OTSUKA Maki 大塚まき

… Alternative Names

大塚まきオオツカマキ

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Researcher Number	40734372
Other IDs
Affiliation (Current)	2026: 東京農業大学, 国際食料情報学部, 助教
Affiliation (based on the past Project Information) *help	2021: 星薬科大学, 薬学部, 助教 2019 – 2020: 星薬科大学, 薬学部, 助手 2017 – 2018: 星薬科大学, 先端生命科学研究所, 特任助教 2016: 星薬科大学, 付置研究所, その他 2014 – 2015: 星薬科大学, 付置研究所, 助教
Review Section/Research Field	Except Principal Investigator Risk sciences of radiation and chemicals / Basic Section 63030:Chemical substance influence on environment-related
Keywords	Except Principal Investigator エピジェネティクス / 化学物質 / DNAメチル化 / エピジェネティック毒性 / トキシコロジー / 有害化学物質 / レポーター / 毒性試験 / ゲノム / レポーターアッセイ / 毒性評価 / 新規レポーターマウス / レポーターマウス

Basic research for the development of an integrated in vivo epigenetic toxicity assessment system
- Principal Investigator
  
  五十嵐勝秀
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Hoshi University
Establishment of practical epigenetic toxicity evaluation system using newly developed reporter mice
- Principal Investigator
  
  Igarashi Katsuhide
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hoshi University
Development of reporter mice enabling detection of epigenetic toxicity in the conventional toxicity tests
- Principal Investigator
  
  Igarashi Katsuhide
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hoshi University
  National Institute of Health Sciences

All 2022 2021 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] アレルギーとエピジェネティクス2014
- Author(s)
  五十嵐　勝秀、大塚　まき
- Total Pages
  95
- Publisher
  医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-25281028
[Journal Article] Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner2022
- Author(s)
  Saeki Noritaka、Inoue Kazuki、Ideta-Otsuka Maky、Watamori Kunihiko、Mizuki Shinichi、Takenaka Katsuto、Igarashi Katsuhide、Miura Hiromasa、Takeda Shu、Imai Yuuki
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 132 Issue: 11
- DOI
  10.1172/jci150533
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-23K24462, KAKENHI-PROJECT-21H03604
[Journal Article] Development of a new <i>in vitro</i> assay system for evaluating the effects of chemicals on DNA methylation2021
- Author(s)
  Ideta-Otsuka Maky、Miyai Misato、Yamamoto Naoki、Tsuchimoto Ayaka、Tamura Hideki、Tanemura Kentaro、Shibutani Makoto、Igarashi Katsuhide
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 2 Pages: 83-90
- DOI
  10.2131/jts.46.83
- NAID
  130007980526
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01882, KAKENHI-PROJECT-18K06470, KAKENHI-PLANNED-16H06532, KAKENHI-PROJECT-19H01142, KAKENHI-PROJECT-21H03604
[Journal Article] Decreased Lamin B1 Levels Affect Gene Positioning and Expression in Postmitotic Neurons2021
- Author(s)
  Noguchi Azumi、Ito Kenji、Uosaki Yuichi、Ideta-Otsuka Maky、Igarashi Katsuhide、Nakashima Hideyuki、Kakizaki Toshikazu、Kaneda Ruri、Uosaki Hideki、Yanagawa Yuchio、Nakashima Kinichi、Arakawa Hirokazu、Takizawa Takumi
- Journal Title
  
  Neuroscience Research
  
  Volume: 173 Pages: 22-33
- DOI
  10.1016/j.neures.2021.05.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03604, KAKENHI-PROJECT-19KK0219
[Journal Article] Aberrant Epigenetic Gene Regulation in GABAergic Interneuron Subpopulations in the Hippocampal Dentate Gyrus of Mouse Offspring Following Developmental Exposure to Hexachlorophene.2018
- Author(s)
  Watanabe Y, Abe H, Nakajima K, Ideta-Otsuka M, Igarashi K, Woo GH, Yoshida T, Shibutani M.
- Journal Title
  
  Toxicol Sci.
  
