HIRAYAMA Tatsuro 平山達朗

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Hirayama Tatsuro 平山達朗

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Researcher Number	40836269
Other IDs
Affiliation (Current)	2026: 長崎大学, 医歯薬学総合研究科(医学系), 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 2021: 長崎大学, 薬学部, 准教授 2019 – 2020: 長崎大学, 病院(医学系), 助教
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Basic Section 49050:Bacteriology-related Except Principal Investigator Basic Section 54030:Infectious disease medicine-related
Keywords	Principal Investigator candida auris / 薬剤耐性 / Candida / 腸管 / マウスモデル / CRISPR/Cas9 / 創薬 / efflux pump / manogepix / 耐性 … More / 抗真菌薬 / キャンディン系 / エキノキャンディン / FKS1 / キャンディン系抗真菌薬 / Candida auris / ｔｒａｎｓｌｏｃａｔｉｏｎ / Candida glabrata / colonization / エルゴステロール / candida albicans / 病原性 / 定着 / candida / Candida albicans / ERG3 / トランスロケーション / カンジダ … More Except Principal Investigator 日和見感染症 / 結核 / 感染症診断 / バイオマーカー / 尿 / 真菌 / アスペルギルス Less

Candida aurisの薬剤耐性機序の解明とその克服Principal Investigator
- Principal Investigator
  
  平山達朗
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagasaki University
Investigation of a new diagnostic method for opportunistic infections by comprehensive analysis of urinary protein fragments
- Principal Investigator
  
  Miyazaki Taiga
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  University of Miyazaki
Elucidation of drug resistance mechanisms in Candida spp. using mouse modelsPrincipal Investigator
- Principal Investigator
  
  Hirayama Tatsuro
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagasaki University
virulence assessment of pathogenic Candida species with a fungal tranlocation mouse modelPrincipal Investigator
- Principal Investigator
  
  Hirayama Tatsuro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Nagasaki University

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] TAC1b mutation in Candida auris decreases manogepix susceptibility owing to increased CDR1 expression.2025
- Author(s)
  Hirayama Tatsuro、Miyazaki Taiga、Tanaka Rina、Kitahori Natsume、Yoshida Masataka、Takeda Kazuaki、Ide Shotaro、Iwanaga Naoki、Tashiro Masato、Takazono Takahiro、Izumikawa Koichi、Yanagihara Katsunori、Makimura Koichi、Tsukamoto Kazuhiro、Mukae Hiroshi
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 69 Issue: 2
- DOI
  10.1128/aac.01508-24
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K11656
[Journal Article] Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations2023
- Author(s)
  Hirayama Tatsuro、Miyazaki Taiga、Sumiyoshi Makoto、Ito Yuya、Ashizawa Nobuyuki、Takeda Kazuaki、Iwanaga Naoki、Takazono Takahiro、Yamamoto Kazuko、Izumikawa Koichi、Yanagihara Katsunori、Makimura Koichi、Tsukamoto Kazuhiro、Kohno Shigeru、Mukae Hiroshi
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 67 Issue: 4
- DOI
  10.1128/aac.01243-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16322
[Journal Article] Virulence assessment of six major pathogenic Candida species in the mouse model of invasive candidiasis caused by fungal translocation2020
- Author(s)
  Hirayama Tatsuro、Miyazaki Taiga、Ito Yuya、Wakayama Megumi、Shibuya Kazutoshi、Yamashita Kohei、Takazono Takahiro、Saijo Tomomi、Shimamura Shintaro、Yamamoto Kazuko、Imamura Yoshifumi、Izumikawa Koichi、Yanagihara Katsunori、Kohno Shigeru、Mukae Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 3814-3814
- DOI
  10.1038/s41598-020-60792-y
- NAID
  120006988274
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16645
[Journal Article] ERG3-Encoding Sterol C5,6-DESATURASE in Candida albicans Is Required for Virulence in an Enterically Infected Invasive Candidiasis Mouse Model2020
- Author(s)
  Hirayama Tatsuro、Miyazaki Taiga、Sumiyoshi Makoto、Ashizawa Nobuyuki、Takazono Takahiro、Yamamoto Kazuko、Imamura Yoshifumi、Izumikawa Koichi、Yanagihara Katsunori、Kohno Shigeru、Mukae Hiroshi
- Journal Title
  
