Kiyonari Hiroshi 清成寛

Researcher Number	40721048
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームディレクター
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームディレクター 2019 – 2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー 2018 – 2019: 国立研究開発法人理化学研究所, 生命機能科学研究センター, ユニットリーダー
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Transformative Research Areas, Section (III) Except Principal Investigator Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Transformative Research Areas, Section (III) / Basic Section 56060:Ophthalmology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Broad Section G
Keywords	Principal Investigator ゲノム編集 / オポッサム / 有袋類 / 生殖工学 / トランスクリプトーム / 神経科学 / 視索前野 / 細胞トランスクリプトーム / ハムスター / 冬眠 / イメージング / 発生工学 / 系統保存 … More Except Principal Investigator … More オポッサム / 休眠 / 冬眠 / 色素上皮層 / 視細胞 / ゲノム編集 / EYS / 網膜色素変性 / 神経科学 / 生理学 / 哺乳類 / 細胞系譜 / 幹細胞 / 脳 / 神経発生 / フェレット / 神経幹細胞 / 脳発生 / 大脳皮質 / スケーリング / RNA sequencing / 非モデル生物 / ミトコンドリア / AMPKシグナル / 細胞周期 / 心臓再生 / AMPK / 心筋細胞 / 心筋再生 / 心筋梗塞 / 遺伝子発現制御 / メカノセンサー / 生物多様性 / Nodal / 繊毛 / 左右非対称性 / 能動的低代謝 / QIH / ハムスター / 日内休眠 / 低温耐性 / 低代謝耐性 / 遺伝子改変ハムスター / 変異マウス作製 / CKI / 概日時計 / 振動子 / 可逆的リン酸化 Less

Development of imaging technology in marsupialsPrincipal Investigator
- Principal Investigator
  
  清成寛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Institute of Physical and Chemical Research
Diversity of neural stem cells lineages and temporal scaling in mammalian complex brain formation
- Principal Investigator
  
  松崎文雄
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  Kyoto University
  Institute of Physical and Chemical Research
冬眠生物学2.0 総括班
- Principal Investigator
  
  山口良文
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Hokkaido University
Generation of genetic and neural manipulation technologies for hibernation researchPrincipal Investigator
- Principal Investigator
  
  清成寛
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
遺伝子改変オポッサムによる、哺乳類網膜でのEYS遺伝子の機能解析と治療シーズ探索
- Principal Investigator
  
  大西暁士
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Ritsumeikan University
Establishment of technologies of next-generation genetics in marsupialPrincipal Investigator
- Principal Investigator
  
  Hiroshi Kiyonari
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Institute of Physical and Chemical Research
Mechanism of Cardiac Regeneration and Developmental Heterochrony
- Principal Investigator
  
  Kimura Wataru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Institute of Physical and Chemical Research
The molecular mechanisms of active hypometabolism
- Principal Investigator
  
  Sunagawa Genshiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
Left-right symmetry breaking in vertebrates: cilia-dependent and independent mechanisms
- Principal Investigator
  
  Hamada Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  Institute of Physical and Chemical Research
Development of embryo manipulation techniques in marsupialsPrincipal Investigator
- Principal Investigator
  
  Kiyonari Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Institute of Physical and Chemical Research
Designing the mammalian biological oscillators
- Principal Investigator
  
  Ueda Hiroki
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section G
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2019

All Journal Article Presentation Book

[Book] 臨床免疫・アレルギー科　ゲノム編集最前線2023
- Author(s)
  吉見　理子、清成　寛
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-21K06006
[Journal Article] Prolonged Myocardial Regenerative Capacity in Neonatal Opossum2022
- Author(s)
  Nishiyama Chihiro、Saito Yuichi、Sakaguchi Akane、Kaneko Mari、Kiyonari Hiroshi、Xu Yuqing、Arima Yuichiro、Uosaki Hideki、Kimura Wataru
- Journal Title
  
  Circulation
  
  Volume: 146 Issue: 2 Pages: 125-139
- DOI
  10.1161/circulationaha.121.055269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18273, KAKENHI-PROJECT-19KK0219, KAKENHI-PROJECT-20H03680, KAKENHI-PROJECT-23K24334
[Journal Article] Left-Right Asymmetric Expression of the Nodal-Lefty-Pitx2 Module in Developing Turtle Forebrain.2022
- Author(s)
  Kajikawa, E., Miki, T., Takeda, M., Kiyonari, H. and Hamada, H.
- Journal Title
  
  Front. Cell Dev. Biol.
  
  Volume: 10 Pages: 929808-929808
- DOI
  10.3389/fcell.2022.929808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00472
[Journal Article] Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex2021
- Author(s)
  Minegishi Katsura、Rothe Benjamin、Komatsu Kaoru R.、Ono Hiroki、Ikawa Yayoi、Nishimura Hiromi、Katoh Takanobu A.、Kajikawa Eriko、Sai Xiaorei、Miyashita Emi、Takaoka Katsuyoshi、Bando Kana、Kiyonari Hiroshi、Yamamoto Tadashi、Saito Hirohide、Constam Daniel B.、Hamada Hiroshi
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4071-4071
- DOI
  10.1038/s41467-021-24295-2
- NAID
  120007141958
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15096, KAKENHI-PROJECT-20H05626, KAKENHI-PROJECT-20H00472
[Journal Article] Targeted gene disruption in a marsupial, Monodelphis domestica, by CRISPR/Cas9 genome editing2021
- Author(s)
  Hiroshi Kiyonari, Mari Kaneko, Takaya Abe, Aki Shiraishi, Riko Yoshimi, Ken-Ichi Inoue, Yasuhide Furuta
- Journal Title
  
