Hasumi Hisashi 蓮見壽史

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Hasumi Hasashi 蓮見壽史

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Researcher Number	40749876
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 横浜市立大学, 医学部, 准教授 2017 – 2021: 横浜市立大学, 医学部, 助教 2015 – 2017: 横浜市立大学, 附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Urology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Basic Section 56030:Urology-related / Urology
Keywords	Principal Investigator エピゲノム / 細胞内輸送 / FLCN/FNIP1/FNIP2複合体 / BHD症候群 / 遺伝性腎癌 / FLCN / 腎癌抑制遺伝子 / シングルセル遺伝子発現解析 / マルチオミクス解析 / 腎癌自然発生マウス … More / 腎癌オルガノイド / 腫瘍内不均一性 / 免疫チェックポイント阻害剤 / がん微小環境 / シングルセル発現解析 / 腎癌 / 代謝と癌 / 家族性腫瘍症候群 / 膜輸送 / 癌と代謝 … More Except Principal Investigator 唾液腺腫瘍 / FLCN遺伝子 / トランスジェニックマウス / 硝子化明細胞癌 / EWSR1-ATF1融合遺伝子 / 条件特異的遺伝子改変マウス / 発癌 / 唾液腺癌 / 頭頸部癌 / 融合遺伝子 / 単一細胞トランスクリプトーム解析 / 治療標的 / 診断マーカー / 稀少発症 / 遺伝性 / 腎癌 / TFE3 / mTOR / ミトコンドリア / Birt-Hogg-Dube症候群 / FNIP1 / 唾液腺特異的ノックアウトマウ / FLCN / 条件特異的遺伝子破壊 / 唾液腺特異的ノックアウトマウス / 腎がん / 遺伝性腫瘍症候群 / BHD症候群 / 遺伝性腎腫瘍 / バート・ホッグ・デュベ症候群 Less

多系統腎癌オルガノイドを用いた腎癌精密医療の開発Principal Investigator
- Principal Investigator
  
  蓮見壽史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Yokohama City University
Functional analysis on the EWSR1-ATF1 fusion gene in salivary gland carcinogenesis
- Principal Investigator
  
  ORIDATE Nobuhiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
Analyses of tumorigenesis and identifications of novel diagnostic marker and therapeutic target in hereditary and rare kidney cancers
- Principal Investigator
  
  YAO Masahiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Yokohama City University
Elucidation of renal tumorigenesis under FLCN deficiencyPrincipal Investigator
- Principal Investigator
  
  HASUMI Hisashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Yokohama City University
Establishment salivary gland-targeted Flcn knockout mice
- Principal Investigator
  
  ORIDATE Nobuhiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
Elucidation of renal tumorigenesis driven by FLCN deficiencyPrincipal Investigator
- Principal Investigator
  
  Hasumi Hasashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Yokohama City University
Molecular Genetic analysis and Tumorigenesis of Birt-Hogg-Dube syndrome in Japan
- Principal Investigator
  
  YAO Masahiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Yokohama City University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Lynch Syndrome-Associated Urological Malignancies2020
- Author(s)
  Hisashi Hasumi, Masahiro Yao
- Total Pages
  5
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-19K09694
[Book] Year Book of RCC20172017
- Author(s)
  蓮見壽史、矢尾正祐
- Total Pages
  8
- Publisher
  メディカルレビュー
- Data Source
  KAKENHI-PROJECT-16K11020
[Journal Article] Single-cell transcriptomes of hereditary kidney cancers underscore genetically defined tumor characteristics and microenvironment2022
- Author(s)
  Ryosuke Jikuya, Hisashi Hasumi, et al.
- Journal Title
  
  iScience
  
  Volume: n/a
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09694
[Journal Article] Targeting chemoresistance in Xp11.2 translocation renal cell carcinoma using a novel polyamide?chlorambucil conjugate2022
- Author(s)
  Funasaki Shintaro、Mehanna Sally、Ma Wenjuan、Nishizawa Hidekazu、Kamikubo Yasuhiko、Sugiyama Hiroshi、Ikeda Shuji、Motoshima Takanobu、Hasumi Hisashi、Linehan W. Marston、Schmidt Laura S.、Ricketts Chris、Suda Toshio、Oike Yuichi、Kamba Tomomi、Baba Masaya
- Journal Title
  
