Nishimune Hiroshi 西宗裕史

Researcher Number	40870043
Other IDs	https://orcid.org/0000-0003-2711-9223
Affiliation (Current)	2026: 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員
Affiliation (based on the past Project Information) *help	2020 – 2024: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Biological Sciences Except Principal Investigator Basic Section 59010:Rehabilitation science-related
Keywords	Principal Investigator ラミニン / 神経筋接合部 / ALS / 筋萎縮性側索硬化症 / iPS細胞 / 幹細胞 / アクティブゾーン / 骨格筋 / 運動神経 Except Principal Investigator サルコペニア … More / 筋血流 / 機械的刺激 / 咽頭 / 血流 / 腰部交感神経 / サルコぺニア / 筋血管 / 筋収縮 / 張力 / 自律神経 / ラット / 老化 / 電気刺激 / 収縮力 / 反射 / 筋収縮力 / 圧受容器 / 大動脈 / 神経筋接合部 / 筋緊張 / 筋力 / 嚥下 / 骨格筋 / 交感神経 Less

Denervation mechanism and intervention methods of the ALS neuromuscular junctionPrincipal Investigator
- Principal Investigator
  
  西宗裕史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tokyo Metropolitan Institute for Geriatrics and Gerontology
Investigation of mechanisms how synapse organizer and mesenchymal stem cells ameliorate ALS neurodegeneration.Principal Investigator
- Principal Investigator
  
  Nishimune Hiroshi
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute for Geriatrics and Gerontology
嚥下にともなう自律神経の活性化が骨格筋におよぼす作用とサルコペニア予防への応用
- Principal Investigator
  
  堀田晴美
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Tokyo Metropolitan Institute for Geriatrics and Gerontology

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation Book

[Book] 実験医学、Vol.38, No.16、神経筋接合部の老化2020
- Author(s)
  西宗裕史、Yomna Badawi
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19K24690
[Journal Article] Muscle-specific Bet1L knockdown induces neuromuscular denervation, motor neuron degeneration, and motor dysfunction in a rat model of familial ALS2025
- Author(s)
  Eckardt Adam、Marble Charles、Fern Bradley、Moritz Henry、Kotula Charles、Ke Jiayi、Rebancos Clarisse、Robertson Samantha、Nishimune Hiroshi、Suzuki Masatoshi
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 19 Pages: 1527181-1527181
- DOI
  10.3389/fnins.2025.1527181
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24690
[Journal Article] Resistance exercise in early-stage ALS patients, ALSFRS-R, Sickness Impact Profile ALS-19, and muscle transcriptome: a pilot study2024
- Author(s)
  Jawdat Omar、Rucker Jason、Nakano Tomoki、Takeno Kotaro、Statland Jeffery、Pasnoor Mamatha、Dimachkie Mazen M.、Sabus Carla、Badawi Yomna、Hunt Suzanne L.、Tomioka Naoko H.、Gunewardena Sumedha、Bloomer Clark、Wilkins Heather M.、Herbelin Laura、Barohn Richard J.、Nishimune Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 21729-21729
- DOI
  10.1038/s41598-024-72355-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24690
[Journal Article] Identification of adrenergic presynaptic and postsynaptic protein locations at neuromuscular junctions, their decrease during aging, and recovery by nicotinamide mononucleotide administration2024
- Author(s)
  Takeno Kotaro、Watanabe Nobuhiro、Morifuji Masashi、Hotta Harumi、Nishimune Hiroshi
- Journal Title
  
  NeuroReport
  
  Volume: 35 Issue: 12 Pages: 805-812
- DOI
  10.1097/wnr.0000000000002070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K24690
[Journal Article] Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity2024
- Author(s)
  Sakamoto Ikko、Shibuya Shuichi、Nojiri Hidetoshi、Takeno Kotaro、Nishimune Hiroshi、Yaku Keisuke、Nakagawa Takashi、Ishijima Muneaki、Shimizu Takahiko
- Journal Title
  
