Umeno Tomohiro 梅野智大

Researcher Number	40879524
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Affiliation (based on the past Project Information) *help	2025: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2023: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2020 – 2022: 昭和薬科大学, 薬学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / 0801:Pharmaceutical sciences and related fields Except Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Keywords	Principal Investigator ペプチド固相合成 / アミン検出試薬 / ドナー・アクセプター / ペプチド / アミン検出 / ジ置換アミノ酸 / エンドソーム / 両親媒性ペプチド / エンドソーム脱出ペプチド / アミノ酸 / カイザーテスト / 酸塩基反応 / 固相合成 … More Except Principal Investigator … More ラジカル / イメージング / 蛍光 / π拡張 / 分析試薬 / 光異性化 / ピリダジン / らせん / 光ラセミ化 / 生体イメージング / 金属イオン検出 / 発光プローブ / プッシュプル型 / ビラジカル / ヘリセン / 発光性化合物 Less

Development of endosomal escape peptides using amphiphilic peptides containing unnatural amino acidsPrincipal Investigator
- Principal Investigator
  
  梅野智大
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kyoto Prefectural University of Medicine
多機能性π拡張型アミノキノリン誘導体の開発
- Principal Investigator
  
  唐澤悟
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Showa Pharmaceutical University
酸塩基反応型ペプチド固相合成用アミン呈色試薬の開発と実用化研究Principal Investigator
- Principal Investigator
  
  梅野智大
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kyoto Prefectural University of Medicine
  Showa Pharmaceutical University
Development of environment-friendly amine detection reagents that contribute to achieving SDGs and their application to peptide synthesisPrincipal Investigator
- Principal Investigator
  
  Umeno Tomohiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Showa Pharmaceutical University

All 2023 2022 2021 2020

All Journal Article Presentation Patent

[Journal Article] Photoisomerization of “Partially Embedded Dihydropyridazine” with a Helical Structure2023
- Author(s)
  Usui Kazuteru、Amano Ami、Murayama Kasumi、Sasaya Miho、Kusumoto Ryota、Umeno Tomohiro、Murase Satsuki、Iizuka Naoko、Matsumoto Shota、Fuchi Yasufumi、Takahashi Kazuyuki、Kawahata Masatoshi、Kobori Yasuhiro、Karasawa Satoru
- Journal Title
  
  Chemistry A European Journal
  
  Volume: 29 Issue: 62
- DOI
  10.1002/chem.202302413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06564, KAKENHI-PROJECT-23K04722, KAKENHI-PROJECT-22K19008, KAKENHI-PLANNED-20H05835
[Journal Article] Quantitative and Nondestructive Colorimetric Amine Detection Method for the Solid-Phase Peptide Synthesis as an Alternative to the Kaiser Test2023
- Author(s)
  Umeno Tomohiro、Fujihara Moeka、Matsumoto Shota、Iizuka Naoko、Usui Kazuteru、Karasawa Satoru
- Journal Title
  
  Analytical Chemistry
  
  Volume: 95 Issue: 42 Pages: 15803-15809
- DOI
  10.1021/acs.analchem.3c03350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15265, KAKENHI-PROJECT-22K06564, KAKENHI-PROJECT-23K04722
[Journal Article] Naphthyridine-Based Electron Push?Pull-Type Amine-Reactive Fluorescent Probe for Sensing Amines and Proteins in Aqueous Media2023
- Author(s)
  Umeno Tomohiro、Muroi Lisa、Kayama Yuto、Usui Kazuteru、Hamada Koichi、Mizutani Akihiro、Karasawa Satoru
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 34 Issue: 8 Pages: 1439-1446
- DOI
  10.1021/acs.bioconjchem.3c00220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15265, KAKENHI-PROJECT-22K06564, KAKENHI-PROJECT-23K04722
[Journal Article] Development of Reversible Acid-Base Detection Reagents Based on Push-pull Type Aminonaphthyridine and Aminoquinoline Derivatives2022
- Author(s)
  MATSUMOTO Shota、UMENO Tomohiro、USUI Kazuteru、KARASAWA Satoru
- Journal Title
  
