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HIGASHIJIMA Yoshiki  東島 佳毅

… Alternative Names

Higashijima Yoshiki  東島 佳毅

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Researcher Number 40780713
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-4489-606X
Affiliation (Current) 2026: 宮崎大学, 研究・産学地域連携推進機構, 准教授
Affiliation (based on the past Project Information) *help 2024 – 2025: 宮崎大学, 研究・産学地域連携推進機構, 准教授
2017 – 2019: 東京医科歯科大学, 難治疾患研究所, 日本学術振興会特別研究員
Review Section/Research Field
Principal Investigator
Basic Section 42020:Veterinary medical science-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Cardiovascular medicine
Keywords
Principal Investigator
エピジェネティクス / 血管新生 / ヒストン修飾 / 血管炎症 / ファシリテーター / エンハンサー / 遺伝子転写 / 発現制御 / ゲノム / 循環器 … More / VCAM-1 / atherosclerosis / SELE / VCAM1 / 接着因子 / miRNA / 動脈硬化 Less
  • Research Projects

    (3 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (5 People)
  •  Development of a novel approach for controlling vascular Inflammation by targeting transcriptional facilitatorsPrincipal Investigator

    • Principal Investigator
      東島 佳毅
    • Project Period (FY)
      2025 – 2026
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 42:Veterinary medical science, animal science, and related fields
    • Research Institution
      University of Miyazaki
  •  Identification of novel epigenomic factors specific to tumor angiogenesisPrincipal Investigator

    • Principal Investigator
      東島 佳毅
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      University of Miyazaki
  •  Identification of novel miRNAs contributing the onset of atherosclerosisPrincipal Investigator

    • Principal Investigator
      Higashijima Yoshiki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Tokyo Medical and Dental University

All 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells2020

    • Author(s)
      Higashijima Y, Matsui Y, Shimamura T, Nakaki R, Nagai N, Tsutsumi S, Abe Y, Link VM, Osaka M, Yoshida M, Watanabe R, Tanaka T, Taguchi A, Miura M, Ruan X, Li G, Inoue T, Nangaku M, Kimura H, Furukawa T, Aburatani H, Wada Y, Ruan Y, Glass CK, Kanki Y
    • Journal Title

      The EMBO Journal

      Volume: 39 Issue: 7 Pages: 1-1

    • DOI

      10.15252/embj.2019103949

    • NAID

      120006902140

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23850, KAKENHI-PUBLICLY-18H04798, KAKENHI-PUBLICLY-18H04899, KAKENHI-PLANNED-18H05527, KAKENHI-PUBLICLY-19H05210, KAKENHI-PLANNED-19H05744, KAKENHI-PROJECT-17H03614, KAKENHI-PROJECT-17J07088, KAKENHI-PROJECT-17K15991, KAKENHI-PROJECT-19K21297, KAKENHI-PROJECT-20K09448, KAKENHI-PROJECT-20K21832, KAKENHI-PROJECT-20K17242, KAKENHI-PUBLICLY-20H04841, KAKENHI-PROJECT-18H02803, KAKENHI-PROJECT-20H04281, KAKENHI-PROJECT-19K22679, KAKENHI-ORGANIZER-19H05739, KAKENHI-PROJECT-18H03207, KAKENHI-PROJECT-20H03432
  • [Journal Article] Lysine demethylase 7a regulates the anterior-posterior development in mouse by modulating the transcription of Hox gene cluster2019

    • Author(s)
      Higashijima Yoshiki、Nagai Nao、Kitazawa Taro、Kawamura Yumiko、Taguchi Akashi、Nakada Natsuko、Nangaku Masaomi、Furukawa Tetsushi、Aburatani Hiroyuki、Kurihara Hiroki、Wada Youichiro、Kanki Yasuharu
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/707125

