MIYATA Naoki 宮田直樹

Researcher Number	50114674
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2015: 名古屋市立大学, 大学院薬学研究科, 特任教授 2015: 名古屋市立大学, 大学院薬学研究科薬化学分野, 教授 2012 – 2014: 名古屋市立大学, 薬学研究科(研究院), 教授 2007 – 2012: 名古屋市立大学, 大学院・薬学研究科, 教授 2006: 名古屋市立大学, 大学院薬学研究科, 教授 … More 2002 – 2005: 名古屋市立大学, 大学院・薬学研究科, 教授 1997 – 2001: 国立医薬品食品衛生研究所, 有機化学部, 部長 1992 – 1996: 国立衛生試験所, 有機化学部, 部長 Less
Review Section/Research Field	Principal Investigator 医薬分子機能学 / Drug development chemistry / Chemical pharmacy / 環境影響評価(含放射線生物学) / 化学系薬学 Except Principal Investigator 医薬分子機能学 / Drug development chemistry / Tumor therapeutics
Keywords	Principal Investigator 制がん剤 / ヒストン脱アセチル化酵素阻害薬 / エピジェネティクス / フラーレン / tocopherol / edaravone / catechin / fullerene / pharmacophore / active oxygen species … More / radical scavenger / oxyl radical / 神経毒性 / スピントラップ剤 / ESR / オキシラジカル / トコフェロール / エダラボン / カテキン / ファーマコフォア / 活性酸素種 / ラジカル消去剤 / オキシルラジカル / Griess-Salzman method / Cytotoxicity / N-nitroso urea / NO-donor / N-nitroso compound / Nitric Oxide / NO / 細胞毒性 / ニトロシル錯体 / グリース反応 / ニトロソウレア / ニトロソ化合物 / 殺細胞効果 / Greiss法 / ニトロソアミド / ニトロソ尿素 / N-ニトロソ化合物 / 一酸化窒素 / ケージド化合物 / ｴﾋﾟｼﾞｪﾈﾃｨｸｽ / 蛍光検出 / 分子標的治療薬 / 光解除性保護基 / 細胞内局在性 / ケミカルバイオロジー / ヒストン脱アセチル化酵素 / チューブリン / ヒストン脱アセチル化酵素阻害剤 / ヒストン脱メチル化酵素阻害剤 / 創薬分子設計 / 遺伝子発現制御 / 酵素 / DNA / CV法 / 酸化還元電位 / 相互作用 / レセプター / リガンド / DPV法 / 分子軌道計算 / 毒性評価 / 分子間相互作用 / 薬物代謝酵素 / ニトロアレーン / 環境化学物質 / 化学計算 / 電子移動 / 一電子還元 / 電気化学 / スーパーオキシド / ニトロアレーンアニオンラジカル / セミキノンアニオンラジカル / 活性酸素 / クロノクーロメトリー … More Except Principal Investigator 一酸化窒素 / DNA切断活性 / 有機化学 / ヒドロキシルラジカル / DNA cleavage / trigger / Bergman reaction / enediyne / トリガー / バーグマン環化反応 / エンジイン / Amidoxime / Nitric Oxide / アミドオキシム / 薬学 / ニトロソアミン / 活性酸素 / 光スイッチ / ケージド化合物 / ケミカルバイオロジー / 抗がん剤耐性 / 分子標的治療 / 光照射 / Nitosamine / Hydroxyl / グルコースオキシダーゼ / ニトロサミン / ヒドロキシラジ / DNA damage / cancer / hydroxyl radical / N-oxide / phenazine / 抗腫瘍化合物 / N-オキシド構造 / Smooth muscular relaxation action / Hydroxy-L-arginine / シアノトリアゼン / 平滑筋弛緩作用 / ヒドロキシアルギニン / 酸化還元 / 細胞・組織 / 分析科学 / ストレス / 活性酸素種 / 生物活性物質 / タンパク質 / 脳神経疾患 / 酵素反応 / 化学プローブ / ドナー化合物 / パーオキシナイトライト / 酸化ストレス / 3-モルホリノシドノニミン / スーパーオキシド / ポリビニルピロリドン / C_<60>-epoxide / P450化学モデル / C_<60> / 生体内毒性 / 炭素クラスター / モルモット回腸 / グルタチオン-S-トランスフェラーゼ / 胎仔細胞分化促進 / 変異原性 / エポキシド / シトクロムP450 / 白色腐朽菌 / 分化促進 / 血管弛緩作用 / 一重項酸素 / フラーレン Less

