sera yasuyuki 世良康如

… Alternative Names

Sera Yasuyuki 世良康如

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Researcher Number	40836532
Other IDs
Affiliation (Current)	2025: 東京女子医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2019 – 2025: 東京女子医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 54010:Hematology and medical oncology-related / Basic Section 54020:Connective tissue disease and allergy-related Except Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator エピジェネティクス / ハプロ不全 / 骨髄系腫瘍 / PTIP / －7/del(7q) / Compass-like複合体 / 自己免疫疾患 / 辺縁帯B細胞 / B-1細胞 / B細胞 / UTX … More Except Principal Investigator … More エピジェネティクス / UTX, UTY / UTX、UTY / ヒストン修飾因子 / ヒストン修飾 / ヒストンメチル化・脱メチル化 / UTY / UTX / ヒストン脱メチル化 / 泌尿器科腫瘍 / 炎症性経路 / 泌尿器科系腫瘍 / COMPASS-like complex / ヒストンメチル化・脱メチル / ヒストンH3K27 / 造血器腫瘍 / 造血幹細胞 / 脱メチル化活性 / 抗加齢療法 / 老化 / 幹細胞 / Uty / 幹細胞老化 / ヒストン脱メチル化酵素 / Utx Less

腫瘍発症におけるヒストン修飾因子UTXの選択的スプライシング脱制御の役割の解明Principal Investigator
- Principal Investigator
  
  世良康如
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Women's Medical University
Elucidation of molecular mechanisms underlying development of malignant tumors with loss-of-function mutations of UTX, a histone modifier, mainly focusing on urological tumors.
- Principal Investigator
  
  本田浩章
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Women's Medical University
Compass-like複合体のハプロ不全型がん抑制機構の解析Principal Investigator
- Principal Investigator
  
  世良康如
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Women's Medical University
Elucidation of mechanisms underlying stem cell aging induced by deregulation of histone modifications and development of anti-aging therapies by maintaining their functions
- Principal Investigator
  
  HONDA HIROAKI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Tokyo Women's Medical University
The role(s) of UTX, histone demethylase for H3K27me3, in B cell regulatory mechanisms and autoimmune disease pathogenesisPrincipal Investigator
- Principal Investigator
  
  Sera Yasuyuki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Tokyo Women's Medical University
Functional analyses of enzymatic activity- and complex formation-dependent roles of UTX in the regulation of hematopoietic stem cells and development of hematopoietic diseases
- Principal Investigator
  
  HONDA HIROAKI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Women's Medical University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] MBTD1 preserves adult hematopoietic stem cell pool size and function2023
- Author(s)
  Takubo Keiyo、Htun Phyo Wai、Ueda Takeshi、Sera Yasuyuki、Iwasaki Masayuki、Koizumi Miho、Shiroshita Kohei、Kobayashi Hiroshi、Haraguchi Miho、Watanuki Shintaro、Honda Zen-ichiro、Yamasaki Norimasa、Nakamura-Ishizu Ayako、Arai Fumio、Motoyama Noboru、Hatta Tomohisa、Natsume Tohru、Suda Toshio、Honda Hiroaki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 32
- DOI
  10.1073/pnas.2206860120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16333, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-23K07134, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-23K27442
[Journal Article] UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death2022
- Author(s)
  Koizumi M, Eto H, Saeki M, Seki M, Fukushima T, Mukai S, Ide H, Sera Y, Iwasaki M, Suzuki Y, Tohei A, Kishi Y, Honda H.
- Journal Title
  
  FASEB journal
  
  Volume: 36(12) Issue: 12 Pages: 22662-22662
- DOI
  10.1096/fj.202201002rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-22K19823, KAKENHI-PROJECT-22K16333, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03179, KAKENHI-PROJECT-19K17918, KAKENHI-PUBLICLY-21H00242, KAKENHI-PUBLICLY-22H04687
[Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021
- Author(s)
  Sera Y; Nakata Y; Ueda T; Yamasaki N; Koide S; Kobayashi H; Ikeda KI; Kobatake K; Iwasaki M; Oda H; Wolff L; Kanai A; Nagamachi A; Inaba T; Sotomaru Y; Ichinohe T; Koizumi M; Miyakawa Y; Honda ZI; Iwama A; Suda T; Takubo K; Honda H
- Journal Title
  
  Blood.
  
