Hatano Takashi 波多野孝

… Alternative Names

HATANO Takashi 波多野孝

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Researcher Number	40807583
Affiliation (Current)	2025: 横浜市立大学, 医学研究科, 客員准教授
Affiliation (based on the past Project Information) *help	2025: 横浜市立大学, 医学研究科, 客員准教授 2023: 横浜市立大学, 附属市民総合医療センター, 講師 2018 – 2022: 横浜市立大学, 附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator HPV / マイクロRNA / 頭頸部癌 / ヒト乳頭腫ウイルス関連中咽頭癌 / 癌微小環境 / 腫瘍関連神経 / ヒトパピローマウイルス関連中咽頭癌 / 神経新生 / 唾液腺腫瘍 / オルガノイド … More / ヒト乳頭腫ウイルス / 中咽頭癌 / microRNA / エピゲノム … More Except Principal Investigator 遺伝子発現制御 / 唾液腺癌 / オルガノイド培養 / PDXモデル / オルガノイド / スーパーエンハンサー / 中咽頭癌 / ヒトパピローマウイルス / HPV関連中咽頭癌 Less

HPV関連中咽頭癌における腫瘍関連神経とNOD like receptorを介した免疫逃避機構の解明Principal Investigator
- Principal Investigator
  
  波多野孝
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
癌関連神経を介したHPV関連中咽頭癌の薬剤耐性・治療抵抗性機構の解明Principal Investigator
- Principal Investigator
  
  波多野孝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
Elucidation of the mechanism of HPV-associated oropharyngeal tumor carcinogenesis through the interaction between tumor-associated nerves and the cancer microenvironment.Principal Investigator
- Principal Investigator
  
  HATANO Takashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
HPV-associated oropharyngeal carcinogenesis by super-enhancer-mediated gene regulation.
- Principal Investigator
  
  SANO Daisuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
Identification of HPV-associated oropharyngeal carcinoma poor prognostic factor using microRNA and epigenome analysisPrincipal Investigator
- Principal Investigator
  
  HATANO Takashi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Establishment of experimental salivary gland cancer models using organoid culture and patientderived xenografting.2023
- Author(s)
  Aizawa Y, Takada K, Aoyama J, Sano D, Yamanaka S, Seki M, Kuze Y, Ramilowski JA, Okuda R, Ueno Y, Nojima Y, Inayama Y, Hatakeyama H, Hatano T, Takahashi H, Nishimura G, Fujii S, Suzuki Y, Taniguchi H, Oridate N
- Journal Title
  
  Cell Oncol.
  
  Volume: 46 Issue: 2 Pages: 409-421
- DOI
  10.1007/s13402-022-00758-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-19K09873, KAKENHI-PROJECT-20K08952, KAKENHI-PROJECT-20K18259, KAKENHI-PROJECT-23K08989, KAKENHI-PROJECT-21K09612, KAKENHI-PROJECT-22K08807
[Journal Article] Effect of HER2-targeted therapy on PDX and PDX-derived organoids generated from HER2-positive salivary duct carcinoma2023
- Author(s)
  Aoyama Jun、Nojima Yusuke、Sano Daisuke、Hirai Yuri、Kijima Natsumi、Aizawa Yoshihiro、Takada Kentaro、Hatano Takashi、Takahashi Hideaki、Nishimura Goshi、Oridate Nobuhiko
- Journal Title
  
  Head & Neck
  
  Volume: online ahead of print Issue: 7 Pages: 1801-1811
- DOI
  10.1002/hed.27395
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09873, KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-23K08989, KAKENHI-PROJECT-21K09612
[Journal Article] P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma2023
- Author(s)
  SATO KANAME、SANO DAISUKE、TAKAHASHI HIDEAKI、KUWAHARA TATSU、AIZAWA YOSHIHIRO、AOYAMA JUN、NOJIMA YUSUKE、HATANO TAKASHI、ARAI YASUHIRO、NISHIMURA GOSHI、HATAKEYAMA HIROMITSU、ORIDATE NOBUHIKO
- Journal Title
  