Development of drug-resistance-overcoming agents targeting histone demethylase JARID1A
- Principal Investigator
  
  Tamio Mizukami
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Photocontrol of NO and H2S treatment as signaling molecules and biological applications
- Principal Investigator
  
  Nakagawa Hidehiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya City University
Synthesis of HDAC inhibitors that locally develop their inhibition activity in cellsPrincipal Investigator
- Principal Investigator
  
  MIYATA Naoki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya City University
Oxidative stress imaging in organelle by novel TEMPO derivatives
- Principal Investigator
  
  NAKAGAWA Hidehiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya City University
Development of drug candidates that epigenetically regulate gene expressionPrincipal Investigator
- Principal Investigator
  
  MIYATA Naoki
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya City University
Oxidative degeneration of neurodegenerative disease-related protein and reactive nitrogen oxide stress
- Principal Investigator
  
  NAKAGAWA Hidehiko
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya City University
Development of novel oxyl-radical quenching pharmacophores as drug candidatesPrincipal Investigator
- Principal Investigator
  
  MIYATA Naoki
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Nagoya City University
MOLECULAR DESIGN AND SYNTHESIS OF A NEW CLASS OF TRIGGERED ENEDIYNE
- Principal Investigator
  
  KURIHARA Masaaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  NATIONAL INSTITUTE OF HEALTH SCIENCES
Studies of Phenazine di N-Oxides as a New Type of Hydroxy Radical Donor
- Principal Investigator
  
  FUKUHARA Kiyoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  National Institute of Health Sciences
Synthesis of NO generating compounds with hydroxyl releasing ability
- Principal Investigator
  
  TANNO Masayuki, 末吉祥子
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  National Institute of Health Sciences (NIHS)
MOLECULAR DESIGN AND SYNTHESIS OF A NEW CLASS OF TRIGGERED ENEDIYNE
- Principal Investigator
  
  KURIHARA Masaaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  NATIONAL INSTITUTE OF HEALTH SCIENCES
DPV法を利用した簡便なリガンドーレセプター相互作用解析手法の開発Principal Investigator
- Principal Investigator
  
  宮田直樹
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  National Institute of Health Sciences
Synthesis of NO-donors as Biotransformation Model Compounds
- Principal Investigator
  
  SUEYOSHI Shoko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  National Institute of Health Sciences (NIHS)
一酸化窒素とスーパーオキシドを同時に発生する化合物の合成と機能解析
- Principal Investigator
  
  TANNO Masayuki
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  国立衛生試験所
化学計算による環境化学物質の毒性評価の新手法の開発Principal Investigator
- Principal Investigator
  
  宮田直樹
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  国立衛生試験所
Synthesis and Characterization of Biologically Active NO-donorsPrincipal Investigator
- Principal Investigator
  
  MIYATA Naoki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  National Institute of Health Sciences(NIHS)
フラーレンの生体におよぼす影響
- Principal Investigator
  
  広部雅和 (広部雅昭)
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
クロノクーロメトリー法を用いた活性酸素ラジカルの発生と消去反応の解析Principal Investigator
- Principal Investigator
  
  宮田直樹
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  化学系薬学
- Research Institution
  国立衛生試験所

