Minoru、Ishikita Hiroshi、Chow Christalle CT、Kambe Gouki、Nishikawa Shigeto、Menju Toshi、Morinibu Akiyo、Okochi Yasushi、Tabuchi Yoshiaki、Onodera Yasuhito、Takeda Norihiko、Date Hiroshi、Semenza Gregg L、Hammond Ester M、Harada Hiroshi
- Journal Title
  
  EMBO reports
  
  Volume: 24 Issue: 1 Pages: 54042-54042
- DOI
  10.15252/embr.202154042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07727, KAKENHI-PROJECT-22K15879, KAKENHI-PROJECT-21KK0144, KAKENHI-PROJECT-20H03621, KAKENHI-PROJECT-21K19445, KAKENHI-PROJECT-18H01186
[Journal Article] 放射線による細胞死と組織障害2022
- Author(s)
  百海享洲、武内智史、王美惠、宮長真広、嶋貫悠、小林稔、原田浩
- Journal Title
  
  医学のあゆみ
  
  Volume: 283 Pages: 23445-23450
- Data Source
  KAKENHI-PROJECT-21K19445
[Journal Article] Tumor microenvironment and radioresistance.2021
- Author(s)
  Suwa T, Kobayashi M, Nam JM, Harada H.
- Journal Title
  
  Exp Mol Med.
  
  Volume: 53 Issue: 6 Pages: 1029-1029
- DOI
  10.1038/s12276-021-00640-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08140, KAKENHI-PUBLICLY-20H05033, KAKENHI-PROJECT-20H03621, KAKENHI-PROJECT-21K07727, KAKENHI-PROJECT-21K19445, KAKENHI-PROJECT-21KK0144
[Journal Article] SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization.2021
- Author(s)
  Suwa T, Kobayashi M, Shirai Y, Nam JM, Tabuchi Y, Takeda N, Akamatsu S, Ogawa O, Mizowaki T, Hammond EM, Harada H.
- Journal Title
  
  JCI Insight.
  
  Volume: 6 Issue: 21
- DOI
  10.1172/jci.insight.148135
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08140, KAKENHI-PUBLICLY-20H05033, KAKENHI-PROJECT-20H03621, KAKENHI-PROJECT-21K07727, KAKENHI-PROJECT-21K19445, KAKENHI-PROJECT-21KK0144
[Journal Article] An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor2021
- Author(s)
  Shirai Y, Chow CCT, Kambe G, Suwa T, Kobayashi M, Takahashi I, Harada H, Nam JM.
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 11 Pages: 2813-2813
- DOI
  10.3390/cancers13112813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08140, KAKENHI-PUBLICLY-20H05033, KAKENHI-PROJECT-20H03621, KAKENHI-PROJECT-21K07727, KAKENHI-PROJECT-21K19445, KAKENHI-PROJECT-21KK0144
[Journal Article] Space radiation biology for “Living in Space”2020
- Author(s)
  Furukawa S, Nagamatsu A, Nenoi M, Fujimori A, Kakinuma S, Katsube T, Wang B, Tsuruoka C, Shirai T, Nakamura AJ, Sakaue-Sawano A, Miyawaki A, Harada H, Kobayashi M, Kobayashi J, Kunieda T, Funayama T, Suzuki M, Miyamoto T, Hidema J, Yoshida Y, Takahashi A.
- Journal Title
  
  BioMed Res Int.
  