    • Open Access
    • Data Source
      KAKENHI-PROJECT-17J07088, KAKENHI-PROJECT-17K15991
  • [Journal Article] Molecular mechanistic insights: The emerging role of SOXF transcription factors in tumorigenesis and development2019

    • Author(s)
      Higashijima Yoshiki、Kanki Yasuharu
    • Journal Title

      Seminars in Cancer Biology

      Volume: - Pages: 39-48

    • DOI

      10.1016/j.semcancer.2019.09.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03614, KAKENHI-PROJECT-17J07088, KAKENHI-PROJECT-17K15991
  • [Journal Article] Persistent expression of neutrophil gelatinase-associated lipocalin and M2 macrophage markers and chronic fibrosis after acute kidney injury2018

    • Author(s)
      Saito Hisako、Tanaka Tetsuhiro、Tanaka Shinji、Higashijima Yoshiki、Yamaguchi Junna、Sugahara Mai、Ito Marie、Uchida Lisa、Hasegawa Sho、Wakashima Takeshi、Fukui Kenji、Nangaku Masaomi
    • Journal Title

      Physiological Reports

      Volume: 6 Issue: 10 Pages: e13707-e13707

    • DOI

      10.14814/phy2.13707

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09688, KAKENHI-PROJECT-17K15991, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-18H02824, KAKENHI-PROJECT-17J07088
  • [Journal Article] Sodium glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice2018

    • Author(s)
      Tanaka Shinji、Sugiura Yuki、Saito Hisako、Sugahara Mai、Higashijima Yoshiki、Yamaguchi Junna、Inagi Reiko、Suematsu Makoto、Nangaku Masaomi、Tanaka Tetsuhiro
    • Journal Title

      Kidney International

      Volume: 94 Issue: 5 Pages: 912-925

    • DOI

      10.1016/j.kint.2018.04.025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09688, KAKENHI-PROJECT-17K15991, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-18H02727, KAKENHI-PROJECT-18H02824, KAKENHI-PROJECT-17J07088
  • [Journal Article] Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells2018

    • Author(s)
      Higashijima Y, Matsui Y, Shimamura T, Tsutsumi S, Nakaki R, Abe Y, Link VM, Osaka M, Yoshida M, Watanabe R, Tanaka T, Taguchi A, Miura M, Inoue T, Nangaku M, Kimura H, Furukawa T, Aburatani H, Wada Y, Glass CK, Kanki Y
    • Journal Title

      bioRxiv

      Volume: - Pages: 456491-456491

    • DOI

      10.1101/456491

    • NAID

      120006902140

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15991, KAKENHI-PLANNED-18H05527, KAKENHI-PROJECT-17H03614, KAKENHI-PROJECT-17J07088, KAKENHI-PROJECT-16K15438
  • [Journal Article] Applications of the CRISPR-Cas9 system in kidney research2017

    • Author(s)
      Higashijima Yoshiki、Hirano Seiichi、Nangaku Masaomi、Nureki Osamu
    • Journal Title

      Kidney International

      Volume: 92 Issue: 2 Pages: 324-335

    • DOI

      10.1016/j.kint.2017.01.037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15991, KAKENHI-PROJECT-17J07088
  • [Journal Article] Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury.2017

    • Author(s)
      Tanaka S, Tanaka T, Kawakami T, Takano H, Sugahara M, Saito H, Higashijima Y, Yamaguchi J, Inagi R, Nangaku M.
    • Journal Title

      Kidney Int

      Volume: 印刷中 Issue: 1 Pages: 154-164

    • DOI

      10.1016/j.kint.2017.01.014

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15H04835, KAKENHI-PROJECT-26461215, KAKENHI-PROJECT-15KT0088, KAKENHI-PROJECT-16K15465, KAKENHI-PROJECT-17K15991, KAKENHI-PROJECT-17J07088, KAKENHI-PROJECT-15K09247
  • [Presentation] Lysine demethylase 7a regulates anterior-posterior development via modulating Hox gene cluster transcription in mice2019