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

[Book] 酸化ストレスの医学(吉川敏一監修, 内藤裕二, 豊国伸哉編, 診断と治療社, 東京)2008
- Author(s)
  中川秀彦, 宮田直樹
- Publisher
  フリーラジカルの測定法
- Data Source
  KAKENHI-PROJECT-17590089
[Journal Article] Identification of Novel SIRT2-Selective Inhibitors Using a Click Chemistry Approach2014
- Author(s)
  109. Prima R. Tatum, Hideyuki Sawada, Yosuke Ota, Yukihiro Itoh, Peng Zhan, Naoya Ieda, Hidehiko Nakagawa, Naoki Miyata, Takayoshi Suzuki.
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 24 Issue: 8 Pages: 1871-1874
- DOI
  10.1016/j.bmcl.2014.03.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659050, KAKENHI-PROJECT-24689007
[Journal Article] Design, Synthesis, and Biological Activity of NCC149 Derivatives as Histone Deacetylase 8-Selective Inhibitors.2014
- Author(s)
  Suzuki T, Muto N, Bando M, Itoh Y, Masaki A, Ri M, Ota Y, Nakagawa H, Iida S, Shirahige K, Miyata N.
- Journal Title
  
  ChemMedChem.
  
  Volume: 9 Issue: 3 Pages: 657-664
- DOI
  10.1002/cmdc.201300414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221009, KAKENHI-PROJECT-24659050, KAKENHI-PROJECT-24689007, KAKENHI-PROJECT-25290065
[Journal Article] Small-molecular modulators of cancer-related epigenetic mechanisms2013
- Author(s)
  Yukihiro Itoh , Takayoshi Suzuki and Naoki Miyata
- Journal Title
  
  Mol. Biosyst.
  
  Volume: 9 Issue: 5 Pages: 873-896
- DOI
  10.1039/c3mb25410k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659050, KAKENHI-PROJECT-24689007
[Journal Article] Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly2013
- Author(s)
  98. Takayoshi Suzuki, Yuki Kasuya, Yukihiro Itoh, Yosuke Ota, Peng Zhan, Kaori Asamitsu, Hidehiko Nakagawa, Takashi Okamoto and Naoki Miyata.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 7 Pages: e68669-e68669
- DOI
  10.1371/journal.pone.0068669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659050, KAKENHI-PROJECT-24689007
[Journal Article] Rapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries2012
- Author(s)
  Takayoshi Suzuki, Yosuke Ota, Masaki Ri, Masashige Bando, Aogu Gotoh, Yukihiro Itoh, Hiroki Tsumoto, Prima R. Tatum, Tamio Mizukami, Hidehiko Nakagawa, Shinsuke Iida, Ryuzo Ueda, Katsuhiko Shirahige, and Naoki Miyata.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Issue: 22 Pages: 9562-9575
- DOI
  10.1021/jm300837y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00812, KAKENHI-PROJECT-22221009, KAKENHI-PROJECT-24659050, KAKENHI-PROJECT-24689007, KAKENHI-PROJECT-221S0001
[Journal Article] Novel bisbenzimide-nitroxides for nuclear redox imaging in living cells2012
- Author(s)
  池田麻美子、中川秀彦, 他2名
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 22 Issue: 5 Pages: 1949-1952
- DOI
  10.1016/j.bmcl.2012.01.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J08121, KAKENHI-PROJECT-22590103
[Journal Article] Loss of deacetylation activity of hdac6 affects emotional behavior in mice2012
- Author(s)
  Masahide Fukada
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 2 Pages: e30924-e30924
- DOI
  10.1371/journal.pone.0030924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390034, KAKENHI-PROJECT-21500364, KAKENHI-PROJECT-22700408, KAKENHI-PROJECT-24591693, KAKENHI-PROJECT-24659050
[Journal Article] Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors2012
- Author(s)
  Takayoshi Suzuki, Mohammed Naseer Ahmed Khan, Hideyuki Sawada, Erika Imai, Yukihiro Itoh, Katsura Yamatsuta, Natsuko Tokuda, Jun Takeuchi, Takuya Seko, Hidehiko Nakagawa, and Naoki Miyata
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Issue: 12 Pages: 5760-5773
- DOI
  10.1021/jm3002108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659050
[Journal Article] Lysine demethylases inhibitors2011
- Author(s)
  Takayoshi Suzuki, Naoki Miyata
- Journal Title
  
  J. Med. Chem.
  
  Volume: 54 Pages: 8236-8250
- Data Source
  KAKENHI-PROJECT-20390034
[Journal Article] An Unexpected Example of Copper-Mediated In Situ Click Chemistry2010
- Author(s)
  Takayoshi Suzuki, Yosuke Ota, Yuki Kasuya, Motoh Mutsuga, Yoko Kawamura, Hiroki Tsumoto, Hidehiko Nakagawa, M. G. Finn, Naoki Miyata
- Journal Title
  
  Angew. Chem. Int. Ed. Engl.
  
