OKADA NAOHIRO 岡田直大

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Okada Naohiro 岡田直大

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Researcher Number	40797122
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 准教授 2025: 東京大学, ニューロインテリジェンス国際研究機構, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 東京大学, ニューロインテリジェンス国際研究機構, 特任准教授 2018: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related Except Principal Investigator Medium-sized Section 61:Human informatics and related fields
Keywords	Principal Investigator 統合失調症 / GABA / MRS / 精神神経科学 / MRI / 脳機能 / 薬物療法 / 機能的結合 / 多剤大量投与 / 抗精神病薬 … More Except Principal Investigator … More Global BioImaging (GBI) / 科研費課題 / 科研費取得者 / 支援活動 / トレーニング / 画像解析 / 磁気共鳴画像 / 電子顕微鏡 / 光学顕微鏡 / 画像解析支援 / 磁気共鳴画像支援 / 電子顕微鏡支援 / 光学顕微鏡支援 / バイオイメージング / 神経疾患 / 抑制性ニューロン / 興奮性ニューロン / 神経科学 / MRI / ネットワークダイナミクス / ネットワーク構造 / 精神疾患 / 興奮性・抑制性ニューロン比率 / グラフ間距離 / テンポラル・ネットワーク / 認知機能 / 学習 / 脳機能画像データ / スパイクタイミング依存学習 / 時空間学習則 / 脳神経系 Less

統合失調症スペクトラムにおける淡蒼球亜領域の構造・機能異常の解明Principal Investigator
- Principal Investigator
  
  岡田直大
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  The University of Tokyo
興奮性・抑制性ニューロン比率の最適性原理に基づく精神疾患発症メカニズムの解明
- Principal Investigator
  
  池口徹
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 61:Human informatics and related fields
- Research Institution
  Tokyo University of Science
Advanced Bioimaging Support
- Principal Investigator
  
  鍋倉淳一
- Project Period (FY)
  2022 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)
- Research Institution
  National Institute for Physiological Sciences
MRSを用いた統合失調症における大脳基底核GABA機能異常の解明Principal Investigator
- Principal Investigator
  
  岡田直大
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  The University of Tokyo
Investigation into the reduction of medication for patients with schizophrenia undergoing polypharmacy with antipsychotics and changes in brain functionPrincipal Investigator
- Principal Investigator
  
  Okada Naohiro
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Cortical white matter microstructural alterations underlying the impaired gamma-band auditory steady-state response in schizophrenia.2024
- Author(s)
  D. Koshiyama， R. Nishimura， K. Usui， M. Fujioka， M. Tada， K. Kirihara， T. Araki， S. Kawakami， N. Okada， S. Koike， H. Yamasue， O. Abe and K. Kasai
- Journal Title
  
  Schizophrenia (Heidelb).
  
  Volume: 10 Issue: 1 Pages: 32-32
- DOI
  10.1038/s41537-024-00454-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18419, KAKENHI-PROJECT-22K15760, KAKENHI-PROJECT-20KK0193, KAKENHI-PROJECT-22K07573, KAKENHI-PROJECT-18K07588, KAKENHI-PLANNED-21H05176, KAKENHI-PROJECT-23K21414
[Journal Article] The ATPase asymmetry: Novel computational insight into coupling diverse FO motors with tripartite F12024
- Author(s)
  Kubo Shintaroh、Okada Yasushi
- Journal Title
  
  Biophysical Journal
  
  Volume: - Issue: 6 Pages: 891-900
- DOI
  10.1016/j.bpj.2024.03.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15070, KAKENHI-PROJECT-22KJ0505, KAKENHI-PROJECT-22H04926
[Journal Article] Longitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization2024
- Author(s)
  N. Okada，N. Yahata，D. Koshiyama，K. Morita，K. Sawada，S. Kanata，S. Fujikawa，N. Sugimoto，R. Toriyama，M. Masaoka，S. Koike，T. Araki，Y. Kano，K. Endo，S. Yamasaki，S. Ando，A. Nishida，M. Hiraiwa-Hasegawa，R. A. E. Edden，A. Sawa and K. Kasai
- Journal Title
  
