Hayashi Gosuke 林剛介

… Alternative Names

HAYASHI Gosuke 林剛介

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Researcher Number	40648268
Other IDs
Affiliation (Current)	2024: 名古屋大学, 工学研究科, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 名古屋大学, 工学研究科, 准教授 2016 – 2017: 東京大学, 大学院工学系研究科(工学部), 助教 2013 – 2015: 東京大学, 工学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Complex systems / Transformative Research Areas, Section (III) / Science and Engineering / Basic Section 37010:Bio-related chemistry / Molecular biology Except Principal Investigator Broad Section D / Basic Section 43030:Functional biochemistry-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Transition State Control
Keywords	Principal Investigator タンパク質化学合成 / 進化分子工学 / 人工抗体 / in vitroセレクション / ペプチド化学 / ペプチド連結反応 / ユビキチン化タンパク質 / モノボディ / 分子進化工学 / ユビキチンプロテオミクス … More / タンパク質標識化 / DNA templated chemistry / ペプチド合成 / 翻訳後修飾 / Native Chemical Ligation / エピジェネティクス / ヒストン … More Except Principal Investigator タンパク質 / ペプチド / 人工抗体 / 一分子ペプチド配列決定 / 1分子シークエンス / リソソーム / 膜脂質 / ユビキチン様タンパク質 / ユビキチン / 抗菌剤 / 細胞運動 / 細菌感染 / ヒュースゲン環化 / 遷移状態 / 発酵 / 蛍光 / 核酸 / バクテリア / 核酸構造 / アプタマー / RNA Less

膜脂質のユビキチン化とユビキチン様タンパク質修飾によるオルガネラ機能制御
- Principal Investigator
  
  坂巻純一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Juntendo University
タンパク質寿命の解析・制御研究をブーストする人工タンパク質創成技術Principal Investigator
- Principal Investigator
  
  林剛介
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Nagoya University
Development of single-molecule peptide sequencing method
- Principal Investigator
  
  村上裕
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section D
- Research Institution
  Nagoya University
International collaboration for the development of new molecular-targeted antimicrobial agents
- Principal Investigator
  
  Kim Minsoo
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyoto University
Ubiquitin Chemo-technology by Chemical Protein Synthesis and Molecular EvolutionPrincipal Investigator
- Principal Investigator
  
  林剛介
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Nagoya University
Mirror-image Artificial Antibody Working in Multimolecular Crowding BiosystemsPrincipal Investigator
- Principal Investigator
  
  林剛介
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Nagoya University
Efficient Chemical Synthesis of Polyubiquitin and Ubiquitinated ProteinsPrincipal Investigator
- Principal Investigator
  
  林剛介
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Nagoya University
Chemical synthesis of protein via simultaneous ligation of multiple peptide segments on DNA scaffoldPrincipal Investigator
- Principal Investigator
  
  Hayashi Gosuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Nagoya University
Development of nucleic acid enzymes for new nucleic acid medicines based on the transition state in molecular degradation
- Principal Investigator
  
  Okamoto Akimitsu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Transition State Control
- Research Institution
  The University of Tokyo
Development of a platform for histone-code research by setting nucleosomes with various modificationsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Gosuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2015 2014 2013 Other

