Hashimoto Takafumi 橋本崇史

Researcher Number	40738126
Affiliation (based on the past Project Information) *help	2021 – 2023: 大分大学, 医学部, 助教 2015 – 2017: 大分大学, 医学部, 特任助教
Review Section/Research Field	Principal Investigator Respiratory surgery Except Principal Investigator Basic Section 55040:Respiratory surgery-related
Keywords	Principal Investigator APOBEC / PD-L1 / 免疫チェックポイント阻害剤 / 免疫組織化学染色 / コピー数変異 / RT-PCR / 免疫染色 / 次世代シーケンス / 腫瘍内不均一性 / tumor evolution / 上皮成長因子受容体 / 非小細胞肺癌 … More Except Principal Investigator … More 腫瘍内不均一性 / cfDNA / バイオマーカー / 分子モニタリング / EGFR / 進化系統樹 / 肺腺癌 / 非小細胞肺癌 / 遺伝子多様性 Less

Development of novel treatments for lung cancer based on genetic heterogeneity
- Principal Investigator
  
  Sugio Kenji
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Oita University
Elucidation of space-time in-tumor heterogeneity in lung cancer with Driver gene mutationPrincipal Investigator
- Principal Investigator
  
  Hashimoto Takafumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Oita University

All 2023 2022 2021 2020 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Osimertinib as first-line treatment for recurrent lung cancer patients with EGFR mutation2023
- Author(s)
  Osoegawa Atsushi、Karashima Takashi、Takumi Yohei、Sato Takahiro、Abe Miyuki、Hashimoto Takafumi、Sugio Kenji
- Journal Title
  
  Journal of Thoracic Disease
  
  Volume: 15 Issue: 10 Pages: 5566-5573
- DOI
  10.21037/jtd-23-537
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09168, KAKENHI-PROJECT-21K08889
[Journal Article] Significance of programmed death‐ligand 1 expression in resected lung cancer and its relationship with EGFR mutation2023
- Author(s)
  Osoegawa Atsushi、Abe Miyuki、Takumi Yohei、Hashimoto Takafumi、Karashima Takashi、Miyawaki Michiyo、Sugio Kenji
- Journal Title
  
  Thoracic Cancer
  
  Volume: 14 Issue: 24 Pages: 2467-2472
- DOI
  10.1111/1759-7714.15031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09168, KAKENHI-PROJECT-21K08889
[Journal Article] Cyclin-dependent kinase (CDK) 4/6 inhibition in non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutations2023
- Author(s)
  Osoegawa Atsushi、Takumi Yohei、Hashimoto Takafumi、Nakatsuji Shotaro、Hori Mayu、Sakai Mayu、Karashima Takashi、Abe Miyuki、Miyawaki Michiyo、Sugio Kenji
- Journal Title
  
  Investigational New Drugs
  
  Volume: 41 Issue: 2 Pages: 183-192
- DOI
  10.1007/s10637-023-01337-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09168, KAKENHI-PROJECT-21K08889
[Journal Article] Clinical significance of part-solid lung cancer in the eighth edition TNM staging system2021
- Author(s)
  Okamoto T, Miyawaki M, Toyokawa G, Karashima T, Abe M, Takumi Y, Hashimoto T, Osoegawa A, Tagawa T, Takeuchi H, Shimokawa M, Sugio K
- Journal Title
  
  Interactive CardioVascular and Thoracic Surgery
  
  Volume: 34 Issue: 2 Pages: 219-226
- DOI
  10.1093/icvts/ivab255
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09168
[Journal Article] Ciliated muconodular papillary tumor of the lung: a case report and literature review.2020
- Author(s)
  Abe M, Osoegawa A, Miyawaki M, Noda D, Karashima T, Takumi Y, Hashimoto T, Okamoto T, Daa T, Sugio K
- Journal Title
  