    • Author(s)
      Higashijima Y, Nagai N, Kitazawa T, Kawamura Y, Nagnaku M, Kurihara H, Wada Y, Kanki Y
    • Organizer
      Cell Symposia: Transcriptional Regulation in Evolution, Development, and Disease
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15991
  • [Presentation] ヒストン脱メチル化酵素Kdm7aはマウスにおいて前後軸形成を制御する2019

    • Author(s)
      東島佳毅、永井直、北沢太郎、河村悠美子、南学正臣、栗原裕基、和田洋一郎、古川哲史、神吉康晴
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K15991
  • [Presentation] 炎症性遺伝子転写制御におけるヒストン脱メチル化の機能解析2019

    • Author(s)
      東島佳毅
    • Organizer
      第27回血管生物医学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K15991
  • [Presentation] クロマチン相互解析による血管炎症関連遺伝子の転写制御機構の解明2019

    • Author(s)
      東島佳毅
    • Organizer
      第1回ダウン症基礎研究会
    • Data Source
      KAKENHI-PROJECT-17K15991
  • [Presentation] ヒストン脱メチル化酵素Kdm7aはHox遺伝子群の転写制御を介して前後軸形成を制御する2019

    • Author(s)
      東島佳毅、永井直、北沢太郎、河村悠美子、南学正臣、栗原裕基、和田洋一郎、古川哲史、神吉康晴
    • Organizer
      第92回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-17K15991
  • [Presentation] miRNA-ヒストン修飾による動脈硬化関連遺伝子の転写制御機構解析2018

    • Author(s)
      東島佳毅、松井佑介、島村徹平、大坂瑞子、吉田雅幸、南学正臣、和田洋一郎、古川哲史、神吉康晴
    • Organizer
      第41回日本分子生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15991
  • [Presentation] Transcriptional control of atherosclerosis-related genes through repressive histone marks and chromosomal interactions2018

    • Author(s)
      東島佳毅、堤修一、松井佑介、島村徹平、井上剛、南学正臣、和田洋一郎、古川哲史、神吉康晴
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-17K15991
  • [Presentation] Lysine demthylase 7A and 6A dynamically modulate chromatin looping to control inflammatory gene transcription in human endothelial cells.2018

    • Author(s)
      Higashijima Y, Tsutsumi S, Link VM, Abe Y, Nangaku M, Wada Y, Glass CK, Furukawa T, Kanki Y.
    • Organizer
      EMBL Conference: Transcription and Chromatin.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15991
  • [Presentation] Lysine Demethylase 6A And 7A Regulated By MicroRNA-3679-5p Mediates TNF-α-induced Inflammatory Signaling In Vascular Endothelium.2017

    • Author(s)
      Yoshiki HIGASHIJIMA,Tsuyoshi INOUE, Masaomi NANGAKU, Youichiro WADA, Tetsushi FURUKAWA,Yasuharu KANKI
    • Organizer
      American Heart Association 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15991
  • [Presentation] 血管内皮細胞における炎症刺激に応じたmiRNA-ヒストン修飾ネットワーク機構2017

    • Author(s)
      東島 佳毅、神吉 康晴、井上 剛、南学 正臣、古川 哲史、和田 洋一郎
    • Organizer
      第40回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K15991
  • [Presentation] MicroRNA-3679-5p modulates the induction of adhesion molecules by targeting histone demethylases, KDM7A and UTX.2017

    • Author(s)
      Yoshiki HIGASHIJIMA, Tsuyoshi INOUE, Masaomi NANGAKU, Tatsuhiko KODAMA, Yasuharu KANKI, Youichiro WADA
    • Organizer
      第43回内藤コンファレンス
    • Data Source
      KAKENHI-PROJECT-17K15991
  • 1.  NANGAKU Masaomi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 2.  TANAKA Tetsuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 3.  KANKI Yasuharu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  永井 直
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  稲城 玲子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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