  BUNSEKI KAGAKU
  
  Volume: 71 Issue: 3 Pages: 119-131
- DOI
  10.2116/bunsekikagaku.71.119
- ISSN
  0525-1931
- Year and Date
  2022-03-05
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06564, KAKENHI-PROJECT-20K05467
[Journal Article] Chelate-free “turn-on”-type fluorescence detection of trivalent metal ions2022
- Author(s)
  Matsumoto Shota、Umeno Tomohiro、Suzuki Noriko、Usui Kazuteru、Kawahata Masatoshi、Karasawa Satoru
- Journal Title
  
  Chemical Communications
  
  Volume: 58 Issue: 89 Pages: 12435-12438
- DOI
  10.1039/d2cc04815a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06564, KAKENHI-PROJECT-20K05467
[Journal Article] Basic Fluorescent Protonation-Type pH Probe Sensitive to Small Δp<i>K</i><sub>a</sub> of Methanol and Ethanol2022
- Author(s)
  Umeno Tomohiro、Seto Remi、Matsumoto Shota、Fujihara Moeka、Karasawa Satoru
- Journal Title
  
  Analytical Chemistry
  
  Volume: 94 Issue: 29 Pages: 10400-10407
- DOI
  10.1021/acs.analchem.2c01415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06564, KAKENHI-PROJECT-20K22721
[Journal Article] Oxidation of an Internal‐Edge‐Substituted [5]Helicene‐Derived Phosphine Synchronously Enhances Circularly Polarized Luminescence2022
- Author(s)
  Usui Kazuteru、Narita Nozomi、Eto Ryosuke、Suzuki Seika、Yokoo Atsushi、Yamamoto Kosuke、Igawa Kazunobu、Iizuka Naoko、Mimura Yuki、Umeno Tomohiro、Matsumoto Shota、Hasegawa Masashi、Tomooka Katsuhiko、Imai Yoshitane、Karasawa Satoru
- Journal Title
  
  Chemistry - A European Journal
  
  Volume: 28 Issue: 65
- DOI
  10.1002/chem.202202922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05043, KAKENHI-PROJECT-22K06564, KAKENHI-PROJECT-20K05467
[Journal Article] π‐Extended Push‐Pull‐Type Bicyclic Fluorophores Based on Quinoline and Naphthyridine Frameworks with an Iminophosphorane Fragment2021
- Author(s)
  Umeno Tomohiro、Usui Kazuteru、Karasawa Satoru
- Journal Title
  
  Asian Journal of Organic Chemistry
  
  Volume: - Issue: 5 Pages: 1123-1130
- DOI
  10.1002/ajoc.202100015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22721, KAKENHI-PROJECT-19K07016, KAKENHI-PROJECT-20K05467
[Journal Article] PushーPull Bisnaphthyridylamine Supramolecular Nanoparticles: Polarity‐Induced Aggregation and Crystallization‐Induced Emission Enhancement and Fluorescence Resonance Energy Transfer2021
- Author(s)
  R. Hagihara, T. Umeno, S. Ueki, D. Yoshihara, Y. Fuchi, K, Usui, M. Sakuma, and Satoru Karasawa,*
- Journal Title
  
  Chem Eur J
  
  Volume: 27 Issue: 9 Pages: 3039-3046
- DOI
  10.1002/chem.202003854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07016, KAKENHI-PROJECT-20K05467, KAKENHI-PROJECT-20K22721, KAKENHI-PROJECT-20H00493
[Journal Article] Characterization of Push-Pull-Type Benzo[X]quinoline Derivatives (X = g or f): Environmentally Responsive Fluorescent Dyes with Multiple Functions2020
- Author(s)
  Y. Fuchi, T. Umeno, Y. Abe, K. Ikeno, R. Yamasaki, I. Okamoto, K. Usui, and Satoru Karasawa
- Journal Title
  
