Nonaka Saori 野中さおり

Researcher Number	40767787
Other IDs
Affiliation (Current)	2025: 安田女子大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 安田女子大学, 薬学部, 講師 2018 – 2019: 安田女子大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 49070:Immunology-related Except Principal Investigator Basic Section 46010:Neuroscience-general-related
Keywords	Principal Investigator アルツハイマー病 / ジンジパイン / OMV / ジンジバリス菌 / 腸上皮バリア / outer membrane vesicle / オクルディン / ZO-1 / 血液脳関門 / 感染非依存の免疫活性化 … More / Sｐｚ5 / 自然免疫 / ショウジョウバエ / Toll / Spz5 … More Except Principal Investigator IFN-beta / グリオーシス制御 / インターフェロン-beta / アストロサイト / インターフェロン-beta / トル様受容体3 / インターフェロンーbeta / Toll様受容体3 / ミクログリア / カテプシンH / グリオーシス Less

歯周病菌OMVによる腸バリア破綻を介したアルツハイマー病発症機構の解析Principal Investigator
- Principal Investigator
  
  野中さおり
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Yasuda Women's University
OMVに着目した脳バリア破綻とアルツハイマー病におけるジンジパイン仮説の検証Principal Investigator
- Principal Investigator
  
  野中さおり
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Yasuda Women's University
Regulatory mechanisms of the gliosis through TLR3/IFN-b signaling mediated by microglia
- Principal Investigator
  
  Nakanishi Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Yasuda Women's University
Infection-independent immunity mediated by a novel endogenious Toll ligand Spz5Principal Investigator
- Principal Investigator
  
  Nonaka Saori
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Yasuda Women's University

All 2024 2023 2022 2021 2018

All Journal Article Presentation

[Journal Article] Gingipain-carrying outer membrane vesicles from Porphyromonas gingivalis cause barrier dysfunction of Caco-2?cells by releasing gingipain into the cytosol2024
- Author(s)
  Nonaka Saori、Okamoto Rin、Katsuta Yui、Kanetsuki Shiori、Nakanishi Hiroshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 707 Pages: 149783-149783
- DOI
  10.1016/j.bbrc.2024.149783
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06383
[Journal Article] Human β-Defensin 3 Inhibition of P. gingivalis LPS-Induced IL-1β Production by BV-2 Microglia through Suppression of Cathepsins B and L2024
- Author(s)
  Inoue E, Minatozaki S, Shimizu S, Miyamoto S, Jo M, Ni J, Tozaki-Saitoh H, Oda K, Nonaka S, Nakanishi H
- Journal Title
  
  Cells
  
  Volume: 13 Issue: 3 Pages: 283-283
- DOI
  10.3390/cells13030283
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07353, KAKENHI-PROJECT-21K06383
[Journal Article] Secreted gingipains from Porphyromonas gingivalis induce increased permeability of human cerebral microvascular endotherial cells through intracellular degradation of tight junction proteins.2022
- Author(s)
  Nonaka S, Kadowaki T, Nakanishi H.
- Journal Title
  
  Neurochemistry International
  
  Volume: 154 Pages: 105282-105282
- DOI
  10.1016/j.neuint.2022.105282
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06383, KAKENHI-PROJECT-22K15287
[Journal Article] ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway2022
- Author(s)
  Hatori Yuta、Kanda Yukina、Nonaka Saori、Nakanishi Hiroshi、Kitazawa Takeo
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 11 Pages: e0276823-e0276823
- DOI
  10.1371/journal.pone.0276823
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06090, KAKENHI-PROJECT-21K06383
[Journal Article] Human β-Defensin 3 Inhibits Porphyromonas Gingivalis Lipopolysaccharide-Induced Oxidative and Inflammatory Responses of Microglia by Suppression of Cathepsins B and L2022
- Author(s)
  Inoue Erika、Minatozaki Shiyo、Katsuta Yui、Nonaka Saori、Nakanishi Hiroshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 23 Pages: 15099-15099
- DOI
  10.3390/ijms232315099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06383
[Journal Article] Microglial circadian clock regulation of microglial structural complexity, dendritic spine density and inflammatory response.2021
- Author(s)
  Nakanishi H., Ni J., Nonaka S., Hayashi Y.
- Journal Title
  