  Volume: 49 Pages: 6817-6820
- Data Source
  KAKENHI-PROJECT-20390034
[Journal Article] Design, Synthesis, Enzyme-inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors2010
- Author(s)
  Shohei Hamada, Takayoshi Suzuki, Koshiki Mino, Koichi Koseki, Felix Oehme, Ingo Flamme, Hiroki Ozasa, Yukihiro Itoh, Daisuke Ogasawara, Haruka Komaarashi, Aiko Katoh, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata
- Journal Title
  
  J.Med.Chem. 53
  
  Pages: 5629-5638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390034
[Journal Article] Development of a DNA-binding TEMPO derivative for evaluation of nuclear oxidative stress and its application in living cells2010
- Author(s)
  Mamiko Ikeda, Hidehiko Nakagawa, Shizuka Ban, Hiroki Tsumoto, Takayoshi Suzuki, and Naoki Miyata
- Journal Title
  
  Free Radic. Biol. Med
  
  Volume: 49 Issue: 11 Pages: 1792-1797
- DOI
  10.1016/j.freeradbiomed.2010.09.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590103
[Journal Article] An Unexpected Example of Copper-Mediated In Situ Click Chemistry2010
- Author(s)
  Takayoshi Suzuki, Yosuke Ota, Yuki Kasuya, Motoh Mutsuga, Yoko Kawamura, Hiroki Tsumoto, Hidehiko Nakagawa, M.G.Finn, Naoki Miyata
- Journal Title
  
  Angew.Chem.Int.Ed.Engl. 49
  
  Pages: 6817-6820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390034
[Journal Article] Identification of Cell-Active Lysine Specific Demethylase 1-Selective Inhibitors2009
- Author(s)
  Rie Ueda, Takayoshi Suzuki, Koshiki Mino, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 131 Pages: 17536-17537
- Data Source
  KAKENHI-PROJECT-20390034
[Journal Article] Design, Synthesis, and Biological Activity of Boronic acid-Based Histone Deacetylase Inhibitors2009
- Author(s)
  Nobuaki Suzuki, Takayoshi Suzuki, Yosuke Ota, Tatsuya Nakano, Masaaki Kurihara, Haruhiro Okuda, Takao Yamori, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
- Journal Title
  
  J. Med. Chem.
  
  Volume: 52 Pages: 2909-2922
- Data Source
  KAKENHI-PROJECT-20390034
[Journal Article] Inhibition of Human Sirtuins by In Situ Generation of an Acetylated Lysine-ADP-ribose Conjugate2009
- Author(s)
  Tomomi Asaba, Takayoshi Suzuki, Rie Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 31 Pages: 6989-6996
- Data Source
  KAKENHI-PROJECT-20390034
[Journal Article] Inhibition of Human Sirtuins by In Situ Generation of an Acetylated Lysine-ADP-ribose Conjugate2009
- Author(s)
  Tomomi Asaba, Takayoshi Suzuki, Rie Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 6989-6996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390034
[Journal Article] Identification of Cell-Active Lysine Specific Demethylase 1-Selective Inhibitors2009
- Author(s)
  Rie Ueda, Takayoshi Suzuki, Koshiki Mino, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 17536-17537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390034
[Journal Article] Design, Synthesis, and Biological Activity of Boronic acid-Based Histone Deacetylase Inhibitors2009
- Author(s)
  Nobuaki Suzuki, Takayoshi Suzuki, Yosuke Ota, Tatsuya Nakano, Masaaki Kurihara, Haruhiro Okuda, Takao Yamori, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
- Journal Title
  