  Mol Psychiatry
  
  Volume: 29 Issue: 4 Pages: 939
- DOI
  10.1038/s41380-023-02382-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18419, KAKENHI-PROJECT-21K15709, KAKENHI-PROJECT-20KK0193, KAKENHI-PROJECT-17K13208, KAKENHI-PLANNED-21H05174, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-20H03951, KAKENHI-PROJECT-23K21414
[Journal Article] Hippocampal Structures Among Japanese Adolescents Before and After the COVID-19 Pandemic.2024
- Author(s)
  L. Cai，N. Maikusa，Y. Zhu，A. Nishida，S. Ando，N. Okada，K. Kasai，Y. Nakamura and S. Koike
- Journal Title
  
  JAMA Netw Open.
  
  Volume: 7 Issue: 2 Pages: e2355292-e2355292
- DOI
  10.1001/jamanetworkopen.2023.55292
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18419, KAKENHI-PROJECT-20KK0193, KAKENHI-PUBLICLY-23H03877, KAKENHI-PROJECT-23K21414
[Journal Article] Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification.2023
- Author(s)
  N. Okada，et al.
- Journal Title
  
  Mol Psychiatry.
  
  Volume: 28 Issue: 12 Pages: 5206-5216
- DOI
  10.1038/s41380-023-02141-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18419, KAKENHI-PROJECT-20KK0193, KAKENHI-PROJECT-21K07498, KAKENHI-PROJECT-22K07617, KAKENHI-PROJECT-23K07001, KAKENHI-PROJECT-23K07015, KAKENHI-PROJECT-20K06920, KAKENHI-PROJECT-20K07945, KAKENHI-PROJECT-21K12153, KAKENHI-PROJECT-18K15478, KAKENHI-PROJECT-21K13727, KAKENHI-PROJECT-20H03605, KAKENHI-PROJECT-19H05467, KAKENHI-PLANNED-21H05174, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-19H00630, KAKENHI-PROJECT-20H03598, KAKENHI-PROJECT-23K21414
[Journal Article] Distinctive alterations in the mesocorticolimbic circuits in various psychiatric disorders2023
- Author(s)
  Nakamura Y, Ishida T, Tanaka SC, Mitsuyama Y, Yokoyama S, Shinzato H, Itai E, Okada G, Kobayashi Y, Kawashima T, Miyata J, Yoshihara Y, Takahashi H, Aoki R, Nakamura M, Ota H, Itahashi T, Morita S, Kawakami S, Abe O, Okada N, et al.
- Journal Title
  
  Psychiatry Clin Neurosci
  
  Volume: Online ahead of print Issue: 6 Pages: 345-354
- DOI
  10.1111/pcn.13542
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18419, KAKENHI-PROJECT-21K13727, KAKENHI-PROJECT-22K15763, KAKENHI-PROJECT-20KK0193, KAKENHI-PUBLICLY-21H05324, KAKENHI-PROJECT-23K21414, KAKENHI-PLANNED-21H05172
[Journal Article] Aberrant large-scale network interactions across psychiatric disorders revealed by large-sample multi-site resting-state functional magnetic resonance imaging datasets2023
- Author(s)
  Ishida T, Nakamura Y, Tanaka SC, Mitsuyama Y, Yokoyama S, Shinzato H, Itai E, Okada G, Kobayashi Y, Kawashima T, Miyata J, Yoshihara Y, Takahashi H, Morita S, Kawakami S, Abe O, Okada N, Kunimatsu A, Yamashita A, Yamashita O, Imamizu H, Morimoto J, Okamoto Y, Murai T, Kasai K, Kawato M, Koike S
- Journal Title
  
  Schizophr Bull
  
  Volume: Online ahead of print Issue: 4 Pages: 933-943
- DOI
  10.1093/schbul/sbad022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18419, KAKENHI-PROJECT-21K13727, KAKENHI-PROJECT-22K15763, KAKENHI-PROJECT-20KK0193, KAKENHI-PUBLICLY-21H05324, KAKENHI-PROJECT-23K21414
[Journal Article] Immotile cilia mechanically sense the direction of fluid flow for left-right determination2023
- Author(s)
  Katoh Takanobu A.、Omori Toshihiro、Mizuno Katsutoshi、Sai Xiaorei、Minegishi Katsura、Ikawa Yayoi、Nishimura Hiromi、Itabashi Takeshi、Kajikawa Eriko、Hiver Sylvain、Iwane Atsuko H.、Ishikawa Takuji、Okada Yasushi、Nishizaka Takayuki、Hamada Hiroshi
- Journal Title
  