  Volume: 163 Issue: 1 Pages: 13-25
- DOI
  10.1093/toxsci/kfx291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01882
[Journal Article] Effects of doxorubicin on sperm DNA methylation in mouse models of testicular toxicity.2018
- Author(s)
  Sakai K, Ideta-Otsuka M, Saito H, Hiradate Y, Hara K, Igarashi K, Tanemura K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 498 Issue: 3 Pages: 674-679
- DOI
  10.1016/j.bbrc.2018.03.044
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-25114004, KAKENHI-PROJECT-17H01882
[Journal Article] DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells.2017
- Author(s)
  Sanosaka T, Imamura T, Hamazaki N, Chai M, Igarashi K, Ideta-Otsuka M, Miura F, Ito T, Fujii N, Ikeo K, Nakashima K
- Journal Title
  
  Cell Rep
  
  Volume: 20 Issue: 12 Pages: 2992-3003
- DOI
  10.1016/j.celrep.2017.08.086
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-16K21734, KAKENHI-PROJECT-26250038, KAKENHI-ORGANIZER-16H06524, KAKENHI-PLANNED-16H06527, KAKENHI-PROJECT-15H04603, KAKENHI-PROJECT-17H01882, KAKENHI-PROJECT-16K15054, KAKENHI-PROJECT-16H06279
[Journal Article] Uhrf1 is indispensable for normal limb growth by regulating chondrocyte differentiation through specific gene expression2017
- Author(s)
  Yamashita Michiko、Inoue Kazuki、Saeki Noritaka、Ideta-Otsuka Maky、Yanagihara Yuta、Sawada Yuichiro、Sakakibara Iori、Lee Jiwon、Ichikawa Koichi、Kamei Yoshiaki、Iimura Tadahiro、Igarashi Katsuhide、Takada Yasutsugu、Imai Yuuki
- Journal Title
  
  Development
  
  Volume: 145 Issue: 1 Pages: 157412-157412
- DOI
  10.1242/dev.157412
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19728, KAKENHI-PROJECT-26293392, KAKENHI-PROJECT-15H04961, KAKENHI-PROJECT-17H01882, KAKENHI-PROJECT-16K20412
[Journal Article] The Current State and Future Development of Epigenetic Toxicology2017
- Author(s)
  五十嵐勝秀、大塚(出田) まき、成田年
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 3 Pages: 265-271
- DOI
  10.1248/yakushi.16-00230-3
- NAID
  130005396878
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-03-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25281028, KAKENHI-PROJECT-17H01882
[Journal Article] Epigenetic toxicity of environmental chemicals upon exposure during development - Bisphenol A and valproic acid may have epigenetic effects2017
- Author(s)
  Ideta-Otsuka Maky、Igarashi Katsuhide、Narita Minoru、Hirabayashi Yoko
- Journal Title
  
  Food and Chemical Toxicology
  
  Volume: 109 Pages: 812-816
- DOI
  10.1016/j.fct.2017.09.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25281028, KAKENHI-PROJECT-17H01882
[Journal Article] Learning and Memory Deficits in Male Adult Mice Treated with a Benzodiazepine Sleep-Inducing Drug during the Juvenile Period2016
- Author(s)
  Yusuke Furukawa, Kentaro Tanemura, Katsuhide Igarashi, Maky Ideta-Otsuka, Ken-IchiAisaki, SatoshiKitajima, Masanobu Kitagawa and JunKanno
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 10 Pages: 339-339
- DOI
  10.3389/fnins.2016.00339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25281028
[Journal Article] Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid2015
- Author(s)
  Juliandi B, Tanemura K, Igarashi K, Tominaga T, Furukawa Y, Otsuka M, Moriyama N, Ikegami D, Abematsu M, Sanosaka T, Tsujimura K, Narita M, Kanno J, Nakashima K
- Journal Title
  