All Journal Article Presentation Book Patent

[Book] 最先端ナノライフシステム研究「進化分子工学を用いた人工抗体創製とその応用」2022
- Author(s)
  近藤太志; 梅本駿; 藤野公茂; 林剛介; 村上裕
- Total Pages
  6
- Publisher
  名古屋大学
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Book] 最先端ナノライフシステム研究「進化分子工学を用いた人工抗体創製とその応用」2022
- Author(s)
  近藤太志; 梅本駿; 藤野公茂; 林剛介; 村上裕
- Total Pages
  6
- Publisher
  名古屋大学
- Data Source
  KAKENHI-PUBLICLY-21H00278
[Book] 創薬研究者がこれだけは知っておきたい最新のウイルス学「新型コロナウイルスに対する迅速な人工抗体創製」2021
- Author(s)
  近藤太志; 梅本駿; 藤野公茂; 林剛介; 村上裕
- Total Pages
  8
- Publisher
  株式会社NTS
- Data Source
  KAKENHI-PUBLICLY-21H00278
[Book] 創薬研究者がこれだけは知っておきたい最新のウイルス学「新型コロナウイルスに対する迅速な人工抗体創製」2021
- Author(s)
  近藤太志; 梅本駿; 藤野公茂; 林剛介; 村上裕
- Total Pages
  10
- Publisher
  株式会社NTS
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Book] 生体分子反応を制御する　化学的手法による機構と反応場の解明　「エピジェネティック修飾の謎を解き明かす核酸およびタンパク質化学」2020
- Author(s)
  林剛介、岡本晃充
- Total Pages
  193
- Publisher
  化学同人
- Data Source
  KAKENHI-PUBLICLY-19H05287
[Book] 生体分子反応を制御する化学的手法による機構と反応場の解明「エピジェネティック修飾の謎を解き明かす核酸およびタンパク質化学」2020
- Author(s)
  林剛介、岡本晃充
- Total Pages
  193
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-18K05313
[Journal Article] Large-scale analysis of mRNA sequences localized near the start and amber codons and their impact on the diversity of mRNA display libraries2023
- Author(s)
  Shun Umemoto , Taishi Kondo , Tomoshige Fujino , Gosuke Hayashi , Hiroshi Murakami
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 14 Pages: 7465-7479
- DOI
  10.1093/nar/gkad555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ1129, KAKENHI-PROJECT-21K05270, KAKENHI-PROJECT-23H05456
[Journal Article] Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern2022
- Author(s)
  Kondo Taishi、Matsuoka Kazuhiro、Umemoto Shun、Fujino Tomoshige、Hayashi Gosuke、Iwatani Yasumasa、Murakami Hiroshi
- Journal Title
  
  Life Science Alliance
  
  Volume: 5 Issue: 6 Pages: e202101322-e202101322
- DOI
  10.26508/lsa.202101322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04704, KAKENHI-PROJECT-19H03482, KAKENHI-PROJECT-20K07533, KAKENHI-PROJECT-21K05270, KAKENHI-PUBLICLY-21H00278
[Journal Article] Base-Resolution Analysis of 5-Hydroxymethylcytidine by Selective Oxidation and Reverse Transcription Arrest2021
- Author(s)
  Koyama, K.; Hayashi, G.; Ueda, H.; Ota, S.; Nagae, G.; Aburatani, H.; Okamoto, A.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 19 Issue: 29 Pages: 6478-6486
- DOI
  10.1039/d1ob00995h
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05504, KAKENHI-PUBLICLY-20H04704, KAKENHI-PROJECT-21K19040, KAKENHI-PROJECT-23K21431, KAKENHI-PUBLICLY-21H00278
[Journal Article] Silyl-Protected Propargyl Glycine for Multiple Labeling of Peptides by Chemoselective Silyl-Deprotection2021
- Author(s)
  Kamo, N.; Hayashi, G.; Okamoto, A.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 73 Pages: 153093-153093
- DOI
  10.1016/j.tetlet.2021.153093
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05504, KAKENHI-PUBLICLY-20H04704, KAKENHI-PROJECT-21K19040, KAKENHI-PUBLICLY-21H00278
[Journal Article] Construction of a Highly Diverse mRNA Library for in vitro Selection of Monobodies2021
- Author(s)
  Kondo Taishi、Eguchi Minori、Tsuzuki Nariaki、Murata Naoya、Fujino Tomoshige、Hayashi Gosuke、Murakami Hiroshi
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: 11 Issue: 16
- DOI
  10.21769/bioprotoc.4125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04704, KAKENHI-PROJECT-21K05270, KAKENHI-PUBLICLY-21H00278
[Journal Article] Organoruthenium-Catalyzed Chemical Protein Synthesis to Elucidate the Functions of Epigenetic Modifications on Heterochromatin Factors2021
- Author(s)
  Kamo, N.; Kujirai, T.; Kurumizaka, H.; Murakami, H.; Hayashi, G.; Okamoto, A.
- Journal Title
  
  Chem. Sci.
  
