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ADACHI Yukihiko  足立 幸彦

ORCIDConnect your ORCID iD *help
Researcher Number 50111026
External Links
Affiliation (based on the past Project Information) *help 2006: 三重大学, 大学院医学系研究科, リサーチアソシエイト
1998 – 2004: 三重大学, 医学部, 教授
1993 – 1995: KINKI UNIVERSITY SCHOOL OF MEDICINE.SECOND DEPARTMENT OF INTERNAL MEDICINE, ASSO, 医学部, 助教授
1992: 近畿大学. 医学部内科学II教室, 助教授
Review Section/Research Field
Principal Investigator
Gastroenterology
Except Principal Investigator
Gastroenterology / Hygiene
Keywords
Principal Investigator
ビリルビン / Gilbert症候群 / organic anion / bilirubin / Gilbert's syndrome / UGT1A1 / fasting hyperbilirubinemia / multidrug resistance-associated protein / organic anion transporting polypeptide / 有機アニオン … More / プラバスタチン / タウロコール酸 / UDPグルクロン酸転移酵素 / 胆汁排泄 / Rotor症候群 / 肝細胞内輸送 / 胆汁中排泄 / グルクロン酸抱合 / 閉塞性黄疸 / pravastatin / taurocholate / UDP-glucuronosyltransferase / biliary excretion / Rotor's syndrome / Crigler-Najjar症候群 / 遺伝子変異 / 絶食高ビリルビン血症 / ビリルビンUDPグルクロン酸転移酵素 / 血清ビリルビン / 遺伝子診断 / 体質性黄疸 / Crigler-Najjan症候群 / 人種差 / 高ビリルビン血症 / 黄疸 / Crigler-Najjar syndrome / gene mutation / トランスポーター / 遺伝子導入 / 遺伝子多型 / Uridine-diphosphate glucuronosyltransferase / organic anion transporting / polypeptide / Gunn rat / uridine-diphosphate glucuronosyltransferase / stem cell / bilirubin UDP-glucronosyltransferase / Eisai hyperbilirubinuria / short interfering RNA / 臓器相関 / transporter / polymorphism / Uridine-diphosphate glucuronosyl transferase … More
Except Principal Investigator
HEV / ATP / Gunn rat / 遺伝子治療 / VLP / UGT1A1 / MRP2 / virus-like particle / 8-ニトログアニン / 8-oxodG / DNA損傷 / 炎症 / 感染 / 活性窒素種 / バイオマーカー / がん予防 / 発がん / リスク評価 / 胆汁排泄 / 有機陰イオン / 黄疸 / 高ビリルビン血症 / 胆汁酸 / Dubin-Johnson症候群 / プラバスタチン / ビリルビン / 毛細胆管 / BILIARY EXCRETION / ORGANIC ANION / JAUNDICE / HYPERBILIRUBINEMIA / BILE ACIDS / DUBIN-JOHNSON SYNDROME / PRAVASTATIN / Crigler-Najjar症候群 / Crigler-Najjar syndrome / gene therapy / HEP / 肝臓 / E型肝炎ウイルス / 遺伝子導入 / liver Less
  • Research Projects

    (7 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (10 People)
  •  Development of the biomarker analysis system for evaluating the risk of carcinogenesis related to infection and inflammation

    • Principal Investigator
      KAWANISHI Shosuke
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hygiene
    • Research Institution
      Suzuka University of Medical Science
  •  Hepatic and renal expression of organic anion transporters during jaundice, and improvement of transcellular organic anion transport after transfection with Multidrug Resistance-associated Protein 2(MRP2) gene.Principal Investigator

    • Principal Investigator
      ADACHI Yukihiko
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Mie University
  •  Establishment of liver-directed gene transfer by hepatitis E virus like particle

    • Principal Investigator
      IMOTO Ichiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Mie University
  •  Gene therapy in the Gunn rat model of Crigler-Najjar syndrome type-1

