KIWAKI Takumi 木脇拓道

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Kiwaki Takumi 木脇拓道

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Researcher Number	40866068
Other IDs	https://orcid.org/0000-0002-6931-8055
Affiliation (Current)	2026: 宮崎大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2026: 宮崎大学, 医学部, 助教 2021 – 2024: 宮崎大学, 医学部, 助教 2020: 宮崎大学, 医学部, 医員
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related
Keywords	Principal Investigator がん / がん周囲微小環境 / HGF / MET / 転移 / 分子標的治療 / プロテアーゼイメージング / HAI-1 / がん三次元培養 / 患者腫瘍由来移植マウス / 患者腫瘍由来オルガノイド / 合成HGF活性化阻害剤 / 分子標的薬

HAI-1/LRP11 によるプロテアーゼ活性制御を介した腫瘍免疫回避機構の解明Principal Investigator
- Principal Investigator
  
  木脇拓道
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  University of Miyazaki
Investigation of HGF-MET dependent metastasis mechanism focusing on HGF activity-regulating molecules in cancer cellsPrincipal Investigator
- Principal Investigator
  
  木脇拓道
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  University of Miyazaki
Investigation of activation mechanisms and exploration of inhibition therapy of HGF-MET signal in cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  Kiwaki Takumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  University of Miyazaki

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Engineered Expression of Hepatocyte Growth Factor Activator Inhibitor-1 (HAI-1) Reduces the Growth of Bladder Cancer Cells2025
- Author(s)
  Katayama Yuichi、Akioka Takahiro、Kimura Shoichi、Fujii Masato、Nagai Takahiro、Kiwaki Takumi、Kawaguchi Makiko、Fukushima Tsuyoshi、Sato Yuichiro、Mukai Shoichiro、Kamoto Toshiyuki、Sawada Atsuro
- Journal Title
  
  Biomedicines
  
  Volume: 13 Issue: 4 Pages: 871-871
- DOI
  10.3390/biomedicines13040871
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06444
[Journal Article] Phosphorylation of MET Is Upregulated in Metastatic Sites of Renal Cell Carcinoma: Possible Role of MET and Hepatocyte Growth Factor Activation-Targeted Combined Therapy.2025
- Author(s)
  Akioka T, Kimura S, Katayama Y, Fujii M, Kiwaki T, Kawaguchi M, Fukushima T, Sato Y, Mukai S, Kamoto T, Sawada A.
- Journal Title
  
  Biomedicines
  
  Volume: 28 Issue: 4 Pages: 811-811
- DOI
  10.3390/biomedicines13040811
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09506, KAKENHI-PROJECT-23K06444, KAKENHI-PROJECT-24K19671
[Journal Article] Loss of tumor cell surface hepatocyte growth factor activator inhibitor-1 predicts worse prognosis in esophageal squamous cell carcinoma2025
- Author(s)
  Umekita Yoshiko、Kiwaki Takumi、Kawaguchi Makiko、Yamamoto Koji、Ikenoue Makoto、Takeno Shinsuke、Fukushima Tsuyoshi、Sato Yuichiro、Kataoka Hiroaki
- Journal Title
  
  Pathology - Research and Practice
  
  Volume: 266 Pages: 155809-155809
- DOI
  10.1016/j.prp.2025.155809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07154, KAKENHI-PROJECT-23K06444
[Journal Article] Possible role of combined therapy targeting MET and pro-HGF activation for renal cell carcinoma: analysis by human HGF-producing SCID mice.2023
- Author(s)
  Fujii M, Akioka T, Kimura S, Nagai T, Kiwaki T, Fukushima T, Mukai S, Kamoto T
- Journal Title
  
  Human cell
  
  Volume: 36 Issue: 2 Pages: 775-785
- DOI
  10.1007/s13577-023-00857-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16175
[Journal Article] Adrenomedullin alleviates mucosal injury in experimental colitis and increases claudin‐4 expression in the colonic epithelium2023
- Author(s)
  Kawaguchi Makiko、Kataoka Hiroaki、Kiwaki Takumi、Weiting Liang、Nagata Sayaka、Kitamura Kazuo、Fukushima Tsuyoshi
- Journal Title
  
  FEBS Open Bio
  
  Volume: 13 Issue: 4 Pages: 713-723
- DOI
  10.1002/2211-5463.13577
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08188, KAKENHI-PROJECT-20K16175, KAKENHI-PROJECT-21H02918
[Journal Article] Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine2022
- Author(s)
  Kiwaki Takumi、Kataoka Hiroaki
- Journal Title
  
  Journal of Personalized Medicine
  
  Volume: 12 Issue: 5 Pages: 695-695
- DOI
  10.3390/jpm12050695
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16175
[Journal Article] Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor‐12022
- Author(s)
  Yamashita Fumiki、Kaieda Takashi、Shimomura Takeshi、Kawaguchi Makiko、Lin Chen‐Yong、Johnson Michael D.、Tanaka Hiroyuki、Kiwaki Takumi、Fukushima Tsuyoshi、Kataoka Hiroaki
- Journal Title
  
