Takehara Masaya 竹原正也

Researcher Number	40742705
Other IDs
Affiliation (Current)	2025: 順天堂大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 順天堂大学, 薬学部, 准教授 2019 – 2023: 徳島文理大学, 薬学部, 講師 2018: 徳島文理大学, 薬学部, 助教 2015 – 2016: 徳島文理大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / Bacteriology (including mycology) Except Principal Investigator Basic Section 49050:Bacteriology-related
Keywords	Principal Investigator 細菌感染 / 好中球 / Toll様受容体 / 自然免疫 / 細菌毒素 / 宿主免疫 / ウエルシュ菌 / 毒素 / 感染 / 敗血症 … More / 炎症 / TLR / α毒素 / A型ウエルシュ菌 / ガス壊疽 / 細胞免疫 / 細胞分化 / ウエルシュ菌α毒素 / 分化 / 免疫回避 / エフェクター Less

顆粒球産生に着目したA型ウエルシュ菌感染症の重症化メカニズムの解明Principal Investigator
- Principal Investigator
  
  竹原正也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Juntendo University
糖脂質含有リポソームのウエルシュ菌感染症治療への応用
- Principal Investigator
  
  小田真隆
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Kyoto Pharmaceutical University
Elucidation of host immune disturbance mechanism by Clostridium perfringens alpha-toxinPrincipal Investigator
- Principal Investigator
  
  Takehara Masaya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Tokushima Bunri University
Elucidation of neutrophil differentiation suppression mechanism by Clostridium perfringens alpha-toxinPrincipal Investigator
- Principal Investigator
  
  Takehara Masaya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Tokushima Bunri University
Clostridium perfringens alpha-toxin-induced impairment of innate immunity by inhibiting granulopoiesisPrincipal Investigator
- Principal Investigator
  
  Takehara Masaya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Tokushima Bunri University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Clostridium perfringens α-toxin up-regulates plasma membrane CD11b expression on murine neutrophils by changing intracellular localization2022
- Author(s)
  Takehara Masaya、Kobayashi Keiko、Nagahama Masahiro
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1864 Issue: 12 Pages: 184054-184054
- DOI
  10.1016/j.bbamem.2022.184054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07033, KAKENHI-PROJECT-20K07505
[Journal Article] Study on the interaction between Clostridium perfringens and the host2021
- Author(s)
 TAKEHARA Masaya
- Journal Title
 
 Nippon Saikingaku Zasshi
 
 Volume: 76 Issue: 3 Pages: 149-160
- DOI
 10.3412/jsb.76.149
- NAID
 130008117196
- ISSN
 0021-4930, 1882-4110
- Language
 Japanese
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-21K07033
[Journal Article] Toll-like receptor 4 protects against Clostridium perfringens infection in mice.2021
- Author(s)
  Takehara M, Kobayashi K, Nagahama M
- Journal Title
  
  Front Cell Infect Microbiol
  
  Volume: 11 Pages: 633440-633440
- DOI
  10.3389/fcimb.2021.633440
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07505, KAKENHI-PROJECT-21K07033
[Journal Article] Clostridium perfringens alpha-toxin inhibits myogenic differentiation of C2C12 myoblasts.2020
- Author(s)
  Takehara M, Kobayashi K, Nagahama M
- Journal Title
  
  Anaerobe
  
  Volume: 65 Pages: 102265-102265
- DOI
  10.1016/j.anaerobe.2020.102265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07505, KAKENHI-PROJECT-18K07129
[Journal Article] Clostridium perfringens alpha-toxin specifically induces endothelial cell death by promoting ceramide-mediated apoptosis.2020
- Author(s)
  Takehara M, Bandou H, Kobayashi K, Nagahama M
- Journal Title
  
  Anaerobe
  
  Volume: 65 Pages: 102262-102262
- DOI
  10.1016/j.anaerobe.2020.102262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07505, KAKENHI-PROJECT-18K07129
[Journal Article] Granulocyte Colony-Stimulating Factor Does Not Influence Clostridium Perfringens α-Toxin-Induced Myonecrosis in Mice2019
- Author(s)
  Takehara Masaya、Sonobe Yuuta、Bandou Hiroto、Kobayashi Keiko、Nagahama Masahiro
- Journal Title
  
