Okamoto Ikuhiro 岡本郁弘

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okamoto ikuhiro 岡本郁弘

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Researcher Number	40648424
Other IDs
Affiliation (Current)	2025: 京都大学, 高等研究院, 特定講師
Affiliation (based on the past Project Information) *help	2019 – 2024: 京都大学, 高等研究院, 特定講師 2018: 京都大学, 医学研究科, 特定講師 2013 – 2016: 京都大学, 医学(系)研究科(研究院), 講師
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Genetics/Chromosome dynamics Except Principal Investigator Transformative Research Areas, Section (III)
Keywords	Principal Investigator X染色体の不活性化 / カニクイザル / 始原生殖細胞 / 霊長類 / SmcHD1 / XIST / X inactivation / 初期胚 / X染色体の再活性化 / XIST RNA … More / X染色体不活性化 / ノックアウト細胞 / ゲノム編集 / ゲノムリプログラミング / リプログラミング / 不活性X染色体 / 不活性X染色体の再活性化 / 始源生殖細胞 / 再活性化 / X染色体 / マウス … More Except Principal Investigator カニクイザル / 次元の呪い / 着床後胚発生 / scRNA-seq / 発生学 / 霊長類 Less

The study of X chromosome inactivation maintenance in primate.Principal Investigator
- Principal Investigator
  
  岡本郁弘
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kyoto University
Analysis of early post-implantation development and establishment of physiological ex vivo culture method in primate
- Principal Investigator
  
  Nakamura Tomonori
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
Study of X chromosome inactivation in the monkey embryosPrincipal Investigator
- Principal Investigator
  
  okamoto ikuhiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kyoto University
The dynamics of X chromosome reactivation in female PGCsPrincipal Investigator
- Principal Investigator
  
  okamoto ikuhiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys2023
- Author(s)
  Gyobu‐Motani Sayuri、Yabuta Yukihiro、Mizuta Ken、Katou Yoshitaka、Okamoto Ikuhiro、Kawasaki Masanori、Kitamura Ayaka、Tsukiyama Tomoyuki、Iwatani Chizuru、Tsuchiya Hideaki、Tsujimura Taro、Yamamoto Takuya、Nakamura Tomonori、Saitou Mitinori
- Journal Title
  
  The EMBO Journal
  
  Volume: - Issue: 9
- DOI
  10.15252/embj.2022112962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19246, KAKENHI-PROJECT-22K15380, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-23K23794, KAKENHI-PROJECT-23K23804, KAKENHI-PROJECT-21K20740, KAKENHI-PROJECT-17H06098
[Journal Article] Generation of functional oocytes from male mice in vitro2023
- Author(s)
  Murakami Kenta、Hamazaki Nobuhiko、Hamada Norio、Nagamatsu Go、Okamoto Ikuhiro、Ohta Hiroshi、Nosaka Yoshiaki、Ishikura Yukiko、Kitajima Tomoya S.、Semba Yuichiro、Kunisaki Yuya、Arai Fumio、Akashi Koichi、Saitou Mitinori、Kato Kiyoko、Hayashi Katsuhiko
- Journal Title
  
  Nature
  
  Volume: 615 Issue: 7954 Pages: 900-906
- DOI
  10.1038/s41586-023-05834-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-21H02407, KAKENHI-PROJECT-20K21500, KAKENHI-ORGANIZER-18H05544, KAKENHI-PLANNED-18H05545, KAKENHI-PLANNED-18H05549, KAKENHI-PROJECT-23K23804, KAKENHI-PROJECT-22K19604, KAKENHI-PROJECT-21H02950
[Journal Article] GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program2021
- Author(s)
  Kojima Yoji、Yamashiro Chika、Murase Yusuke、Yabuta Yukihiro、Okamoto Ikuhiro、Iwatani Chizuru、Tsuchiya Hideaki、Nakaya Masataka、Tsukiyama Tomoyuki、Nakamura Tomonori、Yamamoto Takuya、Saitou Mitinori
- Journal Title
  