  Volume: 137 Issue: 7 Pages: 908-922
- DOI
  10.1182/blood.2019001044
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19K17918, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19H01056, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-21K08395
[Journal Article] Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction2020
- Author(s)
  Kobatake Kohei et al., Honda Zen-ichiro et al. and Honda Hiroaki
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 26 Issue: 8 Pages: 2065-2079
- DOI
  10.1158/1078-0432.ccr-19-2230
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08384, KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19K17918, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19K09729, KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19H01056
[Presentation] Prostate cancer with histone modifier UTX mutations can benefit from olaparib.2023
- Author(s)
  Muramoto N, Iwasaki M, Sera Y, Ide H, Horie S, Honda H.
- Organizer
  European Society for Medical Oncology Asia Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27442
[Presentation] ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血系維持に関与する2021
- Author(s)
  世良康如, 中田雄一郎, 上田健, 山崎憲政, 小出周平, 小林央, 池田健一郎, 小畠浩平, 岩崎正幸, 小田秀明, 金井昭教, 長町安希子, 稲葉俊哉, 外丸祐介, 一戸辰夫, 小泉美穂, 宮川佳彦, 本田善一郎, 岩間厚志, 須田年生, 田久保圭誉, 本田浩章
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K17918
[Presentation] ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血系維持に関与する2021
- Author(s)
  世良康如, 中田雄一郎, 上田健, 山崎憲政, 小出周平, 小林央, 池田健一郎, 小畠浩平, 岩崎正幸, 小田秀明, 金井昭教, 長町安希子, 稲葉俊哉, 外丸祐介, 一戸辰夫, 小泉美穂, 宮川佳彦, 本田善一郎, 岩間厚志, 須田年生, 田久保圭誉, 本田浩章
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03693
[Presentation] ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血系維持に関与する2021
- Author(s)
  世良康如, 中田雄一郎, 上田健, 山崎憲政, 小出周平, 小林央, 池田健一郎, 小畠浩平, 岩崎正幸, 小田秀明, 金井昭教, 長町安希子, 稲葉俊哉, 外丸祐介, 一戸辰夫, 小泉美穂, 宮川佳彦, 本田善一郎, 岩間厚志, 須田年生, 田久保圭誉, 本田浩章
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22546
[Presentation] 2.ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血形維持に関与する2020
- Author(s)
  世良康如, 本田浩章
- Organizer
  第1回レドックスR&D戦略研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03693
[Presentation] 2.ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血形維持に関与する2020
- Author(s)
  世良康如, 本田浩章
- Organizer
  第1回レドックスR&D戦略研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22546
[Presentation] ヒストン脱メチル化酵素JMJD3が白血病を誘導させるエピゲノム制御および蛋白質相互作用の解明2019
- Author(s)
  中田雄一郎、上田健、金井昭教、世良康如、竹田浩之、神沼修、本田浩章
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K22546
[Presentation] ヒストン脱メチル化酵素JMJD3が白血病を誘導させるエピゲノム制御および蛋白質相互作用の解明2019
- Author(s)
  中田雄一郎、上田健、金井昭教、世良康如、竹田浩之、神沼修、本田浩章
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03693
[Presentation] ヒストンの修飾因子UTXの脳特異的な欠損マウスの解析2019
- Author(s)
  小泉美穂、三田村佳勇、世良康如、本田浩章、衛藤光、岸雄介、藤平篤志
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19H03693
[Presentation] ヒストンの修飾因子UTXの脳特異的な欠損マウスの解析2019
- Author(s)
  小泉美穂、三田村佳勇、世良康如、本田浩章、衛藤光、岸雄介、藤平篤志
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K22546

1. HONDA HIROAKI (40245064)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. 本田善一郎 (70238814)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
3. 岩崎正幸 (70790913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 中田雄一郎 (90793430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 堀江重郎 (40190243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. UEDA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. ICHI Ikuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 金井昭教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

sera yasuyuki 世良 康如

Sera Yasuyuki 世良 康如

Research Projects

Research Products

Co-Researchers

腫瘍発症におけるヒストン修飾因子UTXの選択的スプライシング脱制御の役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanisms underlying development of malignant tumors with loss-of-function mutations of UTX, a histone modifier, mainly focusing on urological tumors.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Compass-like複合体のハプロ不全型がん抑制機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanisms underlying stem cell aging induced by deregulation of histone modifications and development of anti-aging therapies by maintaining their functions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role(s) of UTX, histone demethylase for H3K27me3, in B cell regulatory mechanisms and autoimmune disease pathogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analyses of enzymatic activity- and complex formation-dependent roles of UTX in the regulation of hematopoietic stem cells and development of hematopoietic diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] MBTD1 preserves adult hematopoietic stem cell pool size and function2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Prostate cancer with histone modifier UTX mutations can benefit from olaparib.2023

Author(s)

Organizer

Data Source

[Presentation] ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血系維持に関与する2021

Author(s)

Organizer

Data Source

[Presentation] ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血系維持に関与する2021

Author(s)

Organizer

Data Source

[Presentation] ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血系維持に関与する2021

Author(s)

Organizer

Data Source

[Presentation] 2.ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血形維持に関与する2020

Author(s)

Organizer

sera yasuyuki 世良康如

Sera Yasuyuki 世良康如