Shimada Issei 嶋田逸誠

Researcher Number	40833265
Other IDs
Affiliation (Current)	2026: 名古屋市立大学, 医薬学総合研究院(医学), 講師
Affiliation (based on the past Project Information) *help	2020 – 2025: 名古屋市立大学, 医薬学総合研究院(医学), 講師
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 56030:Urology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator 一次繊毛 / 神経幹細胞 / 脳オルガノイド / 脳回 / 神経産生 / 繊毛 / 髄芽腫 / 小児がん Except Principal Investigator iPS細胞 / 結石モデル … More / マクロファージ / 腎オルガノイド / 尿路結石 / 脳オルガノイド / 巨脳症 / 基底放射状グリア / MYCN / 難治性脳腫瘍 / 陽子線 / 超高線量率照射 / FLASH / オルガノイド / 神経幹細胞 / 外側放射状グリア / 神経発生 Less

疾患iPS細胞由来マクロファージと腎オルガノイドを用いた尿路結石形成機序の解明
- Principal Investigator
  
  岡田朋記
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Nagoya City University
To elucidate the mechanisms of tumor development of neural stem cells using medulloblastoma organoid model.Principal Investigator
- Principal Investigator
  
  嶋田逸誠
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nagoya City University
陽子線 FLASH 照射による難治性脳腫瘍根絶へ向けた開発
- Principal Investigator
  
  岩田宏満
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Nagoya City University
Integrative approach for mechanism of megalencephaly
- Principal Investigator
  
  齋藤伸治
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nagoya City University
疾患iPS細胞由来腎オルガノイドの樹立による新規腎結石モデルと結石溶解療法の開発
- Principal Investigator
  
  岡田朋記
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Nagoya City University
To elucidate the mechanisms of gyrus formation using human brain organoids.Principal Investigator
- Principal Investigator
  
  Shimada Issei
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nagoya City University
Uncover pathomechanism of megalencephaly using brain organdies.
- Principal Investigator
  
  Saitoh Shinji
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nagoya City University

All 2024 2023 2022 2021

All Journal Article Presentation Patent

[Journal Article] Phagocytosis model of calcium oxalate monohydrate crystals generated using human induced pluripotent stem cell-derived macrophages2024
- Author(s)
  Okada Tomoki、Okada Atsushi、Aoki Hiromasa、Onozato Daichi、Kato Taiki、Takase Hiroshi、Ohshima Shigeru、Sugino Teruaki、Unno Rei、Taguchi Kazumi、Hamamoto Shuzo、Ando Ryosuke、Shimada Issei S.、Hashita Tadahiro、Iwao Takahiro、Matsunaga Tamihide、Yasui Takahiro
- Journal Title
  
  Urolithiasis
  
  Volume: 52 Issue: 1 Pages: 51-51
- DOI
  10.1007/s00240-024-01553-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18149, KAKENHI-PROJECT-22H00486, KAKENHI-PROJECT-21K07803, KAKENHI-PROJECT-21H04865, KAKENHI-PROJECT-20K09562, KAKENHI-PROJECT-23K27730
[Journal Article] Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia2023
- Author(s)
  Palicharla Vivek Reddy、Hwang Sun-Hee、Somatilaka Bandarigoda N.、Legue Emilie、Shimada Issei S.、Familiari Nicole E.、Tran Vanna M.、Woodruff Jeffrey B.、Liem Karel F.、Mukhopadhyay Saikat
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 34 Issue: 3
- DOI
  10.1091/mbc.e22-10-0473
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07803
[Journal Article] Biallelic null variants in PNPLA8 cause microcephaly through the reduced abundance of basal radial glia2023
- Author(s)
  Y Nakamura, IS Shimada (2/56), R Maroofian, M Falabella, M Fujimoto, E Sato, H Takase, S Aoki, A Miyauchi, E Koshimizu, S Miyatake, Y Arioka, M Honda, T Higashi, F Miya, Y Okubo, I Ogawa, K Haginoya, T Matsunaga, H Osaka, N Matsumoto, N Ozaki, Y Ohkawa, S Oki, T Tsunoda, Y Taketomi, M Murakami, Y Kato and S Saitoh
- Journal Title
  
  medRXiv
  
  Volume: -
- DOI
  10.1101/2023.04.26.23288947
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07803
[Journal Article] Ciliary signaling in stem cells in health and disease: Hedgehog pathway and beyond2022
- Author(s)
  Shimada Issei S.、Kato Yoichi
- Journal Title
  