  Current Biology
  
  Volume: 31 Issue: 17 Pages: 3956-3963
- DOI
  10.1016/j.cub.2021.06.056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] Genetic Approach in New Animal Models with Genome Editing2023
- Author(s)
  Hiroshi Kiyonari
- Organizer
  18th Transgenic Technology Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] 非モデル動物を用いた遺伝学的ツールの確立2023
- Author(s)
  清成　寛
- Organizer
  有性生殖研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] シリアンハムスターの生体外における胚操作技術の確立2023
- Author(s)
  繁田麻葉、戸部有紗、井上健一、阿部高也、清成寛
- Organizer
  第70回日本実験動物学会
- Data Source
  KAKENHI-PLANNED-23H04945
[Presentation] A new experimental animal model in mammalian genetics, "grey short-tailed opossum"2023
- Author(s)
  吉見理子、金子麻里、阿部高也、清成寛
- Organizer
  第56回日本発生生物学会
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] シリアンハムスターの生体外における胚操作技術の確立2023
- Author(s)
  繁田麻葉、戸部有紗、井上健一、阿部高也、清成寛
- Organizer
  第70回日本実験動物学会
- Data Source
  KAKENHI-ORGANIZER-23H04939
[Presentation] ゲノム編集による非モデル動物の遺伝子改変2023
- Author(s)
  清成寛
- Organizer
  第8回日本ゲノム編集学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] A new experimental animal model in mammalian genetics, "grey short-tailed opossum"2023
- Author(s)
  Riko Yoshimi, Mari Kaneko, Takaya Abe, Hiroshi Kiyonari
- Organizer
  18th Transgenic Technology Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] Improbing reproductive technology of gray short-tailed opossum, Monodelphis domestica2023
- Author(s)
  吉見理子、金子麻里、白石亜紀、清成寛
- Organizer
  第70回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] ゲノム編集による遺伝子改変有袋類の誕生2022
- Author(s)
  清成　寛
- Organizer
  日本発生生物学会
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] Generation of first genetically engineered marsupials, Monodelphis domestica2022
- Author(s)
  清成　寛
- Organizer
  ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] Generation of first genetically engineered marsupials, Monodelphis domestica2022
- Author(s)
  清成　寛
- Organizer
  Transgenic Technology Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] Generation of first genetically engineered marsupials, Monodelphis domestica2022
- Author(s)
  清成　寛
- Organizer
  International Mammalian Genome Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] 袋をもたない小さな有袋類”オポッサム”2022
- Author(s)
  清成　寛
- Organizer
  日本実験動物学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] ゲノム編集による遺伝子改変有袋類の誕生2021
- Author(s)
  清成　寛
- Organizer
  関西実験動物研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] ゲノム編集による遺伝子改変有袋類の作製2021
- Author(s)
  清成　寛
- Organizer
  分子生物学会
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] Transgenesis and their use in animal models for human reproduction2021
- Author(s)
  Hiroshi Kiyonari
- Organizer
  The international IVF initiative
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14618
[Presentation] Transgenesis and their use in animal models for human reproduction2021
- Author(s)
  Hiroshi Kiyonari
- Organizer
  International IVF Initiative
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06006
[Presentation] 実験動物としてのハイイロジネズミオポッサム2019
- Author(s)
  金子麻里, 白石亜紀, 吉見理子, 清成寛
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K14618
[Presentation] 実験動物としての有袋類オポッサム2019
- Author(s)
  清成　寛
- Organizer
  実験動物技術者協会　関東支部ＲＥＧ部会　第20回特別講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18K14618
[Presentation] オポッサムを用いた胚操作基盤技術の開発2019
- Author(s)
  清成　寛
- Organizer
  第53回日本実験動物技術者協会総会
- Data Source
  KAKENHI-PROJECT-18K14618

1. Sunagawa Genshiro (70710250)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Ueda Hiroki (20373277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Hamada Hiroshi (00208589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Kimura Wataru (60452182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 大出晃士 (40612122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山田陸裕 (90469924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 史蕭逸 (40803656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 洲崎悦生 (10444803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 内川昌則 (80346147)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 魚崎英毅 (90740803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 松崎文雄 (10173824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山口良文 (10447443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 榎木亮介 (00528341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 田中和正 (10772650)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 黒田真也 (50273850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 桜井武 (60251055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 曽我朋義 (60338217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 金尚宏 (80822931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 岡松優子 (90527178)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 宮道和成 (30612577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 大西暁士 (70569102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 加藤孝信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kiyonari Hiroshi 清成 寛

Research Projects

Research Products

Co-Researchers

Development of imaging technology in marsupialsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Diversity of neural stem cells lineages and temporal scaling in mammalian complex brain formation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

冬眠生物学2.0 総括班

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of genetic and neural manipulation technologies for hibernation researchPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遺伝子改変オポッサムによる、哺乳類網膜でのEYS遺伝子の機能解析と治療シーズ探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of technologies of next-generation genetics in marsupialPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of Cardiac Regeneration and Developmental Heterochrony

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The molecular mechanisms of active hypometabolism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Left-right symmetry breaking in vertebrates: cilia-dependent and independent mechanisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of embryo manipulation techniques in marsupialsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Designing the mammalian biological oscillators

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 臨床免疫・アレルギー科 ゲノム編集最前線2023

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Prolonged Myocardial Regenerative Capacity in Neonatal Opossum2022

Author(s)

Journal Title

DOI

Data Source

Kiyonari Hiroshi 清成寛

[Book] 臨床免疫・アレルギー科　ゲノム編集最前線2023