Chinen Takumi 知念拓実

Researcher Number	40775607
Other IDs
Affiliation (Current)	2026: 東京大学, 大学院薬学系研究科(薬学部), 助教
Affiliation (based on the past Project Information) *help	2026: 東京大学, 大学院薬学系研究科(薬学部), 助教 2019 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 助教 2018: 東京大学, 大学院薬学系研究科(薬学部), 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 44010:Cell biology-related Except Principal Investigator Broad Section H
Keywords	Principal Investigator 分裂期紡錘体 / NuMA / 染色体数 / 紡錘体形状変化 / 分裂期紡錘体プロテオミクス / CRISPR/Cas9ゲノムワイド解析 / 染色体異数性 / 分裂期の脆弱性 / DepMap / 急性骨髄性白血病 … More / 急性リンパ性白血病 / 細胞分裂 / 血球細胞 / 中心体数増加 / 中心体数 / CRISPR/Cas9ゲノムワイドスクリーニング / CEP76 / PLK1 / 紡錘体二極性 / 中心体数増減 / 中心体 … More Except Principal Investigator 抗ガン剤開発 / 紡錘体 / 抗がん薬開発 / 抗がん剤開発 / 染色体分配 / 分裂期紡錘体 / 中心小体間結合 / 小頭症 / 中心小体 / 中心体 / 細胞分裂 Less

分裂期を標的とする相分離誘導薬の創製Principal Investigator
- Principal Investigator
  
  知念拓実
- Project Period (FY)
  2026 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  The University of Tokyo
Elucidation of the mechanism of adaptation of spindle shape according to chromosome numberPrincipal Investigator
- Principal Investigator
  
  知念拓実
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  The University of Tokyo
Understanding the specific mitotic machinery of blood cellsPrincipal Investigator
- Principal Investigator
  
  Chinen Takumi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  The University of Tokyo
Comprehensive analysis of molecular machineries for mitotic spindle formation in human cells and its application to development of next generation anti-cancer drug.
- Principal Investigator
  
  KITAGAWA Daiju
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section H
- Research Institution
  The University of Tokyo
Understanding of molecular machineries that ensure mitotic spindle bipolarity in human cells independently of centrosome numberPrincipal Investigator
- Principal Investigator
  
  Chinen Takumi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  The University of Tokyo

All 2025 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Multimodal mechanisms of human centriole engagement and disengagement2025
- Author(s)
  Ito Kei K、Takumi Kasuga、Matsuhashi Kyohei、Sakamoto Hirokazu、Nagai Kaho、Fukuyama Masamitsu、Yamamoto Shohei、Chinen Takumi、Hata Shoji、Kitagawa Daiju
- Journal Title
  
  The EMBO Journal
  
  Volume: 44 Issue: 5 Pages: 1294-1321
- DOI
  10.1038/s44318-024-00350-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H05651, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K23892, KAKENHI-PROJECT-22K19305, KAKENHI-PROJECT-23KJ0800
[Journal Article] A Method for Analyzing Acentrosomal Mitotic Spindles in Human Cells2024
- Author(s)
  Okuda Shotaro、Chinen Takumi、Kitagawa Daiju
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2872 Pages: 221-231
- DOI
  10.1007/978-1-0716-4224-5_15
- ISBN
  9781071642238, 9781071642245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05651
[Journal Article] A CRISPR-del-based pipeline for complete gene knockout in human diploid cells2023
- Author(s)
  Takuma Komori, Shoji Hata, Akira Mabuchi, Mariya Genova, Tomoki Harada , Masamitsu Fukuyama , Takumi Chinen , Daiju Kitagawa
- Journal Title
  
  J Cell Sci (2023) 136 (6): jcs260000.
  
  Volume: 136 Issue: 6 Pages: 136-136
- DOI
  10.1242/jcs.260000
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KJ1178, KAKENHI-PROJECT-22K19305, KAKENHI-PROJECT-23KJ0810, KAKENHI-PROJECT-19H05651, KAKENHI-PROJECT-23K23892
[Journal Article] Stress-dependent cell stiffening by tardigrade tolerance proteins that reversibly form a filamentous network and gel2022
- Author(s)
  Tanaka Akihiro、Nakano Tomomi、Watanabe Kento、Masuda Kazutoshi、Honda Gen、Kamata Shuichi、Yasui Reitaro、Kozuka-Hata Hiroko、Watanabe Chiho、Chinen Takumi、Kitagawa Daiju、Sawai Satoshi、Oyama Masaaki、Yanagisawa Miho、Kunieda Takekazu
- Journal Title
  
  PLOS Biology
  
  Volume: 20 Issue: 9 Pages: 3001780-3001780
- DOI
  10.1371/journal.pbio.3001780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20580, KAKENHI-PLANNED-21H05279, KAKENHI-PLANNED-21H05280, KAKENHI-PROJECT-21J11385, KAKENHI-PROJECT-19H05651, KAKENHI-ORGANIZER-19H05794, KAKENHI-PROJECT-20H04332, KAKENHI-PROJECT-23K22459
[Journal Article] CRISPRスクリーニングデータベースを活用した創薬標的探索2022
- Author(s)
  新倉竜太、知念拓実
- Journal Title
  