  Anticancer Research
  
  Volume: 43 Issue: 6 Pages: 2571-2582
- DOI
  10.21873/anticanres.16424
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-21K09612
[Journal Article] Real-world Therapeutic Outcomes of the Pembrolizumab Regimen as First-line Therapy for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Single-center Retrospective Cohort Study in Japan2022
- Author(s)
  SANO DAISUKE、TOKUHISA MOTOHIKO、TAKAHASHI HIDEAKI、HATANO TAKASHI、NISHIMURA GOSHI、ICHIKAWA YASUSHI、ORIDATE NOBUHIKO
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 9 Pages: 4477-4484
- DOI
  10.21873/anticanres.15948
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09612, KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-20K18259
[Journal Article] FosL1 Regulates Regional Metastasis of Head and Neck Squamous Cell Carcinoma by Promoting Cell Migration, Invasion, and Proliferation2021
- Author(s)
  Hiroshi Hyakusoku, Kae Sawakuma, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Kaname Sato, Yasuhiro Isono, Shoko Shimada, Kentaro Takada, Tatsu Kuwahara, Yoshihiro Aizawa, Nobuhiko Oridate
- Journal Title
  
  Anticancer research
  
  Volume: 41 Issue: 7 Pages: 3317-3326
- DOI
  10.21873/anticanres.15119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09851, KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-20K18259
[Journal Article] Pathogenic Role of Immune Evasion and Integration of Human Papillomavirus in Oropharyngeal Cancer2021
- Author(s)
  Hatano Takashi、Sano Daisuke、Takahashi Hideaki、Oridate Nobuhiko
- Journal Title
  
  Microorganisms
  
  Volume: 9 Issue: 5 Pages: 891-891
- DOI
  10.3390/microorganisms9050891
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-20K18259
[Journal Article] A risk factor for newly diagnosed secondary cancer in patients with early-stage laryngeal, oropharyngeal, or hypopharyngeal cancer: sub-analysis of a prospective observation study2021
- Author(s)
  Nishimura Goshi、Sano Daisuke、Arai Yasuhiro、Takahashi Hideaki、Hatano Takashi、Kitani Yosuke、Takada Kentaro、Wada Takashi、Hiiragi Yohei、Oridate Nobuhiko
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 27 Issue: 3 Pages: 488-494
- DOI
  10.1007/s10147-021-02080-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-21K09636, KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-20K18259
[Journal Article] Validation of the risk factors for primary control of early T-stage laryngeal, oropharyngeal, and hypopharyngeal squamous cell carcinoma by transoral surgery: a prospective observational study2021
- Author(s)
  Nishimura Goshi、Sano Daisuke、Arai Yasuhiro、Takahashi Hideaki、Hatano Takashi、Kitani Yosuke、Takada Kentaro、Wada Takashi、Hiiragi Yohei、Oridate Nobuhiko
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 26 Issue: 11 Pages: 1995-2003
- DOI
  10.1007/s10147-021-01992-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-21K09636, KAKENHI-PROJECT-20K18259
[Journal Article] Establishment of PDX‐derived salivary adenoid cystic carcinoma cell lines using organoid culture method2020
- Author(s)
  Takada Kentaro、Aizawa Yoshihiro、Sano Daisuke、Okuda Ryo、Sekine Keisuke、Ueno Yasuharu、Yamanaka Shoji、Aoyama Jun、Sato Kaname、Kuwahara Tatsu、Hatano Takashi、Takahashi Hideaki、Arai Yasuhiro、Nishimura Goshi、Taniguchi Hideki、Oridate Nobuhiko
- Journal Title
  
  International Journal of Cancer
  
  Volume: 148 Issue: 1 Pages: 193-202
- DOI
  10.1002/ijc.33315
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09873, KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-20K08952, KAKENHI-PROJECT-19H03718, KAKENHI-PROJECT-17K10057, KAKENHI-PROJECT-18K09382, KAKENHI-PROJECT-20K18259
[Journal Article] 経口的ロボット手術の導入　横浜市立大学における初期経験2020
- Author(s)
  佐野大佑, 波多野孝, 折舘伸彦
- Journal Title
  
  頭頸部外科
  
  Volume: 30 Pages: 139-140
- NAID
  130007945962
- Data Source
  KAKENHI-PROJECT-20K18259
[Journal Article] めずらしい腫瘍に対するアプローチ　病理がめずらしい　肉腫2020
- Author(s)
  高田顕太郎, 波多野孝, 荒井康裕, 西村剛志, 折舘伸彦
- Journal Title
  
  JOHNS
  
  Volume: 36 Pages: 1499-1502
- Data Source
  KAKENHI-PROJECT-20K18259
[Journal Article] The Advances in Research of Human Papillomavirus-Induced Carcinogenesis in Oropharyngeal Cancers2019
- Author(s)
  Hatano Takashi, Sano Daisuke, Oridate Nobuhiko.
- Journal Title
  
  Gan To Kagaku Ryoho.
  