  Cancer Science
  
  Volume: n/a Issue: 7 Pages: 2352-2367
- DOI
  10.1111/cas.15364
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09694, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-20K09560, KAKENHI-PROJECT-21K19721, KAKENHI-PROJECT-21K09374, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-23K24474
[Journal Article] Hereditary Leiomyomatosis and Renal Cell Cancer; HLRCC2021
- Author(s)
  古屋充子、蓮見壽史、矢尾正祐
- Journal Title
  
  Journal of Hereditary Tumors
  
  Volume: 21 Issue: 1 Pages: 1-6
- DOI
  10.18976/jsht.21.1_1
- NAID
  130008037953
- ISSN
  2435-6808
- Year and Date
  2021-05-10
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-19K09717
[Journal Article] Diagnostic Impacts of Clinical Laboratory Based p2PSA Indexes on any Grade, Gleason Grade Group 2 or Greater, or 3 or Greater Prostate Cancer and Prostate Specific Antigen below 10 ng/ml.2020
- Author(s)
  Ito K, Yokomizo A, Tokunaga S, Arai G, Sugimoto M, Akakura K, Hasumi H, Sakai H, Ouraji A, Oki R, Kashiwagi E, Kobori Y, Hirama H, Kitoh H, Uemura H, Hakariya T, Suzuki K
- Journal Title
  
  J Urol.
  
  Volume: 203 Issue: 1 Pages: 83-91
- DOI
  10.1097/ju.0000000000000495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11206, KAKENHI-PROJECT-19K09694
[Journal Article] FLCN Alteration Drives Metabolic Reprogramming Towards Nucleotide Synthesis and Cyst Formation in Salivary Gland2020
- Author(s)
  Isono Y, Furuya M, Kuwahara T, Sano D, Suzuki K, Jikuya R, Mitome T, Otake S, Kawahara T, Ito Y, Muraoka K, Nakaigawa N, Kimura Y, Baba M, Nagahama K, Takahata H, Saito I, Schmidt LS, Linehan WM, Kodama T, Yao M, Oridate N, Hasumi H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 522 Issue: 4 Pages: 931-938
- DOI
  10.1016/j.bbrc.2019.11.184
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09382, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-18K19619, KAKENHI-PROJECT-19K09717, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19H03774
[Journal Article] FLCN alteration drives metabolic reprogramming towards nucleotide synthesis and cyst formation in salivary gland2020
- Author(s)
  Isono Yasuhiro、Furuya Mitsuko、Kuwahara Tatsu、Schmidt Laura S.、Linehan W. Marston、Kodama Tatsuhiko、Yao Masahiro、Oridate Nobuhiko、Hasumi Hisashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 522 Pages: 931-938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09694
[Journal Article] Clinicopathological and molecular features of hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinomas2020
- Author(s)
  Furuya Mitsuko、Iribe Yasuhiro、Hasumi Hisashi、Iwashita Hiromichi、Ohta Junichi、Kitamura Hiroshi、Nakajima Takahiko、Yoshida Takahiro、Nakagawa Masahiro、Tanaka Reiko、Yao Masahiro
- Journal Title
  
  Journal of Clinical Pathology
  
  Volume: 73 Pages: 819-825
- Data Source
  KAKENHI-PROJECT-19K09694
[Journal Article] Clinicopathological and molecular features of hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinomas2020
- Author(s)
  Furuya M, Iribe Y, Nagashima Y, Kambe N, Ohe C, Kinoshita H, Sato C, Kishida T, Okubo Y, Numakura K, Nanjo H, Nakaigawa N, Makiyama K, Hasumi H, Iwashita H, Ohta J, Kitamura H, Nakajima T, Yoshida T, Nakagawa M, Tanaka R, Yao M
- Journal Title
  
  Journal of Clinical Pathology
  
  Volume: 73 Issue: 12 Pages: 819-825
- DOI
  10.1136/jclinpath-2020-206548
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08713, KAKENHI-PROJECT-19K08784, KAKENHI-PROJECT-19K09717, KAKENHI-PROJECT-20K07395
[Journal Article] Blood and lymphatic systems are segregated by the FLCN tumor suppressor2020
- Author(s)
  Tai-Nagara Ikue、Hasumi Yukiko、Hasumi Hisashi、Funasaki Shintaro、Satou Yorifumi、Kubota Yoshiaki
- Journal Title
  
