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Hatano Takashi  波多野 孝

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HATANO Takashi  波多野 孝

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Researcher Number 40807583
Affiliation (Current) 2025: 横浜市立大学, 医学研究科, 客員准教授
Affiliation (based on the past Project Information) *help 2025: 横浜市立大学, 医学研究科, 客員准教授
2023: 横浜市立大学, 附属市民総合医療センター, 講師
2018 – 2022: 横浜市立大学, 附属病院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 56050:Otorhinolaryngology-related
Except Principal Investigator
Basic Section 56050:Otorhinolaryngology-related
Keywords
Principal Investigator
HPV / マイクロRNA / 頭頸部癌 / ヒト乳頭腫ウイルス関連中咽頭癌 / 癌微小環境 / 腫瘍関連神経 / ヒトパピローマウイルス関連中咽頭癌 / 神経新生 / 唾液腺腫瘍 / オルガノイド … More / ヒト乳頭腫ウイルス / 中咽頭癌 / microRNA / エピゲノム … More
Except Principal Investigator
遺伝子発現制御 / 唾液腺癌 / オルガノイド培養 / PDXモデル / オルガノイド / スーパーエンハンサー / 中咽頭癌 / ヒトパピローマウイルス / HPV関連中咽頭癌 Less
  • Research Projects

    (5 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (4 People)
  •  HPV関連中咽頭癌における腫瘍関連神経とNOD like receptorを介した免疫逃避機構の解明Principal Investigator

    • Principal Investigator
      波多野 孝
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Yokohama City University
  •  癌関連神経を介したHPV関連中咽頭癌の薬剤耐性・治療抵抗性機構の解明Principal Investigator

    • Principal Investigator
      波多野 孝
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Yokohama City University
  •  Elucidation of the mechanism of HPV-associated oropharyngeal tumor carcinogenesis through the interaction between tumor-associated nerves and the cancer microenvironment.Principal Investigator

    • Principal Investigator
      HATANO Takashi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Yokohama City University
  •  HPV-associated oropharyngeal carcinogenesis by super-enhancer-mediated gene regulation.

    • Principal Investigator
      SANO Daisuke
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Yokohama City University
  •  Identification of HPV-associated oropharyngeal carcinoma poor prognostic factor using microRNA and epigenome analysisPrincipal Investigator

    • Principal Investigator
      HATANO Takashi
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Yokohama City University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

  • [Journal Article] Establishment of experimental salivary gland cancer models using organoid culture and patientderived xenografting.2023

    • Author(s)
      Aizawa Y, Takada K, Aoyama J, Sano D, Yamanaka S, Seki M, Kuze Y, Ramilowski JA, Okuda R, Ueno Y, Nojima Y, Inayama Y, Hatakeyama H, Hatano T, Takahashi H, Nishimura G, Fujii S, Suzuki Y, Taniguchi H, Oridate N
    • Journal Title

      Cell Oncol.

      Volume: 46 Issue: 2 Pages: 409-421

    • DOI

      10.1007/s13402-022-00758-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-19K09873, KAKENHI-PROJECT-20K08952, KAKENHI-PROJECT-20K18259, KAKENHI-PROJECT-23K08989, KAKENHI-PROJECT-21K09612, KAKENHI-PROJECT-22K08807
  • [Journal Article] Effect of HER2-targeted therapy on PDX and PDX-derived organoids generated from HER2-positive salivary duct carcinoma2023

    • Author(s)
      Aoyama Jun、Nojima Yusuke、Sano Daisuke、Hirai Yuri、Kijima Natsumi、Aizawa Yoshihiro、Takada Kentaro、Hatano Takashi、Takahashi Hideaki、Nishimura Goshi、Oridate Nobuhiko
    • Journal Title

      Head & Neck

      Volume: online ahead of print Issue: 7 Pages: 1801-1811

    • DOI

      10.1002/hed.27395

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09873, KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-23K08989, KAKENHI-PROJECT-21K09612
  • [Journal Article] P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma2023