  Toxins
  
  Volume: 11 Issue: 9 Pages: 509-509
- DOI
  10.3390/toxins11090509
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07129
[Journal Article] Clostridium perfringens α-toxin impairs granulocyte colony-stimulating factor receptor-mediated granulocyte production while triggering septic shock2019
- Author(s)
  Takehara Masaya、Seike Soshi、Sonobe Yuuta、Bandou Hiroto、Yokoyama Saki、Takagishi Teruhisa、Miyamoto Kazuaki、Kobayashi Keiko、Nagahama Masahiro
- Journal Title
  
  Communications Biology
  
  Volume: 2 Issue: 1 Pages: 45-45
- DOI
  10.1038/s42003-019-0280-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07129, KAKENHI-PROJECT-18K15153, KAKENHI-PROJECT-16K08793, KAKENHI-PROJECT-16K08794
[Journal Article] Host Defense against Bacterial Infection and Bacterial Toxin-induced Impairment of Innate Immunity2018
- Author(s)
  Takehara Masaya
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 138 Issue: 10 Pages: 1249-1253
- DOI
  10.1248/yakushi.18-00102
- NAID
  130007493874
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2018-10-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07129
[Journal Article] Cellular Uptake of Clostridium botulinum C2 Toxin Requires Acid Sphingomyelinase Activity.2017
- Author(s)
  Nagahama M, Takehara M, Takagishi T, Seike S, Miyamoto K, Kobayashi K.
- Journal Title
  
  Infect. Immun.
  
  Volume: 85 Issue: 4
- DOI
  10.1128/iai.00966-16
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19099, KAKENHI-PROJECT-16K08793, KAKENHI-PROJECT-16K08794
[Journal Article] Clostridium perfringens Delta-Toxin Induces Rapid Cell Necrosis.2016
- Author(s)
  Seike S, Miyamoto K, Kobayashi K, Takehara M, Nagahama M
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 1 Pages: e0147957-e0147957
- DOI
  10.1371/journal.pone.0147957
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19099, KAKENHI-PROJECT-25460552, KAKENHI-PROJECT-16K08794
[Journal Article] Clostridium perfringens α-Toxin Impairs Innate Immunity via Inhibition of Neutrophil Differentiation.2016
- Author(s)
  Takehara M, Takagishi T, Seike S, Ohtani K, Kobayashi K, Miyamoto K, Shimizu T, Nagahama M
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 28192-28192
- DOI
  10.1038/srep28192
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19099, KAKENHI-PROJECT-15K08460, KAKENHI-PROJECT-16K08794
[Journal Article] Oligomer formation of Clostridium perfringens epsilon-toxin is induced by activation of neutral sphingomyelinase.2016
- Author(s)
  Takagishi T, Oda M, Takehara M, Kobayashi K, Nagahama M.
- Journal Title
  
  Biochim. Biophys. Acta.
  
  Volume: 1858 Issue: 11 Pages: 2681-2688
- DOI
  10.1016/j.bbamem.2016.07.009
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19099, KAKENHI-PROJECT-16K08794, KAKENHI-PROJECT-15H05017
[Journal Article] Role of pannexin 1 in Clostridium perfringens beta-toxin-caused cell death.2016
- Author(s)
  Seike S, Takehara M, Kobayashi K, Nagahama M.
- Journal Title
  
  Biochim. Biophys. Acta.
  
  Volume: 1858 Issue: 12 Pages: 3150-3156
- DOI
  10.1016/j.bbamem.2016.10.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19099, KAKENHI-PROJECT-16K08794
[Journal Article] Clostridium perfringens α-Toxin Impairs Lipid Raft Integrity in Neutrophils.2016
- Author(s)
  Takehara M, Takagishi T, Seike S, Oishi K, Fujihara Y, Miyamoto K, Kobayashi K, Nagahama M
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 39 Pages: 1694-1700
- NAID
  130005598486
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19099
[Journal Article] Clostridium perfringens TpeL Induces Formation of Stress Fibers via Activation of RhoA-ROCK Signaling Pathway2015
- Author(s)
 Nagahama M, Ohkubo A, Kinouti Y, Kobayashi K, Miyamoto K, Takehara M, Sakurai J
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 38 Issue: 5 Pages: 732-739
- DOI
 10.1248/bpb.b14-00842
- NAID
 130005068100
- ISSN
 0918-6158, 1347-5215
- Language
 English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
 KAKENHI-PROJECT-25460552, KAKENHI-PROJECT-15K19099
[Journal Article] Identification of the replication region in pBCNF5603, a bacteriocin-encoding plasmid, in the enterotoxigenic Clostridium perfringens strain F5603.2015
- Author(s)
  Miyamoto K, Seike S, Takagishi T, Okui K, Oda M, Takehara M, Nagahama M
- Journal Title
  
  BMC Microbiol.
  