  Nature Communications
  
  Volume: 11 Pages: 6314-6314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09694
[Journal Article] Complete response of hereditary leiomyomatosis and renal cell cancer (HLRCC)-associated renal cell carcinoma to nivolumab and ipilimumab combination immunotherapy by: a case report2020
- Author(s)
  Iribe Yasuhiro、Furuya Mitsuko、Shibata Yousuke、Yasui Masato、Funahashi Makoto、Ota Junichi、Iwashita Hiromichi、Nagashima Yoji、Hasumi Hisashi、Hayashi Narihiko、Makiyama Kazuhide、Kondo Keiichi、Tanaka Reiko、Yao Masahiro、Nakaigawa Noboru
- Journal Title
  
  Familial Cancer
  
  Volume: 20 Issue: 1 Pages: 75-80
- DOI
  10.1007/s10689-020-00195-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09717, KAKENHI-PROJECT-20K07395
[Journal Article] Early assessment with 18F-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography to predict short-term outcome in clear cell renal carcinoma treated with nivolumab2019
- Author(s)
  Tabei T, Nakaigawa N, Kaneta T, Ikeda I, Kondo K, Makiyama K, Hasumi H, Hayashi N, Kawahara T, Izumi K, Osaka K, Muraoka K, Teranishi JI, Miyoshi Y, Yumura Y, Uemura H, Kobayashi K, Inoue T, Yao M.
- Journal Title
  
  BMC Cancer
  
  Volume: 19 Issue: 1 Pages: 298-298
- DOI
  10.1186/s12885-019-5510-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11021, KAKENHI-PROJECT-19K09676, KAKENHI-PROJECT-19K09694
[Journal Article] Birt‐Hogg‐Dube syndrome‐associated renal cell carcinoma: Histopathological features and diagnostic conundrum2019
- Author(s)
  Furuya M, Hasumi Y, Yao M, Nagashima Y.
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 1 Pages: 15-22
- DOI
  10.1111/cas.14255
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09717, KAKENHI-PROJECT-17K11162, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19K09694
[Journal Article] Fluorescence Enhancement Effect of TiO2 Nanoparticles and Application for Photodynamic Diagnosis2019
- Author(s)
  Kanehira Koki、Yano Yukiko、Hasumi Hisashi、Fukuhara Hideo、Inoue Keiji、Hanazaki Kazuhiro、Yao Masahiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 15 Pages: 3698-3698
- DOI
  10.3390/ijms20153698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09694
[Journal Article] 遺伝性腎がんのup-to-date2019
- Author(s)
  蓮見壽史, 矢尾正祐
- Journal Title
  
  腎臓内科・泌尿器科
  
  Volume: 9 Pages: 483-490
- Data Source
  KAKENHI-PROJECT-19K09694
[Journal Article] The Pretherapeutic Neutrophil-to-Lymphocyte Ratio for Docetaxel-Based Chemotherapy Is Useful for Predicting the Prognosis of Japanese Patients with Castration-Resistant Prostate Cancer2019
- Author(s)
  Tatenuma Tomoyuki、Kawahara Takashi、Hayashi Narihiko、Hasumi Hisashi、Makiyama Kazuhide、Nakaigawa Noboru、Kishida Takeshi、Miyoshi Yasuhide、Yao Masahiro、Uemura Hiroji
- Journal Title
  