  Science
  
  Volume: 379 Issue: 6627 Pages: 66-71
- DOI
  10.1126/science.abq8148
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06220, KAKENHI-PROJECT-21K15096, KAKENHI-PLANNED-21H05308, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-20H00472, KAKENHI-PROJECT-21H04999, KAKENHI-PROJECT-23K23853
[Journal Article] Functional Connectivity Pattern Using Resting-state fMRI as an Assessment Tool for Spatial Neglect during the Recovery Stage of Stroke: A Pilot Study2023
- Author(s)
  Toshihiko Ebisu, Masaki Fukunaga, Tomokazu Murase, Toyoshi Matsuura, Naoya Tomura, Yasuhiro Miyazaki, Shinpei Osaki, Tsutomu Okada, Toshihiro Higuchi, Masahiro Umeda
- Journal Title
  
  MRMS
  
  Volume: 22 Issue: 3 Pages: 313-324
- DOI
  10.2463/mrms.mp.2022-0010
- ISSN
  1347-3182, 1880-2206
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11251, KAKENHI-PROJECT-22H04926
[Journal Article] Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals.2023
- Author(s)
  J. Matsumoto，M. Fukunaga，K. Miura，K. Nemoto K，N. Okada, et al.
- Journal Title
  
  Mol Psychiatry
  
  Volume: 28 Issue: 11 Pages: 4915-4923
- DOI
  10.1038/s41380-023-02224-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18419, KAKENHI-PROJECT-20KK0193, KAKENHI-PROJECT-21K07498, KAKENHI-PROJECT-22K07617, KAKENHI-PROJECT-23K07001, KAKENHI-PROJECT-23K07015, KAKENHI-PROJECT-20K06920, KAKENHI-PROJECT-20K07945, KAKENHI-PROJECT-21K12153, KAKENHI-PROJECT-21K13727, KAKENHI-PROJECT-19H05467, KAKENHI-PLANNED-21H05174, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-19H00630, KAKENHI-PROJECT-20H03598, KAKENHI-PROJECT-23K21414
[Journal Article] Single‐molecule tracking of Nanog and Oct4 in living mouse embryonic stem cells uncovers a feedback mechanism of pluripotency maintenance2023
- Author(s)
  Okamoto Kazuko、Fujita Hideaki、Okada Yasushi、Shinkai Soya、Onami Shuichi、Abe Kuniya、Fujimoto Kenta、Sasaki Kensuke、Shioi Go、Watanabe Tomonobu M
- Journal Title
  
  The EMBO Journal
  
  Volume: 42 Issue: 18
- DOI
  10.15252/embj.2022112305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06201, KAKENHI-PUBLICLY-23H04297, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H03599
[Journal Article] Biophysical Analysis of Mechanical Signals in Immotile Cilia of Mouse Embryonic Nodes Using Advanced Microscopic Techniques2023
- Author(s)
  Katoh Takanobu、Omori Toshihiro、Ishikawa Takuji、Okada Yasushi、Hamada Hiroshi
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: 13 Issue: 14
- DOI
  10.21769/bioprotoc.4715
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15096, KAKENHI-PROJECT-22H04926
[Journal Article] The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy2023
- Author(s)
  Fukuda Tomoyuki, Furukawa Kentaro, Maruyama Tatsuro, ..., Klionsky J. Daniel, Noda N. Nobuo, Kanki Tomotake.
- Journal Title
  
  Molecular Cell
  
  Volume: - Issue: 12 Pages: 2045-2058.e9
- DOI
  10.1016/j.molcel.2023.04.022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15045, KAKENHI-PROJECT-23K05679, KAKENHI-PROJECT-21K05500, KAKENHI-PROJECT-21K06173, KAKENHI-PLANNED-19H05707, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-23K23878
[Journal Article] Structural brain abnormalities in schizophrenia patients with a history and presence of auditory verbal hallucination2022
- Author(s)
  Sone M, Koshiyama D, Zhu Y, Maikusa N, Okada N, Yamasue H, Abe O, Kasai K, Koike S
- Journal Title
  