  Gen Thorac Cardiovasc Surg
  
  Volume: 68(11) Issue: 11 Pages: 1344-1349
- DOI
  10.1007/s11748-019-01252-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09168
[Journal Article] Acquired resistance to an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) in an uncommon G719S EGFR mutation.2018
- Author(s)
  Osoegawa A, Hashimoto T, Takumi Y, Abe M, Yamada T, Kobayashi R, Miyawaki M, Takeuchi H, Okamoto T, Sugio K.
- Journal Title
  
  Invest New Drugs
  
  Volume: 印刷中 Issue: 6 Pages: 999-1005
- DOI
  10.1007/s10637-018-0592-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10265, KAKENHI-PROJECT-15K19941
[Journal Article] The Positive Relationship Between γH2AX and PD-L1 Expression in Lung Squamous Cell Carcinoma.2018
- Author(s)
  Osoegawa A, Hiraishi H, Hashimoto T, Takumi Y, Abe M, Takeuchi H, Miyawaki M, Okamoto T, Sugio K.
- Journal Title
  
  In Vivo
  
  Volume: 32(1) Pages: 171-177
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] EGFR遺伝子変異陽性肺癌におけるCyclinD1発現の意義2023
- Author(s)
  小副川敦、橋本崇文、内匠陽平、酒井麻有、中辻祥太郎、辛島高志、安部美幸、杉尾賢二
- Organizer
  第40回日本呼吸器外科学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09168
[Presentation] 上皮成長因子受容体(EGFR)変異陽性肺癌における細胞周期関連因子の意義と治療標的としての可能性2022
- Author(s)
  小副川敦、橋本崇史、内匠陽平、堀真優、中辻祥太郎、前田有珠、鎌田紘輔、安部美幸、宮脇美千代、杉尾賢二
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K09168
[Presentation] First line osimertinib in lung cancer patients with postoperative ocurrence2022
- Author(s)
  Osoegawa A, Takumi Y, Karashima T, Abe M, Hashimoto T, Miyawaki M, Sugio K
- Organizer
  2023 World Conference on Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09168
[Presentation] 術後脳転移再発に対するエヌトレクチニブが奏効したROS1陽性肺癌の１例2022
- Author(s)
  内匠陽平、辛島高志、安部美幸、橋本崇史、小副川敦、宮脇美千代、杉尾賢二
- Organizer
  第60回日本がん治療学会
- Data Source
  KAKENHI-PROJECT-20K09168
[Presentation] 術後再発に対するosimertinibの有効性について2022
- Author(s)
  小副川敦、内匠陽平、橋本崇史、辛島高志、安部美幸、宮脇美千代、杉尾賢二
- Organizer
  第63回日本肺癌学会
- Data Source
  KAKENHI-PROJECT-20K09168
[Presentation] 肺腺癌外科切除症例におけるTTF-1発現と臨床病理学的因子の関係の検討2022
- Author(s)
  橋本崇史、前田有珠、鎌田紘輔、安部美幸、内匠陽平、宮脇美千代、小副川敦、杉尾賢二
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K09168
[Presentation] Analysis of outcome of cancer immunotherapy for recurrent cancer after surgery for non-small cell lung cancer2022
- Author(s)
  Hashimoto T, Karashima T, Abe M, Takumi Y, Miyawaki M, Inagaki T, Nishikawa K, Osoegawa A, Sugio K
- Organizer
  2022 Asia Conference on Lung Cancer (IASLC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09168
[Presentation] まれなEGFR遺伝子変異陽性肺癌におけるPD-L1発現の検討2022
- Author(s)
  小副川敦、内匠陽平、鎌田紘輔、安部美幸、橋本崇史、宮脇美千代、杉尾賢二
- Organizer
  第39回日本呼吸器外科学会
- Data Source
  KAKENHI-PROJECT-20K09168
[Presentation] ROS1もしくはMET変異陽性肺癌の術後脳転移再発に対して分子標的薬が奏効した2例2022
- Author(s)
  内匠陽平、辛島高志、安部美幸、橋本崇史、宮脇美千代、小副川敦、杉尾賢二
- Organizer
  第63回日本肺癌学会
- Data Source
  KAKENHI-PROJECT-20K09168
[Presentation] 免疫チェックポイント阻害薬投与患者の血清学的効果予測因子の検討2022
- Author(s)
  辛島高志、稲墻崇、安部美幸、西川和男、内匠陽平、橋本崇史、宮脇美千代、小副川敦、杉尾賢二
- Organizer
  第63回日本肺癌学会
- Data Source
  KAKENHI-PROJECT-20K09168
[Presentation] EGFR陽性肺腺癌における腫瘍内不均一性の検討2018
- Author(s)
  橋本崇史、小副川敦、安部美幸、内匠陽平、小林良司、宮脇美千代、武内秀也、岡本龍郎、杉尾賢二
- Organizer
  第58回日本肺癌学会九州支部学術集会・第41回日本呼吸器内視鏡学会九州支部総会