  BioMed Research International
  
  Volume: 2019 Pages: 1-5
- DOI
  10.1155/2019/2535270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09694
[Journal Article] TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease.2019
- Author(s)
  Baba M, Furuya M, Motoshima T, Lang M, Funasaki S, Ma W, Sun HW, Hasumi H, Huang Y, Kato I, Kadomatsu T, Satou Y, Morris N, Karim BO, Ileva L, Kalen JD, Wilan Krisna LA, Hasumi Y, Sugiyama A, Kurahashi R, Nishimoto K, Oyama M, Nagashima Y, Kuroda N, Araki K, Eto M, Yao M, Kamba T, Suda T, Oike Y, Schmidt LS, Linehan WM
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 印刷中 Issue: 8 Pages: 1613-1626
- DOI
  10.1158/1541-7786.mcr-18-1235
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19619, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-18K07236, KAKENHI-PROJECT-19K09717, KAKENHI-PROJECT-18KK0230, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-18H02809, KAKENHI-PROJECT-19J15484, KAKENHI-PROJECT-17K08745, KAKENHI-PROJECT-17K09016, KAKENHI-PROJECT-17K11162, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19K09694
[Journal Article] FDG PET/CT after first molecular targeted therapy predicts survival of patients with renal cell carcinoma.2018
- Author(s)
  Nakaigawa N, Kondo K, Kaneta T, Tateishi U, Minamimoto R, Namura K, Ueno D, Kobayashi K, Kishida T, Ikeda I, Hasumi H, Makiyama K, Hayashi N, Osaka K, Muraoka K, Izumi K, Kawahara T, Teranishi JI, Miyoshi Y, Yumura Y, Uemura H, Inoue T, Yao M.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 81 Issue: 4 Pages: 739-744
- DOI
  10.1007/s00280-018-3542-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11021, KAKENHI-PROJECT-16K11020
[Journal Article] Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation2018
- Author(s)
  3.Baba M, Endoh M, Ma W, Toyama H, Hirayama A, Nishikawa K, Takubo K, Hano H, Hasumi H, Umemoto T, Hashimoto M, Irie N, Esumi C, Kataoka M, Nakagata N, Soga T, Yao M, Kamba T, Minami T, Ishii M, and Suda T.
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: 33 Issue: 10 Pages: 1785-1798
- DOI
  10.1002/jbmr.3477
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0026, KAKENHI-PROJECT-18K18455, KAKENHI-PROJECT-18K19619, KAKENHI-PUBLICLY-17H05530, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-18H02614, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-16K07372, KAKENHI-PROJECT-16K11020, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H03580
[Journal Article] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes2018
- Author(s)
  Hisashi Hasumi, Hiroyuki Aburatani, W. Marston Linehan and Masahiro Yao
- Journal Title
  
  Human Molecular Genetics
  
  Volume: n/a
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11020
[Journal Article] 遺伝性腎がん2018
- Author(s)
  矢尾正祐, 蓮見壽史, 近藤慶一, 中井川昇
- Journal Title
  
  最新医学
  
  Volume: 73 Pages: 398-404
- Data Source
  KAKENHI-PROJECT-15K10600
[Journal Article] Hereditary kidney cancer syndromes: Genetic disorders driven by alterations in metabolism and epigenome regulation2018
- Author(s)
  Hasumi Hisashi, Yao Masahiro
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 3 Pages: 581-586
- DOI
  10.1111/cas.13503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10600, KAKENHI-PROJECT-16K11020
[Journal Article] Histopathological analysis of aggressive renal cell carcinoma harboring a unique germline mutation in fumarate hydratase2018
- Author(s)
  Matsumoto Kana、Udaka Naoko、Hasumi Hisashi、Nakaigawa Noboru、Nagashima Yoji、Tanaka Reiko、Kato Ikuma、Yao Masahiro、Furuya Mitsuko
- Journal Title
  
  Pathology International
  
  Volume: 68 Issue: 8 Pages: 473-478
- DOI
  10.1111/pin.12684
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08745, KAKENHI-PROJECT-17K11162, KAKENHI-PROJECT-16K11020, KAKENHI-PROJECT-16K19085
[Journal Article] Hereditary kidney cancer syndromes: Genetic disorders driven by alterations in metabolism and epigenome regulation.2018
- Author(s)
  Hisashi Hasumi, Masahiro Yao
- Journal Title
  
  Cancer Sci.
  
  Volume: 109 Pages: 581-586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11020
[Journal Article] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes2018
- Author(s)
  Hasumi Hisashi、Furuya Mitsuko、Tatsuno Kenji、Aburatani Hiroyuki、Linehan W Marston、Yao Masahiro, et al.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 印刷中 Issue: 15 Pages: 2712-2724
- DOI
  10.1093/hmg/ddy181
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10600, KAKENHI-PROJECT-17K08745, KAKENHI-PROJECT-17K11162, KAKENHI-PROJECT-18K19619, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-16K11020, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17K07195
[Journal Article] 遺伝性腎癌症候群2018
- Author(s)
  蓮見壽史、矢尾正祐
- Journal Title
  
  臨床泌尿器科
  
  Volume: 72 Pages: 892-901
- Data Source
  KAKENHI-PROJECT-16K11020
[Journal Article] 遺伝性腎細胞癌基礎研究の進歩2017
- Author(s)
  蓮見壽史
- Journal Title
  