    • Author(s)
      SATO KANAME、SANO DAISUKE、TAKAHASHI HIDEAKI、KUWAHARA TATSU、AIZAWA YOSHIHIRO、AOYAMA JUN、NOJIMA YUSUKE、HATANO TAKASHI、ARAI YASUHIRO、NISHIMURA GOSHI、HATAKEYAMA HIROMITSU、ORIDATE NOBUHIKO
    • Journal Title

      Anticancer Research

      Volume: 43 Issue: 6 Pages: 2571-2582

    • DOI

      10.21873/anticanres.16424

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-21K09612
  • [Journal Article] Real-world Therapeutic Outcomes of the Pembrolizumab Regimen as First-line Therapy for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Single-center Retrospective Cohort Study in Japan2022

    • Author(s)
      SANO DAISUKE、TOKUHISA MOTOHIKO、TAKAHASHI HIDEAKI、HATANO TAKASHI、NISHIMURA GOSHI、ICHIKAWA YASUSHI、ORIDATE NOBUHIKO
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 9 Pages: 4477-4484

    • DOI

      10.21873/anticanres.15948

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09612, KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-20K18259
  • [Journal Article] FosL1 Regulates Regional Metastasis of Head and Neck Squamous Cell Carcinoma by Promoting Cell Migration, Invasion, and Proliferation2021

    • Author(s)
      Hiroshi Hyakusoku, Kae Sawakuma, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Kaname Sato, Yasuhiro Isono, Shoko Shimada, Kentaro Takada, Tatsu Kuwahara, Yoshihiro Aizawa, Nobuhiko Oridate
    • Journal Title

      Anticancer research

      Volume: 41 Issue: 7 Pages: 3317-3326

    • DOI

      10.21873/anticanres.15119

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09851, KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-20K18259
  • [Journal Article] Pathogenic Role of Immune Evasion and Integration of Human Papillomavirus in Oropharyngeal Cancer2021

    • Author(s)
      Hatano Takashi、Sano Daisuke、Takahashi Hideaki、Oridate Nobuhiko
    • Journal Title

      Microorganisms

      Volume: 9 Issue: 5 Pages: 891-891

    • DOI

      10.3390/microorganisms9050891

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-20K18259
  • [Journal Article] A risk factor for newly diagnosed secondary cancer in patients with early-stage laryngeal, oropharyngeal, or hypopharyngeal cancer: sub-analysis of a prospective observation study2021

    • Author(s)
      Nishimura Goshi、Sano Daisuke、Arai Yasuhiro、Takahashi Hideaki、Hatano Takashi、Kitani Yosuke、Takada Kentaro、Wada Takashi、Hiiragi Yohei、Oridate Nobuhiko
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 27 Issue: 3 Pages: 488-494

    • DOI

      10.1007/s10147-021-02080-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-21K09636, KAKENHI-PROJECT-22K09746, KAKENHI-PROJECT-20K18259
  • [Journal Article] Validation of the risk factors for primary control of early T-stage laryngeal, oropharyngeal, and hypopharyngeal squamous cell carcinoma by transoral surgery: a prospective observational study2021

    • Author(s)
      Nishimura Goshi、Sano Daisuke、Arai Yasuhiro、Takahashi Hideaki、Hatano Takashi、Kitani Yosuke、Takada Kentaro、Wada Takashi、Hiiragi Yohei、Oridate Nobuhiko
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 11 Pages: 1995-2003

    • DOI

      10.1007/s10147-021-01992-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-21K09636, KAKENHI-PROJECT-20K18259
  • [Journal Article] Establishment of PDX‐derived salivary adenoid cystic carcinoma cell lines using organoid culture method2020