  Seminars in Cell & Developmental Biology
  
  Volume: _ Pages: 115-125
- DOI
  10.1016/j.semcdb.2022.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07803
[Patent] 背側脳オルガノイドの製造方法およびその利用2023
- Inventor(s)
  嶋田逸誠、　加藤洋一
- Industrial Property Rights Holder
  嶋田逸誠、　加藤洋一
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21K07803
[Presentation] GPR161 KO 脳オルガノイドモデルを活用した、神経幹細胞の背側／腹側の運命制御機構の解明2024
- Author(s)
  3.嶋田逸誠　加藤洋一
- Organizer
  第17回神経発生討論会・第20回成体脳のニューロン新生懇談会合同大会
- Data Source
  KAKENHI-PROJECT-21K07803
[Presentation] Gain-of-function MYCN controls cell death and proliferation, leading to macrocephaly.2024
- Author(s)
  Fujimoto M, Nakamura Y, Shimada IS, Sato E, Iwaki T, Ieda D, Negishi Y, Hattori A, Okumura H, Arioka Y, Ozawa H, Ozaki N, Kato Y, Saitoh S
- Organizer
  第66回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-24K02424
[Presentation] 名古屋陽子線治療センターにおけるシンクロトロン加速器による FLASH 照射 : 今後の展望2024
- Author(s)
  岩田宏満、歳藤利行、大町千尋、田中堅一郎、中嶌晃一朗、梅澤真澄、柴田泰宏、嶋田一逸、冨田淳、中嶋智佳子、坡下真大、松本貴裕、松本和久、荻野浩幸
- Organizer
  第28回癌治療増感研究会
- Data Source
  KAKENHI-PROJECT-24K02406
[Presentation] GPR161欠損脳オルガノイドモデルを活用した、背側／腹側運命制御機構の解明2023
- Author(s)
  5.嶋田逸誠　加藤洋一
- Organizer
  第13回繊毛研究会
- Data Source
  KAKENHI-PROJECT-21K07803
[Presentation] 脳オルガノイドモデルを活用した、神経幹細胞の背側／腹側の運命制御機構の解明2023
- Author(s)
  4.嶋田逸誠　加藤洋一
- Organizer
  第４６回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K07803
[Presentation] GPR161 regulates ventral/dorsal fate of neural stem cells in a brain organoid model.2023
- Author(s)
  嶋田逸誠
- Organizer
  Cold Spring Harbor Asia Cilia & Centrosomes, Awaji Japan,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07803
[Presentation] Basal suppression of Sonic Hedgehog signaling confers dorsal neural stem cell identity in a brain organoid model.2023
- Author(s)
  嶋田逸誠
- Organizer
  The 21st Takeda Science Foundation symposium on Bioscience.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07803
[Presentation] ヒト脳オルガノイドを用いた、GPR161欠損神経幹細胞の研究2023
- Author(s)
  嶋田逸誠
- Organizer
  第12回繊毛研究会
- Data Source
  KAKENHI-PROJECT-21K07803
[Presentation] Biallelic variants in PNPLA8 disrupt cortical gyrification through aberrant mitochondrial dynamics.2022
- Author(s)
  Nakamura Y, Shimada IS, Fujimoto M, Sato E, Ieda D, Hattori A, Miya F, Tsunoda T, Okubo Y, Haginoya K, Koshimizu E, Miyatake S, Matsumoto N, Arioka Y, Ozaki N, Kato Y, Saitoh S.
- Organizer
  第64回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03646
[Presentation] PNPLA8 deficiency induces microcephaly and reduces neurogenesis in a brain organoid model.2021
- Author(s)
  Nakamura Y, Shimada I, Fujimoto M, Sato E, Ieda D, Hattori A, Miya F, Tsunoda T, Okubo Y, Haginoya K, Koshimizu E, Miyatake S, Matsumoto N, Arioka Y, Ozaki N, Kato Y, Saitoh S
- Organizer
  第63回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03646
[Presentation] 疾患iPS細胞を用いた尿路結石モデル腎オルガノイドの樹立2021
- Author(s)
  岡田　朋記、岡田　淳志、服部　竜也、杉野　輝明、田口　和己、濵本　周造、嶋田　逸誠、松永　民秀、安井　孝周
- Organizer
  第64回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21K09405
[Presentation] ミトコンドリアホスホリパーゼPNPLA8機能喪失は神経系細胞においてミトコンドリアダイナミクス異常を引き起こす.2021
- Author(s)
  中村勇治、嶋田逸誠、加藤洋一、齋藤伸治
- Organizer
  第66回日本人類遺伝学会
- Data Source
  KAKENHI-PROJECT-20H03646
[Presentation] 患者由来iPS細胞を用いた尿路結石形成に関わる新規解析モデルの作製2021
- Author(s)
  岡田　朋記、岡田　淳志、磯谷　正彦、服部　竜也、茶谷　亮輔、河瀬　健吾、田中　勇太朗、杉野　輝明、海野　怜、田口　和己、宇佐美　雅之、濵本　周造、安藤　亮介、嶋田　逸誠、松永　民秀、戸澤　啓一、安井　孝周
- Organizer
  日本尿路結石症学会第31回学術集会
- Data Source
  KAKENHI-PROJECT-21K09405
[Presentation] 尿路結石患者由来の iPS 細胞を用いた新規結石モデル腎オルガノイドの開発2021
- Author(s)
  岡田　朋記、岡田　淳志、服部　竜也、杉野　輝明、海野　怜、田口　和己、濵本　周造、安藤　亮介、嶋田　逸誠、松永　民秀、戸澤　啓一、安井　孝周
- Organizer
  第109回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-21K09405