  日本臨牀
  
  Volume: 75 Pages: 148-156
- Data Source
  KAKENHI-PROJECT-16K11020
[Journal Article] H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.2017
- Author(s)
  Hasumi H, Hasumi Y, Baba M, Nishi H, Furuya M, Vocke CD, Lang M, Irie N, Esumi C, Merino MJ, Kawahara T, Isono Y, Makiyama K, Warner AC, Haines DC, Wei MH, Zbar B, Hagenau H, Feigenbaum L, Kondo K, Nakaigawa N, Yao M, Metwalli AR, Marston Linehan W, Schmidt LS
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Pages: 354-366
- DOI
  10.1093/hmg/ddw392
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14370, KAKENHI-PROJECT-15K10600, KAKENHI-PROJECT-16K11020, KAKENHI-PROJECT-17K08745, KAKENHI-PROJECT-15H04975
[Journal Article] 家族性腫瘍症候群と腎細胞癌2017
- Author(s)
  蓮見壽史、矢尾正祐
- Journal Title
  
  病理と臨床
  
  Volume: 35 Pages: 910-914
- Data Source
  KAKENHI-PROJECT-16K11020
[Journal Article] 癌遺伝子・癌抑制遺伝子2017
- Author(s)
  蓮見壽史
- Journal Title
  
  日本臨牀
  
  Volume: 75 Pages: 47-52
- Data Source
  KAKENHI-PROJECT-16K11020
[Journal Article] 家族性腫瘍症候群と腎細胞癌2017
- Author(s)
  蓮見壽史, 矢尾正祐
- Journal Title
  
  病理と臨床
  
  Volume: 35 Pages: 910-914
- Data Source
  KAKENHI-PROJECT-15K10600
[Journal Article] Establishment and characterization of BHD-F59RSVT, an immortalized cell line derived from a renal cell carcinoma in a patient with Birt-Hogg-Dube syndrome2017
- Author(s)
  Furuya M, Hasumi H, Baba M, Tanaka R, Iribe Y, Onishi T, Nagashima Y, Nakatani Y, Isono Y, Yao M.
- Journal Title
  
  Laboratory Investigation
  
  Volume: 97 Issue: 3 Pages: 343-351
- DOI
  10.1038/labinvest.2016.137
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04975, KAKENHI-PROJECT-15K14370, KAKENHI-PROJECT-15K08374, KAKENHI-PROJECT-16K11020, KAKENHI-PROJECT-17K08745
[Journal Article] Establishment and characterization of BHD-F59RSVT, an immortalized cell line derived from a renal cell carcinoma in a patient with Birt-Hogg-Dube syndrome.2017
- Author(s)
  Furuya M, Hasumi H, Baba M, Tanaka R, Iribe Y, Onishi T, Nagashima Y, Nakatani Y, Isono Y, Yao M.
- Journal Title
  
  Lab Invest
  
  Volume: ９７ Pages: 343-351
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10600
[Journal Article] Fluorescent and chromogenic in situ hybridization of CEN17q as a potent useful diagnostic marker for Birt-Hogg-Dube syndrome-associated chromophobe renal cell carcinomas.2016
- Author(s)
  Kato I, Iribe Y, Nagashima Y, Kuroda N, Tanaka R, Nakatani Y, Hasumi H, Yao M, Furuya M.
- Journal Title
  
  Hum Pathol
  
  Volume: ５２ Pages: 74-82
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10600
[Journal Article] Fluorescent and Chromogenic in situ Hybridization of CEN17q as a Potent Useful Diagnostic Marker for Birt-Hogg-Dube; Syndrome-associated Chromophobe Renal Cell Carcinomas.2016
- Author(s)
  Kato I, Iribe Y, Nagashima Y, Kuroda N, Tanaka R, Nakatani Y, Hasumi H, Yao M, Furuya M
- Journal Title
  
  Hum Pathol
  
  Volume: 52 Pages: 74-82
- DOI
  10.1016/j.humpath.2016.01.004
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08374, KAKENHI-PROJECT-15K10600, KAKENHI-PROJECT-26460422
[Journal Article] 家族性腎癌に対する手術治療2016
- Author(s)
  逢坂公人, 横溝由美子, 蓮見壽史, 林成彦, 槙山和秀, 近藤慶一, 中井川昇, 矢尾正祐
- Journal Title
  