  The FEBS Journal
  
  Volume: - Issue: 12 Pages: 3422-3439
- DOI
  10.1111/febs.16348
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16175
[Journal Article] Insufficiency of hepatocyte growth factor activator inhibitor-1 confers lymphatic invasion of tongue carcinoma cells2022
- Author(s)
  Aya Izumi, Koji Yamamoto, Makiko Kawaguchi, Fumiki Yamashita, Tsuyoshi Fukushima, Takumi Kiwaki, Hiroyuki Tanaka, Yoshihiro Yamashita, Hiroaki Kataoka
- Journal Title
  
  Cancer Science
  
  Volume: 00 Issue: 6 Pages: 1-15
- DOI
  10.1111/cas.15346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18483, KAKENHI-PROJECT-20K16175
[Journal Article] Decreased prostasin expression is associated with aggressiveness of oral squamous cell carcinoma2021
- Author(s)
  Koji Yamamoto, Fumiki Yamashita, Makiko Kawaguchi, Aya Izumi, Takumi Kiwaki, Hiroaki Kataoka, Takeshi Kaneuji, Yoshihiro Yamashita & Tsuyoshi Fukushima
- Journal Title
  
  Human Cell
  
  Volume: 34 Issue: 5 Pages: 1434-1445
- DOI
  10.1007/s13577-021-00575-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18483, KAKENHI-PROJECT-20K16175
[Presentation] Low-density lipoprotein receptor related protein 11 (LRP11) suppresses ubiquitin like modifier activating enzyme 7 (UBA7) and promotes proliferation of lung adenocarcinoma cells.2024
- Author(s)
  Takumi Kiwaki, Makiko Kawaguchi, Tsuyoshi Fukushima, Yuichiro Sato
- Organizer
  第 83 回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06444
[Presentation] LRP11はUBA7発現を抑制し，肺腺癌の増殖を亢進させる2024
- Author(s)
  木脇拓道，川口真紀子，福島剛，佐藤勇一郎
- Organizer
  日本患者由来がんモデル学会・日本ヒト細胞学会合同学術集会2024
- Data Source
  KAKENHI-PROJECT-23K06444
[Presentation] LRP11は肺腺癌の予後不良と関連する2023
- Author(s)
  木脇拓道，川口真紀子，福島剛，片岡寛章
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K06444
[Presentation] 患者由来がんオルガノイドを用いた新規抗がん療法の開発2021
- Author(s)
  木脇　拓道
- Organizer
  第３９回日本ヒト細胞学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16175
[Presentation] ヒト HGF 導入 SCID マウスを用いた HGF-MET シグナル解析と阻害治療の開発2020
- Author(s)
  木脇　拓道
- Organizer
  第３８回日本ヒト細胞学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16175

1. 賀本敏行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 秋岡貴弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 向井尚一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 藤井将人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 山本晃士

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 川口真紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 永田さやか

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 北村和雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIWAKI Takumi 木脇 拓道

Kiwaki Takumi 木脇 拓道

Research Projects

Research Products

Co-Researchers

HAI-1/LRP11 によるプロテアーゼ活性制御を介した腫瘍免疫回避機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of HGF-MET dependent metastasis mechanism focusing on HGF activity-regulating molecules in cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of activation mechanisms and exploration of inhibition therapy of HGF-MET signal in cancer microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Engineered Expression of Hepatocyte Growth Factor Activator Inhibitor-1 (HAI-1) Reduces the Growth of Bladder Cancer Cells2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of MET Is Upregulated in Metastatic Sites of Renal Cell Carcinoma: Possible Role of MET and Hepatocyte Growth Factor Activation-Targeted Combined Therapy.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of tumor cell surface hepatocyte growth factor activator inhibitor-1 predicts worse prognosis in esophageal squamous cell carcinoma2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible role of combined therapy targeting MET and pro-HGF activation for renal cell carcinoma: analysis by human HGF-producing SCID mice.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adrenomedullin alleviates mucosal injury in experimental colitis and increases claudin‐4 expression in the colonic epithelium2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor‐12022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insufficiency of hepatocyte growth factor activator inhibitor-1 confers lymphatic invasion of tongue carcinoma cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased prostasin expression is associated with aggressiveness of oral squamous cell carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Low-density lipoprotein receptor related protein 11 (LRP11) suppresses ubiquitin like modifier activating enzyme 7 (UBA7) and promotes proliferation of lung adenocarcinoma cells.2024

Author(s)

Organizer

Data Source

[Presentation] LRP11はUBA7発現を抑制し，肺腺癌の増殖を亢進させる2024

Author(s)

Organizer

Data Source

[Presentation] LRP11は肺腺癌の予後不良と関連する2023

Author(s)

Organizer

Data Source

KIWAKI Takumi 木脇拓道

Kiwaki Takumi 木脇拓道