Terasaka Naohiro 寺坂尚紘

Researcher Number	40830071
Other IDs	https://orcid.org/0000-0002-4988-6899
Affiliation (Current)	2026: 東京科学大学, 未来社会創成研究院, 特任准教授
Affiliation (based on the past Project Information) *help	2024 – 2026: 東京科学大学, 未来社会創成研究院, 特任准教授 2024: 東京科学大学, 地球生命研究所, 特任准教授 2023: 東京工業大学, 地球生命研究所, 特任准教授 2022: 東京大学, 大学院理学系研究科(理学部), 助教 2019 – 2021: 東京大学, 大学院理学系研究科(理学部), 特任助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Medium-sized Section 28:Nano/micro science and related fields / Basic Section 37030:Chemical biology-related / Transformative Research Areas, Section (II) / Basic Section 45020:Evolutionary biology-related Except Principal Investigator Transformative Research Areas, Section (III) / Basic Section 28050:Nano/micro-systems-related / Medium-sized Section 38:Agricultural chemistry and related fields / Transformative Research Areas, Section (II)
Keywords	Principal Investigator タンパク質工学 / 分子進化 / 合成生物学 / ハイスループットスクリーニング / 分子進化工学 / バイオインフォマティクス / メタボロン / 核酸工学 / DNAオリガミ / 自己集合タンパク質 … More / 無細胞翻訳系 / タンパク質 / マイクロデバイス / 非天然アミノ酸 / 蛋白質工学 / マイクロ流体デバイス / マイクロ流路 / 無細胞翻訳 / RNA ワールド / アミノアシル化 / RNAワールド / ペプチド / リボザイム … More Except Principal Investigator 酵素反応機構 / 生合成 / 天然物化学 / 無細胞翻訳系 / マイクロ流路 / 液滴流路 / バイオセンサー / 出芽酵母 / Casタンパク質 / CRISPR-Cas系 / クライオ電子顕微鏡単粒子解析 / ウイルス模倣粒子 / PAM / 耐熱性Cas / 小型Cas / メタゲノム / 耐熱性Casタンパク質 / 小型Casタンパク質 / ゲノム編集 / CRISPR-Cas / 分子進化法 / バイオマテリアル / 人工酵素 / 分子進化 / タンパク質集合体 / タンパク質デザイン / タンパク質工学 Less

Development of a high-throughput directed evolution method for biosensors
- Principal Investigator
  
  磯崎瑛宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28050:Nano/micro-systems-related
- Research Institution
  Ritsumeikan University
Development of cell-free evolution system to rapidly produce drug canditatesPrincipal Investigator
- Principal Investigator
  
  寺坂尚紘
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Institute of Science Tokyo
特化メタボロン・総括班
- Principal Investigator
  
  森貴裕
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Development of artificial specialized metabolonPrincipal Investigator
- Principal Investigator
  
  寺坂尚紘
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Science Tokyo
独自に発見したCRISPR-Casエフェクターの機能構造解析と新たなゲノム編集技術の開発
- Principal Investigator
  
  沼田倫征
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Kyushu University
Construction of ribonucleoprotein nanoarchitecture in cellsPrincipal Investigator
- Principal Investigator
  
  寺坂尚紘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 28:Nano/micro science and related fields
- Research Institution
  Institute of Science Tokyo
Droplet-based microfluidics for directed evolution of higher-order protein assemblies containing noncanonical amino acidsPrincipal Investigator
- Principal Investigator
  
  Terasaka Naohiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Institute of Science Tokyo
  The University of Tokyo
Superior Protein Engineering by Evolution and Design
- Principal Investigator
  
  Suzuki Yuta
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Kyoto University
In vitro evolution of a peptide-ribozyme complex catalyzing aminoacylationPrincipal Investigator
- Principal Investigator
  
  Terasaka Naohiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 45020:Evolutionary biology-related
- Research Institution
  The University of Tokyo

All 2025 2024 2023 2022 2020 2019

All Journal Article Presentation Patent

[Journal Article] A High-Accuracy Pair Matching Method for Droplet Microfluidics with Two-State Measurement Points2025
- Author(s)
  Akihiro Isozaki, Yusuke Nasu, Naohiro Terasaka
- Journal Title
  