  Volume: 12 Issue: 16 Pages: 5926-5937
- DOI
  10.1039/d1sc00731a
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05504, KAKENHI-PLANNED-18H05534, KAKENHI-PUBLICLY-20H04704, KAKENHI-PROJECT-18H03931, KAKENHI-PROJECT-19J13608, KAKENHI-PROJECT-19K22245, KAKENHI-PUBLICLY-19H05287, KAKENHI-PROJECT-18K05313
[Journal Article] cDNA TRAP display for rapid and stable in vitro selection of antibody-like proteins2021
- Author(s)
  Kondo Taishi、Eguchi Minori、Kito Seita、Fujino Tomoshige、Hayashi Gosuke、Murakami Hiroshi
- Journal Title
  
  Chemical Communications
  
  Volume: 57 Issue: 19 Pages: 2416-2419
- DOI
  10.1039/d0cc07541h
- NAID
  120007169556
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04704, KAKENHI-PROJECT-18K14332, KAKENHI-PUBLICLY-19H05287, KAKENHI-PROJECT-18K05313
[Journal Article] Acetylation-modulated communication between the H3 N-terminal tail domain and the intrinsically disordered H1 C-terminal domain2020
- Author(s)
  Hao, F; Murphy, K. J.; Kujirai, T.; Kamo, N.; Kato, J.; Koyama, M.; Okamato, A.; Hayashi, G.; Kurumizaka, H.; Hayes, J. J.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 48 Issue: 20 Pages: 11510-11520
- DOI
  10.1093/nar/gkaa949
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05504, KAKENHI-PLANNED-18H05534, KAKENHI-PUBLICLY-20H04704, KAKENHI-PROJECT-18H03931, KAKENHI-PROJECT-19J13608, KAKENHI-PROJECT-19K22245, KAKENHI-PUBLICLY-19H05287, KAKENHI-PROJECT-18K05313
[Journal Article] Novel Strategies of Peptide Ligation for Accelerating Chemical Protein Synthesis2020
- Author(s)
  Hayashi Gosuke、Okamoto Akimitsu
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 78 Issue: 2 Pages: 130-139
- DOI
  10.5059/yukigoseikyokaishi.78.130
- NAID
  130007795912
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2020-02-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05313, KAKENHI-PUBLICLY-19H05287
[Journal Article] Fmoc-Compatible and C-terminal-Sequence-Independent Peptide Alkyl Thioester Formation Using Cysteinylprolyl Imide2020
- Author(s)
  Nakatsu, K.; Yanase, M.; Hayashi, G.; Okamoto, A.
- Journal Title
  
  Org. Lett.
  
  Volume: 22 Issue: 12 Pages: 4670-4674
- DOI
  10.1021/acs.orglett.0c01450
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05504, KAKENHI-PUBLICLY-20H04704, KAKENHI-PROJECT-18H03931, KAKENHI-PROJECT-19K22245, KAKENHI-PUBLICLY-19H05287, KAKENHI-PROJECT-18K05313
[Journal Article] Toolbox for chemically synthesized histone proteins2020
- Author(s)
  Nakatsu, K.; Hayashi, G.; Okamoto, A.
- Journal Title
  
  Curr. Opin. Chem. Biol.
  
  Volume: 58 Pages: 10-19
- DOI
  10.1016/j.cbpa.2020.04.016
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05504, KAKENHI-PUBLICLY-20H04704, KAKENHI-PROJECT-18H03931, KAKENHI-PROJECT-19K22245, KAKENHI-PUBLICLY-19H05287, KAKENHI-PROJECT-18K05313
[Journal Article] タンパク質化学合成を活用した翻訳後修飾研究2020
- Author(s)
  林剛介
- Journal Title
  