  Antioxidants
  
  Volume: 13 Issue: 11 Pages: 1421-1421
- DOI
  10.3390/antiox13111421
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24762, KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-19K24690
[Journal Article] Neuronal Plasticity and Age-Related Functional Decline in the Motor Cortex2023
- Author(s)
  Inoue Ritsuko、Nishimune Hiroshi
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 17 Pages: 2142-2142
- DOI
  10.3390/cells12172142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K24690, KAKENHI-PROJECT-22K11306
[Journal Article] Forelimb Resistance Exercise Protects Against Neuromuscular Junction Denervation in the SOD1-G93A Rat Model of ALS2022
- Author(s)
  Nishimune Hiroshi、Stanford Kimberly G、Chen Jie、Odum James D、Rorie Alexander D、Rogers Robert S、Wheatley Joshua L、Geiger Paige C、Stanford John A
- Journal Title
  
  Degenerative Neurological and Neuromuscular Disease
  
  Volume: Volume 12 Pages: 145-155
- DOI
  10.2147/dnnd.s388455
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24690
[Journal Article] Similarity and Diversity of Presynaptic Molecules at Neuromuscular Junctions and Central Synapses2022
- Author(s)
  Takikawa Kenji、Nishimune Hiroshi
- Journal Title
  
  Biomolecules
  
  Volume: 12 Issue: 2 Pages: 1-25
- DOI
  10.3390/biom12020179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15196, KAKENHI-PROJECT-20K22699, KAKENHI-PROJECT-19K24690
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)12021
- Author(s)
  Daniel J Klionsky、Shu Aizawa、Amal Kamal Abdel-Aziz、Sara Abdelfatah、Mahmoud Abdellatif、Asghar Abdoli、Steffen Abel、Hagai Abeliovich、Marie H Abildgaard、Yakubu Princely Abudu、Abraham Acevedo-Arozena、Iannis E Adamopoulos、Khosrow Adeli、Timon E Adolph、Annagrazia Adornetto、Elma Aflaki、Galila Agam et al.
- Journal Title
  
  Autophagy
  
  Volume: 17 Issue: 1 Pages: 1-382
- DOI
  10.1080/15548627.2020.1797280
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06375, KAKENHI-PROJECT-19K07568, KAKENHI-PROJECT-20K06501, KAKENHI-PROJECT-20K06636, KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-20K21769, KAKENHI-PLANNED-20H05772, KAKENHI-PROJECT-19H01042, KAKENHI-PROJECT-18H02439, KAKENHI-PROJECT-18H02656, KAKENHI-PROJECT-18H02807, KAKENHI-PROJECT-20J00363, KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-18K09427, KAKENHI-PROJECT-19K08851, KAKENHI-PROJECT-18KK0193, KAKENHI-PLANNED-19H05710, KAKENHI-PROJECT-18H02901, KAKENHI-PROJECT-20H02990, KAKENHI-PUBLICLY-20H05504, KAKENHI-PROJECT-19H03471, KAKENHI-PROJECT-19H03791, KAKENHI-PROJECT-20H03249, KAKENHI-PROJECT-19K09677, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-20K08460, KAKENHI-PROJECT-20K08662, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-19K24690, KAKENHI-PROJECT-23K21397
[Journal Article] Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord2021
- Author(s)
  Tungtur Sudheer K.、Wilkins Heather M.、Rogers Robert S.、Badawi Yomna、Sage Jessica M.、Agbas Abdulbaki、Jawdat Omar、Barohn Richard J.、Swerdlow Russell H.、Nishimune Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 11051-11051
- DOI
  10.1038/s41598-021-90438-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24690
[Journal Article] A deletion in the N-terminal polymerizing domain of laminin β2 is a new mouse model of chronic nephrotic syndrome.2020
- Author(s)
  Steven D Funk, Raymond H Bayer, Karen K McKee, Kazushi Okada, Hiroshi Nishimune, Peter D Yurchenco, Jeffrey H Miner.
- Journal Title
  