  Life Science Alliance
  
  Volume: 4 Issue: 5 Pages: 202000974-202000974
- DOI
  10.26508/lsa.202000974
- NAID
  120006979739
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21370, KAKENHI-PROJECT-19K16023, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-18K06030, KAKENHI-PROJECT-17H06098, KAKENHI-PLANNED-20H05761, KAKENHI-PROJECT-18K14714, KAKENHI-PROJECT-20K06654
[Journal Article] Capturing human trophoblast development with naive pluripotent stem cells in vitro2021
- Author(s)
  S Io M Kabata Y Lemura N Morone A Minagawa B Wong I Okamoto T Nakamura Y Kojima C Iwatani H Tsuchiya B Kawswandy E KondohS Kaneko K Woltjen M Saitou T Yamanoto M Mandai Y Takashima
- Journal Title
  
  Cell Stem Cell
  
  Volume: 21 Issue: 6 Pages: 10-10
- DOI
  10.1016/j.stem.2021.03.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16688, KAKENHI-ORGANIZER-20H05760, KAKENHI-PROJECT-18K06030, KAKENHI-PROJECT-16H02465, KAKENHI-PLANNED-20H05762, KAKENHI-PROJECT-21K19189, KAKENHI-PROJECT-21K20987, KAKENHI-PROJECT-19J13503, KAKENHI-PLANNED-20H05761, KAKENHI-PROJECT-18K14714
[Journal Article] Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts.2020
- Author(s)
  Matsumoto S, Porter CJ, Ogasawara N, Iwatani C, Tsuchiya H, Seita Y, Chang YW, Okamoto I, Saitou M, Ema M, Perkins TJ, Stanford WL, Tanaka S.
- Journal Title
  
  Sci Rep
  
  Volume: 10(1) Issue: 1 Pages: 6827-6827
- DOI
  10.1038/s41598-020-63602-7
- NAID
  120006888480
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06030, KAKENHI-PROJECT-17H06098
[Journal Article] Induction of the germ cell fate from pluripotent stem cells in cynomolgus monkeys.2020
- Author(s)
  Sakai Y, Nakamura T, Okamoto I, Gyobu-Motani S, Ohta H, Yabuta Y, Tsukiyama T, Iwatani C, Tsuchiya H, Ema M, Morizane A, Takahashi J, Yamamoto T, Saitou M.
- Journal Title
  
  Biol Reprod
  
  Volume: 102(3) Issue: 3 Pages: 620-638
- DOI
  10.1093/biolre/ioz205
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06030, KAKENHI-PROJECT-19K16013, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-18K14714, KAKENHI-PROJECT-17H06098
[Journal Article] A symmetric toggle switch explains the onset of random X inactivation in different mammals.2019
- Author(s)
  Mutzel V, Okamoto I, Dunkel I, Saitou M, Giorgetti L, Heard E, Schulz EG.
- Journal Title
  
  Nat Struct Mol Biol.
  
  Volume: 26(5) Issue: 5 Pages: 350-360
- DOI
  10.1038/s41594-019-0214-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06030, KAKENHI-PROJECT-17H06098
[Journal Article] Generation of human oogonia from induced pluripotent stem cells in vitro.2018
- Author(s)
  30.Yamashiro C, Sasaki K, Yabuta Y, Kojima Y, Nakamura T, Okamoto I, Yokobayashi S, Murase Y, Ishikura Y, Shirane K, Sasaki H, Yamamoto T, Saitou M.
- Journal Title
  
