YOSHII Yoshihiko 吉井與志彦

… Alternative Names

吉井輿志彦ヨシイヨシヒコ

吉井興志彦

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Researcher Number	50110507
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2007: University of the Ryukyus, Faculty of Medicine, Professor 2004 – 2007: 琉球大学, 医学部, 教授 1997 – 2002: 琉球大学, 医学部, 教授 1999: Professor, Fucalty of Medicine, Ryukyu University 1994 – 1996: 筑波大学, 臨床医学系, 助教授 … More 1989 – 1992: 筑波大学, 臨床医学系, 助教授 1990: Univ. of Tsukuba, Inst. Clin. Med. Sci., Associate Prof., 臨末医学系, 助教授 1986 – 1988: Institute of Clinical Medicine,Univ.Tsukuba.,Assistant Professor., 臨床医学系, 講師 1986: 筑大, 臨床医学系, 講師 1985: 筑波大学, 臨医, 講師 Less
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Cerebral neurosurgery Except Principal Investigator Cerebral neurosurgery / Radiation science / Cerebral neurosurgery / Radiation science
Keywords	Principal Investigator 陽子線 / 脳腫瘍 / ハブ毒 / L-aminoacid oxidase / OHAP-1 / アポトーシス / metalloprotease / oxidative stress / clonality / ラジカル … More / 免疫組織化学 / in vivo / in vitro / Proton Beam / 抗腫瘍効果 / 悪性脳腫瘍 / Therapy / CT-MRI imagings / Histopathology / Delayed Radiation Injury / Brain Tumor / 脳血流 / 病理組織所見 / 放射線壊死 / 脳腫瘍脳 / 年齢 / Gd-MRI / 照射線量 / 病理組織 / 治療法 / 画像所見 / 組織学的変化 / 放射線障害 / 予防、対策 / 病態解析 / CTーMRI画像 / 症理組織学的変化 / 晩発性脳放射線障害 / Brain tumor / dye laser / Interstitial or extratumoral PDT / 内照射法 / 電磁波 / Photofrin【I】 / Argon-Dye Laser / PDT内照射 / PDT外照射 / HPD / Argon-dye Laser / Caffeine / cell cycle / cytotoxity / snake venom / Okinawa Habu / malignant glioma / P53変異株 / MTT / P53野生株 / ハブ毒素 / 細胞周期 / カフェイン / p53 / 悪性神経膠腫 / apoptosis / glioma cell / vascular endothel / Okinawa Habu venom / 殺細胞効果 / プロティン / 皮下移植腫瘍 / クリオーマ / OHAP-II / OHAP-I / アミノ酸構造 / グリオーマ / 移植腫瘍 / 酸化ストレス / グリオーマ細胞 / 血管内皮細胞 / L-amino acid oxidase / 沖縄ハブ毒 / apoptsis / Vitamin K2 / immunohistochemical study / resistant factor / gliomas / 治療予後 / DNA Ploidy / 防御因子 / 単一クローン / Clonality / 免疫組織学 / 治療抵抗性因子 / Glioma / Scavengers / Immunohistochemistry / Antioxidants / Oxidative Stress (Oxidants) / lonizing Radiation / 神経膠腫細胞 / 細胞致死効果 / CDDP / U251細胞 / 蛍光測定 / スカベンジャー薬剤 / ラジカル刺激剤 / Immunohistochemical / GST-Tc / SOD / DCFHDA / 抗酸化因子 / 抗酸化効果(剤) / 活性酸素 / 電離放射線 / In vivo Diagnosis / Heterogeneity / Lntraartenal Therapy / Antitumor Effect / Morphometry / Targeting Therapy / Malignant Brain Tumor / 超選択的動注療法 / 正常脳障害 / GFAP / DNA量 / ターゲティング / in vivo診断 / ヘテロジェナイティー / 動注療法 / 形態計測 / ターゲティング治療 / 抗BrdU抗体 / ACNU / BrdU / 実験脳腫瘍 / 9L-Gliosarcoma … More Except Principal Investigator 脳腫瘍 / Glioblastoma / Glioma / 組織反応 / 細胞反応 / 粒子線治療 / 難治性腫瘍 / 放射線治療 / 悪性神経膠腫 / p21 / p53 / 膠芽腫 / tumor vaccine / glioma / glioblastoma / gene therapy / costimulatory signal / B7 / Southern / Northern / anti-sense / flg / Proton therapy / 照射技術 / 放射線照射技術 / 標識埋没法 / 陽子線治療 / malignant glioma / Human monoclonal antibody / マウス-ヒト細胞融合 / ヒト免疫グロブリン / モノクローナル抗体 / Immunohistochemistry / Thyrotropin-releasing-hormone / Growth hormone / Pituitary adenoma / レーザー治療 / 免疫組織化学 / TRH / 成長ホルモン / 下垂体腺腫 / Intracerebral Hemorrhage / Gd-DTPA / Expelimental Brain Disease / Nuclear Magnetic Resonancce Image / 脳内血腫 / 実験モデル / 中枢神経疾患 / 核磁気共鳴画像 / endovascular electrode / epilepsy / electroencepharogram / endovascular therapy / brain / 脳神経 / 血管内導出電極 / てんかん / 脳波 / 血管内治療 / 脳・神経 / Hypoxia / tumor response / Radiotherapy / High-grade gliomas / 低酸素 / 治療効果 / 3-D imaging / Animal Experiment / Catheter / X-ray / lntravascular Neurosurgery / Ultrasound / 脳動脈瘤 / 3次元イメージ / 動物実験 / カテーテル / X線 / 脳血管内手術 / 超音波 / linear-quadratic / cell cycle / cell death / apoptosis / Carbon beam / High LET Charged Particle / Brain tumor / Apoptosis / Charged Particle / High-LET / APOPTOSIS / HIGH LET / HEAVY ION / GLIOMA / DNA-PK / High LET / Heavy Ion / アポトーシス / 細胞周期 / 細胞死 / 重粒子線 / Tumor vaccine / Gene therapy / 遺伝子治療 / ワクチン療法 / 腫瘍増殖 / bFGF / 神経膠腫 / Growth / FLG Less