  Volume: 46(7) Pages: 1128-1130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16850
[Journal Article] A prospective clinical trial of the second-look procedure for transoral surgery in patients with T1 and T2 laryngeal, oropharyngeal, and hypopharyngeal cancer.2019
- Author(s)
  Nishimura Goshi, Sano Daisuke, Arai Yasuhiro, Hatano Takashi, Takahashi Hideaki, Tanabe Teruhiko, Wada Takashi, Morishita Daiki, Oridate Nobuhiko.
- Journal Title
  
  Cancer Medecine.
  
  Volume: 8(17) Issue: 17 Pages: 7197-7206
- DOI
  10.1002/cam4.2588
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16850
[Journal Article] Real-world Treatment Outcomes of the EXTREME Regimen as First-line Therapy for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Multi-center Retrospective Cohort Study in Japan2019
- Author(s)
  Sano D, Fujisawa T, Tokuhisa M, Shimizu M, Sakagami T, Hatano T, Nishimura G, Ichikawa Y, Iwai H, Oridate N
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 12 Pages: 6819-6827
- DOI
  10.21873/anticanres.13898
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-18K16850
[Presentation] ヒトHER2陽性唾液腺導管癌由来オルガノイドによるin vitro/in vivoでの薬効評価(Drug evaluation using patient-derived organoid of HER2-positive salivary duct carcinoma in vitro and in vivo)2022
- Author(s)
  青山準, 野島雄介, 相澤圭洋, 高田顕太郎, 鬼島菜摘, 平井友梨, 波多野孝, 高橋秀聡, 佐野大佑, 藤井誠志, 折舘伸彦
- Organizer
  日本癌学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18259
[Presentation] ヒトHER2陽性唾液腺導管癌由来オルガノイドによるin vitro/in vivoでの薬効評価(Drug evaluation using patient-derived organoid of HER2-positive salivary duct carcinoma in vitro and in vivo)2022
- Author(s)
  青山準, 野島雄介, 相澤圭洋, 高田顕太郎, 鬼島菜摘, 平井友梨, 波多野孝, 高橋秀聡, 佐野大佑, 藤井誠志, 折舘伸彦
- Organizer
  日本癌学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09746
[Presentation] μオピオイド受容体を標的とした治療の開発2022
- Author(s)
  高橋秀聡, 佐野大佑, 波多野孝, 木谷洋輔, 柊陽平, 大平彩菜, 折舘伸彦
- Organizer
  日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-22K09746
[Presentation] μオピオイド受容体を標的とした治療の開発2022
- Author(s)
  高橋秀聡, 佐野大佑, 波多野孝, 木谷洋輔, 柊陽平, 大平彩菜, 折舘伸彦
- Organizer
  日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-20K18259
[Presentation] Therapeutic value of neck dissection for patients with advanced hypopharyngeal squamous cell carcinoma2022
- Author(s)
  Sano D, Takahashi H, Hatano T, Oridate N
- Organizer
  The 60th Annual meeting of Japanese Society of Clinical Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09895
[Presentation] Treatment outcome of pembrolizumab±chemotherapy as first-line therapy for recurrent/metastatic squamous cell carcinoma of the head and neck in a single-center study2021
- Author(s)
  Sano D, Tokuhisa M, Takahashi H, Hatano T, Ichikawa Y, Oridate N
- Organizer
  The 59th Annual meeting of Japanese Society of Clinical Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09895
[Presentation] ウイルス感染と頭頸部腫瘍　HPV関連中咽頭癌発癌におけるHPVの免疫逃避機構および組み込み機構の役割2021
- Author(s)
  波多野孝, 佐野大佑, 高橋秀聡, 折舘伸彦
- Organizer
  日本耳鼻咽喉科免疫アレルギー感染症学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K18259
[Presentation] 頭頸部扁平上皮癌における再発、転移病変腫瘍径のニボルマブ治療効果予測に対する有用性について2020
- Author(s)
  佐野大佑, 波多野孝, 高橋秀聡, 西村剛志, 折舘伸彦
- Organizer
  日本耳鼻咽喉科学会学術総会・学術講演会
- Data Source
  KAKENHI-PROJECT-20K18259
[Presentation] 根治治療としてCRTを施行した中咽頭扁平上皮癌症例の予後予測におけるF-NLRの有用性2020
- Author(s)
  波多野孝, 高橋秀聡, 佐野大佑
- Organizer
  日本癌治療学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18259
[Presentation] 癌細胞のp53喪失は癌微小環境における神経の成長と再プログラムを通じて癌の進展を促す2020
- Author(s)
  高橋秀聡, 佐野大佑, 波多野孝, 佐藤要, 桑原達, 相沢圭洋, 青山準, 折舘伸彦
- Organizer
  日本癌学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18259
[Presentation] Establishment of PDX-derived salivary gland adenoid cystic carcinoma cell lines using organoid culture method2019
- Author(s)
  高田顕太郎, 相澤圭洋, 佐野大佑, 奥田諒, 関根圭輔, 上野康晴, 青山準, 波多野孝, 荒井康裕, 谷口英樹, 折舘伸彦
- Organizer
  第78回日本癌学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16850
[Presentation] FOSL1 promotes regional metastasis of head and neck squamous cell carcinoma2018
- Author(s)
  佐野大佑, 澤熊香衣, 百束紘, 波多野孝, 磯野泰大, 高田顕太郎, 佐藤要, 桑原達, 相澤圭洋, 折舘伸彦
- Organizer
  第77回日本癌学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16850