  臨床泌尿器科
  
  Volume: 70 Pages: 565-572
- NAID
  40020890601
- Data Source
  KAKENHI-PROJECT-15K10600
[Journal Article] Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN couplex localization and promotes renal cancer progression2016
- Author(s)
  Nagashima, K., Fukushima, H., Shimizu, K., Hidaka, M., Hasumi, H., Ikebe, T., Fukumoto, S., Okabe, K., Inuzuka, H.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 6 Pages: 9947-9960
- DOI
  10.18632/oncotarget.14221
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-26253092, KAKENHI-PROJECT-16H05509, KAKENHI-PROJECT-16H05529, KAKENHI-PROJECT-16H05548, KAKENHI-PROJECT-16K11020, KAKENHI-PROJECT-15K15689, KAKENHI-PROJECT-26462829
[Journal Article] Genetic, epidemiologic and clinicopathologic studies of Japanese Asian patients with Birt-Hogg-Dube syndrome.2016
- Author(s)
  Furuya M, Yao M, Tanaka R, Nagashima Y, Kuroda N, Hasumi H, Baba M, Matsushima J, Nomura F, Nakatani Y
- Journal Title
  
  Clinical Genetics
  
  Volume: 90 Issue: 5 Pages: 403-412
- DOI
  10.1111/cge.12807
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04975, KAKENHI-PROJECT-26460422, KAKENHI-PROJECT-26460456, KAKENHI-PROJECT-15K14370, KAKENHI-PROJECT-15K08374, KAKENHI-PROJECT-15K10600, KAKENHI-PROJECT-16K11020
[Journal Article] Birt-Hogg-Dube(BHD)症候群．2015
- Author(s)
  蓮見壽史, 馬場理也, 古屋充子, 矢尾正祐.
- Journal Title
  
  泌尿器外科
  
  Volume: 28 Pages: 1607-1612
- Data Source
  KAKENHI-PROJECT-15K10600
[Journal Article] Birt-Hogg-Dubé syndrome: Clinical and molecular aspects of recently identified kidney cancer syndrome.2015
- Author(s)
  Hasumi H, Baba M, Hasumi Y, Furuya M, Yao M.
- Journal Title
  