  Transl Psychiatry
  
  Volume: 12 Issue: 1 Pages: 511-511
- DOI
  10.1038/s41398-022-02282-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18419, KAKENHI-ORGANIZER-21H05171, KAKENHI-PLANNED-21H05174, KAKENHI-PROJECT-20H03596
[Journal Article] “World-Informed” Neuroscience for Diversity and Inclusion: An Organizational Change in Cognitive Sciences2022
- Author(s)
  Kasai K, Kumagaya SI, Takahashi Y, Sawai Y, Uno A, Kumakura Y, Yamagishi M, Kanehara A, Morita K, Tada M, Satomura Y, Okada N, Koike S, Yagishita S.
- Journal Title
  
  Clin EEG Neurosci
  
  Volume: Online ahead of print Issue: 6 Pages: 560-566
- DOI
  10.1177/15500594221105755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18419, KAKENHI-ORGANIZER-21H05171, KAKENHI-PLANNED-21H05174, KAKENHI-PLANNED-21H05175, KAKENHI-PROJECT-20H03596
[Journal Article] Shared functional impairment in the prefrontal cortex affects symptom severity across psychiatric disorders2021
- Author(s)
  Koike Shinsuke、Sakakibara Eisuke、Satomura Yoshihiro、Sakurada Hanako、Yamagishi Mika、Matsuoka Jun、Okada Naohiro、Kasai Kiyoto
- Journal Title
  