  Farumashia
  
  Volume: 56 Issue: 1 Pages: 46-50
- DOI
  10.14894/faruawpsj.56.1_46
- NAID
  130007779027
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K05313, KAKENHI-PUBLICLY-19H05287
[Journal Article] Antibody-like proteins that capture and neutralize SARS-CoV-22020
- Author(s)
  Kondo T.、Iwatani Y.、Matsuoka K.、Fujino T.、Umemoto S.、Yokomaku Y.、Ishizaki K.、Kito S.、Sezaki T.、Hayashi G.、Murakami H.
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 42 Pages: 3916-3916
- DOI
  10.1126/sciadv.abd3916
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07533, KAKENHI-PUBLICLY-20H04704, KAKENHI-PROJECT-19H03482, KAKENHI-PROJECT-18K14332, KAKENHI-PUBLICLY-19H05287, KAKENHI-PROJECT-18K05313
[Journal Article] L-DNA-tagged fluorescence in situ hybridization for highly sensitive imaging of RNAs in single cells2020
- Author(s)
  Ogata, M.; Hayashi, G.; Ichiu, A.; Okamoto, A.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 18 Issue: 40 Pages: 8084-8088
- DOI
  10.1039/d0ob01635g
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05504, KAKENHI-PUBLICLY-20H04704, KAKENHI-PROJECT-18H03931, KAKENHI-PROJECT-19K22245, KAKENHI-PUBLICLY-19H05287, KAKENHI-PROJECT-18K05313
[Journal Article] Cysteinylprolyl imide (CPI) peptide: a highly reactive and easily accessible crypto-thioester for chemical protein synthesis2019
- Author(s)
  Yanase Masafumi、Nakatsu Koki、Cardos Charlane Joy、Konda Yoshiki、Hayashi Gosuke、Okamoto Akimitsu
- Journal Title
  
  Chemical Science
  
  Volume: 10 Issue: 23 Pages: 5967-5975
- DOI
  10.1039/c9sc00646j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05313, KAKENHI-PROJECT-19K22245, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05504, KAKENHI-PUBLICLY-19H05287, KAKENHI-PROJECT-18H03931
[Journal Article] Chemical Synthesis of Cys-Containing Protein via Chemoselective Deprotection with Different Palladium Complexes2019
- Author(s)
  Kamo, N.; Hayashi, G.; Okamoto, A.
- Journal Title
  
  Org. Lett.
  
  Volume: 21 Issue: 20 Pages: 8378-8382
- DOI
  10.1021/acs.orglett.9b03152
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22245, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05504, KAKENHI-PUBLICLY-19H05287, KAKENHI-PROJECT-18H03931, KAKENHI-PROJECT-19J13608
[Journal Article] Simultaneous and Traceless Ligation of Peptide Fragments on DNA Scaffold.2019
- Author(s)
  Hayashi G, Yanase M, Nakatsuka Y, Okamoto A.
- Journal Title
  
  Biomaclomolecules
  
  Volume: 20 Issue: 3 Pages: 1246-1253
- DOI
  10.1021/acs.biomac.8b01655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05313, KAKENHI-PROJECT-19K22245, KAKENHI-PLANNED-18H05504, KAKENHI-PROJECT-18H03931
[Journal Article] Diazirine Photocrosslinking Recruits Activated FTO Demethylase Complexes for Specific N6-methyladenosine Recognition2015
- Author(s)
  Jeong HS, Hayashi G, Okamoto A
- Journal Title
  
  ACS Chemical Biology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870186
[Journal Article] 2-oxazoline formation for selective chemical labeling of 5-hydroxylysine2015
- Author(s)
  Hayashi G, Sakamoto R, Okamoto A
- Journal Title
  
  Chemistry An Asian Journal
  
  Volume: 10 Issue: 5 Pages: 1138-1141
- DOI
  10.1002/asia.201500172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870186
[Journal Article] Hybridization-sensitive fluorescent oligonucleotide probe conjugated with a bulky module for compartment-specific mRNA monitoring in a living cell2015
- Author(s)
  Hayashi G, Yanase M, Takeda K, Sakakibara D, Sakamoto R, Wang DO, Okamoto A
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 26 Issue: 3 Pages: 412-417
- DOI
  10.1021/acs.bioconjchem.5b00090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870186, KAKENHI-PROJECT-26702038
[Journal Article] An orthogonal ribosome-tRNAs pair via engineering of peptidyl transferase center2014
- Author(s)
  Terasaka N*, Hayashi G*, Katoh T, Suga, H (*contributed equally)
- Journal Title
  