  Volume: 2020 Issue: 1 Pages: 4703286-4703286
- DOI
  10.1155/2020/4703286
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05945, KAKENHI-PUBLICLY-18H04964, KAKENHI-PUBLICLY-18H04990, KAKENHI-PUBLICLY-18H04991, KAKENHI-PUBLICLY-18H04992, KAKENHI-PROJECT-19H03140, KAKENHI-PROJECT-15K09988, KAKENHI-PROJECT-18K15589, KAKENHI-PROJECT-20K08044, KAKENHI-PUBLICLY-20H05033, KAKENHI-PROJECT-18H02624, KAKENHI-PROJECT-20H03621, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-PROJECT-20H04332, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05943, KAKENHI-WRAPUP-20H05615
[Journal Article] HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance2019
- Author(s)
  Nagao Ayako、Kobayashi Minoru、Koyasu Sho、Chow Christalle C. T.、Harada Hiroshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 2 Pages: 238-238
- DOI
  10.3390/ijms20020238
- NAID
  120006778264
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10474, KAKENHI-PROJECT-18K15589, KAKENHI-PROJECT-18KK0241, KAKENHI-PUBLICLY-18H04977, KAKENHI-PROJECT-17H04261, KAKENHI-PROJECT-17J07699
[Journal Article] Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge2018
- Author(s)
  Koyasu Sho、Kobayashi Minoru、Goto Yoko、Hiraoka Masahiro、Harada Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 3 Pages: 560-571
- DOI
  10.1111/cas.13483
- NAID
  120006454672
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01573, KAKENHI-PUBLICLY-16H01640, KAKENHI-PROJECT-17J07699, KAKENHI-PROJECT-16K15576, KAKENHI-PROJECT-16K15577, KAKENHI-PROJECT-17K10474, KAKENHI-PROJECT-18K15589, KAKENHI-PROJECT-18KK0241, KAKENHI-PUBLICLY-18H04977, KAKENHI-PROJECT-17H04261, KAKENHI-ORGANIZER-15H05935
[Journal Article] HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog2018
- Author(s)
  Katagiri Tomohiro、Kobayashi Minoru、Yoshimura Michio、Morinibu Akiyo、Itasaka Satoshi、Hiraoka Masahiro、Harada Hiroshi
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 12 Pages: 10525-10535
- DOI
  10.18632/oncotarget.24156
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01573, KAKENHI-PUBLICLY-16H01640, KAKENHI-PROJECT-15K15454, KAKENHI-PROJECT-16K15576, KAKENHI-PROJECT-16K15577, KAKENHI-PROJECT-17K10474, KAKENHI-PROJECT-18KK0241, KAKENHI-PUBLICLY-18H04977, KAKENHI-PROJECT-17H04261, KAKENHI-ORGANIZER-15H05935
[Journal Article] The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategies2017
- Author(s)
  Goto Yoko、Koyasu Sho、Kobayashi Minoru、Harada Hiroshi
- Journal Title
  
  Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
  
  Volume: 803-805 Pages: 76-81
- DOI
  10.1016/j.mrfmmm.2017.07.007
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01573, KAKENHI-PUBLICLY-16H01640, KAKENHI-PROJECT-17H04261, KAKENHI-PROJECT-16K15576, KAKENHI-PROJECT-16K15577, KAKENHI-PROJECT-17K16433, KAKENHI-ORGANIZER-15H05935
[Journal Article] UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization2017
- Author(s)
  Nakashima Ryota、Goto Yoko、Koyasu Sho、Kobayashi Minoru、Morinibu Akiyo、Yoshimura Michio、Hiraoka Masahiro、Hammond Ester M.、Harada Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 6879-6879
- DOI
  10.1038/s41598-017-06605-1
- NAID
  120006355750
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10474, KAKENHI-PUBLICLY-16H01573, KAKENHI-PUBLICLY-16H01640, KAKENHI-PROJECT-17H04261, KAKENHI-PROJECT-17H06812, KAKENHI-PROJECT-15K15454, KAKENHI-PROJECT-16K15576, KAKENHI-PROJECT-16K15577, KAKENHI-PROJECT-17K16433, KAKENHI-ORGANIZER-15H05935
[Journal Article] A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes2017
- Author(s)
  Kobayashi Minoru、Morinibu Akiyo、Koyasu Sho、Goto Yoko、Hiraoka Masahiro、Harada Hiroshi
- Journal Title
  
  The FEBS Journal
  
  Volume: 284 Issue: 22 Pages: 3804-3816
- DOI
  10.1111/febs.14280
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10474, KAKENHI-PUBLICLY-16H01573, KAKENHI-PUBLICLY-16H01640, KAKENHI-PROJECT-17H04261, KAKENHI-PROJECT-17J07699, KAKENHI-PROJECT-16K15576, KAKENHI-PROJECT-16K15577, KAKENHI-ORGANIZER-15H05935
[Journal Article] LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis2016
- Author(s)
  Harada H et al.
- Journal Title
  