  Volume: 15 Issue: 1 Pages: 118-118
- DOI
  10.1186/s12866-015-0443-3
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19099, KAKENHI-PROJECT-15H05017, KAKENHI-PROJECT-25460552
[Journal Article] Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury.2015
- Author(s)
  Nagahama M, Seike S, Shirai H, Takagishi T, Kobayashi K, Takehara M, Sakurai J
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1850 Issue: 11 Pages: 2159-2167
- DOI
  10.1016/j.bbagen.2015.08.011
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19099, KAKENHI-PROJECT-25460552
[Presentation] ウエルシュ菌α毒素によるCD11b抗原の発現増加2023
- Author(s)
  竹原正也、小林敬子、永浜政博
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K07033
[Presentation] A型ウエルシュ菌感染マウスの大腿筋におけるトランスクリプトーム解析2023
- Author(s)
  石原知明、阪口義彦、小林敬子、永浜政博、竹原正也
- Organizer
  第76回日本細菌学会中四国支部総会
- Data Source
  KAKENHI-PROJECT-21K07033
[Presentation] ウエルシュ菌α毒素は好中球でCD11b抗原の発現を増加させる2022
- Author(s)
  竹原正也、小林敬子、永浜政博
- Organizer
  第75回日本細菌学会中四国支部総会
- Data Source
  KAKENHI-PROJECT-21K07033
[Presentation] A型ウエルシュ菌感染時のToll様受容体4の役割2022
- Author(s)
  竹原正也、小林敬子、永浜政博
- Organizer
  第95回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K07033
[Presentation] Toll様受容体4はウエルシュ菌感染に対して生体を防御する2021
- Author(s)
  南山優、竹原正也、小林敬子、永浜政博
- Organizer
  第74回日本細菌学会中四国支部総会
- Data Source
  KAKENHI-PROJECT-21K07033
[Presentation] ウエルシュ菌と宿主の相互作用に関する研究2021
- Author(s)
  竹原正也
- Organizer
  第94回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07129
[Presentation] A型ウエルシュ菌の病原性発現機構の解明2021
- Author(s)
  竹原正也、小林敬子、永浜政博
- Organizer
  第74回日本細菌学会中四国支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07033
[Presentation] A型ウエルシュ菌の病原性発現機構に関する研究2020
- Author(s)
  竹原正也、小林敬子、永浜政博
- Organizer
  第73回日本細菌学会中国・四国支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07129
[Presentation] ウエルシュ菌α毒素による宿主免疫撹乱の分子機構2020
- Author(s)
  竹原正也、小林敬子、永浜政博
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07129
[Presentation] ウエルシュ菌α毒素によるToll様受容体を介した宿主免疫の撹乱2019
- Author(s)
  竹原正也、小林敬子、永浜政博
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K07129
[Presentation] ウエルシュ菌α毒素による宿主免疫応答の活性化2019
- Author(s)
  竹原正也、小林敬子、永浜政博
- Organizer
  第66回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-18K07129
[Presentation] ウエルシュ菌α毒素による宿主免疫応答の撹乱2019
- Author(s)
  竹原正也、小林敬子、永浜政博
- Organizer
  第31回微生物シンポジウム
- Data Source
  KAKENHI-PROJECT-18K07129
[Presentation] ウエルシュ菌α毒素による血管内皮細胞の障害2019
- Author(s)
  竹原正也、小林敬子、永浜政博
- Organizer
  第72回日本細菌学会中国・四国支部総会
- Data Source
  KAKENHI-PROJECT-18K07129
[Presentation] Toll様受容体を介した宿主の免疫反応に対するウエルシュ菌α毒素の影響2018
- Author(s)
  竹原正也、小林敬子、永浜政博
- Organizer
  第71回日本細菌学会中国・四国支部総会
- Data Source
  KAKENHI-PROJECT-18K07129
[Presentation] ウエルシュ菌α毒素による好中球の産生抑制機構の解明2018
- Author(s)
  竹原正也, 小林敬子, 永浜政博
- Organizer
  第65回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-18K07129
[Presentation] ウエルシュ菌α毒素による新しい宿主免疫回避機構2017
- Author(s)
  竹原　正也, 永浜　政博
- Organizer
  第90回　日本細菌学会総会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2017-03-19
- Invited
- Data Source
  KAKENHI-PROJECT-15K19099
[Presentation] 細菌感染に対する生体の好中球産生亢進を介した防御機構とその破綻2016
- Author(s)
  竹原正也
- Organizer
  第69回　日本細菌学会関西支部総会・学術講演会
- Place of Presentation
  大阪府大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-15K19099
[Presentation] ウエルシュ菌α毒素による好中球分化抑制と脂質ラフト障害との関連2016
- Author(s)
  竹原正也，高岸照久，清家総史，宮本和明, 小林敬子, 永浜政博
- Organizer
  第69回　日本細菌学会中国・四国支部総会
- Place of Presentation
  香川県高松市
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-15K19099
[Presentation] ウエルシュ菌α毒素を用いた新規宿主免疫回避機構の解明2016
- Author(s)
  竹原　正也, 高岸　照久, 清家総史, 宮本　和明, 小林　敬子, 永浜　政博
- Organizer
  第63回　トキシンシンポジウム
- Place of Presentation
  山形県天童市
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-15K19099
[Presentation] ウエルシュ菌α毒素による好中球分化抑制機構の解明2016
- Author(s)
  竹原正也，高岸照久，清家総史，小林敬子, 永浜政博
- Organizer
  第55回　日本薬学会中国四国支部会
- Place of Presentation
  岡山県岡山市
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-15K19099
[Presentation] ウエルシュ菌α毒素の好中球分化抑制による自然免疫系の障害2016
- Author(s)
  竹原正也, 高岸照久, 大石恭平, 宮本和明, 小林敬子, 永浜政博
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪府
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-15K19099
[Presentation] ウエルシュ菌α毒素の好中球産生障害による宿主感染機構2015
- Author(s)
  竹原正也，高岸照久，清家総史，小林敬子，永浜政博
- Organizer
  第68回日本細菌学会中国・四国支部総会
- Place of Presentation
  岡山県
- Year and Date
  2015-10-04
- Data Source
  KAKENHI-PROJECT-15K19099
[Presentation] ウエルシュ菌α毒素は好中球の分化を抑制することで宿主免疫を障害する2015
- Author(s)
  竹原正也, 高岸照久, 清家総史, 小林敬子, 永浜政博
- Organizer
  第27回微生物シンポジウム
- Place of Presentation
  岡山県
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-15K19099
[Presentation] ウエルシュ菌α毒素を用いた新規宿主免疫回避機構の解明2015
- Author(s)
  竹原正也, 高岸照久, 清家総史, 小林敬子, 永浜政博
- Organizer
  第54回日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学術大会
- Place of Presentation
  高知県
- Year and Date
  2015-11-01
- Data Source
  KAKENHI-PROJECT-15K19099