  Nature Chemical Biology
  
  Volume: in press
- NAID
  120006348461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870186
[Journal Article] Development of photo switchable RNA aptamer-ligand complexes2014
- Author(s)
  Hayashi G, Nakatani K
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1111 Pages: 29-40
- DOI
  10.1007/978-1-62703-755-6_3
- ISBN
  9781627037549, 9781627037556
- Data Source
  KAKENHI-PROJECT-25870186
[Journal Article] 生命現象を司るDNAのメチル化ーエピジェネティック因子を検出する化学2014
- Author(s)
  林剛介、岡本晃充
- Journal Title
  
  化学
  
  Volume: 69 Pages: 66-67
- Data Source
  KAKENHI-PROJECT-25870186
[Journal Article] A nucleic acid probe labeled with desmethyl thiazole orange : A new type of hybridization-sensitive fluorescent oligonucleotide for live-cell RNA imaging2013
- Author(s)
  Okamoto, A. ; Sugizaki, K. ; Yuki, M. ; Yanagisawa, H. ; Ikeda, S. ; Sueoka, T. ; Hayashi, G. ; Wang, D. O
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 11-2 Issue: 2 Pages: 362-371
- DOI
  10.1039/c2ob26707a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13F03342, KAKENHI-PROJECT-24650216, KAKENHI-PROJECT-25870186
[Journal Article] Probe Design for Effective Fluorescent Imaging of Intracellular RNA2013
- Author(s)
  Hayashi, G. ; Okamoto, A.
- Journal Title
  
  Chem. Rec.
  
