koyama Natsu 小山なつ

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Koyama Natsu 小山なつ

KOYAMA Natsu 小山なつ

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Researcher Number	50135464
Other IDs
External Links
Affiliation (Current)	2025: 滋賀医科大学, 医学部, 客員准教授
Affiliation (based on the past Project Information) *help	2023: 滋賀医科大学, 医学部, 客員准教授 2015 – 2022: 滋賀医科大学, 医学部, 准教授 1999 – 2000: 滋賀医科大学, 医学部, 助教授 1995 – 1997: 滋賀医科大学, 医学部, 助手 1989 – 1993: 滋賀医科大学, 医学部, 助手 1986 – 1987: 滋賀医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator 神経・脳内生理学 / Basic Section 51030:Pathophysiologic neuroscience-related / Pain science / Biological Sciences Except Principal Investigator Neurophysiology and muscle physiology / Basic Section 55050:Anesthesiology-related / Anesthesiology
Keywords	Principal Investigator アロディニア / 恐怖回避モデル / 恐怖記憶 / 痛み / allodynia / 軸索反射 / ピクロトキシン / サーモグラフィー / メリチン / 記憶の消去 … More / ニューロスフェアアッセイ / 恐怖条件付けテスト / オープンフィールドテスト / BrdU / 神経新生 / 気分安定薬 / 恐怖記憶の消去 / Brdu / ニューロスフェア / 神経幹細胞 / ラモトリギン / 慢性疼痛 / 短期記憶 / 報酬系 / 恐怖記憶の忘却 / 恐怖記憶消去学習 / 恐怖の忘却 / 恐怖消去学習 / 自発運動 / エンリッチ環境 / rat / PHN / sympathetic reflex / axon reflex / thermograph / pain / melittin / 無髄C線維 / メリチンテスト / ラット / 帯状疱疹後神経痛 / 交感神経反射 / 疼痛 / Fos-like immunoreactive neurons / nucleus raphe dorsalis / periaqueductal gray / wide dynamic range neuron / antinociception / Picrotoxin / GABA_A receptor antagonists / 脊髄 / c-FOS / Fosタンパク / 背側縫線核 / 中脳中心灰白質 / 広作動域ニューロン / 抗侵害受容 / GABA_A受容体拮抗物質 / メリケン / NGF / Edinger-Westphal核 / c-Fos / CGRP / 神経成長因子 … More Except Principal Investigator 脳MRI / 脳の可塑性変化 / 慢性疼痛 / 後外側腹側核 / 視床 / 腹側基底核群 / 乳酸 / MRスペクトロスコピー(MR-S) / NAA / 神経障害性疼痛 / thalamus / wide dynamic range neuron / nociceptive specific neuron / ventrobasal complex / 侵害受容 / 上行性疼痛抑制系 / グリシン作動性神経伝達 / タウリン / アストロサイト / エネルギー代謝 / 脳内鎮痛メカニズム / 脳機能画像 / 漢方薬（牛車腎気丸） / マクロファージ / 絞扼性神経損傷モデル / 坐骨神経部分損傷モデル / MRS / MRI / 牛車腎気丸 / nucleus ventralis posterolateralis / pain / 腹痛 / 心臓病 / 侵害受容ニューロン / 内臓病 / 内蔵痛 / 腹側基底核群被殻領域 / 広作動域ニューロン / 特異的侵害受容ニューロン / 痛覚 / Morphine / Dorsal colunm simulation / Descending inhibition / Ascending inhibition / Analgesia / Intralaminar nuclei / Nucleus ventralis posterolateralis / Thalamus / 前側索 / 後索 / モルヒネ / 下行性疼痛抑制系 / 後索刺激鎮痛 / 疼痛抑制 / 髄板内核 / ascending inhibition / periaqueductal gray / visceral pain / shell theory / 大縫線核 / ブラジキニン / 延髄大縫線核 / 視床髄板内核 / 背側縫線核 / 中脳中心灰白質 / 内臓痛 / 広作動域ニュ-ロン / 特異的侵害受容ニュ-ロン / 被殻説 Less

Elucidation and application of the mechanism of chronic pain from the perspective of taurine metabolism in the brain
- Principal Investigator
  
  中西美保
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Shiga University of Medical Science
脳のエネルギー代謝からみる慢性疼痛のメカニズムの解明
- Principal Investigator
  
  中西美保
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Shiga University of Medical Science
The involvement of neural stem cells in promoting elimination of pain-fear memory by lamotriginePrincipal Investigator
- Principal Investigator
  
  Koyama Natsu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
Elucidation of the analgesic mechanism of Japanese herbal medicine resulting from changes in brain plasticity
- Principal Investigator
  
  Nakanishi Miho
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Shiga University of Medical Science
Involvement of the environmental enrichment causing neurogenesis for the pain-related fear extinctionPrincipal Investigator
- Principal Investigator
  
