Taira Chiaki 平千明

Researcher Number	40779310
Other IDs
Affiliation (Current)	2025: 信州大学, 学術研究院保健学系, 助教
Affiliation (based on the past Project Information) *help	2017 – 2022: 信州大学, 学術研究院保健学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related Except Principal Investigator Basic Section 52010:General internal medicine-related / Laboratory medicine
Keywords	Principal Investigator SNP / 頭痛 / SNP genotyping / 緊張型頭痛 / 片頭痛 / LF/HF比 / 心拍変動解析 / PHACTR1 / ASTN2 Except Principal Investigator フィブリノゲン … More / NETs / 形質転換能 / 遊走能 / 皮膚線維芽細胞 / 血管内皮細胞 / フィブリン / THP-1 / M1-マクロファージ / NETｓ形成能 / 好中球 / NETs形成能 / 内皮間葉転換能 / 細胞遊走能 / アミロイドβ1-42 / M1-Mφ分化 / 管状構造形成能 / 異常フィブリノゲン / 臨床検査 / 遺伝子変異 / 蛋白質機能異常 / 血液凝固 / IgA-λ型Ｍタンパク / 出血 / 血栓症 / フィブリノゲン機能異常症 / トロンビン / B:b結合 / A:a結合 / D:D結合能部位 / Ca結合部位 / aホール / フィブリン重合反応 Less

Evaluation for extra-cellular function of dysfunctional fibrinogen and identification of its important residues
- Principal Investigator
  
  Okumura Nobuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University
Verification of novel methods to identify migraines using genetic polymorphism analysis and spectral analysis of heart rate variabilityPrincipal Investigator
- Principal Investigator
  
  Taira Chiaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University
Mechanisms of fibrin polymerization based on analysis for dysfunctional fibrinogen variants
- Principal Investigator
  
  Okumura Nobuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Shinshu University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Laboratory diagnosis of fibrinogen disorder using clot waveform analysis2023
- Author(s)
  新井慎平、奥村伸生
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 34 Issue: 1 Pages: 22-28
- DOI
  10.2491/jjsth.34.22
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] フィブリノゲンの偽低値　IgA M蛋白血症2022
- Author(s)
  新井慎平
- Journal Title
  
  臨床検査
  
  Volume: 66 Pages: 1236-1239
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] 28年間で解析した長野県内のフィブリノゲン異常症18家系28例2021
- Author(s)
  上條途夢，海藤貴大, 依田将宏, 平千明,　樋口由美子，新井慎平,　竹澤由夏，奥村伸生．
- Journal Title
  
  長臨技会誌
  
  Volume: 10 Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] Novel variant fibrinogen γ p.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment2021
- Author(s)
  Yoda M, Kaido T, Kamijo T, Taira C, Higuchi Y, Arai S, Okumura N.
- Journal Title
  
  Int J Hematology
  
  Volume: 114 Issue: 3 Pages: 325-333
- DOI
  10.1007/s12185-021-03174-y
- NAID
  120007180888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799, KAKENHI-PROJECT-21K15945
[Journal Article] The heterozygous variant fibrinogen, γA289V (Kanazawa III), was confirmed as hypodysfibrinogenemia by plasma and recombinant fibrinogens2020
- Author(s)
  Kaido T, Yoda M, KamijoT, Taira C, Higuchi Y, Okumura N.
- Journal Title
  
  Int J Lab Hematol
  
  Volume: 42 Issue: 2 Pages: 190-197
- DOI
  10.1111/ijlh.13152
- NAID
  120007099524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] Congenital fibrinogen disorder with a compound heterozygote possessing two novel FGB mutations, one qualitative and the other quantitative2020
- Author(s)
  Yoda M, Kaido T, Taira C, Higuchi Y, Arai S, Okumura N.
- Journal Title
  
  Thromb Res
  
  Volume: 196 Pages: 152-158
- DOI
  10.1016/j.thromres.2020.08.031
- NAID
  120007180892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] A novel amino acid substitution, fibrinogen Bβp.Pro234Leu, associated with hypofibrinogenemia causing impairment of fibrinogen assembly and secretion2020
- Author(s)
  Kaido T, Yoda M, Kamijo T, Arai S, Taira C, Higuchi Y, Okumura N.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 24 Pages: 9422-9422
- DOI
  10.3390/ijms21249422
- NAID
  120007180887
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] γD318Y fibrinogen shows no fibrin polymerization due to defective “A-a” and “B-b” interactions, whereas that of γK321E fibrinogen is nearly normal2019
- Author(s)
  KamijoT, Mukai S, Taira C, Higuchi Y, Okumura N.
- Journal Title
  
  Thromb Res
  
  Volume: 182 Pages: 150-158
- DOI
  10.1016/j.thromres.2019.08.017
- NAID
  120007180893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] フィブリノゲン蓄積病を呈する異常フィブリノゲン産生細胞の線維状封入体形成と小胞体ストレス応答2018
- Author(s)
  上條途夢，大久保奈緒，平千明，樋口由美子，新井慎平，奥村伸生
- Journal Title
  