  Neurochemistry International
  
  Volume: 142 Pages: 104905-104905
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06383
[Journal Article] Stem cells from human exfoliated deciduous teeth attenuate mechanical allodynia in mice through distinct from the siglec-9/MCP-1-mediated tissue-repairing mechanism2021
- Author(s)
  Hayashi Yoshinori、Kato Hiroki、Nonaka Kazuaki、Nakanishi Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 20053-20053
- DOI
  10.1038/s41598-021-99585-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09896, KAKENHI-PROJECT-21K06383
[Journal Article] Characterization of Spz5 as a novel ligand for Drosophila Toll-1 receptor2018
- Author(s)
  Saori Nonaka, Koichiro Kawamura, Aki Hori, Emil Salim, Kazuki Fukushima, Yoshinobu Nakanishi, and Takayuki Kuraishi
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 506 Issue: 3 Pages: 510-515
- DOI
  10.1016/j.bbrc.2018.10.096
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15181, KAKENHI-PROJECT-16H04762
[Presentation] 主要な歯周病菌「ジンジバリス菌」が分泌する外膜ベシクル（OMV）による脳ならびに腸バリア機能の破綻メカニズムの解明2024
- Author(s)
  野中さおり, 中西博
- Organizer
  第144回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K15287
[Presentation] Gingipains from Porphyromonas gingivalis cause leaky brain and leaky gut through intracellular degradation of tight junction proteins.2023
- Author(s)
  Saori Nonaka, Shiho Tochigi, Rin Okamoto, Hiroshi Nakanishi.
- Organizer
  11th IBRO World Congress of Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15287
[Presentation] ジンジバリス菌由来リポ多糖類（LPS）刺激によるミクログリアにおけるIL-1beta産生に対するbeta-ディフェンシン3の抑制メカニズムの解析2023
- Author(s)
  井上瑛里加、湊崎紫陽、小田康祐、野中さおり、中西博
- Organizer
  第144回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-21K06383
[Presentation] ジンジバリス菌リポ多糖類（LPS）ならびに外膜ベシクル（OMV）によるミクログリアにおけるIL-1beta産生経路の解明2023
- Author(s)
  宮本彩也華、井上瑛里加、清水咲至、城美紗桃、湊崎紫陽、齋藤秀俊、小田康祐、野中さおり、中西博
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K06383
[Presentation] beta-ディフェンシン3のジンジバリス菌リポ多糖類ならびに外膜ベシクルによるミクログリアにおけるIL-1bbeta産生に及ぼす作用の解析2023
- Author(s)
  清水咲至、井上瑛里加、宮本彩也華、城美紗桃、湊崎紫陽、齋藤秀俊、野中さおり、小田康祐、中西博
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K06383
[Presentation] 主要な歯周病菌「ジンジバリス菌」が分泌する外膜ベシクル（OMV）による脳ならびに腸バリア機能の破綻メカニズムの解明2023
- Author(s)
  野中さおり、中西博
- Organizer
  第144回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-21K06383
[Presentation] Gingipains from P. gingivalis destroy blood-brain barrier and intestinal barrier through intracellular degradation of tight junction proteins2023
- Author(s)
  Nonaka S, Tochigi S, Okamoto R, Nakanishi H.
- Organizer
  11th IBRO World Congress of Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06383
[Presentation] ジンジバリス菌が分泌する外膜小胞による腸上皮バリア破綻機構2023
- Author(s)
  野中さおり、岡本凜、勝田結衣、金築志織、中西博
- Organizer
  第９６回日本生化学会
- Data Source
  KAKENHI-PROJECT-21K06383
[Presentation] ヒト beta-ディフェンシン-３の歯周病菌LPSにより誘発されるミクログリアの酸化ストレス・炎症反応に対する抑制メカニズム2022
- Author(s)
  井上瑛里加、湊崎紫陽、野中さおり、中西博
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K06383
[Presentation] ヒト beta-ディフェンシン-３の歯周病菌LPSにより誘発されるミクログリアの酸化ストレスならびに炎症反応に対する抑制作用2022
- Author(s)
  崎紫陽、井上瑛里加、野中さおり、中西博
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K06383
[Presentation] 歯周病菌LPSによりミクログリアにおいて産生・分泌されるサイトカイン類の網羅的解析2022
- Author(s)
  大森朱莉、大本凜、野中さおり、中西博
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K06383
[Presentation] 歯周病菌が分泌するジンジパインによる脳バリア破綻機構2022
- Author(s)
  野中さおり
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K15287

1. Nakanishi Hiroshi (20155774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
2. SAITOH Hidetoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 羽鳥勇太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 林良憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nonaka Saori 野中 さおり

Research Projects

Research Products

Co-Researchers

歯周病菌OMVによる腸バリア破綻を介したアルツハイマー病発症機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

OMVに着目した脳バリア破綻とアルツハイマー病におけるジンジパイン仮説の検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanisms of the gliosis through TLR3/IFN-b signaling mediated by microglia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Infection-independent immunity mediated by a novel endogenious Toll ligand Spz5Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Gingipain-carrying outer membrane vesicles from Porphyromonas gingivalis cause barrier dysfunction of Caco-2?cells by releasing gingipain into the cytosol2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human β-Defensin 3 Inhibition of P. gingivalis LPS-Induced IL-1β Production by BV-2 Microglia through Suppression of Cathepsins B and L2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Secreted gingipains from Porphyromonas gingivalis induce increased permeability of human cerebral microvascular endotherial cells through intracellular degradation of tight junction proteins.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human β-Defensin 3 Inhibits Porphyromonas Gingivalis Lipopolysaccharide-Induced Oxidative and Inflammatory Responses of Microglia by Suppression of Cathepsins B and L2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microglial circadian clock regulation of microglial structural complexity, dendritic spine density and inflammatory response.2021

Author(s)

Journal Title

Data Source

[Journal Article] Stem cells from human exfoliated deciduous teeth attenuate mechanical allodynia in mice through distinct from the siglec-9/MCP-1-mediated tissue-repairing mechanism2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of Spz5 as a novel ligand for Drosophila Toll-1 receptor2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] 主要な歯周病菌「ジンジバリス菌」が分泌する外膜ベシクル（OMV）による脳ならびに腸バリア機能の破綻メカニズムの解明2024

Author(s)

Organizer

Data Source

[Presentation] Gingipains from Porphyromonas gingivalis cause leaky brain and leaky gut through intracellular degradation of tight junction proteins.2023

Author(s)

Organizer

Data Source

[Presentation] ジンジバリス菌由来リポ多糖類（LPS）刺激によるミクログリアにおけるIL-1beta産生に対するbeta-ディフェンシン3の抑制メカニズムの解析2023

Author(s)

Organizer

Data Source

[Presentation] ジンジバリス菌リポ多糖類（LPS）ならびに外膜ベシクル（OMV）によるミクログリアにおけるIL-1beta産生経路の解明2023

Nonaka Saori 野中さおり