  Oncotarget
  
  Volume: 7(40) Issue: 40 Pages: 65837-65848
- DOI
  10.18632/oncotarget.11670
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05935, KAKENHI-PUBLICLY-16H01573, KAKENHI-PUBLICLY-16H01640, KAKENHI-PROJECT-26293276, KAKENHI-PROJECT-26461886, KAKENHI-PROJECT-16K15576, KAKENHI-PROJECT-16K15577
[Journal Article] UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1alpha2015
- Author(s)
  Goto Y, Zeng L, YeomCJ, Zhu Y, Morinibu A, Shinoyam K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H.
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 1-10
- DOI
  10.1038/ncomms7153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592322, KAKENHI-PROJECT-24592336, KAKENHI-PROJECT-24659563, KAKENHI-PROJECT-25861088, KAKENHI-PROJECT-26461886, KAKENHI-PROJECT-26462125, KAKENHI-PROJECT-26670555, KAKENHI-PROJECT-26670558, KAKENHI-PROJECT-26670693, KAKENHI-PROJECT-15K10551, KAKENHI-PROJECT-15K15577, KAKENHI-PROJECT-25462457, KAKENHI-PROJECT-26293276
[Journal Article] PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.2015
- Author(s)
  Inoue M, Yoshimura M, Kobayashi M, Morinibu A, Itasaka S, Hiraoka M, *Harada H.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 15666-15666
- DOI
  10.1038/srep15666
- NAID
  120005753886
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461886, KAKENHI-PROJECT-15K15454, KAKENHI-PROJECT-26670555, KAKENHI-PROJECT-26670558, KAKENHI-PROJECT-26293276
[Journal Article] HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs.2014
- Author(s)
  1. Zhao T, Zhu Y, Morinibu A, Kobayashi M, Shinomiya K, Itasaka S, Yoshimura M,　Guo G, Hiraoka M, Harada H.
- Journal Title
  
  Scientific Reports
  
  Volume: 4.3793 Issue: 1 Pages: 1-7
- DOI
  10.1038/srep03793
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659563, KAKENHI-PROJECT-24791293, KAKENHI-PROJECT-25861088, KAKENHI-PROJECT-26293276, KAKENHI-PROJECT-26461886, KAKENHI-PROJECT-26670555, KAKENHI-PROJECT-26670558
[Journal Article] Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.2014
- Author(s)
  Zeng L, Morinibu A, Kobayashi M, Zhu Y, Wang X, Goto Y, Yeom CJ, Zhao T,Hirota K, Shinomiya K, Itasaka S, Yoshimura M, Guo G, Hammond EM, Hiraoka M, Harada H.
- Journal Title
  
  Oncogene
  
  Volume: epub Issue: 36 Pages: 4758-4766
- DOI
  10.1038/onc.2014.411
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659563, KAKENHI-PROJECT-25861088, KAKENHI-PROJECT-26461886, KAKENHI-PROJECT-26670555, KAKENHI-PROJECT-26670558, KAKENHI-PROJECT-26670693, KAKENHI-PROJECT-26293276
[Journal Article] 低酸素ストレスとHIF2013
- Author(s)
  小林　稔、原田　浩
- Journal Title
  