  Stem Cell Rep
  
  Volume: 5 Issue: 6 Pages: 996-1009
- DOI
  10.1016/j.stemcr.2015.10.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00413, KAKENHI-PROJECT-15K10411, KAKENHI-PUBLICLY-15H01514, KAKENHI-PROJECT-26640015, KAKENHI-PROJECT-25281028, KAKENHI-PROJECT-26293346
[Journal Article] VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome2014
- Author(s)
  Guo W, Tsujimura K, Otsuka I M, Irie K, Igarashi K, Nakashima K, Zhao X.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 6 Pages: e100215-e100215
- DOI
  10.1371/journal.pone.0100215
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24240051, KAKENHI-PUBLICLY-25110721, KAKENHI-PROJECT-25281028
[Journal Article] Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.2014
- Author(s)
  Yokoyama A, Igarashi K, Sato T, Takagi K, Otsuka I M, Shishido Y, Baba T, Ito R, Kanno J, Ohkawa Y, Morohashi K, Sugawara A.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Issue: 26 Pages: 18152-18162
- DOI
  10.1074/jbc.m114.566448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25281028, KAKENHI-PROJECT-25461381, KAKENHI-PROJECT-26860229, KAKENHI-PLANNED-22132002
[Presentation] 創薬評価に向けた化学物質の新規in vitro DNAメチル化影響レポーターシステムの開発2021
- Author(s)
  宮井美知、大塚まき、土本彩加、渋谷淳、五十嵐勝秀
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03604
[Presentation] 疾患におけるエピゲノム変化の解析とエピゲノム調節をターゲットにした治療法の開発2019
- Author(s)
  大塚まき、五十嵐勝秀
- Organizer
  第25回日本未病システム学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01882
[Presentation] クリニカルエピゲノム研究に学ぶエピジェネティック毒性2017
- Author(s)
  五十嵐勝秀, 大塚まき
- Organizer
  第44回日本毒性学会学術年会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H01882
[Presentation] ラットへのオクラトキシンA反復投与による腎臓におけるDNA修復遺伝子Rad51及びRNA翻訳制御遺伝子Rbm38のエピゲノム遺伝子発現制御の変化2017
- Author(s)
  長谷川也須子, 水上さやか, 大塚（出田）まき, 五十嵐勝秀, 吉田敏則, 渋谷淳
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-17H01882
[Presentation] 内分泌かく乱化学物質とエピジェネティクス2017
- Author(s)
  五十嵐勝秀、山本直樹、大塚まき
- Organizer
  環境ホルモン学会第20回研究発表会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01882
[Presentation] ラットへのオクラトキシンA反復投与による腎臓におけるDNA修復遺伝子Rad51及びRNA翻訳制御遺伝子Rbm38のエピゲノム遺伝子発現制御の変化2017
- Author(s)
  長谷川也須子, 水上さやか, 大塚（出田）まき, 五十嵐勝秀, 吉田敏則, 渋谷淳
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] クリニカルエピゲノム研究に学ぶエピジェネティック毒性2017
- Author(s)
  五十嵐勝秀, 大塚まき
- Organizer
  第44回日本毒性学会学術年会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] エピジェネティック毒性評価の実用化に向けたバイオマーカー探索研究の動向2016
- Author(s)
  五十嵐勝秀, 大塚まき
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] エピジェネティック毒性研究の現状と今後の展開2016
- Author(s)
  五十嵐勝秀, 大塚まき, 成田年
- Organizer
  日本薬学会第136年会, シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2016-03-29
- Invited
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] エピジェネティック毒性研究の現状2015
- Author(s)
  五十嵐勝秀, 大塚まき
- Organizer
  第42回日本毒性学会学術年会、シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2015-07-01
- Invited
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] 化学物質と神経回路再編成（行動からエピジェネティクスまで）
- Author(s)
  五十嵐勝秀、冨永貴志、古川佑介、大塚まき、森山紀子、菅野純、種村健太郎
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] 今後のエピジェネティック毒性研究への提言
- Author(s)
  五十嵐勝秀, 大塚まき, 中島欽一
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] Voltage-sensitive dye imaging of whole hippocampal circuit activity showing alteration in excitability after maternal bisphenol A exposure in mice.
- Author(s)
  Tominaga Takashi, Tominaga Yoko, Igarashi Katsuhide, Otsuka Maky I, Furukawa Yusuke, kanno Jun, Tanemura Kentaro
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] 脳発達期におけるGABAシグナルの一過性活性化による遅発中枢神経系影響の解析
- Author(s)
  五十嵐勝秀，種村健太郎，古川佑介，大塚まき，森山紀子，相﨑健一，北嶋聡，菅野純
- Organizer
  第40回日本毒性学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] マウスセロトニントランスポーター発現のDNAメチル化依存的制御領域の探索
- Author(s)
  大塚まき, 中島欽一, 加藤忠史, 成田年
- Organizer
  第8回日本エピジェネティクス研究会年会
- Place of Presentation
  東京
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] 神経細胞特異的DNMT1欠損マウスにおける不安様行動誘発メカニズムの解明
- Author(s)
  木村文香, 野口浩史, 大塚まき, 五十嵐勝秀, 今村拓也, 波平昌一, 中島欽一
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] 発生-発達期ビスフェノールA曝露に伴う成長後のマウス脳DNAメチル化変化の網羅的解析
- Author(s)
  五十嵐勝秀、大塚まき、古川佑介、森山紀子、中島欽一、種村健太郎、菅野純
- Organizer
  第7回エピジェネティクス研究会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] マウスセロトニントランスポーター発現のDNAメチル化依存的制御領域の探索
- Author(s)
  大塚まき, 中島欽一, 加藤忠史, 成田年, 五十嵐勝秀
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25281028
[Presentation] DNMT3L部分配列を用いた人為的DNAメチル化亢進技術開発の試み
- Author(s)
  五十嵐勝秀, 大塚まき, 中島欽一, 成田年
- Organizer
  第8回日本エピジェネティクス研究会年会
- Place of Presentation
  東京
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-25281028