  J. Org. Chem.
  
  Volume: 85 Issue: 20 Pages: 13177-13190
- DOI
  10.1021/acs.joc.0c01878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07016, KAKENHI-PROJECT-20K05467, KAKENHI-PROJECT-20K15963, KAKENHI-PROJECT-20K22721
[Patent] アミン類検出薬2021
- Inventor(s)
  唐澤悟、梅野智大、松本祥汰、臼井一晃
- Industrial Property Rights Holder
  昭和薬科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] 水環境下で強く発光するハロゲン化ナフチリジンの開発2023
- Author(s)
  室井梨沙、梅野智大、臼井一晃、唐澤悟
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15265
[Presentation] 極性置換基を有するNOラジカルの合成、X線構造と物性評価2023
- Author(s)
  飯塚直子、白石諒馬、梅野智大、臼井一晃、唐澤悟
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] 塩酸塩型色素を用いたアミノ基検出試薬のペプチド固相合成への適用2023
- Author(s)
  藤原萌圭、梅野智大、臼井一晃、唐澤悟
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15265
[Presentation] 塩酸塩型色素を用いたアミノ基検出試薬のペプチド固相合成への適用2023
- Author(s)
  藤原萌圭、梅野智大、臼井一晃、唐澤悟
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] ジヒドロアザ[5]ヘリセン類の合成と物性評価2023
- Author(s)
  石井一歩、村瀬早槻、梅野智大、臼井一晃、唐澤悟
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] エナミン型可逆的アミン蛍光誘導体化試薬の開発研究2023
- Author(s)
  梅野智大、河原朋希、臼井一晃、唐澤悟
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] ドナー・アクセプター型分子の特性を利用した分析試薬の開発2023
- Author(s)
  梅野智大
- Organizer
  日本薬学会関東支部「受賞記念オンライン講演会」
- Invited
- Data Source
  KAKENHI-PROJECT-22K15265
[Presentation] 発光性イミダゾナフチリジン誘導体の自己集合化挙動と物性評価2023
- Author(s)
  松本祥汰、梅野智大、臼井一晃、濵田浩一、水谷顕洋、唐澤悟
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] 水環境下で強く発光するハロゲン化ナフチリジンの開発2023
- Author(s)
  室井梨沙、梅野智大、臼井一晃、唐澤悟
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] ドナー・アクセプター型分子の特性を利用した分析試薬の開発2023
- Author(s)
  梅野智大
- Organizer
  第67回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15265
[Presentation] エナミン型可逆的アミン蛍光誘導体化試薬の開発研究2023
- Author(s)
  梅野智大、河原朋希、臼井一晃、唐澤悟
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15265
[Presentation] らせん性ピリリウム塩の合成と物性評価2023
- Author(s)
  臼井一晃、江藤亮介、有野陸、松本祥汰、梅野智大、唐澤悟
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] 螺旋構造内部置換型ヘリセンのキラル光学特性2022
- Author(s)
  臼井一晃、成田望実、江藤亮介、飯塚直子、梅野智大、井川和宣、友岡克彦、今井喜胤、唐澤悟
- Organizer
  第32回基礎有機化学討論会
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] グアニジノ基を有する蛍光分子によるメタノール選択的蛍光検出法の開発2022
- Author(s)
  梅野智大、瀬戸玲美、臼井一晃、唐澤悟
- Organizer
  第33回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] 酸塩基反応型アミン検出試薬の開発とペプチド合成への適用2022
- Author(s)
  梅野智大、藤原萌圭、臼井一晃、唐澤悟
- Organizer
  日本分析化学会　第71年会
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] ペプチド固相合成のための定量的なアミノ基検出法の開発2022
- Author(s)
  藤原萌圭、梅野智大、臼井一晃、唐澤悟
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] ペプチド固相合成のための酸塩基反応型アミン検出法の開発2022
- Author(s)
  梅野智大、藤原萌圭、臼井一晃、唐澤悟
- Organizer
  第34回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] 酸塩基反応に基づく三価金属検出プローブの開発?2022
- Author(s)
  松本祥汰、梅野智大、臼井一晃、川幡正俊、唐澤悟
- Organizer
  日本分析化学会　第71年会
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] NOラジカル型MRI造影剤開発のための基礎研究2022
- Author(s)
  飯塚直子、金子知世、白石諒馬、梅野智大、臼井一晃、唐澤悟
- Organizer
  日本分析化学会　第71年会
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] 塩基性蛍光分子によるメタノール選択的蛍光検出法の開発2022
- Author(s)
  梅野智大、瀬戸玲美、松本祥汰、臼井一晃、唐澤悟
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] D-A 型アミン検出試薬の開発とペプチド固相合成への応用2022
- Author(s)
  梅野智大、臼井一晃、唐澤悟
- Organizer
  第31回基礎有機化学討論会
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] ペプチド固相合成のための酸塩基反応型アミン検出法の開発2022
- Author(s)
  梅野智大、藤原萌圭、臼井一晃、唐澤悟
- Organizer
  第34回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] pKa値に基づいた三価アクア錯体の新しい検出法の開発2022
- Author(s)
  松本祥汰、梅野智大、臼井一晃、川幡正俊、唐澤悟
- Organizer
  バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] 高極性置換基を有した有機NOラジカルのMRI造影剤に対する機能性の検討2022
- Author(s)
  飯塚直子、金子知世、白石諒馬、梅野智大、臼井一晃、唐澤悟
- Organizer
  第34回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06564
[Presentation] 酸塩基反応型アミン検出試薬の開発とペプチド合成への適用2022
- Author(s)
  梅野智大、藤原萌圭、臼井一晃、唐澤悟
- Organizer
  日本分析化学会第71年会
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] Ｎ末をチオウレアで修飾したヘリカルペプチド触媒による不斉1,4-付加反応2021
- Author(s)
  佐藤和樹、梅野智大、上田篤志、土井光暢、加藤巧馬、田中正一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] 光異性化に基づくエストロゲン受容体の活性制御2021
- Author(s)
  土屋圭輔、梅野智大、辻厳一郎、横尾英知、福原潔、三澤隆史、出水庸介
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] ペプチド固相合成のための新規アミノ基検出法の開発研究2021
- Author(s)
  梅野智大、臼井一晃、唐澤悟
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] ペプチド側鎖におけるE選択的i,i+4閉環メタセシス反応2021
- Author(s)
  真倉唯、上田篤志、梅野智大、加藤巧馬、平山和浩、土井光暢、大庭誠、田中正一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] ジヒドロピリダジン環を含むアザ[5]ヘリセンの合成と物性評価2021
- Author(s)
  臼井一晃、天野亜美、村瀬早槻、梅野智大、唐澤悟
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22721
[Presentation] ヘリカルペプチドを基盤とした高活性有機分子触媒および不斉配位子としての展開2020
- Author(s)
  上田篤志，佐藤和樹，梅野智大，田中正一
- Organizer
  反応と合成の進歩2020特別企画シンポジウム
- Data Source
  KAKENHI-PROJECT-20K22721