  Int J Urol
  
  Volume: 23 Issue: 3 Pages: 204-210
- DOI
  10.1111/iju.13015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10600, KAKENHI-PROJECT-26460422, KAKENHI-PROJECT-15K14370, KAKENHI-PROJECT-15H04975
[Presentation] 唾液腺においてFLCN欠失が引き起こす代謝変化とその腫瘍化における意義2020
- Author(s)
  蓮見壽史、磯野泰大、古屋充子、馬場理也、矢尾正祐、折舘伸彦
- Organizer
  第26回日本遺伝性腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09694
[Presentation] 本邦の遺伝性平滑筋腫症-腎細胞癌症候群(HLRCC)10家系における腎癌と関連疾患の病態、および遺伝カウンセリング2019
- Author(s)
  古屋充子, 蓮見壽史, 中井川昇, 神戸直智, 大江知里, 長嶋洋治, 矢尾正祐
- Organizer
  第43回日本遺伝カウンセリング学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09717
[Presentation] 遺伝性平滑筋腫症および腎細胞癌症候群関連腎細胞癌に対しニボルマブ・イピリムマブ併用療法が奏功した一例2019
- Author(s)
  入部康弘, 中井川昇, 古屋充子, 長嶋洋治, 松元加奈, 中島健寛, 荒木あずみ, 伊藤悠亮, 蓮見壽史, 柴田洋佑, 太田純一, 岩下広道, 林成彦, 槙山和秀, 近藤慶一, 矢尾正祐
- Organizer
  第50回腎癌研究会
- Data Source
  KAKENHI-PROJECT-19K09717
[Presentation] International Session I「Treatment strategy for rare hereditary RCC」2019
- Author(s)
  蓮見壽史
- Organizer
  第50回腎癌研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09694
[Presentation] Xp11.2転座腎細胞癌モデルマウスの解析による新規治療標的分子の同定2019
- Author(s)
  馬場理也, 元島崇信, 馬文娟, 蓮見壽史, 佐藤賢文, 古屋充子, 長嶋洋治, 矢尾正祐, 尾池雄一, Schmidt Laura S, Linehan W. Marston, 神波大己
- Organizer
  第107回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-19K09717
[Presentation] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of mutations in chromatin remodeling genes2018
- Author(s)
  Ryosuke Jikuya, Hisashi Hasumi
- Organizer
  AACR
- Data Source
  KAKENHI-PROJECT-16K11020
[Presentation] BHD関連腎癌の分子背景2018
- Author(s)
  蓮見壽史
- Organizer
  第24回日本家族性腫瘍学会
- Data Source
  KAKENHI-PROJECT-16K11020
[Presentation] BHD関連腎癌の発癌機構解析2017
- Author(s)
  蓮見壽史, 古屋充子, 辰野健二, 馬場理也, 横溝由美子, 逢坂公人, 林成彦, 槙山和秀, 近藤慶一, 中井川昇, 山本尚吾, 油谷浩幸, 矢尾正祐
- Organizer
  第105回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-15K10600
[Presentation] Birt-Hogg-Dube症候群における腎癌の分子病理学的特徴2017
- Author(s)
  古屋充子, 蓮見壽史, 加藤生真, 馬場理也, 長嶋洋治, 入部康弘, 中谷行雄, 矢尾正祐
- Organizer
  第76回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-15K10600
[Presentation] BHD関連腎癌の発癌機構解析2017
- Author(s)
  蓮見壽史
- Organizer
  第105回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-16K11020
[Presentation] BHD関連腎癌の発癌機構解析2017
- Author(s)
  蓮見壽史
- Organizer
  第48回腎癌研究会
- Data Source
  KAKENHI-PROJECT-16K11020
[Presentation] ゲノム変異から紐解く腎癌分子機構2017
- Author(s)
  蓮見壽史
- Organizer
  神奈川県mRCC講演会
- Place of Presentation
  ホテルキャメロットジャパン（神奈川県横浜市）
- Year and Date
  2017-02-04
- Invited
- Data Source
  KAKENHI-PROJECT-16K11020
[Presentation] VHL遺伝子に対するFISHはBirt-Hogg-Dube症候群の淡明細胞型腎細胞癌診断において有用と期待される2017
- Author(s)
  松元加奈, 加藤生真, 入部康弘, 長嶋洋治, 中谷行雄, 蓮見寿史, 矢尾正祐, 古屋充子.
- Organizer
  第76回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-15K10600
[Presentation] BHD関連腎癌の発癌機構解析2017
- Author(s)
  蓮見壽史
- Organizer
  第26回泌尿器分子細胞研究会
- Data Source
  KAKENHI-PROJECT-16K11020
[Presentation] BHD関連腎癌の発癌機構解析2017
- Author(s)
  蓮見壽史
- Organizer
  第23回日本家族性腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-16K11020
[Presentation] FISH/CISH法によるCEN17qの検索は、BHD症候群関連の嫌色素性腎細胞癌を孤発例と鑑別する際の助けとなる2016
- Author(s)
  加藤生真, 入部康弘, 長嶋洋治, 黒田直人, 田中玲子, 中谷行雄, 蓮見壽史, 矢尾正祐, 古屋充子
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター（宮城県）
- Data Source
  KAKENHI-PROJECT-15K10600
[Presentation] ゲノム変異から紐解く腎癌分子機構2016
- Author(s)
  蓮見壽史
- Organizer
  東海核医学セミナー
- Place of Presentation
  愛知県
- Year and Date
  2016-12-17
- Invited
- Data Source
  KAKENHI-PROJECT-16K11020
[Presentation] 腎癌抑制遺伝子FLCNにおけるミスセンス変異の病原性の検討2016
- Author(s)
  蓮見壽史
- Organizer
  第47回腎癌研究会
- Place of Presentation
  品川インターシティーホール（東京都品川区）
- Year and Date
  2016-07-09
- Data Source
  KAKENHI-PROJECT-16K11020
[Presentation] Birt-Hogg-Dube（BHD）症候群に発症した腎腫瘍に対する腎温存手術の検討2016
- Author(s)
  新堀萌香, 蓮見壽史, 荒木あずみ, 横溝由美子, 逢坂公人, 林成彦, 槙山和秀, 近藤慶一
- Organizer
  第81回日本泌尿器科学会東部総会
- Place of Presentation
  リンクステーション青森（青森県）
- Data Source
  KAKENHI-PROJECT-15K10600
[Presentation] 腎癌抑制遺伝子FLCNにおけるミスセンス変異の病原性の検討2016
- Author(s)
  蓮見壽史
- Organizer
  第81回日本泌尿器科学会東部総会
- Place of Presentation
  ホテル青森（青森県青森市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-16K11020
[Presentation] 腎癌抑制遺伝子FLCNにおけるミスセンス変異の病原性の検討2016
- Author(s)
  蓮見壽史
- Organizer
  第22回日本家族性腫瘍学会学術集会
- Place of Presentation
  ひめぎんホール（愛媛県松山市）
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-16K11020
[Presentation] Birt-Hogg-Dubé症候群100家系における臨床病理像の特徴と腎癌およびその他の悪性腫瘍発症率の検討.2015
- Author(s)
  古屋充子, 入部康弘, 矢尾正祐, 蓮見壽史, 長嶋洋治, 馬場理也, 野村文夫, 中谷行雄.
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K10600
[Presentation] A Clinicopathological Study of 300 Individuals in 115 Japanese BHD Families.2015
- Author(s)
  Furuya M, Tanaka R, Yao M, Hasumi H, Kuroda N, Nagashima Y, Iribe Y, Nakatani Y.
- Organizer
  6th BHD ｓymposium
- Place of Presentation
  Upstate Medical University（シラキュース・米国）
- Year and Date
  2015-09-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10600
[Presentation] Birt-Hogg-Dubé症候群における肺腫瘍発生の病理学的検討.2015
- Author(s)
  中谷行雄, 奥寺康司, 入部康弘, 矢尾正祐, 蓮見壽史, 長嶋洋治, 馬場理也, 野村文夫, 古屋充子.
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K10600
[Presentation] Birt-Hogg-Dubé症候群に発症する腎癌の臨床病理像, 遺伝子変異および網羅的染色体解析.2015
- Author(s)
  入部康弘, 矢尾正祐, 蓮見壽史, 長嶋洋治, 馬場理也, 野村文夫, 中谷行雄, 古屋充子.
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K10600
[Presentation] BHD 症候群関連腎癌の発生メカニズムの解析.2015
- Author(s)
  蓮見壽史，馬場理也，古屋充子，矢尾正祐.
- Organizer
  第21回日本家族性腫瘍学会学術集会
- Place of Presentation
  ラフレさいたま（さいたま市、埼玉県）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15K10600