  Volume: 13-2 Issue: 2 Pages: 209-217
- DOI
  10.1002/tcr.201200026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13F03342, KAKENHI-PROJECT-25870186
[Patent] 63.SARS-CoV-2 Binding Molecule2020
- Inventor(s)
  村上裕、近藤大志、藤野公茂、林剛介、梅本駿、岩谷靖雅
- Industrial Property Rights Holder
  村上裕、近藤大志、藤野公茂、林剛介、梅本駿、岩谷靖雅
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PUBLICLY-19H05287
[Patent] 63.SARS-CoV-2 Binding Molecule2020
- Inventor(s)
  村上裕、近藤大志、藤野公茂、林剛介、梅本駿、岩谷靖雅
- Industrial Property Rights Holder
  村上裕、近藤大志、藤野公茂、林剛介、梅本駿、岩谷靖雅
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-18K05313
[Patent] フィブロネクチンIII型ドメイン骨格を含むポリペプチド2020
- Inventor(s)
  村上裕、都築成晃、近藤大志、林剛介、藤野公茂、築地真也、吉井達之
- Industrial Property Rights Holder
  村上裕、都築成晃、近藤大志、林剛介、藤野公茂、築地真也、吉井達之
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K05313
[Patent] 62.フィブロネクチンIII型ドメイン骨格を含むポリペプチド2020
- Inventor(s)
  村上裕、都築成晃、近藤大志、林剛介、藤野公茂、築地真也、吉井達之
- Industrial Property Rights Holder
  村上裕、都築成晃、近藤大志、林剛介、藤野公茂、築地真也、吉井達之
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PUBLICLY-19H05287
[Patent] 63.SARS-CoV-2のSタンパク質に結合する人工抗体2020
- Inventor(s)
  村上裕、近藤大志、藤野公茂、林剛介、梅本駿
- Industrial Property Rights Holder
  村上裕、近藤大志、藤野公茂、林剛介、梅本駿
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Patent] 62.フィブロネクチンIII型ドメイン骨格を含むポリペプチド2020
- Inventor(s)
  村上裕、都築成晃、近藤大志、林剛介、藤野公茂
- Industrial Property Rights Holder
  村上裕、都築成晃、近藤大志、林剛介、藤野公茂
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Presentation] Large-scale Analysis of the Effect of mRNA Sequences on the diversity of mRNA display libraries2023
- Author(s)
  梅本駿,近藤太志,藤野公茂,林剛介,村上裕
- Organizer
  第24回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-23H05456
[Presentation] 1分子ペプチドアミノ酸配列決定法の開発を目指したN末端Gly・Phe結合人工抗体の創製2023
- Author(s)
  菅野晃矢,近藤太志,梅本駿,藤野公茂,林剛介,村上裕
- Organizer
  第17回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-23H05456
[Presentation] mRNA提示法における人工抗体モノボディ・大環状ペプチドライブラリの多様性最大化2023
- Author(s)
  梅本駿,近藤太志,藤野公茂,林剛介,村上裕
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23H05456
[Presentation] mRNA提示法のライブラリ多様性に対してmRNA配列が与える影響の大規模解析2023
- Author(s)
  梅本駿,近藤太志,藤野公茂,林剛介,村上裕
- Organizer
  第17回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-23H05456
[Presentation] タンパク質化学合成 -低分子抗体の高機能化を目指して-2022
- Author(s)
  林剛介
- Organizer
  日本薬学会第142年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Presentation] タンパク質化学合成 -低分子抗体の高機能化を目指して-2022
- Author(s)
  林剛介
- Organizer
  日本薬学会第142年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00278
[Presentation] Fluorophore-labeled Synthetic Histone Proteins for Investigation of Nucleosome Dynamics2021
- Author(s)
  Gosuke Hayashi
- Organizer
  PACIFICHEM2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Presentation] タンパク質を全合成するための最先端分子技術2021
- Author(s)
  林剛介
- Organizer
  令和3年度有機合成化学協会東海支部若手研究者のためのセミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Presentation] 有機化学と進化分子工学を活用したユビキチンケモテクノロジー2021
- Author(s)
  林剛介
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00278
[Presentation] Advanced Chemical Synthesis of Modified Histone Proteins for Epigenetic Research2021
- Author(s)
  Gosuke Hayashi
- Organizer
  PACIFICHEM2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00278
[Presentation] もう今はタンパク質もつくれます2021
- Author(s)
  林剛介
- Organizer
  第11回CSJ化学フェスタ2021
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00278
[Presentation] タンパク質に代表されるポリアミド型定序配列分子の化学合成2021
- Author(s)
  林剛介
- Organizer
  第25回VBLシンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00278
[Presentation] Fluorophore-labeled Synthetic Histone Proteins for Investigation of Nucleosome Dynamics2021
- Author(s)
  Gosuke Hayashi
- Organizer
  PACIFICHEM2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00278
[Presentation] 有機化学と進化分子工学を活用したユビキチンケモテクノロジー2021
- Author(s)
  林剛介
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Presentation] Advanced Chemical Synthesis of Modified Histone Proteins for Epigenetic Research2021
- Author(s)
  Gosuke Hayashi
- Organizer
  PACIFICHEM2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Presentation] タンパク質を全合成するための最先端分子技術2021
- Author(s)
  林剛介
- Organizer
  令和3年度有機合成化学協会東海支部若手研究者のためのセミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00278
[Presentation] New Peptide Ligation Techniques for Enhanced Chemical Protein Synthesis2021
- Author(s)
  Gosuke Hayashi
- Organizer
  PACIFICHEM2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00278
[Presentation] 修飾ヒストンの効率的化学合成法とヒストン動態解析2021
- Author(s)
  林剛介
- Organizer
  第14回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Presentation] タンパク質に代表されるポリアミド型定序配列分子の化学合成2021
- Author(s)
  林剛介
- Organizer
  第25回VBLシンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Presentation] New Peptide Ligation Techniques for Enhanced Chemical Protein Synthesis2021
- Author(s)
  Gosuke Hayashi
- Organizer
  PACIFICHEM2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Presentation] 修飾ヒストンの効率的化学合成法とヒストン動態解析2021
- Author(s)
  林剛介
- Organizer
  第14回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] 修飾ヒストンの効率的化学合成法とヒストン動態解析2021
- Author(s)
  林剛介
- Organizer
  第14回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PUBLICLY-19H05287
[Presentation] もう今はタンパク質もつくれます2021
- Author(s)
  林剛介
- Organizer
  第11回CSJ化学フェスタ2021
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Presentation] 修飾タンパク質作製を可能にする最先端技術 ~生合成 vs 化学合成~2020
- Author(s)
  林剛介
- Organizer
  第568回東北大学薬学研究科セミナー
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] Challenges and prospects in chemoselective ligations: from protein synthesis to site-specific conjugation2020