  生化学
  
  Volume: 85 Pages: 187-195
- NAID
  10031164201
- Data Source
  KAKENHI-PROJECT-25861088
[Patent] 低酸素バイオマーカー及びその利2023
- Inventor(s)
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Holder
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K27546
[Patent] 低酸素バイオマーカー及びその利用2023
- Inventor(s)
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Holder
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-21KK0144
[Patent] 低酸素バイオマーカー及びその利用2023
- Inventor(s)
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Holder
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K18274
[Patent] 低酸素バイオマーカー及びその利用2022
- Inventor(s)
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Holder
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-21K19445
[Patent] 低酸素バイオマーカー及びその利用2022
- Inventor(s)
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Holder
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-21KK0144
[Patent] 低酸素バイオマーカー及びその利用2021
- Inventor(s)
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Holder
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-108196
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K19445
[Patent] 低酸素バイオマーカー及びその利用2021
- Inventor(s)
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-108196
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-17H04261
[Patent] 低酸素バイオマーカー及びその利用2021
- Inventor(s)
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Holder
  諏訪達也、小林稔、原田浩
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-108196
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21KK0144
[Presentation] Crosstalk between cellular hypoxia signaling and DNA damage response mediated by a HIF-1 activator, ZBTB22023
- Author(s)
  Gouki KAMBE, Minoru KOBAYASHI, Sho KOYASU, Hiroshi HARADA
- Organizer
  ATW2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0144
[Presentation] Crosstalk between cellular hypoxia signaling and DNA damage response mediated by a HIF-1 activator, ZBTB22023
- Author(s)
  Gouki KAMBE, Minoru KOBAYASHI, Sho KOYASU, Hiroshi HARADA
- Organizer
  ATW2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19445
[Presentation] Tumor Hypoxic Fraction (THF)を予測する血漿バイオマーカーSPINK12022
- Author(s)
  諏訪達也、小林稔、白井友香理、武田憲彦、溝脇尚志、原田浩
- Organizer
  がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-21K19445
[Presentation] Decreased expression levels of a histone acetyl reader, ATAD2, induces chemoresistance of cancer cells under severe hypoxia by inhibiting cell cycle progression in S phase2022
- Author(s)
  灰谷崇夫、小林稔、原田浩
- Organizer
  第18回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-21K07727
[Presentation] Tumor Hypoxic Fraction (THF)を予測する血漿バイオマーカーSPINK12022
- Author(s)
  諏訪達也、小林稔、白井友香理、武田憲彦、溝脇尚志、原田浩
- Organizer
  がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-21KK0144
[Presentation] Gene expression regulatory mechanism of a novel radioresistance-related gene, HISP22020
- Author(s)
  Shirai Y, Suwa T, Kobayashi M, Harada H
- Organizer
  第79回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K22595
[Presentation] Importance of ATAD2 proteolysis in both growth retardation and resultant chemoresistance of hypoxic tumor cells2020
- Author(s)
  灰谷崇夫、小林稔、子安翔、小川修、原田浩
- Organizer
  第79回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K22595
[Presentation] 新規低酸素誘導性分泌タンパク質hypoxia-inducible secretory protein2 (HISP2)の発現機構の解析2020
- Author(s)
  白井友香理、諏訪達也、小林稔、原田浩
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22595
[Presentation] Importance of ATAD2 proteolysis in both growth retardation and resultant chemoresistance of hypoxic tumor cells2020
- Author(s)
  灰谷崇夫、小林稔、子安翔、小川修、原田浩
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18KK0241
[Presentation] A novel mode of HIF-1-mediated gene regulation: hypoxia-dependent splicing2020
- Author(s)
  Christalle C.T. Chow, Minoru Kobayashi, Hiroshi Harada
- Organizer
  2020 NTU-KU-UT Virtual-Physical Student Mini-Symposium on Cancer Biology & Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22595
[Presentation] A novel mode of HIF-1-mediated gene regulation: hypoxia-dependent splicing2020
- Author(s)
  Christalle C.T. Chow, Minoru Kobayashi, Hiroshi Harada
- Organizer
  2020 NTU-KU-UT Virtual-Physical Student Mini-Symposium on Cancer Biology & Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0241
[Presentation] Generation of EGFP-53BP1 knock-in mouse which is able to be visualized DNA double-strand break2019
- Author(s)
  Minoru Kobayashi, Hiroshi Harada
- Organizer
  第62回放射線影響学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15589
[Presentation] Elucidation of regulatory mechanisms underlying hypoxic responses and its physiological role.2019
- Author(s)
  Minoru Kobayashi
- Organizer
  第21回生命科学研究科シンポジウム
- Data Source
  KAKENHI-PROJECT-18K15589
[Presentation] 低酸素下でのp53タンパク質の蓄積メカニズムの解明2019
- Author(s)
  長尾綾子、小林稔、諏訪達也、河原康一、古川龍彦、原田浩
- Organizer
  第17回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-18K15589
[Presentation] A Circadian Clock Gene, PER2, Activates HIF-1 as an Effector Molecule for Recruitment of HIF-1α to Promoter Regions of Its Downstream Genes2018
- Author(s)
  Minoru Kobayashi, Akiyo Morinibu, Sho Koyasu, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada
- Organizer
  第34回放生研国際シンポジウム
- Data Source
  KAKENHI-PROJECT-18K15589
[Presentation] A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of Its downstream genes2018
- Author(s)
  Minoru Kobayashi, Akiyo Morinibu, Sho Koyasu, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada
- Organizer
  The 17th International Joint Mini-Symposium on Molecular and Cell Biology
- Data Source
  KAKENHI-PROJECT-18K15589
[Presentation] A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of Its downstream genes2018
- Author(s)
  5.Minoru Kobayashi, Akiyo Morinibu, Sho Koyasu, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada
- Organizer
  Keystone symposia Therapeutic Targeting of Hypoxia-Sensitive Pathways (V1)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15589
[Presentation] HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating Shh.2018
- Author(s)
  Minoru Kobayashi, Tomohiro Katagiri, Masahiro Hiraoka, Hiroshi Harada
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15589
[Presentation] A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of Its downstream genes2018
- Author(s)
  ⑧Minoru Kobayashi, Akiyo Morinibu, Sho Koyasu, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada
- Organizer
  Keystone Symposia on Molecular and Cellular Biology, Therapeutic Targeting of Hypoxia-Sensitive Pathways (V1)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15577
[Presentation] A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes.2017
- Author(s)
  小林稔, 森鳰章代, 子安翔, 後藤容子, 平岡真寛, 原田浩
- Organizer
  第15回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-16K15577
[Presentation] A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to its enhancer regions2017
- Author(s)
  ⑤Minoru Kobayashi, Syo Koyasu, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15577
[Presentation] Circadian Clock Gene, PER2, activates HIF-1 by promoting recruitment of HIF-1α to a promoter region of its downstream gene2017
- Author(s)
  Minoru Kobayashi, Akiyo Morinibu, Sho Koyasu, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada
- Organizer
  Keystone Symposia on Molecular and Cellular Biology, Adaptations to Hypoxia in Physiology and Disease (X4)
- Place of Presentation
  Whistler
- Year and Date
  2017-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15577
[Presentation] A Circadian Clock Gene, PER2, Activates HIF-1 as an Effector Molecule for Recruitment of HIF-1α to Promoter Regions of Its Downstream Genes2017
- Author(s)
  ⑦Minoru Kobayashi, Akiyo Morinibu, Sho Koyasu, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada
- Organizer
  第33回放生研国際シンポジウム
- Data Source
  KAKENHI-PROJECT-16K15577
[Presentation] Molecular mechanisms underlying the crosstalk between period circadian clock 2 (PER2) and hypoxia-inducible factor 1 (HIF-1)2016
- Author(s)
  小林稔、森鳰章代、子安翔、後藤容子、平岡真寛、原田浩
- Organizer
  第14回がんとハイポキシア研究会
- Place of Presentation
  岐阜
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-16K15577
[Presentation] Molecular mechanisms underlying the crosstalk between circadian clock gene, PER2, and hypoxia-inducible factor 1 (HIF-1).2016
- Author(s)
  Minoru Kobayashi, Yoko Goto, Michio Yoshimura, Masahiro Hiraoka, Hiroshi Harada
- Organizer
  第32回放生研国際シンポジウム
- Place of Presentation
  京都
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-16K15577
[Presentation] Molecular mechanisms underlying the crosstalk between circadian clock gene, PER2, and hypoxia-inducible factor 1 (HIF-1)2016
- Author(s)
  Minoru Kobayashi, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K15577
[Presentation] Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels.2014
- Author(s)
  Minoru Kobayashi, Hiraoka Masahiro, Harada Hiroshi
- Organizer
  Radiation Research Society 60th Annual Meeting
- Place of Presentation
  Las Vegas, Nevada
- Year and Date
  2014-09-21
- Data Source
  KAKENHI-PROJECT-25861088
[Presentation] IDH3はHIF-1αを安定化して腫瘍増殖を亢進する
- Author(s)
  小林　稔. 曽麗華. 後藤容子. 井上実. 板坂聡. 吉村通央. 原田浩. 平岡真寛
- Organizer
  第19回国際癌治療増感研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25861088
[Presentation] 時計遺伝子PER2と低酸素応答機構の相互作用メカニズムの解析
- Author(s)
  小林　稔、平岡真寛、原田浩
- Organizer
  第12回がんとhypoxia研究会
- Place of Presentation
  佐賀
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25861088

1. Harada Hiroshi (80362531)

# of Collaborated Projects: 13 results

# of Collaborated Products: 29 results
2. Yoshimura Michio (40597936)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
3. 子安翔 (80781913)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. Morinibu Akiyo (20722648)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 諏訪達也 (00914863)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. ITASAKA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. NAM Jin-min

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 高橋昭久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 日出間純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 廣田喜一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Minoru 小林 稔

KOBAYASHI minoru 小林 稔

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腫瘍微小環境内で放射線抵抗性を担うHIF活性化間質細胞の同定Principal Investigator

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Construct of realtime DNA damage-repair responce detention system and analysis of intratumor DNA damage-repair responcePrincipal Investigator

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Development of novel therapies targeting the dynamics of tumor microenvironment and HIF-1Principal Investigator

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Search for factors inducing radioresistance using lentivirus librariesPrincipal Investigator

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Kobayashi Minoru 小林稔

KOBAYASHI minoru 小林稔

[Book] 実験医学2020年6月号「酸素環境感知の基本メカニズムとがん」2020