  J.Med.Chem. 52
  
  Pages: 2909-2922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390034
[Journal Article] Photoactivatable HNO-releasing compounds using the retro-Diels-Alder reaction2008
- Author(s)
  Yusuke Adachi, Hidehiko Nakagawa, Kazuya Matsuo, Takayoshi Suzuki, Naoki Miyata
- Journal Title
  
  Chem. Commun
  
  Pages: 5149-5151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590089
[Journal Article] Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane2007
- Author(s)
  Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki, Naoki Miyata
- Journal Title
  
  Bioorg. Med. Chem. Lett 17
  
  Pages: 1451-1454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590089
[Journal Article] New Series of Antiprion Compounds : Pyrazolone Derivatives Have the Potent Activity of Inhibiting Protease-Resistant Prion Protein Accumulation2007
- Author(s)
  Ayako Kimata, Hidehiko Nakagawa, Ryo Ohyama, Tomoko Fukuuchi, Shigeru Ohta, Takayoshi Suzuki, Naoki Miyata
- Journal Title
  
  J. Med. Chem 50
  
  Pages: 5053-5056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590089
[Journal Article] Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria, Bioorg2007
- Author(s)
  Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki, Naoki Miyata
- Journal Title
  
  Med. Chem. Lett 17
  
  Pages: 2055-2058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590089
[Journal Article] Photoinduced Nitric Oxide Release from Nitrobenzene Derivatives2005
- Author(s)
  Takayoshi Suzuki, Osamu Nagae, Yuka Kato, Hidehiko Nakagawa, Kiyoshi Fukuhara, Naoki Miyata
- Journal Title
  
  J. Am. Chem. Soc 127
  
  Pages: 11720-11726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590089
[Journal Article] 2, 2, 6, 6-Tetramethylpiperidin-1-oxyl probes for evaluating oxidative stress on the cell membrane and mitochondria, Methods in Molecular Biology
- Author(s)
  Hidehiko Nakagawa, Naoki Miyata
- Journal Title
  
  477 : Advanced Protocols in Oxidative Stress I,(Edited by : D. Armstrong, Humana Press, New York, NY)(依頼)
  