  Science
  
  Volume: 362(6412) Issue: 6412 Pages: 356-360
- DOI
  10.1126/science.aat1674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06030, KAKENHI-PROJECT-18H05214, KAKENHI-PROJECT-18H02613, KAKENHI-PROJECT-17H06802, KAKENHI-PROJECT-17H06098, KAKENHI-PROJECT-18K14714
[Journal Article] Combined Immunofluorescence, RNA FISH, and DNA FISH in Preimplantation Mouse Embryos.2018
- Author(s)
  Okamoto I.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1861 Pages: 149-159
- DOI
  10.1007/978-1-4939-8766-5_12
- ISBN
  9781493987658, 9781493987665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06030
[Journal Article] In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells2016
- Author(s)
  Ishikura Y, Yabuta Y, Ohta H, Hayashi K, Nakamura T, Okamoto I, Yamamoto T, Kurimoto K, Shirane K, Sasaki H, Saitou M
- Journal Title
  
  Cell Rep
  
  Volume: 17 Issue: 10 Pages: 2789-2804
- DOI
  10.1016/j.celrep.2016.11.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01216, KAKENHI-PLANNED-25112010, KAKENHI-PROJECT-16H04720, KAKENHI-PROJECT-14J04310, KAKENHI-PROJECT-25291076, KAKENHI-ORGANIZER-25112001
[Journal Article] The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion.2016
- Author(s)
  Sasaki K, Nakamura T, Okamoto I, Yabuta Y, Iwatani C, Tsuchiya H, Seita Y, Nakamura S, Shiraki N, Takakuwa T, Yamamoto T, Saitou M.
- Journal Title
  
  Dev Cell.
  
  Volume: 39 Issue: 2 Pages: 169185-169185
- DOI
  10.1016/j.devcel.2016.09.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25291076
[Journal Article] A developmental coordinate of pluripotency among mice, monkeys and humans.2016
- Author(s)
  Nakamura T, Okamoto I, Sasaki K, Yabuta Y, Iwatani C, Tsuchiya H, Seita Y, Nakamura S, Yamamoto T, Saitou M.
- Journal Title
  
  Nature
  
  Volume: 537 Issue: 7618 Pages: 5762-5762
- DOI
  10.1038/nature19096
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25291076
[Journal Article] SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression2015
- Author(s)
  Nakamura, T., Yabuta, Y., Okamoto, I., Aramaki, S., Yokobayashi, S., Kurimoto, K., Sekiguchi, K., Nakagawa, M., Yamamoto, T., Saitou, M.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: - Issue: 9 Pages: e60-e60
- DOI
  10.1093/nar/gkv134
- NAID
  120005825922
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24681039, KAKENHI-PROJECT-25291076, KAKENHI-PROJECT-25650065
[Journal Article] Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells2015
- Author(s)
  Sasaki, K., Yokobayash, S., Nakamura, T., Okamoto, I., Yabuta, Y., Kurimoto, K., Ohta, H., Moritoki, Y., Iwatani, C., Tsuchiya, H., Nakamura, S., Sekiguchi, K., Sakuma, T., Yamamoto, T., Mori, T., Woltjen, K., Nakagawa, M., Yamamoto, T., Takahashi, K., Yamanaka, S., Saitou, M.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 17 Issue: 2 Pages: 178-94
- DOI
  10.1016/j.stem.2015.06.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25650065, KAKENHI-PROJECT-25291076
[Journal Article] The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network2014
- Author(s)
  Edda G. Schulzsend, Johannes Meisig, Tomonori Nakamura, Ikuhiro Okamoto, Anja Sieber, Christel Picard, Maud Borensztein, Mitinori Saitou, Nils Bluthgen, Edith Heard
- Journal Title
  
  Cell Stem Cell
  
  Volume: 14 Issue: 2 Pages: 203-216
- DOI
  10.1016/j.stem.2013.11.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21677003, KAKENHI-PROJECT-25291076
[Journal Article] The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammals.2014
- Author(s)
  Duffié R, Ajjan S, Greenberg MV, Zamudio N, Escamilla del Arenal M, Iranzo J, Okamoto I, Barbaux S, Fauque P, Bourc'his D
- Journal Title
  
  Genes Dev
  
  Volume: 1;28(5) Issue: 5 Pages: 463-78
- DOI
  10.1101/gad.232058.113
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25291076
[Journal Article] RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells.2013
- Author(s)
  Ciaudo C, Jay F, Okamoto I, Chen CJ, Sarazin A, Servant N, Barillot E, Heard E, Voinnet O.
- Journal Title
  
  PLoS Genet.
  