    • Author(s)
      Takada Kentaro、Aizawa Yoshihiro、Sano Daisuke、Okuda Ryo、Sekine Keisuke、Ueno Yasuharu、Yamanaka Shoji、Aoyama Jun、Sato Kaname、Kuwahara Tatsu、Hatano Takashi、Takahashi Hideaki、Arai Yasuhiro、Nishimura Goshi、Taniguchi Hideki、Oridate Nobuhiko
    • Journal Title

      International Journal of Cancer

      Volume: 148 Issue: 1 Pages: 193-202

    • DOI

      10.1002/ijc.33315

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09873, KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-20K08952, KAKENHI-PROJECT-19H03718, KAKENHI-PROJECT-17K10057, KAKENHI-PROJECT-18K09382, KAKENHI-PROJECT-20K18259
  • [Journal Article] 経口的ロボット手術の導入 横浜市立大学における初期経験2020

    • Author(s)
      佐野 大佑, 波多野 孝, 折舘 伸彦
    • Journal Title

      頭頸部外科

      Volume: 30 Pages: 139-140

    • NAID

      130007945962

    • Data Source
      KAKENHI-PROJECT-20K18259
  • [Journal Article] めずらしい腫瘍に対するアプローチ 病理がめずらしい 肉腫2020

    • Author(s)
      高田 顕太郎, 波多野 孝, 荒井 康裕, 西村 剛志, 折舘 伸彦
    • Journal Title

      JOHNS

      Volume: 36 Pages: 1499-1502

    • Data Source
      KAKENHI-PROJECT-20K18259
  • [Journal Article] The Advances in Research of Human Papillomavirus-Induced Carcinogenesis in Oropharyngeal Cancers2019

    • Author(s)
      Hatano Takashi, Sano Daisuke, Oridate Nobuhiko.
    • Journal Title

      Gan To Kagaku Ryoho.

      Volume: 46(7) Pages: 1128-1130

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K16850
  • [Journal Article] A prospective clinical trial of the second-look procedure for transoral surgery in patients with T1 and T2 laryngeal, oropharyngeal, and hypopharyngeal cancer.2019

    • Author(s)
      Nishimura Goshi, Sano Daisuke, Arai Yasuhiro, Hatano Takashi, Takahashi Hideaki, Tanabe Teruhiko, Wada Takashi, Morishita Daiki, Oridate Nobuhiko.
    • Journal Title

      Cancer Medecine.

      Volume: 8(17) Issue: 17 Pages: 7197-7206

    • DOI

      10.1002/cam4.2588

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16850
  • [Journal Article] Real-world Treatment Outcomes of the EXTREME Regimen as First-line Therapy for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Multi-center Retrospective Cohort Study in Japan2019

    • Author(s)
      Sano D, Fujisawa T, Tokuhisa M, Shimizu M, Sakagami T, Hatano T, Nishimura G, Ichikawa Y, Iwai H, Oridate N
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 12 Pages: 6819-6827

    • DOI

      10.21873/anticanres.13898

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09895, KAKENHI-PROJECT-18K16850
  • [Presentation] ヒトHER2陽性唾液腺導管癌由来オルガノイドによるin vitro/in vivoでの薬効評価(Drug evaluation using patient-derived organoid of HER2-positive salivary duct carcinoma in vitro and in vivo)2022

    • Author(s)
      青山 準, 野島 雄介, 相澤 圭洋, 高田 顕太郎, 鬼島 菜摘, 平井 友梨, 波多野 孝, 高橋 秀聡, 佐野 大佑, 藤井 誠志, 折舘 伸彦
    • Organizer
      日本癌学会総会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K18259
  • [Presentation] ヒトHER2陽性唾液腺導管癌由来オルガノイドによるin vitro/in vivoでの薬効評価(Drug evaluation using patient-derived organoid of HER2-positive salivary duct carcinoma in vitro and in vivo)2022

    • Author(s)
      青山 準, 野島 雄介, 相澤 圭洋, 高田 顕太郎, 鬼島 菜摘, 平井 友梨, 波多野 孝, 高橋 秀聡, 佐野 大佑, 藤井 誠志, 折舘 伸彦
    • Organizer
      日本癌学会総会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K09746
  • [Presentation] μオピオイド受容体を標的とした治療の開発2022