  Seibutsu-kogaku Kaishi
  
  Volume: 100 Issue: 8 Pages: 449-449
- DOI
  10.34565/seibutsukogaku.100.8_449
- ISSN
  0919-3758, 2435-8630
- Year and Date
  2022-08-25
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-19H05651
[Journal Article] CEP76 regulates mitotic PLK1 and ensures proper mitotic progression2022
- Author(s)
  竹田穣、知念拓実、北川大樹
- Journal Title
  
  生化学
  
  Volume: 94 Issue: 3 Pages: 419-422
- DOI
  10.14952/SEIKAGAKU.2022.940419
- ISSN
  0037-1017
- Year and Date
  2022-06-25
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-19H05651
[Journal Article] Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.2021
- Author(s)
  Takumi Chinen, Kaho Yamazaki, Kaho Hashimoto, Ken Fujii, Koki Watanabe, Yutaka Takeda, Shohei Yamamoto, Yuka Nozaki, Yuki Tsuchiya, Daisuke Takao and Daiju Kitagawa
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 220 Issue: 2
- DOI
  10.1083/jcb.202006085
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23718, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19H05651
[Journal Article] Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle.2021
- Author(s)
  Kei Ito, Koki Watanabe, Haruki Ishida, Kyohei Matsuhashi, Takumi Chinen, Shoji Hata and Daiju Kitagawa
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 220 Issue: 3
- DOI
  10.1083/jcb.202005153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23718, KAKENHI-PROJECT-19H05651
[Journal Article] Mechanisms of spindle bipolarity establishment in acentrosomal human cells.2020
- Author(s)
  Kaho Hashimoto, Takumi Chinen and Daiju Kitagawa
- Journal Title
  
  Molecular and Cellular Oncology
  
  Volume: 7 Issue: 3 Pages: 1743899-1743899
- DOI
  10.1080/23723556.2020.1743899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05651
[Journal Article] Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes2020
- Author(s)
  Yutaka Takeda, Kanako Kuroki, Takumi Chinen and Daiju Kitagawa
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 45 Issue: 1 Pages: 57-64
- DOI
  10.1247/csf.20007
- NAID
  130007845714
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05651
[Journal Article] The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression2020
- Author(s)
  Yutaka Takeda, Kaho Yamazaki, Kaho Hashimoto, Koki Watanabe, Takumi Chinen, Daiju Kitagawa
- Journal Title
  
  Journal of Cell Science
  
  Volume: 133
- DOI
  10.1242/jcs.241281
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19H05651
[Journal Article] NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells.2020
- Author(s)
  Takumi Chinen, Shohei Yamamoto, Yutaka Takeda, Koki Watanabe, Kanako Kuroki, Kaho Hashimoto, Daisuke Takao and Daiju Kitagawa
- Journal Title
  
  EMBO journal
  
  Volume: 39 Issue: 2
- DOI
  10.15252/embj.2019102378
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H05651, KAKENHI-PROJECT-18K14705
[Journal Article] 分裂期紡錘体形成を阻害する抗がん薬開発の動向2019
- Author(s)
  竹田穣, 知念拓実, 北川大樹
- Journal Title
  
  ファルマシア
  
  Volume: 55 Pages: 954-958
- NAID
  130007722320
- Data Source
  KAKENHI-PROJECT-19H05651
[Journal Article] Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae2019
- Author(s)
  Sakai, K., Unten, Y., Iwatsuki, M., Matsuo, H., Fukasawa, W., Hirose, T., Chinen, T., Nonaka, K., Nakashima, T., Sunazuka, T., Usui, T., Murai, M., Miyoshi, H., Asami, Y., Omura, S., and Shiomi, K.
- Journal Title
  
  Journal of Antibiotics
  
  Volume: 72 Issue: 9 Pages: 645-652
- DOI
  10.1038/s41429-019-0197-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05458, KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-18K14705
[Journal Article] Pyrenocine A induces monopolar spindle formation and suppresses proliferation of cancer cells2019
- Author(s)
  Myobatake Yusuke、Kamisuki Shinji、Tsukuda Senko、Higashi Tsunehito、Chinen Takumi、Takemoto Kenji、Hachisuka Masami、Suzuki Yuka、Takei Maya、Tsurukawa Yukine、Maekawa Hiroaki、Takeuchi Toshifumi、Matsunaga Tomoko M.、Sahara Hiroeki、Usui Takeo、Matsunaga Sachihiro、Sugawara Fumio
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 23 Pages: 115149-115149
- DOI
  10.1016/j.bmc.2019.115149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-18K11654, KAKENHI-PROJECT-19K05726, KAKENHI-ORGANIZER-15H05955, KAKENHI-PLANNED-15H05962, KAKENHI-PROJECT-19H03259, KAKENHI-PROJECT-18K14705
[Journal Article] Structure-activity relationship study of gatastatin based on the Topliss tree approach2019
- Author(s)
  Hayakawa Ichiro、Shida Shuya、Chinen Takumi、Usui Takeo、Kigoshi Hideo
- Journal Title
  
