Adachi Koichiro 安達昂一郎

… Alternative Names

安達昂一郎アダチコウイチロウ

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Researcher Number	40963286
Other IDs
Affiliation (Current)	2026: 昭和薬科大学, 薬学部, 特任助教
Affiliation (based on the past Project Information) *help	2026: 昭和薬科大学, 薬学部, 特任助教 2023 – 2024: 昭和薬科大学, 薬学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator 薬物動態 / PBPK / 活性炭 / 救急医療 / 過量服用 / 血中濃度 / 薬物過量服用 / 生理学的薬物動態モデル / 急性薬物中毒

Research Projects
(2 results)
Research Products
(17 results)

アシクロビル脳症におけるアシクロビル代謝産物の毒性と診断補助指標の妥当性評価Principal Investigator
- Principal Investigator
  
  安達昂一郎
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Applying physiologically based pharmacokinetic to cases of acute drug intoxixation for visualizing the effective time of activated carbon administrationPrincipal Investigator
- Principal Investigator
  
  安達昂一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University

All 2025 2024 2023

All Journal Article Presentation

[Journal Article] Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman2024
- Author(s)
  Adachi Koichiro、Murata Maki、Inada Akiyoshi、Morimoto Takeyori、Shimizu Makiko、Beppu Satoru、Yamazaki Hiroshi
- Journal Title
  