1. 唐澤悟 (80315100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. HASEGAWA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 唐沢悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 19 results
4. 渕靖史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Umeno Tomohiro 梅野 智大

Research Projects

Research Products

Co-Researchers

Development of endosomal escape peptides using amphiphilic peptides containing unnatural amino acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

多機能性π拡張型アミノキノリン誘導体の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酸塩基反応型ペプチド固相合成用アミン呈色試薬の開発と実用化研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of environment-friendly amine detection reagents that contribute to achieving SDGs and their application to peptide synthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Photoisomerization of “Partially Embedded Dihydropyridazine” with a Helical Structure2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative and Nondestructive Colorimetric Amine Detection Method for the Solid-Phase Peptide Synthesis as an Alternative to the Kaiser Test2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Naphthyridine-Based Electron Push?Pull-Type Amine-Reactive Fluorescent Probe for Sensing Amines and Proteins in Aqueous Media2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of Reversible Acid-Base Detection Reagents Based on Push-pull Type Aminonaphthyridine and Aminoquinoline Derivatives2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Chelate-free “turn-on”-type fluorescence detection of trivalent metal ions2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Basic Fluorescent Protonation-Type pH Probe Sensitive to Small Δp<i>K</i><sub>a</sub> of Methanol and Ethanol2022

Author(s)

Journal Title

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[Journal Article] Oxidation of an Internal‐Edge‐Substituted [5]Helicene‐Derived Phosphine Synchronously Enhances Circularly Polarized Luminescence2022

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[Journal Article] π‐Extended Push‐Pull‐Type Bicyclic Fluorophores Based on Quinoline and Naphthyridine Frameworks with an Iminophosphorane Fragment2021

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[Journal Article] PushーPull Bisnaphthyridylamine Supramolecular Nanoparticles: Polarity‐Induced Aggregation and Crystallization‐Induced Emission Enhancement and Fluorescence Resonance Energy Transfer2021

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[Journal Article] Characterization of Push-Pull-Type Benzo[X]quinoline Derivatives (X = g or f): Environmentally Responsive Fluorescent Dyes with Multiple Functions2020

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Umeno Tomohiro 梅野智大