  Heterocycles
  
  Volume: 99 Issue: 1 Pages: 238-238
- DOI
  10.3987/com-18-s(f)16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01949, KAKENHI-PROJECT-16K07710, KAKENHI-PUBLICLY-18H04606, KAKENHI-PROJECT-18K14705
[Presentation] Centriole microtubule assembly by a ciliopathy protein2023
- Author(s)
  Yutaka Takeda, Takumi Chinen, Shunnosuke Honda, Sho Takatori, Taisuke Tomita, Shoji Hata, Daiju Kitagawa
- Organizer
  Cold Spring Harbor Asia, CILIA & CENTROSOMES Awaji
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05651
[Presentation] マイクロウェルを用いた白血病細胞株の長期シングルセルイメージング法の確立(Long-term single-cell imaging of leukemia cell lines using microwells)2023
- Author(s)
  新倉竜太, 山本昌平, 知念拓実, 鈴木宏明, 北川大樹
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19H05651
[Presentation] ヒト細胞において中心体性の極と非中心体性の極を統合し,二極紡錘体を形成するメカニズム2022
- Author(s)
  深作明日香,知念拓実,山﨑香穂,北川大樹
- Organizer
  第21回次世代を担う若手のためのファーマ・バイオフォーラム 2022
- Data Source
  KAKENHI-PROJECT-19H05651
[Presentation] 中心体構成因子 CEP76 はがん化関連キナーゼ PLK1 の過剰な活性化を抑制し,適切な分裂期進行を保証する2021
- Author(s)
  竹田穣, 山崎香穂, 橋本佳歩, 渡辺紘己, 知念拓実, 北川大樹
- Organizer
  日本薬学会第 141 年会
- Data Source
  KAKENHI-PROJECT-19H05651
[Presentation] 分裂期における中心体構成因子CEP76を介したPLK1の制御2020
- Author(s)
  竹田穣、山崎香穂、橋本佳歩、渡辺紘己、知念拓実、北川大樹
- Organizer
  第140回日本薬学会大会
- Data Source
  KAKENHI-PROJECT-18K14705
[Presentation] 中心体構成因子による細胞分裂期のPLK1凝集抑制2019
- Author(s)
  竹田穣、知念拓実、北川大樹
- Organizer
  第92回日本生化学大会
- Data Source
  KAKENHI-PROJECT-18K14705
[Presentation] 中心体構成因子による細胞分裂期の PLK1 凝集抑制2019
- Author(s)
  竹田穣, 知念拓実, 北川大樹
- Organizer
  第 92 回日本生化学大会
- Data Source
  KAKENHI-PROJECT-19H05651
[Presentation] NuMAを含むタンパク質複合体は非中心体性紡錘体の二極性形成を促進する2019
- Author(s)
  知念拓実, 山本昌平, 竹田穣, 渡辺紘己, 高尾大輔, 北川大樹
- Organizer
  第92回日本生化学大会
- Data Source
  KAKENHI-PROJECT-19H05651
[Presentation] ゲノムワイドCRISPRスクリーニングによる一次繊毛解体・細胞周期再エントリー制御因子の同定2019
- Author(s)
  黒木花菜子、高尾大輔、知念拓実、豊田敦、寺井悟朗、岩切淳一、浅井潔、北川大樹
- Organizer
  第92回日本生化学大会
- Data Source
  KAKENHI-PROJECT-18K14705
[Presentation] NuMAを含むタンパク質複合体は非中心体性紡錘体の二極性形成を促進する2019
- Author(s)
  知念拓実、山本昌平、竹田穣、渡辺紘己、高尾大輔、北川大樹
- Organizer
  第92回日本生化学大会
- Data Source
  KAKENHI-PROJECT-18K14705

1. KITAGAWA Daiju (80605725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. 高尾大輔 (10548811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. MURAI Masatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. KAMISUKI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 國枝武和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 渡辺紘己

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 早川一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Chinen Takumi 知念 拓実

Research Projects

Research Products

Co-Researchers

分裂期を標的とする相分離誘導薬の創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of adaptation of spindle shape according to chromosome numberPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the specific mitotic machinery of blood cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of molecular machineries for mitotic spindle formation in human cells and its application to development of next generation anti-cancer drug.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of molecular machineries that ensure mitotic spindle bipolarity in human cells independently of centrosome numberPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Multimodal mechanisms of human centriole engagement and disengagement2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Method for Analyzing Acentrosomal Mitotic Spindles in Human Cells2024

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] A CRISPR-del-based pipeline for complete gene knockout in human diploid cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stress-dependent cell stiffening by tardigrade tolerance proteins that reversibly form a filamentous network and gel2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPRスクリーニングデータベースを活用した創薬標的探索2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] CEP76 regulates mitotic PLK1 and ensures proper mitotic progression2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle.2021

Author(s)

Journal Title

DOI

Chinen Takumi 知念拓実

[Presentation] ヒト細胞において中心体性の極と非中心体性の極を統合し,二極紡錘体を形成するメカニズム2022