  2025 IEEE 38th International Conference on Micro Electro Mechanical Systems (MEMS)
  
  Volume: - Pages: 1237-1240
- DOI
  10.1109/mems61431.2025.10918267
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Journal Article] An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch2020
- Author(s)
  Ishida Satoshi、Terasaka Naohiro、Katoh Takayuki、Suga Hiroaki
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 16 Issue: 6 Pages: 702-709
- DOI
  10.1038/s41589-020-0500-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16200, KAKENHI-PROJECT-20H05618, KAKENHI-PLANNED-16H06444
[Patent] 液滴分取装置及び液滴分取方法2025
- Inventor(s)
  磯崎瑛宏、那須雄介、寺坂尚紘
- Industrial Property Rights Holder
  東京科学大学、学校法人立命館大学、東京大学
- Industrial Property Rights Type
  特許
- Filing Date
  2025
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] Structural expansion of nonviral nucleocapsids by laboratory evolution2025
- Author(s)
  Hualin Li, Naohiro Terasaka
- Organizer
  13th ELSI International Symposium 2025
- Data Source
  KAKENHI-PROJECT-24H00505
[Presentation] In vitro assembly of protein capsule and cargo molecules into a virus-like particle2024
- Author(s)
  Kenya Tajima, Yusuke Sakai, Naohiro Terasaka
- Organizer
  21st IUPAB Congress 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21708
[Presentation] 進化工学による機能性分子の創出と生命起源研究への展開2024
- Author(s)
  寺坂尚紘
- Organizer
  第11回バイオ関連化学シンポジウム若手フォーラム
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] Directed evolution of virus-like ribonucleoprotein particles2024
- Author(s)
  Naohiro Terasaka
- Organizer
  The 3rd International Symposium on Biofunctional Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] 油中水滴型ドロップレットに封入した無細胞翻訳系を用いたタンパク質進化システム2024
- Author(s)
  寺坂尚紘
- Organizer
  第24回日本蛋白質科学会年会
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] Development of nonviral nucleocapsid by laboratory evolution and its biotechnological application2024
- Author(s)
  Naohiro Terasaka
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] Directed evolution of nonviral ribonucleoproteins to virus-like particles2024
- Author(s)
  Naohiro Terasaka
- Organizer
  Joint CO world & 12th ELSI Symposium
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] Tandem artificial nucleocapsid to package longer RNA genome and expand protein architectures2024
- Author(s)
  Hualin Li, Naohiro Terasaka
- Organizer
  21st IUPAB Congress 2024
- Data Source
  KAKENHI-PROJECT-24H00505
[Presentation] 非ウイルス性蛋白質ケージへの多様なカーゴ分子の封入2024
- Author(s)
  田島研也, 酒井雄介, 寺坂尚紘
- Organizer
  第24回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-24K21708
[Presentation] RNAとタンパク質の協奏的進化による機能性複合体の創成2023
- Author(s)
  寺坂尚紘
- Organizer
  生命創成探究センター・分子科学研究所主催学術研究会
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] 実験室内進化によるウイルス模倣粒子の創成2022
- Author(s)
  寺坂尚紘
- Organizer
  第47回生命の起原および進化学会学術講演会
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] Aminoacylation ribozymes evolved from a natural riboswitch2022
- Author(s)
  Naohiro Terasaka
- Organizer
  Symposium on Evolution and Emergence of Living Systems: from Geochemistry to Synthetic Biology（
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] 分子進化によるタンパク質・RNA 高次複合体の創成2022
- Author(s)
  寺坂尚紘
- Organizer
  第１回発動分子科学サロン「発動分子と生体材料」
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] 原始ウイルスの進化を実験室内で再現する2022
- Author(s)
  寺坂尚紘
- Organizer
  日本進化学会年大会第24回沼津大会
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] 分子進化によるタンパク質集合体の構築2022
- Author(s)
  寺坂尚紘
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-ORGANIZER-21H05116
[Presentation] An aminoacylation ribozyme evolved from a natural tRNA sensing riboswitch2020
- Author(s)
  寺坂尚紘、石田啓、加藤敬行、菅裕明
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16200
[Presentation] 天然リボスイッチ配列から進化させ、翻訳系中で働くアミノアシル tRNA合成リボザイム2019
- Author(s)
  寺坂尚紘, 石田啓, 加藤敬行, 菅裕明
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16200
[Presentation] An aminoacylation ribozyme evolved from a natural tRNA sensing riboswitch2019
- Author(s)
  Terasaka Naohiro、Ishida Satoshi、Katoh Takayuki、Suga Hiroaki
- Organizer
  The 24th Annual Meeting of the RNA Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16200
[Presentation] T-box リボスイッチをベースにした tRNA 認識アミノアシル化リボザイムの創出2019
- Author(s)
  石田啓, 寺坂尚紘, 加藤敬行, 菅裕明
- Organizer
  第21回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-19K16200

1. 古林太郎 (20902620)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Suzuki Yuta (00827743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岡本泰典 (50843405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 沼田倫征 (10401564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 岡田悟 (30734488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 磯崎瑛宏 (10732555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 那須雄介 (60831328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 酒井雄介 (10895501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 森貴裕 (60734564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 佐々木栄太 (00803157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 和氣駿之 (10793705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中野祥吾 (80748541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Terasaka Naohiro 寺坂 尚紘

Research Projects

Research Products

Co-Researchers

Development of a high-throughput directed evolution method for biosensors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of cell-free evolution system to rapidly produce drug canditatesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

特化メタボロン・総括班

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of artificial specialized metabolonPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

独自に発見したCRISPR-Casエフェクターの機能構造解析と新たなゲノム編集技術の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of ribonucleoprotein nanoarchitecture in cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Droplet-based microfluidics for directed evolution of higher-order protein assemblies containing noncanonical amino acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Superior Protein Engineering by Evolution and Design

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In vitro evolution of a peptide-ribozyme complex catalyzing aminoacylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A High-Accuracy Pair Matching Method for Droplet Microfluidics with Two-State Measurement Points2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch2020

Author(s)

Journal Title

DOI

Data Source

[Patent] 液滴分取装置及び液滴分取方法2025

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] Structural expansion of nonviral nucleocapsids by laboratory evolution2025

Author(s)

Organizer

Data Source

[Presentation] In vitro assembly of protein capsule and cargo molecules into a virus-like particle2024

Author(s)

Terasaka Naohiro 寺坂尚紘

[Presentation] 天然リボスイッチ配列から進化させ、翻訳系中で働くアミノアシル tRNA合成リボザイム2019