  Psychological Medicine
  
  Volume: in press Issue: 13 Pages: 1-10
- DOI
  10.1017/s0033291720004742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04878, KAKENHI-PLANNED-16H06399, KAKENHI-PROJECT-19H03579, KAKENHI-PROJECT-22K18419, KAKENHI-PROJECT-20KK0193, KAKENHI-PROJECT-23K21414
[Presentation] 国内多施設共同データベースを用いた疾患横断的な淡蒼球亜領域の機能結合解析2024
- Author(s)
  庄司瑛武、岡田直大、頓所詩文、フェーバー・オミレケ、森俊輔、清田正紘、森田健太郎、石田卓也、中村優子、岡本泰昌、岡田剛、加藤進昌、橋本龍一郎、髙橋英彦、齋藤洋一、田中沙織、山下歩、川人光男、小池進介、笠井清登
- Organizer
  第26 回日本ヒト脳機能マッピング学会
- Data Source
  KAKENHI-PROJECT-18K15478
[Presentation] Cortical structural mega-analysis across four major psychiatric disorders in 5432 individuals.2023
- Author(s)
  J. Matsumoto，M. Fukunaga，K. Miura，K. Nemoto，N. Okada，et al.
- Organizer
  第119回日本精神神経学会
- Data Source
  KAKENHI-PROJECT-22K18419
[Presentation] 脳画像による精神疾患の病態解明とバイオマーカー開発2023
- Author(s)
  岡田直大
- Organizer
  第12回精神病態セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K18419
[Presentation] Brain Metabolic Substrates of Subclinical Psychotic Experiences in Early Adolescence.2023
- Author(s)
  N. Okada，A. Nishida A and K. Kasai
- Organizer
  The 2023 Congress of the Schizophrenia International Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18419
[Presentation] Molecular Aging in Schizophrenia and Its Effect on Brain Structure.2023
- Author(s)
  N. Okada，T. Ikegame and K. Kasai
- Organizer
  The 2023 Society of Biological Psychiatry Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18419
[Presentation] 多施設共同研究によるdrug freeの統合失調症患者における大脳皮質構造への疾患の効果の検討2023
- Author(s)
  伊藤颯姫、松本純弥、福永雅喜、三浦健一郎、根本清貴、岡田直大、橋本直樹、森田健太郎、...(22名)...、小池進介、松原敏郎、岡田剛、吉村玲児、阿部修、鬼塚俊明、渡邊嘉之、松尾幸治、山末英典、岡本泰昌、鈴木道雄、尾崎紀夫、笠井清登、橋本亮太
- Organizer
  第45回日本生物学的精神医学会年会
- Data Source
  KAKENHI-PROJECT-22H04926
[Presentation] 児童思春期発症のうつ病の多施設大規模データによる大脳皮質構造解析2023
- Author(s)
  松本純弥、福永雅喜、三浦健一郎、根本清貴、岡田直大、橋本直樹、森田健太郎、...(23名)...、小池進介、松原敏郎、岡田剛、吉村玲児、阿部修、鬼塚俊明、渡邊嘉之、松尾幸治、山末英典、岡本泰昌、鈴木道雄、尾崎紀夫、笠井清登、橋本亮太
- Organizer
  第45回日本生物学的精神医学会年会
- Data Source
  KAKENHI-PROJECT-22H04926
[Presentation] Brain Metabolic Substrates of Subclinical Psychotic Experiences in Early Adolescence2023
- Author(s)
  Naohiro Okada, Atsushi Nishida, Kiyoto Kasai
- Organizer
  The 2023 Congress of the Schizophrenia International Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15709
[Presentation] Whole-body/tissue atlas enables mapping DNA damage responses and cell-cycle status with a single-cell resolution2023
- Author(s)
  Hoshi Yuko, Iizawa Naomi, Okada Mikie, Tsuta Erina, Furukawa Chiharu, Susaki Etsuo, Otsuka Kensuke
- Organizer
  The 19th Ataxia-Telangiectasia Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04926
[Presentation] The Asian Consortium on MRI Studies in Psychosis (ACMP).2022
- Author(s)
  Shinsuke Koike and Naohiro Okada
- Organizer
  9th BESETO International Psychiatry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18419
[Presentation] 若手研究者育成プログラムプログレスレポート2021
- Author(s)
  岡田直大
- Organizer
  第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同大会
- Data Source
  KAKENHI-PROJECT-21K15709
[Presentation] 脳画像所見からわかる精神疾患の病態2020
- Author(s)
  岡田直大
- Organizer
  NPBPPP2020合同年会
- Data Source
  KAKENHI-PROJECT-18K15478
[Presentation] 統合失調症における皮質下体積とその側性の変化2019
- Author(s)
  岡田　直大
- Organizer
  第41回日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-18K15478
[Presentation] Circuits/Physiology biomarkers based on RDoC.2018
- Author(s)
  Naohiro Okada
- Organizer
  WFSBP 2018 KOBE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15478

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OKADA NAOHIRO 岡田 直大

Okada Naohiro 岡田 直大

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統合失調症スペクトラムにおける淡蒼球亜領域の構造・機能異常の解明Principal Investigator

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興奮性・抑制性ニューロン比率の最適性原理に基づく精神疾患発症メカニズムの解明

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Advanced Bioimaging Support

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MRSを用いた統合失調症における大脳基底核GABA機能異常の解明Principal Investigator

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Investigation into the reduction of medication for patients with schizophrenia undergoing polypharmacy with antipsychotics and changes in brain functionPrincipal Investigator

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[Journal Article] Cortical white matter microstructural alterations underlying the impaired gamma-band auditory steady-state response in schizophrenia.2024

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[Journal Article] The ATPase asymmetry: Novel computational insight into coupling diverse FO motors with tripartite F12024

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[Journal Article] Longitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization2024

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[Journal Article] Hippocampal Structures Among Japanese Adolescents Before and After the COVID-19 Pandemic.2024

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[Journal Article] Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification.2023

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[Journal Article] Distinctive alterations in the mesocorticolimbic circuits in various psychiatric disorders2023

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[Journal Article] Aberrant large-scale network interactions across psychiatric disorders revealed by large-sample multi-site resting-state functional magnetic resonance imaging datasets2023

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[Journal Article] Immotile cilia mechanically sense the direction of fluid flow for left-right determination2023

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[Journal Article] Functional Connectivity Pattern Using Resting-state fMRI as an Assessment Tool for Spatial Neglect during the Recovery Stage of Stroke: A Pilot Study2023

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OKADA NAOHIRO 岡田直大

Okada Naohiro 岡田直大