Kiguchi Yuki 木口裕貴

Researcher Number	40845880
Other IDs
Affiliation (Current)	2026: 京都薬科大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 京都薬科大学, 薬学部, 助教 2022: 神戸薬科大学, 薬学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Keywords	Principal Investigator ファージ提示 / 試験管内親和性成熟 / 抗体工学 / scFv / 一本鎖Fvフラグメント / 抗体 / アミノ酸挿入 / 枠組み配列

Research Projects
(2 results)
Research Products
(7 results)

Development of a high-throughput system identifying high-affinity antibody mutants for the next-generation diagnostic drugsPrincipal Investigator
- Principal Investigator
  
  木口裕貴
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kyoto Pharmaceutical University
Establishment of an efficient method generating high-affinity mutant antibodies for the development of next-generation diagnostic agentsPrincipal Investigator
- Principal Investigator
  
  Kiguchi Yuki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kyoto Pharmaceutical University
  Kobe Pharmaceutical University

All 2023 2022

All Journal Article Presentation

[Journal Article] Framework-Directed Amino-Acid Insertions Generated over 55-Fold Affinity-Matured Antibody Fragments That Enabled Sensitive Luminescent Immunoassays of Cortisol2023
- Author(s)
  Kiguchi Yuki、Morita Izumi、Yamaki Kouya、Takegami Shigehiko、Kobayashi Norihiro
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 12 Pages: 1661-1665
- DOI
  10.1248/bpb.b23-00656
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06523, KAKENHI-PROJECT-22K15268
[Journal Article] Retrieving Dissociation-Resistant Antibody Mutants: An Efficient Strategy for Developing Immunoassays with Improved Sensitivities2022
- Author(s)
  Yuki Kiguchi, Izumi Morita, Akari Tsuruno, Norihiro Kobayashi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 10 Pages: 1432-1437
- DOI
  10.1248/bpb.b22-00454
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-10-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-22K15268
[Journal Article] More than 370-Fold Increase in Antibody Affinity to Estradiol-17β by Exploring Substitutions in the V<sub>H</sub>-CDR32022
- Author(s)
  Izumi Morita, Yuki Kiguchi, Saya Nakamura, Ayano Yoshida, Haruna Kubo, Momo Ishida, Hiroyuki Oyama, Norihiro Kobayashi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 7 Pages: 851-855
- DOI
  10.1248/bpb.b22-00187
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-07-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-22K15268
[Presentation] 解離非依存型 CAP 法により取得した高親和力変異 scFv を用いるコルチゾールの高感度生物発光 ELISA2023
- Author(s)
  木口裕貴，森田いずみ，武上茂彦, 小林典裕
- Organizer
  日本抗体学会学
- Data Source
  KAKENHI-PROJECT-22K15268
[Presentation] 解離非依存型CAP法による高親和力抗コルチゾールscFvの創製2023
- Author(s)
  木口裕貴, 森田いずみ, 鶴野朱里, 小林典裕
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-22K15268
[Presentation] CAP法を活かしたVH-CDR3を変異標的とする高親和力抗エストラジオール-17β抗体フラグメントの創製2023
- Author(s)
  森田いずみ, 木口裕貴, 久保晴菜, 石田もも, 大山浩之, 小林典裕
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-22K15268
[Presentation] 免疫測定法の高感度化に資する高親和力変異抗体探索システムの開発と応用2022
- Author(s)
  木口裕貴
- Organizer
  日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-22K15268

Kiguchi Yuki 木口 裕貴

Research Projects

Research Products

Development of a high-throughput system identifying high-affinity antibody mutants for the next-generation diagnostic drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of an efficient method generating high-affinity mutant antibodies for the development of next-generation diagnostic agentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Framework-Directed Amino-Acid Insertions Generated over 55-Fold Affinity-Matured Antibody Fragments That Enabled Sensitive Luminescent Immunoassays of Cortisol2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Retrieving Dissociation-Resistant Antibody Mutants: An Efficient Strategy for Developing Immunoassays with Improved Sensitivities2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] More than 370-Fold Increase in Antibody Affinity to Estradiol-17β by Exploring Substitutions in the V<sub>H</sub>-CDR32022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Presentation] 解離非依存型 CAP 法により取得した高親和力変異 scFv を用いるコルチゾールの高感度生物発光 ELISA2023

Author(s)

Organizer

Data Source

[Presentation] 解離非依存型CAP法による高親和力抗コルチゾールscFvの創製2023

Author(s)

Organizer

Data Source

[Presentation] CAP法を活かしたVH-CDR3を変異標的とする高親和力抗エストラジオール-17β抗体フラグメントの創製2023

Author(s)

Organizer

Data Source

[Presentation] 免疫測定法の高感度化に資する高親和力変異抗体探索システムの開発と応用2022

Author(s)

Organizer

Data Source

Kiguchi Yuki 木口裕貴