  Pages: 99-112
- Data Source
  KAKENHI-PROJECT-17590089
[Patent] 新規アミド化合物及びその用途2012
- Inventor(s)
  宮田直樹、他
- Industrial Property Rights Holder
  名古屋市立大学
- Filing Date
  2012-02-23
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] 新規アミド化合物及びその用途2012
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  公立大学法人名古屋市立大学
- Industrial Property Number
  2012-037082
- Filing Date
  2012-02-23
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] 新規ヒドロキサム酸誘導体及びその用途2012
- Inventor(s)
  宮田直樹、他
- Industrial Property Rights Holder
  名古屋市立大学、他
- Filing Date
  2012-02-24
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] 新規ヒドロキサム酸誘導体及びその用途2012
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  公立大学法人名古屋市立大学, 他
- Industrial Property Number
  2012-038977
- Filing Date
  2012-02-24
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] ヒドロキサム酸誘導体及びJHDM阻害剤2010
- Inventor(s)
  宮田直樹、他
- Industrial Property Rights Holder
  名古屋市立大学、他
- Filing Date
  2010-01-20
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] ヒドロキサム酸誘導体及びJHDM阻害剤2010
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  名古屋市立大学, 他
- Industrial Property Number
  2010-009834
- Filing Date
  2010-01-20
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] HIV複製阻害剤2010
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  名古屋市立大学, 他
- Filing Date
  2010-08-06
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] ヒドロキサム酸誘導体及びJHDM阻害剤2010
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  名古屋市立大学, 他
- Filing Date
  2010-01-20
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] 抗うつ薬及びその用途2010
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  名古屋市立大学, 他
- Filing Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] HIV複製阻害剤2010
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  名古屋市立大学, 他
- Filing Date
  2010-08-06
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] ヒドロキサム酸誘導体及びそれを用いたHDAC8阻害剤2010
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  名古屋市立大学, 他
- Filing Date
  2010-01-21
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] ヒドロキサム酸誘導体及びそれを用いたHDAC8阻害剤2010
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  名古屋市立大学, 他
- Industrial Property Number
  2010-011431
- Filing Date
  2010-01-21
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] ヒドロキサム酸誘導体及びそれを用いたHDAC8阻害剤2010
- Inventor(s)
  宮田直樹、他
- Industrial Property Rights Holder
  名古屋市立大学、他
- Filing Date
  2010-01-21
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] 抗うつ薬及びその用途2010
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  名古屋市立大学, 他
- Filing Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] HIV複製阻害剤2010
- Inventor(s)
  宮田直樹、他
- Industrial Property Rights Holder
  名古屋市立大学、他
- Filing Date
  2010-08-06
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] LSD阻害剤2010
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  名古屋市立大学, 他
- Filing Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] 抗うつ薬及びその用途2010
- Inventor(s)
  宮田直樹、他
- Industrial Property Rights Holder
  名古屋市立大学、他
- Filing Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] LSD阻害剤2009
- Inventor(s)
  宮田直樹、他
- Industrial Property Rights Holder
  名古屋市立大学、他
- Filing Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] LSD阻害剤2009
- Inventor(s)
  宮田直樹, 他
- Industrial Property Rights Holder
  名古屋市立大学, 他
- Industrial Property Number
  2009-140553
- Filing Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-20390034
[Patent] アシルニトロソ誘導体環化付加アントラセン誘導体及び光作動性HNO供与体2008
- Inventor(s)
  宮田直樹、中川秀彦、松尾和哉、鈴木孝禎
- Industrial Property Rights Holder
  名古屋市立大学
- Industrial Property Number
  2008-284899
- Filing Date
  2008-11-05
- Data Source
  KAKENHI-PROJECT-17590089
[Patent] アシルニトロソ誘導体環化付加アントラセン誘導体及び光作動性HNO供与体2008
- Inventor(s)
  宮田直樹中川秀彦ほか
- Industrial Property Rights Holder
  名古屋市立大学
- Industrial Property Number
  2008-284899
- Filing Date
  2008-11-05
- Data Source
  KAKENHI-PROJECT-17590089
[Presentation] HDAC8選択的阻害薬の創製研究2014
- Author(s)
  太田庸介、伊藤幸裕、武藤伸輔、中川秀彦、宮田直樹、鈴木孝禎
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  広島
- Invited
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] クリックケミストリーを用いたHDAC阻害薬の探索研究2013
- Author(s)
  後藤仰、鈴木孝禎、伊藤幸裕、粕谷佑輝、太田庸介、中川秀彦、宮田直樹
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] クリックケミストリーを用いたHDAC8選択的阻害薬の創製研究：リード化合物探索から構造最適化研究まで2013
- Author(s)
  太田庸介、武藤伸輔、伊藤幸裕、中川秀彦、宮田直樹、鈴木孝禎
- Organizer
  第６３回日本薬学会近畿支部大会
- Place of Presentation
  京田辺
- Invited
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] HDAC3選択的阻害薬の創製と化学遺伝学的応用研究2013
- Author(s)
  伊藤幸裕、粕谷侑輝、中川秀彦、水上民夫、宮田直樹、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会　第8回年会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] 新規SIRT2選択的阻害薬の創製　～Structure-based Drug DesignによるSIR2013
- Author(s)
  澤田英之、鈴木孝禎、今井英里佳、Mohammed Naseer Ahmed KHAN、中川秀彦、宮田直樹
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] Click chemistryによるHDAC阻害薬ライブラリーの構築とアイソザイム選択的阻害薬の同定2013
- Author(s)
  伊藤幸裕、太田庸介、粕谷侑輝、中川秀彦、宮田直樹、鈴木孝禎
- Organizer
  第11回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] クリックケミストリーを用いたHDAC3 選択的阻害薬の迅速探索2012
- Author(s)
  後藤仰，鈴木孝禎，粕谷侑輝，中川秀彦2，宮田直樹
- Organizer
  第３０回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] クリックケミストリーを用いたHDAC阻害薬用トリアゾール化合物ライブラリーの構築2012