  Volume: 9 Issue: 11 Pages: 1-12
- DOI
  10.1371/journal.pgen.1003791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25291076
[Presentation] The X-chromosome dosage compensation program during the development of cynomolgus monkeys2023
- Author(s)
  Ikuhiro Okamoto
- Organizer
  EMBO work shop, X-chromosome inactivation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23804
[Presentation] カニクイザルの発生過程におけるX染色体遺伝子量補正プログラム2022
- Author(s)
  岡本郁弘
- Organizer
  第45回日本分子生物学会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23804
[Presentation] カニクイザルの発生過程におけるX染色体遺伝子量補正プログラム2022
- Author(s)
  岡本郁弘
- Organizer
  日本人類遺伝学会第６７大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23804
[Presentation] Developmental dynamics of X-chromosome inactivation in the crab-eating macaque embryos2019
- Author(s)
  Ikuhiro Okamoto
- Organizer
  六甲医学研究会
- Data Source
  KAKENHI-PROJECT-18K06030
[Presentation] Developmental dynamics of X-chromosome inactivation in the crab-eating macaque embryos2019
- Author(s)
  Ikuhiro Okamoto
- Organizer
  Edith HEARD 17 years of e(Xist)ing at Curie
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06030
[Presentation] Developmental dynamics of X-chromosome inactivation in the Cynomolgus monkey embryos2016
- Author(s)
  岡本郁弘
- Organizer
  X 染色体研究会
- Place of Presentation
  鳥取大学医学部（米子）
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25291076
[Presentation] カニクイザル胚におけるX染色体不活性化のダイナミクス
- Author(s)
  岡本郁弘、佐々木恒太郎、中村友紀、熊木勇一、岩谷千鶴、土屋英明、斎藤通規
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-25291076
[Presentation] Developmental dynamics of X-chromosome inactivation in eutherian
- Author(s)
  岡本郁弘
- Organizer
  新学術領域『性差』若手研究集会
- Place of Presentation
  静岡（熱海）
- Year and Date
  2014-12-09 – 2014-12-10
- Invited
- Data Source
  KAKENHI-PROJECT-25291076
[Presentation] Developmental dynamics of X-chromosome inactivation in eutherian
- Author(s)
  岡本郁弘
- Organizer
  X 染色体研究会
- Place of Presentation
  近畿大学、農学部（奈良）
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25291076

1. Nakamura Tomonori (90648429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 築山智之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 斎藤通紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 栗本一基

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 南川淳隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 大田浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okamoto Ikuhiro 岡本 郁弘

okamoto ikuhiro 岡本 郁弘

Research Projects

Research Products

Co-Researchers

The study of X chromosome inactivation maintenance in primate.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of early post-implantation development and establishment of physiological ex vivo culture method in primate

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of X chromosome inactivation in the monkey embryosPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The dynamics of X chromosome reactivation in female PGCsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of functional oocytes from male mice in vitro2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Capturing human trophoblast development with naive pluripotent stem cells in vitro2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Induction of the germ cell fate from pluripotent stem cells in cynomolgus monkeys.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A symmetric toggle switch explains the onset of random X inactivation in different mammals.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of human oogonia from induced pluripotent stem cells in vitro.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combined Immunofluorescence, RNA FISH, and DNA FISH in Preimplantation Mouse Embryos.2018

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells2016

Author(s)

Journal Title

Okamoto Ikuhiro 岡本郁弘

okamoto ikuhiro 岡本郁弘