1. Saitoh Shinji (00281824)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 加藤洋一 (10815161)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. 大石久史 (30375513)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 岡田朋記 (10881774)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 安井孝周 (40326153)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. 岡田淳志 (70444966)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. 濱本周造 (80551267)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. 岩田宏満 (40611588)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 伊藤雅之 (50243407)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. 宮冬樹 (50415311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 田口和己 (00595184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 松永民秀 (40209581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 堀江健生 (10455925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 海野怜 (40755683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 岩尾岳洋 (50581740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 柴田泰宏 (10534745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 鵜川眞也 (20326135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 粂和彦 (30251218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 歳藤利行 (30377965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 冨田淳 (40432231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 荻野浩幸 (60315885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 平山亮一 (90435701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 有岡祐子 (10709497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 永田浩一 (50252143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 加藤大貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 斉藤伸治

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Shimada Issei 嶋田 逸誠

Research Projects

Research Products

Co-Researchers

疾患iPS細胞由来マクロファージと腎オルガノイドを用いた尿路結石形成機序の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

To elucidate the mechanisms of tumor development of neural stem cells using medulloblastoma organoid model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

陽子線 FLASH 照射による難治性脳腫瘍根絶へ向けた開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrative approach for mechanism of megalencephaly

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

疾患iPS細胞由来腎オルガノイドの樹立による新規腎結石モデルと結石溶解療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

To elucidate the mechanisms of gyrus formation using human brain organoids.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Uncover pathomechanism of megalencephaly using brain organdies.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Phagocytosis model of calcium oxalate monohydrate crystals generated using human induced pluripotent stem cell-derived macrophages2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biallelic null variants in PNPLA8 cause microcephaly through the reduced abundance of basal radial glia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ciliary signaling in stem cells in health and disease: Hedgehog pathway and beyond2022

Author(s)

Journal Title

DOI

Data Source

[Patent] 背側脳オルガノイドの製造方法およびその利用2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] GPR161 KO 脳オルガノイドモデルを活用した、神経幹細胞の背側／腹側の運命制御機構の解明2024

Author(s)

Organizer

Data Source

[Presentation] Gain-of-function MYCN controls cell death and proliferation, leading to macrocephaly.2024

Author(s)

Organizer

Data Source

Shimada Issei 嶋田逸誠

[Presentation] ミトコンドリアホスホリパーゼPNPLA8機能喪失は神経系細胞においてミトコンドリアダイナミクス異常を引き起こす.2021