1. 永浜政博 (40164462)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
2. 小林敬子 (90170315)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
3. 小田真隆 (00412403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山本博文 (70461366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Takehara Masaya 竹原 正也

Research Projects

Research Products

Co-Researchers

顆粒球産生に着目したA型ウエルシュ菌感染症の重症化メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

糖脂質含有リポソームのウエルシュ菌感染症治療への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of host immune disturbance mechanism by Clostridium perfringens alpha-toxinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of neutrophil differentiation suppression mechanism by Clostridium perfringens alpha-toxinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clostridium perfringens alpha-toxin-induced impairment of innate immunity by inhibiting granulopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Clostridium perfringens α-toxin up-regulates plasma membrane CD11b expression on murine neutrophils by changing intracellular localization2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Study on the interaction between <i>Clostridium perfringens</i> and the host2021

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DOI

NAID

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Data Source

[Journal Article] Toll-like receptor 4 protects against Clostridium perfringens infection in mice.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clostridium perfringens alpha-toxin inhibits myogenic differentiation of C2C12 myoblasts.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clostridium perfringens alpha-toxin specifically induces endothelial cell death by promoting ceramide-mediated apoptosis.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Granulocyte Colony-Stimulating Factor Does Not Influence Clostridium Perfringens α-Toxin-Induced Myonecrosis in Mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clostridium perfringens α-toxin impairs granulocyte colony-stimulating factor receptor-mediated granulocyte production while triggering septic shock2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Host Defense against Bacterial Infection and Bacterial Toxin-induced Impairment of Innate Immunity2018

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Takehara Masaya 竹原正也