  Pathogens
  
  Volume: 10 Issue: 1 Pages: 23-23
- DOI
  10.3390/pathogens10010023
- NAID
  120006956193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07540, KAKENHI-PROJECT-19K16645
[Presentation] 新規抗真菌薬manogepixに対するCandida aurisの耐性機構の解析2024
- Author(s)
  田中里奈、平山達朗、宮崎泰可、中田奈々、武田和明、吉田將孝、井手昇太郎、岩永直樹、高園貴弘、泉川公一、柳原克紀、槇村浩一、迎寛
- Organizer
  第72回日本化学療法学会
- Data Source
  KAKENHI-PROJECT-24K11656
[Presentation] TAC1b変異によるCDR1の高発現によりCandida aurisのmanogepix感受性が低下する2024
- Author(s)
  平山達朗、宮崎泰可、中田奈々、吉田將孝、井手昇太郎、岩永直樹、高園貴弘、泉川公一、槇村浩一、迎寛
- Organizer
  第68回日本医真菌学会
- Data Source
  KAKENHI-PROJECT-24K11656
[Presentation] マウスモデルを用いたキャンディン系抗真菌薬曝露によって生じるCandida aurisの薬剤耐性化の検討2022
- Author(s)
  平山達朗、宮崎泰可、芦澤信之、武田和明、岩永直樹、高園貴弘、山本和子、泉川公一、栁原克紀、迎寛
- Organizer
  第70回日本化学療法学会総会
- Data Source
  KAKENHI-PROJECT-21K16322
[Presentation] トランスロケーションマウスモデルを用いたCandida albicansにおけるerg3欠損株の病原性の検討2021
- Author(s)
  平山達朗、宮崎泰可、芦澤信之、高園貴弘、山本和子、今村圭文、泉川公一、栁原克紀、河野茂、迎寛
- Organizer
  第95回日本感染症学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K16645
[Presentation] 腸管に着目したキャンディン系抗真菌薬曝露によって生じるCandida aurisの薬剤耐性化の検討2021
- Author(s)
  平山達朗、宮崎泰可、芦澤信之、岩永直樹、高園貴弘、山本和子、泉川公一、栁原克紀、河野茂、迎寛
- Organizer
  第65回日本医真菌学会総会
- Data Source
  KAKENHI-PROJECT-21K16322

1. Miyazaki Taiga (60448496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 高尾敏文 (10197048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 坪内拡伸 (60573988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 岩見真吾 (90518119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIRAYAMA Tatsuro 平山 達朗

Hirayama Tatsuro 平山 達朗

Research Projects

Research Products

Co-Researchers

Candida aurisの薬剤耐性機序の解明とその克服Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of a new diagnostic method for opportunistic infections by comprehensive analysis of urinary protein fragments

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of drug resistance mechanisms in Candida spp. using mouse modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

virulence assessment of pathogenic Candida species with a fungal tranlocation mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] TAC1b mutation in Candida auris decreases manogepix susceptibility owing to increased CDR1 expression.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Virulence assessment of six major pathogenic Candida species in the mouse model of invasive candidiasis caused by fungal translocation2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] ERG3-Encoding Sterol C5,6-DESATURASE in Candida albicans Is Required for Virulence in an Enterically Infected Invasive Candidiasis Mouse Model2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] 新規抗真菌薬manogepixに対するCandida aurisの耐性機構の解析2024

Author(s)

Organizer

Data Source

[Presentation] TAC1b変異によるCDR1の高発現によりCandida aurisのmanogepix感受性が低下する2024

Author(s)

Organizer

Data Source

[Presentation] マウスモデルを用いたキャンディン系抗真菌薬曝露によって生じるCandida aurisの薬剤耐性化の検討2022

Author(s)

Organizer

Data Source

[Presentation] トランスロケーションマウスモデルを用いたCandida albicansにおけるerg3欠損株の病原性の検討2021

Author(s)

Organizer

Data Source

[Presentation] 腸管に着目したキャンディン系抗真菌薬曝露によって生じるCandida aurisの薬剤耐性化の検討2021

Author(s)

Organizer

Data Source

HIRAYAMA Tatsuro 平山達朗

Hirayama Tatsuro 平山達朗