- Author(s)
  後藤仰, 鈴木孝禎, 粕谷侑輝, 中川秀彦, 宮田直樹
- Organizer
  第４２回複素環化学討論会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] 新規SIRT2選択的阻害薬の創製2012
- Author(s)
  澤田英之, 鈴木孝禎, 今井英里佳, Mohammed Naseer Ahmed Khan, 中川秀彦, 宮田直樹
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] Discovery of isozyme-selective histone deacetylase inhibitors by click chemistry2012
- Author(s)
  Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata, et. al.
- Organizer
  ACS National Meetng, Sprong 2012
- Place of Presentation
  San Diego
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] 創薬化学のすすめ:タンパク質の翻訳後修飾酵素を阻害する化合物の創製を例にして2011
- Author(s)
  宮田直樹
- Organizer
  創薬懇話会2011 in岡山
- Place of Presentation
  岡山(招待講演)
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] Design, Synthesis, and Biological Activity of cyclopropylamine-based LSD1 inhibitor2011
- Author(s)
  Daisuke Ogasawara, Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata, et. al.
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] 創薬化学のすすめ:タンパク質の翻訳後修飾を阻害する化合物の創生を例にして2011
- Author(s)
  宮田直樹
- Organizer
  創薬懇話会2011
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] エピジェネティックに遺伝子発現を制御する低分子化合物の設計と合成2010
- Author(s)
  宮田直樹
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島大学(徳島)招待講演
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] Identification of isozyme-selective histone deacetylase inhibitors by click chemistry2010
- Author(s)
  Y. Kasuya, N. Miyata, et. al.
- Organizer
  Pacifichem2010
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] Identification of isozyme-selective histone deacetylase inhibitors by click chemistry2010
- Author(s)
  Y. Kasuya, 宮田直樹, et.al.
- Organizer
  Pacifichem2010
- Place of Presentation
  Honolulu, USA.
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] エピジェネティックに遺伝子発現を制御する低分子化合物の設計と合成2010
- Author(s)
  宮田直樹
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島大学(徳島)(招待講演)
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] Discovery of selective inhibitors of lysine specific demethylase-12010
- Author(s)
  T.Suzuki, 宮田直樹, et.al.
- Organizer
  Pacifichem2010
- Place of Presentation
  Honolulu, USA.
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] エピジェネティックに遺伝子発現を制御する低分子化合物の設計と合成2010
- Author(s)
  宮田直樹
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] Discovery of selective inhibitors of lysine specific demethylase-12010
- Author(s)
  T. Suzuki, H. Nakagawa, N. Miyata, et. al.
- Organizer
  Pacifichem 2010
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] HDAC6非感受性阻害薬の創製とその多発性骨髄腫細胞増殖抑制機構の解明2009
- Author(s)
  宮田直樹, 他
- Organizer
  日本ケミカルバイオロジー学会第4回年会
- Place of Presentation
  神戸(兵庫)
- Year and Date
  2009-05-19
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] HDAC6非感受性阻害薬の創製とその多発性骨髄腫細胞増殖抑制機構の解明2009
- Author(s)
  宮田直樹、他
- Organizer
  日本ケミカルバイオロジー学会第4回年会
- Place of Presentation
  兵庫
- Year and Date
  2009-05-19
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] エエピジェネティックに遺伝子発現を制御する化合物:新たな制がん剤の開発をめざして2009
- Author(s)
  宮田直樹
- Organizer
  第2回Cancer Research Seminar
- Place of Presentation
  名古屋市立大学(愛知)
- Year and Date
  2009-11-18
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] HDAC6非感受性障害薬の創製とその多発性骨髄腫細胞増殖抑制機構の解明2009
- Author(s)
  宮田直樹
- Organizer
  日本ケミカルバイオロジー学会第4回年会
- Place of Presentation
  神戸
- Year and Date
  2009-05-19
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] エエピジェネティックに遺伝子発現を制御する化合物:新たな制がん剤の開発をめざして2009
- Author(s)
  宮田直樹
- Organizer
  第2回Cancer Research Seminar
- Place of Presentation
  愛知
- Year and Date
  2009-11-18
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] エピジェネティックに遺伝子発現を制御する化合物:新たな制がん剤の開発をめざして2009
- Author(s)
  宮田直樹
- Organizer
  第2回 Cancer Research Seminar
- Place of Presentation
  名古屋
- Year and Date
  2009-11-18
- Data Source
  KAKENHI-PROJECT-20390034
[Presentation] ニトロベンゼン構造に基づく新規光誘起型NOドナーの開発2006
- Author(s)
  中川秀彦, 鈴木孝禎, 加藤友香, 長江修, 福原潔, 宮田直樹
- Organizer
  日本ケミカルバイオロジー研究会第1回年会
- Place of Presentation
  東京
- Year and Date
  2006-05-08
- Data Source
  KAKENHI-PROJECT-17590089
[Presentation] 7-Diethylaminocoumarin型光解除性保護基を導入したケージドHDAC阻害剤の合成と機能評価
- Author(s)
  山田創太、家田直弥、川口充康、宮田直樹、中川秀彦
- Organizer
  日本ケミカルバイオロジー学会第９回年会
- Place of Presentation
  大阪
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] 新規HDAC8選択的阻害薬の開発と生物活性評価
- Author(s)
  3. 太田庸介、伊藤幸裕、武藤伸輔、中川秀彦、宮田直樹、鈴木孝禎
- Organizer
  日本薬学会　第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] Development of a caged HDAC inhibitor with 7-diethylaminocoumarin-type photolabile protecting group
- Author(s)
  Sota Yamada, Naoya Ieda, Mitsuyasu Kawaguchi, Naoki Miyata, Hidehiko Nakagawa
- Organizer
  ICBS2014
- Place of Presentation
  San Francisco
- Year and Date
  2014-11-17 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] クマリン構造を有する光で活性制御可能な HDAC 阻害剤の開発
- Author(s)
  山田創太、家田直弥、川口充康、宮田直樹、中川秀彦
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24659050
[Presentation] 7-Diethylaminocoumarin型光解除性保護基を用いたケージドHDAC阻害剤の開発
- Author(s)
  山田創太、家田直弥、川口充康、宮田直樹、中川秀彦
- Organizer
  第67回日本酸化ストレス学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24659050