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] Acquired resistance to EGFR-TKI in the uncommon EGFR mutation, G719S2017
- Author(s)
  Osoegawa A、Hashimoto T、Takumi Y、Kobayashi R、Miyawaki M、Takeuchi H、Okamoto T、Sugio K
- Organizer
  IASLC 18th World Conference on Lung Cancer
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] EGFR特異的抗体を用いたEGFR変異蛋白の腫瘍内不均一発現の検討2017
- Author(s)
  橋本崇史、小副川敦、安部美幸、内匠陽平、小林良司、末廣修治、宮脇美千代、杉尾賢二
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] Acquired resistance to EGFR-TKI in an uncommon G719S EGFR mutation.2017
- Author(s)
  Osoegawa A、Yamada T、Hashimoto T、Takumi Y、Kobayashi R、Suehiro S、Miyawaki M、Takeuchi H、Okamoto T、Sugio K
- Organizer
  AACR Annual Meeting 2017
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] 非小細胞肺癌のリンパ節転移とFDG-PETの原発巣SUV値との関連の検討2017
- Author(s)
  内匠陽平、安部美幸、小林良司、橋本崇史、末廣修治、小副川敦、宮脇美千代、杉尾賢二
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] EGFR G719S 変異に対するEGFR-TKI 獲得耐性のメカニズム2017
- Author(s)
  小副川敦、橋本崇史、内匠陽平、安部美幸、小林良司、宮脇美千代、武内秀也、岡本龍郎、杉尾賢二
- Organizer
  第76回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] 稀なEGFR遺伝子変異，G719S変異のTKI耐性メカニズムに関する検討2017
- Author(s)
  小副川敦、橋本崇史、内匠陽平、小林良司、末廣修治、宮脇美千代、杉尾賢二
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] 肺扁平上皮癌におけるPD-L1の発現に関する検討2016
- Author(s)
  小副川敦、平石瞳美、内匠陽平、安部美幸、橋本崇史、亀井美玲、末廣修治、宮脇美千代、杉尾賢二
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場、リーガロイヤルホテル大阪(大阪府大阪市)
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] ROCK阻害剤を使ったヒト肺癌細胞の初代培養2016
- Author(s)
  小副川敦、橋本崇史、内匠陽平、安部美幸、小林良司、末廣修治、宮脇美千代、杉尾賢二
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡国際会議場/福岡サンパレス/福岡国際センター(福岡県福岡市)
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] Positive correlation between the gamma-H2AX and PD-L1 expression in lung squamous cell carcinoma.2016
- Author(s)
  Osoegawa A、Hashimoto T、Takumi Y、Abe M、Hiraishi H、Suehiro S、Miyawaki M、Sugio K
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  Ernest N, Morial Convention Center(New Orleans, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] 肺扁平上皮癌におけるPD-L1発現とDNA損傷との関連2016
- Author(s)
  小副川敦、内匠陽平、橋本崇史、安部美幸、宮脇美千代、杉尾賢二
- Organizer
  第33回日本呼吸器外科学会総会
- Place of Presentation
  国立京都国際会館(京都府京都市)
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] Invasive mucinous adenocarcinomaにおける遺伝子異常の解析2016
- Author(s)
  小副川敦、橋本崇史、内匠陽平、安部美幸、小林良司、末廣修治、宮脇美千代、杉尾賢二
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡国際会議場/福岡サンパレス/福岡国際センター(福岡県福岡市)
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] 当科におけるEGFR-TKI耐性肺癌に対するRe-biopsyの現状2016
- Author(s)
  橋本崇史、安部美幸、内匠陽平、小林良司、末廣修治、小副川敦、宮脇美千代、杉尾賢二
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡国際会議場/福岡サンパレス/福岡国際センター(福岡県福岡市)
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] EGFR-TKI耐性肺腺癌に対するRe-biopsyによる耐性機序の検討2015
- Author(s)
  橋本崇史、安部美幸、末廣修治、小副川敦、宮脇美千代、杉尾賢二
- Organizer
  第56回日本肺癌学会学術集会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-15K19941
[Presentation] 小細胞癌転化を来したEGFR-TKI治療後の獲得耐性肺腺癌の一例2015
- Author(s)
  小副川敦、橋本崇史、内匠陽平、安部美幸、末廣修治、宮脇美千代、杉尾賢二
- Organizer
  第13回日本臨床腫瘍学会学術集会
- Place of Presentation
  ロイトン札幌、ホテルさっぽろ芸文館、札幌市教育文化会館(北海道札幌市)
- Year and Date
  2015-07-18
- Data Source
  KAKENHI-PROJECT-15K19941