1. YAO Masahiro (00260787)

# of Collaborated Projects: 4 results

# of Collaborated Products: 39 results
2. ORIDATE Nobuhiko (90312355)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 中井川昇 (00237207)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. 古屋充子 (10361445)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
5. 近藤慶一 (80363836)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. Hirano Hisashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Linehan W. Marston

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. TANAKA Reiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. NAKATANI Yukio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 南敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 馬場理也

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
12. 小堀善友

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 長嶋洋治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 日高真純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 大久保陽一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 杉山弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hasumi Hisashi 蓮見 壽史

Hasumi Hasashi 蓮見 壽史

Research Projects

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Co-Researchers

多系統腎癌オルガノイドを用いた腎癌精密医療の開発Principal Investigator

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Functional analysis on the EWSR1-ATF1 fusion gene in salivary gland carcinogenesis

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Analyses of tumorigenesis and identifications of novel diagnostic marker and therapeutic target in hereditary and rare kidney cancers

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Elucidation of renal tumorigenesis under FLCN deficiencyPrincipal Investigator

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Establishment salivary gland-targeted Flcn knockout mice

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Elucidation of renal tumorigenesis driven by FLCN deficiencyPrincipal Investigator

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Molecular Genetic analysis and Tumorigenesis of Birt-Hogg-Dube syndrome in Japan

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[Book] Lynch Syndrome-Associated Urological Malignancies2020

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[Book] Year Book of RCC20172017

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[Journal Article] Single-cell transcriptomes of hereditary kidney cancers underscore genetically defined tumor characteristics and microenvironment2022

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[Journal Article] Targeting chemoresistance in Xp11.2 translocation renal cell carcinoma using a novel polyamide?chlorambucil conjugate2022

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[Journal Article] Hereditary Leiomyomatosis and Renal Cell Cancer; HLRCC2021

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[Journal Article] Diagnostic Impacts of Clinical Laboratory Based p2PSA Indexes on any Grade, Gleason Grade Group 2 or Greater, or 3 or Greater Prostate Cancer and Prostate Specific Antigen below 10 ng/ml.2020

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Hasumi Hisashi 蓮見壽史

Hasumi Hasashi 蓮見壽史