1. FUKUHARA Kiyoshi (70189968)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. NAKAGAWA Hidehiko (80281674)

# of Collaborated Projects: 6 results

# of Collaborated Products: 38 results
3. SUZUKI Takayoshi (90372838)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
4. SUEYOSHI Shoko (80171114)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. TANNO Masayuki (60171914)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. 中島葉子 (40239926)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KURIHARA Masaaki (20205206)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. TSUMOTO Hiroki (00409385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. KOHDA Kouhuku (60124286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Tamio Mizukami (80367896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SASAKI Ryuzo (60077378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HASEGAWA Makoto (10367899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAGAI Nobuo (90260281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Wada Shuichi (20378607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Yoshida Minoru (80191617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Itoh Akihiro (40391859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Ieda Naoya (00642026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 広部雅和 (20012594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 今井一洋 (50012620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 高柳一成 (70012599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. YAMADA Souta

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
22. ITOH Takehiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. TATUM Prima

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. TATUM PrimaRoechelle

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 池田麻美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 白髭克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIYATA Naoki 宮田 直樹

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Synthesis of HDAC inhibitors that locally develop their inhibition activity in cellsPrincipal Investigator

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Development of drug candidates that epigenetically regulate gene expressionPrincipal Investigator

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Development of novel oxyl-radical quenching pharmacophores as drug candidatesPrincipal Investigator

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DPV法を利用した簡便なリガンドーレセプター相互作用解析手法の開発Principal Investigator

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化学計算による環境化学物質の毒性評価の新手法の開発Principal Investigator

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MIYATA Naoki 宮田直樹