1. Sugio Kenji (70235927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
2. 宮脇美千代 (30404388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
3. 阿南健太郎 (60468006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小副川敦 (90432939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results

Hashimoto Takafumi 橋本 崇史

Research Projects

Research Products

Co-Researchers

Development of novel treatments for lung cancer based on genetic heterogeneity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of space-time in-tumor heterogeneity in lung cancer with Driver gene mutationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Osimertinib as first-line treatment for recurrent lung cancer patients with EGFR mutation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significance of programmed death‐ligand 1 expression in resected lung cancer and its relationship with EGFR mutation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cyclin-dependent kinase (CDK) 4/6 inhibition in non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutations2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of part-solid lung cancer in the eighth edition TNM staging system2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ciliated muconodular papillary tumor of the lung: a case report and literature review.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acquired resistance to an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) in an uncommon G719S EGFR mutation.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Positive Relationship Between γH2AX and PD-L1 Expression in Lung Squamous Cell Carcinoma.2018

Author(s)

Journal Title

Data Source

[Presentation] EGFR遺伝子変異陽性肺癌におけるCyclinD1発現の意義2023

Author(s)

Organizer

Data Source

[Presentation] 上皮成長因子受容体(EGFR)変異陽性肺癌における細胞周期関連因子の意義と治療標的としての可能性2022

Author(s)

Organizer

Data Source

[Presentation] First line osimertinib in lung cancer patients with postoperative ocurrence2022

Author(s)

Organizer

Data Source

[Presentation] 術後脳転移再発に対するエヌトレクチニブが奏効したROS1陽性肺癌の１例2022

Author(s)

Organizer

Data Source

[Presentation] 術後再発に対するosimertinibの有効性について2022

Author(s)

Organizer

Data Source

[Presentation] 肺腺癌外科切除症例におけるTTF-1発現と臨床病理学的因子の関係の検討2022

Author(s)

Organizer

Data Source

[Presentation] Analysis of outcome of cancer immunotherapy for recurrent cancer after surgery for non-small cell lung cancer2022

Author(s)

Organizer

Data Source

[Presentation] まれなEGFR遺伝子変異陽性肺癌におけるPD-L1発現の検討2022

Author(s)

Hashimoto Takafumi 橋本崇史