  Kidney International
  
  Volume: 98 Issue: 1 Pages: 133-146
- DOI
  10.1016/j.kint.2020.01.033
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24690
[Journal Article] Impairment mechanisms and intervention approaches for aged human neuromuscular junctions2020
- Author(s)
  Yomna Badawi and Hiroshi Nishimune
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 13 Pages: 568426-568426
- DOI
  10.3389/fnmol.2020.568426
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24690
[Presentation] Mechanism of age-related denervation in aged animals and development of intervention methods, Sponsoring organization2024
- Author(s)
  Hiroshi Nishimune
- Organizer
  Molecular and Cell Biology of the Neuromuscular System
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24690
[Presentation] The mechanism of age-related motor function decline and intervention for the elderly with nicotinamide mononucleotide2024
- Author(s)
  Hiroshi Nishimune
- Organizer
  The 66th Annual Meeting of the Japan Geriatrics Society
- Invited
- Data Source
  KAKENHI-PROJECT-19K24690
[Presentation] Super-resolution microscopic analysis of the active zone protein organization of the neuromuscular junction2023
- Author(s)
  西宗裕史
- Organizer
  2022年度　生理研研究会　ナノ・メゾスケールから捉えるシナプス制御機構の新展開
- Invited
- Data Source
  KAKENHI-PROJECT-19K24690
[Presentation] 筋萎縮性側索硬化症（ALS）の治療を目指した神経筋接合部の研究2023
- Author(s)
  西宗裕史
- Organizer
  国立長寿医療研究センターセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K24690
[Presentation] Super-resolution imaging of synaptic proteins of neuromuscular junctions in adults and aged mice2023
- Author(s)
  Naoko H. Tomioka, Yomna Badawi, Kenji Takikawa, Hiroshi Nishimune
- Organizer
  International Association of Gerontology & Geriatrics-Asia Oceania Regional Congress2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24690
[Presentation] Expression mechanism analysis of synapse-organizers essential for maintaining motor function and neuromuscular junctions2023
- Author(s)
  Tomoyuki Nakano, Kotaro Takeno, Yomna Badawi, Hiroshi Nishimune
- Organizer
  International Association of Gerontology & Geriatrics-Asia Oceania Regional Congress2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24690
[Presentation] 筋萎縮性側索硬化症の治療を目指したヒト間葉系幹細胞の利用2023
- Author(s)
  西宗裕史
- Organizer
  山口大学医学部、メディバイオ事業研究会　第28回講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K24690
[Presentation] Analysis of protein organization near the active zone of mouse NMJs2022
- Author(s)
  西宗裕史
- Organizer
  Molecular and Cell Biology of the Neuromuscular System, Guarda, Switzerland
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24690
[Presentation] 神経筋接合部におけるラミニンβ2鎖の機能2021
- Author(s)
  西宗裕史
- Organizer
  第53回日本結合組織学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K24690
[Presentation] A treatment strategy for ALS neuromuscular junction degeneration using human mesenchymal stem cells2020
- Author(s)
  Yomna Badawi, Takashi Matsuda, Sudheer Tungtur, Tomohiro Tanaka, Rupal Soder, Kleiton Silv, Tadashi Yoshida, Richard Barohn, and Hiroshi Nishimune(発表者、西宗裕史)
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K24690

1. 堀田晴美 (70199511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 重本和宏 (40284400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 相澤修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 瀧川健司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 中川崇

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# of Collaborated Products: 1 results

Nishimune Hiroshi 西宗 裕史

Research Projects

Research Products

Co-Researchers

Denervation mechanism and intervention methods of the ALS neuromuscular junctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of mechanisms how synapse organizer and mesenchymal stem cells ameliorate ALS neurodegeneration.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

嚥下にともなう自律神経の活性化が骨格筋におよぼす作用とサルコペニア予防への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 実験医学、Vol.38, No.16、神経筋接合部の老化2020

Author(s)

Publisher

Data Source

[Journal Article] Muscle-specific Bet1L knockdown induces neuromuscular denervation, motor neuron degeneration, and motor dysfunction in a rat model of familial ALS2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resistance exercise in early-stage ALS patients, ALSFRS-R, Sickness Impact Profile ALS-19, and muscle transcriptome: a pilot study2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of adrenergic presynaptic and postsynaptic protein locations at neuromuscular junctions, their decrease during aging, and recovery by nicotinamide mononucleotide administration2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuronal Plasticity and Age-Related Functional Decline in the Motor Cortex2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Forelimb Resistance Exercise Protects Against Neuromuscular Junction Denervation in the SOD1-G93A Rat Model of ALS2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Similarity and Diversity of Presynaptic Molecules at Neuromuscular Junctions and Central Synapses2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)12021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A deletion in the N-terminal polymerizing domain of laminin β2 is a new mouse model of chronic nephrotic syndrome.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impairment mechanisms and intervention approaches for aged human neuromuscular junctions2020

Author(s)

Journal Title

DOI

Nishimune Hiroshi 西宗裕史