  Acute Medicine & Surgery
  
  Volume: 11 Issue: 1
- DOI
  10.1002/ams2.985
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14393
[Journal Article] Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database2024
- Author(s)
  Adachi Koichiro、Ohyama Katsuhiro、Tanaka Yoichi、Murayama Norie、Shimizu Makiko、Saito Yoshiro、Yamazaki Hiroshi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 5 Pages: 1028-1032
- DOI
  10.1248/bpb.b24-00145
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-05-24
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06217, KAKENHI-PROJECT-23K14393
[Journal Article] Octanol/water partition coefficients estimated using retention times in reverse-phase liquid chromatography and calculated in silico as one of the determinant factors for pharmacokinetic parameter estimations of general chemical substances2024
- Author(s)
 Adachi Koichiro、Shimizu Makiko、Shono Fumiaki、Funatsu Kimito、Yamazaki Hiroshi
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 49 Issue: 4 Pages: 127-137
- DOI
 10.2131/jts.49.127
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-23K14393
[Journal Article] Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome P450 2C9*3 as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database2024
- Author(s)
 Adachi Koichiro、Ohyama Katsuhiro、Tanaka Yoichi、Saito Yoshiro、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 47 Issue: 3 Pages: 635-640
- DOI
 10.1248/bpb.b24-00012
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2024-03-15
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-23K14393
[Journal Article] Impact of variability of in silico and in vitro octanol/water partition coefficients of compounds on the input parameters and results of simplified human physiologically based pharmacokinetic models after virtual oral administrations2024
- Author(s)
 Adachi Koichiro、Sasaki Tsubasa、Arai Atsuo、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 49 Issue: 10 Pages: 459-466
- DOI
 10.2131/jts.49.459
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-23K14393
[Journal Article] Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in Silico Liver-to-Plasma Partition Coefficients2023
- Author(s)
 Adachi Koichiro、Utsumi Masayoshi、Sato Tasuku、Nakano Hina、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 46 Issue: 9 Pages: 1316-1323
- DOI
 10.1248/bpb.b23-00371
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2023-09-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-23K14393
[Journal Article] Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using in Silico Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats2023
- Author(s)
 Adachi Koichiro、Nakano Hina、Sato Tasuku、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 46 Issue: 8 Pages: 1133-1140
- DOI
 10.1248/bpb.b23-00358
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2023-08-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-23K14393
[Journal Article] A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis ? A potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir2023
- Author(s)
  Unita Ryo、Adachi Koichiro、Inada Akiyoshi、Shimizu Makiko、Beppu Satoru、Yamazaki Hiroshi
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 29 Issue: 11 Pages: 1068-1070
- DOI
  10.1016/j.jiac.2023.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14393
[Presentation] 脊髄損傷によりセフォゾプラン髄液濃度が高値となり生じたと考えられる抗菌薬関連脳症の1例2025
- Author(s)
  宇仁田亮, 安達昂一郎, 寺嶋真理子, 内田康雄, 山崎浩史, 平田淳一
- Organizer
  第52回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14393
[Presentation] 当院救命科及び薬剤部と薬学部連携による薬物過量症例の血中濃度測定の取り組み2025
- Author(s)
  稲田顕慶, 東垂水郁圭 ,杉野太亮 , 森本健幹 ,小原直紘 ,福田利明 ,安達昂一郎, 増永直久, 別府賢 , 趙晃済
- Organizer
  第52回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14393
[Presentation] N-アセチルシステイン投与のみで良好な経過を得た致死量摂取のアセトアミノフェン中毒の一例2025
- Author(s)
  須賀友子, 趙晃済, 安達昂一郎, 橋本賢吾, 吉岡崇 , 増永直久, 村田真紀, 吉田浩輔 , 田中博之, 笹橋望
- Organizer
  第52回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14393
[Presentation] 血中濃度高値が持続したが保存的加療にて救命可能であった急性カフェイン中毒の1例2024
- Author(s)
  村田真紀、中川貴美子、別府賢、安達昂一郎、元濱啓介、橋本賢吾、田中博之、寺嶋真理子、笹橋望、趙晃済
- Organizer
  第51回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14393
[Presentation] 9-carboxymethoxymethylguanine (CMMG) 血中濃度測定は帯状疱疹治療中の意識障害の原因推定に有用である2024
- Author(s)
  宇仁田亮、安達昂一郎、別府賢、山崎浩史
- Organizer
  第51回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14393
[Presentation] 一般化学物質の薬物動態パラメータ決定因子であるオクタノール／水分配係数の逆相液体クロマトグラフィー保持時間を利用した実験的検証2024
- Author(s)
  安達昂一郎、清水万紀子、庄野文章、船津公人、山崎浩史
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K14393
[Presentation] 高度腎機能障害症例におけるダビガトラングルクロニド血中濃度と凝固異常との関連について2024
- Author(s)
  宇仁田亮, 安達昂一郎, 寺嶋真理子, 山崎浩史, 平田淳一
- Organizer
  第52回日本救急医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14393
[Presentation] アロチノロール内服後に徐脈や低血圧をきたし、心原性失神や心原性ショックに至った2症例の報告2024
- Author(s)
  中川貴美子、趙晃済、安達昂一郎、橋本賢吾、佐治雅史、増永直久、村田真紀、別府賢、寺嶋真理子、笹橋望
- Organizer
  第51回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14393
[Presentation] 生理学的薬物動態モデルを用いた薬物過量服用患者の体内動態解析2023
- Author(s)
  安達昂一郎、別府賢、山崎浩史
- Organizer
  第45回日本中毒学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K14393

Adachi Koichiro 安達 昂一郎

安達 昂一郎 アダチ コウイチロウ

Research Projects

Research Products

アシクロビル脳症におけるアシクロビル代謝産物の毒性と診断補助指標の妥当性評価Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Applying physiologically based pharmacokinetic to cases of acute drug intoxixation for visualizing the effective time of activated carbon administrationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Octanol/water partition coefficients estimated using retention times in reverse-phase liquid chromatography and calculated <i>in silico</i> as one of the determinant factors for pharmacokinetic parameter estimations of general chemical substances2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome <i>P450 2C9*3</i> as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Impact of variability of <i>in silico</i> and <i>in vitro</i> octanol/water partition coefficients of compounds on the input parameters and results of simplified human physiologically based pharmacokinetic models after virtual oral administrations2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of <i>in Silico</i> Liver-to-Plasma Partition Coefficients2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using <i>in Silico</i> Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis ? A potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] 脊髄損傷によりセフォゾプラン髄液濃度が高値となり生じたと考えられる抗菌薬関連脳症の1例2025

Author(s)

Organizer

Data Source

[Presentation] 当院救命科及び薬剤部と薬学部連携による薬物過量症例の血中濃度測定の取り組み2025

Author(s)

Organizer

Data Source

Adachi Koichiro 安達昂一郎

安達昂一郎アダチコウイチロウ