- Author(s)
  Gosuke Hayashi
- Organizer
  LE STUDIUM CONFERENCES
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] タンパク質化学合成技術を駆使した修飾タンパク質の創製と生化学研究への展開2020
- Author(s)
  林剛介
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05287
[Presentation] タンパク質化学合成技術を駆使した修飾タンパク質の創製と生化学研究への展開2020
- Author(s)
  林剛介
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04704
[Presentation] 修飾タンパク質作製を可能にする最先端技術　～生合成 vs 化学合成～2020
- Author(s)
  林剛介
- Organizer
  第568回東北大学薬学研究科セミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05287
[Presentation] Challenges and prospects in chemoselective ligations: from protein synthesis to site-specific conjugation2020
- Author(s)
  Gosuke Hayashi
- Organizer
  LE STUDIUM CONFERENCES
- Data Source
  KAKENHI-PUBLICLY-19H05287
[Presentation] Novel Peptide Ligation Strategies for Chemical Protein Synthesis2020
- Author(s)
  Gosuke Hayashi
- Organizer
  Seminar at University of Paris
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] タンパク質化学合成技術を駆使した修飾タンパク質の創製と生化学研究への展開2020
- Author(s)
  林剛介
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] Novel Peptide Ligation Strategies for Chemical Protein Synthesis2020
- Author(s)
  Gosuke Hayashi
- Organizer
  Seminar at University of Paris
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05287
[Presentation] Chemical Protein Synthesis with Novel Ligation Strategies2020
- Author(s)
  Gosuke Hayashi
- Organizer
  Seminar at CBM, CNRS Orleans Campus
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05287
[Presentation] Chemical Protein Synthesis with Novel Ligation Strategies2020
- Author(s)
  Gosuke Hayashi
- Organizer
  Seminar at CBM, CNRS Orleans Campus
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] Novel technologies for studying chromatin modifications2019
- Author(s)
  Gosuke Hayashi
- Organizer
  42nd MBSJ
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] Novel technologies for studying chromatin modifications2019
- Author(s)
  Gosuke Hayashi
- Organizer
  42nd MBSJ
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05287
[Presentation] エピジェネティクス研究とタンパク質化学合成2019
- Author(s)
  林剛介
- Organizer
  大阪大学蛋白質研究所セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] タンパク質化学合成を加速するペプチドライゲーション戦略2018
- Author(s)
  林剛介、梁瀬将史、加茂直己、誉田祥己、岡本晃充
- Organizer
  第12回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] One-pot Multiple Peptide Ligation Strategies Harnessing Palladium Complex or DNA Scaffold2018
- Author(s)
  Gosuke Hayashi, Naomi Kamo, Masafumi Yanase, and Akimitsu Okamoto
- Organizer
  International Peptide Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] DNA Scaffold-mediated Peptide Ligation2018
- Author(s)
  Gosuke Hayashi, Masafumi Yanase, Yoshiki Konda, Yu Nakatsuka and Akimitsu Okamoto
- Organizer
  ISNAC2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] 効率的タンパク質合成を指向したペプチド連結法の開発2018
- Author(s)
  林剛介、梁瀬将史、加茂直己、岡本晃充
- Organizer
  第13回ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] One-pot Sequential or Simultaneous Ligation of Multiple Peptide Fragments for Facilitating Chemical Protein Synthesis2018
- Author(s)
  Gosuke Hayashi
- Organizer
  ICPAC Langkawi2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] アミノ酸の精密重合体であるタンパク質の化学的全合成とその効率化2018
- Author(s)
  林剛介
- Organizer
  第165回東海高分子研究会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18K05313
[Presentation] FISH法を応用した単一細胞レベルでのメチル化検出法の開発と高感度化への試み2014
- Author(s)
  林剛介、須藤周、豊村誠、杉崎香織、岡本晃充
- Organizer
  第8回日本エピジェネティクス研究会年会
- Place of Presentation
  東京大学伊藤国際学術研究センター、東京都
- Data Source
  KAKENHI-PROJECT-25870186
[Presentation] Metal-mediated reactions to detect 5-methylcytosine and 5-hydroxymethylcytosine in DNA2014
- Author(s)
  Gosuke Hayashi, Akimitsu Okamoto
- Organizer
  XVIth Symposium on Chemistry of Nucleic Acid Components
- Place of Presentation
  Cesky Krumlov, Czech Republic
- Data Source
  KAKENHI-PROJECT-25870186
[Presentation] 細胞内RNAを可視化するECHOプローブの開発と細胞内局在制御2013
- Author(s)
  林剛介、池田修司、武田勝也、榊原大輔、王丹、岡本晃充
- Organizer
  第8回バイオ関連化学シンポジウム
- Place of Presentation
  名古屋大学豊田講堂・野依学術交流間、愛知県
- Data Source
  KAKENHI-PROJECT-25870186
[Presentation] 配列選択的な化学的DNAメチルシトシン検出法の開発と検出感度向上への試み2013
- Author(s)
  林剛介、豊村誠、杉崎香織、岡本晃充
- Organizer
  第7回日本エピジェネティクス研究会年会
- Place of Presentation
  新公会堂、奈良県
- Data Source
  KAKENHI-PROJECT-25870186
[Presentation] ヒストンH2Aの化学的合成と生細胞イメージング
- Author(s)
  末岡拓馬、林剛介、岡本晃充
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  日本大学船橋キャンパス
- Year and Date
  2015-03-25 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25870186
[Presentation] ヒストンH2Aの化学合成とエピジェネティクス研究への応用
- Author(s)
  林剛介、末岡拓馬、岡本晃充
- Organizer
  バイオ関連化学シンポジウム
- Place of Presentation
  岡山大学
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25870186
[Presentation] エピジェネティクス研究に向けたリンカーヒストンH1の化学的合成
- Author(s)
  坂元亮介、林剛介、岡本晃充
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  日本大学船橋キャンパス
- Year and Date
  2015-03-25 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25870186
[Presentation] 化学合成ヒストンを用いた細胞内エピジェネティック情報取得への試み
- Author(s)
  林剛介
- Organizer
  日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2015-06-30 – 2015-07-02
- Invited
- Data Source
  KAKENHI-PROJECT-25870186
[Presentation] エピジェネティクス研究を指向したヒストンH2Bの化学合成
- Author(s)
  榊原大輔、林剛介、岡本晃充
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  日本大学船橋キャンパス
- Year and Date
  2015-03-25 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25870186