Predicting the tumor response to radiotherapy for high-grade gliomas: Clinical significance of hypoxia-related genes
- Principal Investigator
  
  OGAWA Kazuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  University of the Ryukyus
Clinical application and renovation of endovascular electrode for endovascular electroencepharogram used for the detection of the focus of epilepsy
- Principal Investigator
  
  HYODO Akio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of the Ryukyus
The antiproliferative effect of Okinawa Habu Apoxin Protein-1 (OHAP-1) on human glioma cellsPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of the Ryukyus
Apoptotic effect by specific proteins extracted from Okinawa Habu (Trimeresurus Flavoviridis) snake venom into glioma and vascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of the Ryukyus
Development of Intravascular Ultrasound Dimensional Imaging System with Diagnostic Support and Its Application for Intravascular Neurosurgery
- Principal Investigator
  
  HYODO Akio
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  UNIVERSITY OF THE KYUKYUS
  University of Tsukuba
Sensitivity of malignant gliom cells against accelerated heavy ion beams
- Principal Investigator
  
  TSUBOI Koji
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
Clinicopathological study in the relationship among sensitivity, clonality, and growth potential after treatment in human gliomasPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  UNIVERSITY OF THE RYUKYUS
Vaccine therapy for malignant glioma with costimulatory signal genemodified syngenic glioma cells
- Principal Investigator
  
  MIYAGI Koichi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  UNIVERSITY OF THE RYUKYUS
Oncological study for brain tumors by using Proton radiosurgery and enhanced drugs to oxidative stressPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
Molecular analysis of flg and its products for targeted therapy on brain tumors
- Principal Investigator
  
  TSUBOI Koji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
粒子線治療展開のための基礎的研究
- Principal Investigator
  
  増田康治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
Basic and clinical studies for the targeting therapy by using the morphometrical analysis in malignant brain tumors.Principal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba, Institution of Clinical Medicine
粒子線治療展開のための基礎的研究
- Principal Investigator
  
  増田康治
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
粒子線治療展開のための基礎的研究
- Principal Investigator
  
  増田康治
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
Delayed Radiation Injury to the Brain : In Relation to Therapeutic View PointPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
Clinical device for accurate irradiation of tumors in deep-seated organs in proton beam therapy.
- Principal Investigator
  
  KITAGAWA Toshio
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  University of Tsukuba
陽子線応用による悪性脳腫瘍の選択的治療法に関する基礎的臨床的研究Principal Investigator
- Principal Investigator
  
  吉井与志彦
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  University of Tsukuba
Basic Study of Laser-Treatment for GH-Producing Pituitary Adenoma Using Fluorescein-TRH
- Principal Investigator
  
  TOMONO Yuji
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  UNIVERSITY OF TSUKUBA
Human monoclonal antibody against human, malignant glioma obtained from mouse-human hetero hybridoma system
- Principal Investigator
  
  NAKAGAWA Kunio
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  The University of Tsukuba
Experimental and Clinical Study for Brain Tumor Treatment by Using both external energy and porphyrine drugsPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihoko
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
Investigation of expelimental brain diseases with nuclear magnetic resonance images.
- Principal Investigator
  
  NOSE Tadao
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Institute of Clinical Medicine, Tsukuba University,

All 2007 2006

All Journal Article Presentation

[Journal Article] Phase II trial of radiotherapy after hyperbaric oxygenation with chem otherapy for high-grade gliomas2006
- Author(s)
  Ogawa K, Yoshii Y, Murayama S, et al.
- Journal Title
  