1. Igarashi Katsuhide (30342885)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
2. 山本直樹 (50757432)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 大久保佑亮 (80596247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HARA Kenshiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. TSUJIMURA Keita

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. TOMINAGA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. IMAI Yuuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. Yanagihara Yuta

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. Iimura Tadahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. Saeki Noritaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. Lee Jiwon

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 中島欽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 種村健太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OTSUKA Maki 大塚 まき

大塚 まき オオツカ マキ

Research Projects

Research Products

Co-Researchers

Basic research for the development of an integrated in vivo epigenetic toxicity assessment system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of practical epigenetic toxicity evaluation system using newly developed reporter mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of reporter mice enabling detection of epigenetic toxicity in the conventional toxicity tests

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] アレルギーとエピジェネティクス2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a new <i>in vitro</i> assay system for evaluating the effects of chemicals on DNA methylation2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Decreased Lamin B1 Levels Affect Gene Positioning and Expression in Postmitotic Neurons2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aberrant Epigenetic Gene Regulation in GABAergic Interneuron Subpopulations in the Hippocampal Dentate Gyrus of Mouse Offspring Following Developmental Exposure to Hexachlorophene.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of doxorubicin on sperm DNA methylation in mouse models of testicular toxicity.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uhrf1 is indispensable for normal limb growth by regulating chondrocyte differentiation through specific gene expression2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Current State and Future Development of Epigenetic Toxicology2017

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Epigenetic toxicity of environmental chemicals upon exposure during development - Bisphenol A and valproic acid may have epigenetic effects2017

Author(s)

Journal Title

DOI

Data Source

OTSUKA Maki 大塚まき

大塚まきオオツカマキ