1. SANO Daisuke (10620990)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. 折舘伸彦 (90312355)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. 高橋秀聡 (50727196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. 百束紘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hatano Takashi 波多野 孝

HATANO Takashi 波多野 孝

Research Projects

Research Products

Co-Researchers

HPV関連中咽頭癌における腫瘍関連神経とNOD like receptorを介した免疫逃避機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌関連神経を介したHPV関連中咽頭癌の薬剤耐性・治療抵抗性機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of HPV-associated oropharyngeal tumor carcinogenesis through the interaction between tumor-associated nerves and the cancer microenvironment.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

HPV-associated oropharyngeal carcinogenesis by super-enhancer-mediated gene regulation.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of HPV-associated oropharyngeal carcinoma poor prognostic factor using microRNA and epigenome analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Establishment of experimental salivary gland cancer models using organoid culture and patientderived xenografting.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of HER2-targeted therapy on PDX and PDX-derived organoids generated from HER2-positive salivary duct carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Real-world Therapeutic Outcomes of the Pembrolizumab Regimen as First-line Therapy for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Single-center Retrospective Cohort Study in Japan2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FosL1 Regulates Regional Metastasis of Head and Neck Squamous Cell Carcinoma by Promoting Cell Migration, Invasion, and Proliferation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathogenic Role of Immune Evasion and Integration of Human Papillomavirus in Oropharyngeal Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A risk factor for newly diagnosed secondary cancer in patients with early-stage laryngeal, oropharyngeal, or hypopharyngeal cancer: sub-analysis of a prospective observation study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Validation of the risk factors for primary control of early T-stage laryngeal, oropharyngeal, and hypopharyngeal squamous cell carcinoma by transoral surgery: a prospective observational study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of PDX‐derived salivary adenoid cystic carcinoma cell lines using organoid culture method2020

Author(s)

Journal Title

DOI

Data Source

Hatano Takashi 波多野孝

HATANO Takashi 波多野孝

[Journal Article] 経口的ロボット手術の導入　横浜市立大学における初期経験2020

[Journal Article] めずらしい腫瘍に対するアプローチ　病理がめずらしい　肉腫2020

[Presentation] ウイルス感染と頭頸部腫瘍　HPV関連中咽頭癌発癌におけるHPVの免疫逃避機構および組み込み機構の役割2021