  臨床病理
  
  Volume: 66 Pages: 1058-1064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] DVTを発症した先天性フィブリノゲン異常症患者Fibrinogen Matsumoto I のFDP-E分画異常高値の精査2018
- Author(s)
  新井慎平，中越りつこ，倉田淳一，川崎健治，菅野光俊，上原剛，本田孝行，奥村伸生
- Journal Title
  
  検査血液
  
  Volume: 19 Pages: 306-313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] Fibrin monomers derived from thrombogenic dysfibrinogenemia, Naples-type variant (BβAla68Thr), showed almost entirely normal polymerization2018
- Author(s)
  Kamijo T, Nagata K, Taira C, Higuchi Y, Arai S, Okumura N.
- Journal Title
  
  Thromb Res
  
  Volume: 172 Pages: 1-3
- DOI
  10.1016/j.thromres.2018.10.004
- NAID
  120007099533
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] ファクターオートフィブリノーゲンの基礎的性能評価とフィブリノーゲン異常症例における測定値の検討2018
- Author(s)
  永田和宏，新井慎平，向井早紀，竹澤由夏，菅野光俊，本田孝行，奥村伸生．
- Journal Title
  
  医学検査
  
  Volume: 67 Pages: 7-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] A novel frameshift mutation in the fibrinogen γC terminal region, FGG c.1169_1170 del AT, leading to hypofibrinogenemia2017
- Author(s)
  Nagata K, Arai S, Taira C, Sugano M, Honda T, Okumura N.
- Journal Title
  
  Thromb Res
  
  Volume: 159 Pages: 82-85
- DOI
  10.1016/j.thromres.2017.10.002
- NAID
  120007099532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] A novel mutation in the fibrinogen Bβ chain (c.490G>A; End of Exon 3) causes a splicing abnormality and ultimately leads to congenital hypofibrinogenemia2017
- Author(s)
  Taira C, Matsuda K, Arai S, Sugano M, Uehara T, Okumura N.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 18 Issue: 11 Pages: 2470-2470
- DOI
  10.3390/ijms18112470
- NAID
  120007099522
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 先天性フィブリノゲン異常症の変異フィブリノゲンとアミロイドβの結合性の検討2021
- Author(s)
  新井慎平、上條途夢、海藤貴大
- Organizer
  第68回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] フィブリノゲンにおけるアミノ酸変異BβP204Lとフィブリノゲン低下症の関係2021
- Author(s)
  海藤貴大，上條途夢，平　千明，山内一由，奥村伸生
- Organizer
  第61回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] Verification of novel methods to identify migraines using genetic polymorphism analysis and spectral analysis of heart rate variability2021
- Author(s)
  Chiaki Taira
- Organizer
  IFBLS 34rd World Congress of Biomedical Laboratory Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15413
[Presentation] γG287～G292領域のアミノ酸置換（特にγA289V　KanazawaIII）によるフィブリノゲン合成と分泌に対する影響する2019
- Author(s)
  海藤貴大，依田将大，上條途夢，平　千明，奥村伸生
- Organizer
  第59回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] FGG c.112+62_65 del AATAとFGG c.1299+4 del Aのコンパウンドヘテロ型フィブリノゲン異常症Tsukuba Iの解析2019
- Author(s)
  向井早紀，新井慎平，竹澤由夏，菅野光俊，本田孝行，奥村伸生
- Organizer
  第20回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] SNPと心拍変動を組み合わせた頭痛鑑別システムの構築と検証2019
- Author(s)
  平　千明, 花輪みさき, 千田実穂, 矢﨑正英
- Organizer
  第66回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15413
[Presentation] PT-derived法と凝固反応曲線変化量dHによるフィブリノゲン異常症検出法の検討2019
- Author(s)
  新井慎平，上條途夢，篠原　翔，新井信夫，菅野光俊，柳沢　龍，上原　剛，本田孝行，奥村伸生
- Organizer
  第20回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 変異型フィブリノゲンBβ44Arg->Cysがフィブリノゲン重合反応に与える影響の検討2019
- Author(s)
  海藤貴大，依田将大，上條途夢，平　千明，樋口由美子，新井慎平，竹澤由夏，奥村伸生
- Organizer
  第44回長野県臨床検査学会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 無フィブリノゲン血症を疑い遺伝子検査を実施した重度DIC患者の1例2019
- Author(s)
  依田将大，海藤貴大，上條途夢，平　千明，塚田唯子，奥村伸生
- Organizer
  第66回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] フィブリンに全く転換できないリコンビナントフィブリノゲンγD318Yの機能解析2019
- Author(s)
  上條途夢，依田将大，海藤貴大，平　千明，奥村伸生
- Organizer
  第66回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 27年間で認められた長野県内のフィブリノゲン異常症17家系27症例の解析2019
- Author(s)
  上條途夢，海藤貴大，依田将大，平　千明，樋口由美子，新井慎平，竹澤由夏，奥村伸生
- Organizer
  第44回長野県臨床検査学会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] Residues　in　the　fibrinogen　γD-module　are　essential　for　fibrinogen　secretion　and　fibrin　polymerization using hole ‘a’ or hole ‘b’.2019
- Author(s)
  Kamijo T, Mukai S, Taira C, Higuchi Y, Okumura N
- Organizer
  The 57th Congress of the Korean Association of Medical Technologists and International Conference
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] フィブリノゲン蓄積病を呈するフィブリノゲン低下症型フィブリノゲン産生細胞の小胞体ストレスの研究2018
- Author(s)
  上條途夢，大久保奈緒，平　千明，奥村伸生
- Organizer
  第58回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 血栓形成性異常フィブリノゲン(Shizuoka)のトロンビンによる凝固関連機能の解析2018
- Author(s)
  上條途夢，平　千明，樋口由美子，新井慎平，奥村伸生
- Organizer
  第65回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] FGA1238bp欠失を有する無フィブリノゲン血症2例のハプロタイプ解析2018
- Author(s)
  平　千明，上條途夢，菅野光俊，奥村伸生
- Organizer
  第58回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 自動分析装置による測定でフィブリノゲン活性値の偽低値と異常凝固波形を示したIgA Mタンパク症例の解析2018
- Author(s)
  新井慎平，上條途夢，竹澤由夏，川崎健治，菅野光俊，本田孝行，奥村伸生
- Organizer
  第65回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 新規遺伝子変異を有する先天性フィブリノゲン低下症の分子生物学的解析2017
- Author(s)
  平　千明，菅野光俊，奥村伸生
- Organizer
  第57回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] Analysis of acquired dysfibrinogenemia caused by IgA monoclonal gammopathy with anaphylactoid purpura2017
- Author(s)
  Arai S, Takezawa Y, Mukai S, Nakagoshi R, Miyazaki A, Ishimine N, Kawasaki K, Taira C, Sugano M, Honda T, Okumura N
- Organizer
  29 th World Congress of World Association of Societies of Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09009