1. Okamoto Akimitsu (60314233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. Kim Minsoo (50466835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Raudzus Fabian (10906358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 西出旭 (80807652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 坂巻純一 (10825938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 村上裕 (10361669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 日野智也 (40373360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 松岡和弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Gosuke 林 剛介

HAYASHI Gosuke 林 剛介

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Co-Researchers

膜脂質のユビキチン化とユビキチン様タンパク質修飾によるオルガネラ機能制御

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タンパク質寿命の解析・制御研究をブーストする人工タンパク質創成技術Principal Investigator

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Development of single-molecule peptide sequencing method

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International collaboration for the development of new molecular-targeted antimicrobial agents

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Ubiquitin Chemo-technology by Chemical Protein Synthesis and Molecular EvolutionPrincipal Investigator

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Mirror-image Artificial Antibody Working in Multimolecular Crowding BiosystemsPrincipal Investigator

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Efficient Chemical Synthesis of Polyubiquitin and Ubiquitinated ProteinsPrincipal Investigator

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Chemical synthesis of protein via simultaneous ligation of multiple peptide segments on DNA scaffoldPrincipal Investigator

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Development of nucleic acid enzymes for new nucleic acid medicines based on the transition state in molecular degradation

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Development of a platform for histone-code research by setting nucleosomes with various modificationsPrincipal Investigator

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[Book] 最先端ナノライフシステム研究「進化分子工学を用いた人工抗体創製とその応用」2022

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[Book] 最先端ナノライフシステム研究「進化分子工学を用いた人工抗体創製とその応用」2022

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[Book] 創薬研究者がこれだけは知っておきたい最新のウイルス学「新型コロナウイルスに対する迅速な人工抗体創製」2021

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Hayashi Gosuke 林剛介

HAYASHI Gosuke 林剛介

[Book] 生体分子反応を制御する　化学的手法による機構と反応場の解明　「エピジェネティック修飾の謎を解き明かす核酸およびタンパク質化学」2020

[Book] 生体分子反応を制御する化学的手法による機構と反応場の解明「エピジェネティック修飾の謎を解き明かす核酸およびタンパク質化学」2020