  British Journal of Cancer 95
  
  Pages: 862-868
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591386
[Journal Article] Hyperfractionated radiotherapy and multi-agent chemotherapy (procarbazine, ACNU and vincristine) for high-grade gliomas: a prospective study.2006
- Author(s)
  Ogawa K, Yoshii Y, Toita T, Saito A, Kakinohana Y, Iraha S, Sugimoto K, Tsuchida Y, Tamaki W, Adachi G, Hyodo A, Murayama S.
- Journal Title
  
  Anticancer Research 26
  
  Pages: 2457-2462
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591386
[Journal Article] Phase II trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas.2006
- Author(s)
  Ogawa K, Yoshii Y, Inoue O, Toita T, Saito A, Kakinohana Y, Adachi G, Iraha S, Tamaki W, Sugimoto K, Hyodo A, Murayama S.
- Journal Title
  
  British Journal of Cancer 95
  
  Pages: 862-868
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591386
[Journal Article] Hyperfractionated radiotherapy and multi-agent chemotherapy (procarbazine, ACNU and vincristine) for high-grade gliomas : a prospective study2006
- Author(s)
  Ogawa K, Yoshii Y, Tsuchida Y Murayama S, et al.
- Journal Title
  
  Anticancer Research 26
  
  Pages: 2457-2462
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591386
[Presentation] 脳腫瘍治療の最前線悪性グリオーマに対する放射線治療、HBOと化学療法の併用療法第II相試験2007
- Author(s)
  小川和彦, 吉井與志彦, 土田幸広, 村山貞之, 他
- Organizer
  第45回日本癌治療学会
- Place of Presentation
  京都
- Year and Date
  2007-10-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591386
[Presentation] 悪性グリオーマに対する放射線照射とHBOの併用療法2006
- Author(s)
  小川和彦, 吉井與志彦, 土田幸広, 村山貞之, 他
- Organizer
  第41回日本高気圧環境・潜水医学会
- Place of Presentation
  沖縄
- Year and Date
  2006-10-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591386

1. TSUBOI Koji (90188615)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. NAKAGAWA Kunio (40092077)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. HYODO A (40167606)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SAITO Atsushi (40305199)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. NOSE Tadao (10009699)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 増田康治 (10037377)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 阿部光幸 (00025587)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 坪内進 (70073137)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 鈴木捷三 (30012743)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 大原弘 (20160608)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. HAYAKAWA Y (90101740)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MARUHASHI A (30114135)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. TOMONO Yuuji (70110335)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. MIYAGI Koichi (60102274)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. TSURUSHIMA Hideo (50315470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. TSUCHIDA Yukihiro (90363663)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
17. NOSAKI Masatosi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. ISHIKAWA Y (10026932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TSUJII H (50088853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. AOYAGI Kazumasa (40114029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TADANO Masayuki (80179712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. MAKINO Yoshihiro (60039930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ANDO Koichi (00159526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. ITO Etsuo (40031968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MIYATA Seizou (90015066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SUN L.K. (40325840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. OGAWA Kazuhiko (40253984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
28. KINJO Takao (30284962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. ENOMOTO Takao (10134230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. HOMMA Kazuhiro (80357970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. KUSUMI Takenori (70015882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. KOZIMA Seiiji (90134204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. INOUE Yukinobu (00015570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. ISHIZAKA Shouzo (10062499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. KITAGAWA Toshio (80076942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. NISHIDA Masato (00110875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. OTANI Mikinobu (80133081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. ARIMOTO Takuro (50168027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. TAKASE Yasuhiro (50075339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. OHARA Kiyoshi (10034125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. OGATA Takesaburou (60009115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 銘苅晋 (50200316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 田邊将夫 (30049077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 石川悟 (70168194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 金子実 (00111378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. OKUNO Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHII Yoshihiko 吉井 與志彦

吉井 輿志彦 ヨシイ ヨシヒコ

吉井 興志彦

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The antiproliferative effect of Okinawa Habu Apoxin Protein-1 (OHAP-1) on human glioma cellsPrincipal Investigator

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Apoptotic effect by specific proteins extracted from Okinawa Habu (Trimeresurus Flavoviridis) snake venom into glioma and vascular endothelial cellsPrincipal Investigator

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Clinicopathological study in the relationship among sensitivity, clonality, and growth potential after treatment in human gliomasPrincipal Investigator

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Oncological study for brain tumors by using Proton radiosurgery and enhanced drugs to oxidative stressPrincipal Investigator

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Basic and clinical studies for the targeting therapy by using the morphometrical analysis in malignant brain tumors.Principal Investigator

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Delayed Radiation Injury to the Brain : In Relation to Therapeutic View PointPrincipal Investigator

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YOSHII Yoshihiko 吉井與志彦

吉井輿志彦ヨシイヨシヒコ

吉井興志彦