1. Okumura Nobuo (60252110)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
2. 樋口由美子 (40757241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 新井慎平 (70866053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

Taira Chiaki 平 千明

Research Projects

Research Products

Co-Researchers

Evaluation for extra-cellular function of dysfunctional fibrinogen and identification of its important residues

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Verification of novel methods to identify migraines using genetic polymorphism analysis and spectral analysis of heart rate variabilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of fibrin polymerization based on analysis for dysfunctional fibrinogen variants

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Laboratory diagnosis of fibrinogen disorder using clot waveform analysis2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] フィブリノゲンの偽低値 IgA M蛋白血症2022

Author(s)

Journal Title

Data Source

[Journal Article] 28年間で解析した長野県内のフィブリノゲン異常症18家系28例2021

Author(s)

Journal Title

Data Source

[Journal Article] Novel variant fibrinogen γ p.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] The heterozygous variant fibrinogen, γA289V (Kanazawa III), was confirmed as hypodysfibrinogenemia by plasma and recombinant fibrinogens2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Congenital fibrinogen disorder with a compound heterozygote possessing two novel FGB mutations, one qualitative and the other quantitative2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A novel amino acid substitution, fibrinogen Bβp.Pro234Leu, associated with hypofibrinogenemia causing impairment of fibrinogen assembly and secretion2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] γD318Y fibrinogen shows no fibrin polymerization due to defective “A-a” and “B-b” interactions, whereas that of γK321E fibrinogen is nearly normal2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] フィブリノゲン蓄積病を呈する異常フィブリノゲン産生細胞の線維状封入体形成と小胞体ストレス応答2018

Author(s)

Journal Title

Data Source

[Journal Article] DVTを発症した先天性フィブリノゲン異常症患者Fibrinogen Matsumoto I のFDP-E分画異常高値の精査2018

Author(s)

Journal Title

Data Source

[Journal Article] Fibrin monomers derived from thrombogenic dysfibrinogenemia, Naples-type variant (BβAla68Thr), showed almost entirely normal polymerization2018

Author(s)

Journal Title

DOI

NAID

Taira Chiaki 平千明

[Journal Article] フィブリノゲンの偽低値　IgA M蛋白血症2022

[Presentation] γG287～G292領域のアミノ酸置換（特にγA289V　KanazawaIII）によるフィブリノゲン合成と分泌に対する影響する2019

[Presentation] Residues　in　the　fibrinogen　γD-module　are　essential　for　fibrinogen　secretion　and　fibrin　polymerization using hole ‘a’ or hole ‘b’.2019