    • Author(s)
      高橋 秀聡, 佐野 大佑, 波多野 孝, 木谷 洋輔, 柊 陽平, 大平 彩菜, 折舘 伸彦
    • Organizer
      日本頭頸部癌学会
    • Data Source
      KAKENHI-PROJECT-22K09746
  • [Presentation] μオピオイド受容体を標的とした治療の開発2022

    • Author(s)
      高橋 秀聡, 佐野 大佑, 波多野 孝, 木谷 洋輔, 柊 陽平, 大平 彩菜, 折舘 伸彦
    • Organizer
      日本頭頸部癌学会
    • Data Source
      KAKENHI-PROJECT-20K18259
  • [Presentation] Therapeutic value of neck dissection for patients with advanced hypopharyngeal squamous cell carcinoma2022

    • Author(s)
      Sano D, Takahashi H, Hatano T, Oridate N
    • Organizer
      The 60th Annual meeting of Japanese Society of Clinical Oncology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09895
  • [Presentation] Treatment outcome of pembrolizumab±chemotherapy as first-line therapy for recurrent/metastatic squamous cell carcinoma of the head and neck in a single-center study2021

    • Author(s)
      Sano D, Tokuhisa M, Takahashi H, Hatano T, Ichikawa Y, Oridate N
    • Organizer
      The 59th Annual meeting of Japanese Society of Clinical Oncology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09895
  • [Presentation] ウイルス感染と頭頸部腫瘍 HPV関連中咽頭癌発癌におけるHPVの免疫逃避機構および組み込み機構の役割2021

    • Author(s)
      波多野 孝, 佐野 大佑, 高橋 秀聡, 折舘 伸彦
    • Organizer
      日本耳鼻咽喉科免疫アレルギー感染症学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K18259
  • [Presentation] 頭頸部扁平上皮癌における再発、転移病変腫瘍径のニボルマブ治療効果予測に対する有用性について2020

    • Author(s)
      佐野 大佑, 波多野 孝, 高橋 秀聡, 西村 剛志, 折舘 伸彦
    • Organizer
      日本耳鼻咽喉科学会学術総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-20K18259
  • [Presentation] 根治治療としてCRTを施行した中咽頭扁平上皮癌症例の予後予測におけるF-NLRの有用性2020

    • Author(s)
      波多野 孝, 高橋 秀聡, 佐野 大佑
    • Organizer
      日本癌治療学会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K18259
  • [Presentation] 癌細胞のp53喪失は癌微小環境における神経の成長と再プログラムを通じて癌の進展を促す2020

    • Author(s)
      高橋 秀聡, 佐野 大佑, 波多野 孝, 佐藤 要, 桑原 達, 相沢 圭洋, 青山 準, 折舘 伸彦
    • Organizer
      日本癌学会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K18259
  • [Presentation] Establishment of PDX-derived salivary gland adenoid cystic carcinoma cell lines using organoid culture method2019

    • Author(s)
      高田 顕太郎, 相澤 圭洋, 佐野 大佑, 奥田 諒, 関根 圭輔, 上野 康晴, 青山 準, 波多野 孝, 荒井 康裕, 谷口 英樹, 折舘 伸彦
    • Organizer
      第78回日本癌学会総会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16850
  • [Presentation] FOSL1 promotes regional metastasis of head and neck squamous cell carcinoma2018

    • Author(s)
      佐野 大佑, 澤熊 香衣, 百束 紘, 波多野 孝, 磯野 泰大, 高田 顕太郎, 佐藤 要, 桑原 達, 相澤 圭洋, 折舘 伸彦
    • Organizer
      第77回日本癌学会総会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16850
  • 1.  SANO Daisuke (10620990)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 2.  折舘 伸彦 (90312355)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 3.  高橋 秀聡 (50727196)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 4.  百束 紘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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