    • Principal Investigator
      IMOTO Ichiro
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Mie University
  •  Relationship between UGT1A1 mutation and occurrence of Gilbert's syndromePrincipal Investigator

    • Principal Investigator
      ADACHI Yukihiko
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Gastroenterology
    • Research Institution
      Mie University
  •  Studies on Hepatic Transport and Metabolism of Bilirubin, Bile Acids, and Other Organic Substances.Principal Investigator

    • Principal Investigator
      ADACHI Yukihiko
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kinki University, Second Department of Internal Miedicine.
  •  HEPAIOCYTE MEMBRANE TRANSPORT MECHANISM OF VARIOUS SUBSTANCES

    • Principal Investigator
      YAMAMOTO Toshio
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      SECOND DEPARTMENT OF INTERNAL MEDICINE.KINKI UNIVERSITY SCHOOL OF MEDICINE.

All 2007 2005 2004 2003

All Journal Article Book

  • [Book] 肝疾患 Review 20042004

    • Author(s)
      小林由直, 黒田 誠, 足立幸彦
    • Total Pages
      237
    • Publisher
      日本メディカルセンター
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370178
  • [Journal Article] Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients2007

    • Author(s)
      Fujita N, Horiike S, Sugimoto R,Tanaka H, Iwasa M, Kobayashi Y,Hasegawa K, Ma N, Kawanishi S, Adachi Y, Kaito M
    • Journal Title

      Free Radic Biol Med. 42(3)

      Pages: 353-62

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390179
  • [Journal Article] Hepatic uptake of bilirubin revisited.2005

    • Author(s)
      Yukihiko Adachi, Yoshinao Kobayashi
    • Journal Title

      Hepatol Res (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370178
  • [Journal Article] Increased hepatic and renal expression of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rat2004

    • Author(s)
      Kuroda M., Kobayashi Y., Tanaka Y, Itani T, Mifuji R, Araki J, Kaito M, Adachi Y
    • Journal Title

      Journal of Gastroenterology and Hepatology 19

      Pages: 146-153

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370178
  • [Journal Article] Modulation of organic anion transporting polypeptide 1 and multidrug resistance protein 3 expression in the liver and kidney of Gunn rats.2004

    • Author(s)
      Higuchi K, Kobayashi Y, Kuroda M, Tanaka Y, Itani T, Araki J, Mifuji K, Kaito M, Adachi Y
    • Journal Title

      Hepatology Research 29

      Pages: 60-66

    • NAID

      10018024061

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370178
  • [Journal Article] Genetic polymorphisms of bilirubin uridine diphoshate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects2004

    • Author(s)
      Takeuchi K, Kobayashi Y, Tamaki S, Ishihara, T, Maruo Y, Araki J, Mifuji R, Itani T, Kuroda M, Sato H, Kaito M, Adachi Y
    • Journal Title

      Journal of Gastroenterology and Hepatology 19

      Pages: 1023-1028

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370178
  • [Journal Article] 体質性黄疸2003

    • Author(s)
      小林由直, 足立幸彦
    • Journal Title

      肝臓 44

      Pages: 483-491

    • NAID

      130000875238

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370178
  • [Journal Article] Expression of hepatobiliary organic anion transporters and bilirubin-conjugating enzymes in differentiating embryonic stem cells.2003

    • Author(s)
      Tanaka Y., Yoshikawa M., Kobayashi Y, Kuroda M, Kaito M, Shiroi A, Yamao J, Fukui H, Ishizuka S, Adachi Y
    • Journal Title

      Biochemical and Biophysical Research Communication 309

      Pages: 324-330

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370178
  • 1.  TAMAKI Sigenori (80260602)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 2.  YAMAMOTO Toshio (50088522)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  IMOTO Ichiro (90176511)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  KAWANISHI Shosuke (10025637)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  MURATA Mariko (10171141)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  OIKAWA Shinji (10277006)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  HIRAKU Yusuke (30324510)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  OHNISHI Shiho (80511914)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NANNO Tatsuo (40189220)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KOBAYASHI Yoshinao (70378298)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results

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