  Koyama Natsu
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Shiga University of Medical Science
アロディニアにおける神経成長因子の役割Principal Investigator
- Principal Investigator
  
  小山なつ
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
Algogenic auction of melittin ; bee venomPrincipal Investigator
- Principal Investigator
  
  KOYAMA Natsu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Shiga University of Medical Science
Role of GABA in activation and mechanism of antinociceptive system.Principal Investigator
- Principal Investigator
  
  KOYAMA Natsu
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Shiga University of Medical Science
Studies on thalamic inhibitory mechanisms of nociception
- Principal Investigator
  
  YOKOTA Toshikatsu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Department of Physiology, Shiga University of Medical Sciennce
Examination of the shell theory of nociception
- Principal Investigator
  
  YOKOTA Toshikatsu
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Shiga University of Medical Science
Studies on pain transmission in the thalamus
- Principal Investigator
  
  YOKOTA Toshikatsu
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Shiga University of Medical Science

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] 痛みのバイオマーカーとしての機能的脳画像診断法2020
- Author(s)
  小山なつ（分担執筆）
- Total Pages
  374
- Publisher
  真興交易
- ISBN
  9784880039299
- Data Source
  KAKENHI-PROJECT-18K07390
[Book] 疼痛医学2020
- Author(s)
  小山なつ（分担執筆）
- Total Pages
  382
- Publisher
  医学書院
- ISBN
  9784260040839
- Data Source
  KAKENHI-PROJECT-18K07390
[Book] 痛みと鎮痛の基礎知識.　増補改訂新版2016
- Author(s)
  小山なつ
- Total Pages
  430
- Publisher
  技術評論社
- Data Source
  KAKENHI-PROJECT-15K08669
[Book] ガイドライン準拠　NICUに入院している新生児の痛みのケア実践テキスト.2016
- Author(s)
  小山なつ、等誠司（分担）
- Total Pages
  18
- Publisher
  メディカ出版
- Data Source
  KAKENHI-PROJECT-15K08669
[Book] 痛みの集学的診療：痛みの教育コアカリキュラム2016
- Author(s)
  小山なつ、等誠司（分担）
- Total Pages
  19
- Publisher
  真興交易（株）医書出版部
- Data Source
  KAKENHI-PROJECT-15K08669
[Book] NICUに入院している新生児の痛みのケア実践テキスト2016
- Author(s)
  小山なつ、等誠司
- Total Pages
  157
- Publisher
  メディカ出版
- Data Source
  KAKENHI-PROJECT-15K08669
[Journal Article] Early maternal and social deprivation expands neural stem cell population size and reduces hippocampus/amygdala-dependent fear memory2020
- Author(s)
  Daun KA, Fuchigami T, Koyama N, Maruta N, Ikenaka K, Hitoshi S
- Journal Title
  
  Front Neurosci
  
  Volume: 14 Pages: 22-22
- DOI
  10.3389/fnins.2020.00022
- NAID
  120006797557
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07390, KAKENHI-PROJECT-16H04671
[Journal Article] 痛みの基礎知識2019
- Author(s)
  小山なつ
- Journal Title
  
  臨床化学
  
  Volume: 48 Pages: 197-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07390
[Journal Article] 脊髄の上行性伝導路と局所回路2019
- Author(s)
  小山なつ
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 37 Pages: 650-652
- Data Source
  KAKENHI-PROJECT-18K07390
[Journal Article] 急性痛と慢性痛の基礎知識2018
- Author(s)
  小山なつ
- Journal Title
  
  理療
  
  Volume: 48 Pages: 21-25
- Data Source
  KAKENHI-PROJECT-15K08669
[Journal Article] 急性痛と慢性痛の基礎知識2018
- Author(s)
  小山なつ
- Journal Title
  
  理療
  
  Volume: 48 Pages: 21-25
- Data Source
  KAKENHI-PROJECT-18K07390
[Journal Article] 慢性の痛みはどのように考えられてきたのか？2017
- Author(s)
  小山なつ、等誠司: 慢性の痛みはどのように考えられてきたのか？
- Journal Title
  
  医学のあゆみ
  
  Volume: 260 Pages: 131-134
- Data Source
  KAKENHI-PROJECT-15K08669
[Journal Article] 性の痛みはどのように考えられてきたのか？ : 慢性の痛み　－何によって生み出されているのか？2017
- Author(s)
  小山なつ、等誠司
- Journal Title
  
  医学のあゆみ
  
  Volume: 260 Pages: 131-134
- Data Source
  KAKENHI-PROJECT-15K08669
[Journal Article] Minocycline Directly Enhances the Self-Renewal of Adult Neural Precursor Cells2017
- Author(s)
  Kuroda Anri、Fuchigami Takahiro、Fuke Satoshi、Koyama Natsu、Ikenaka Kazuhiro、Hitoshi Seiji
- Journal Title
  
  Neurochemical Research
  
  Volume: 43 Issue: 1 Pages: 219-226
- DOI
  10.1007/s11064-017-2422-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08669, KAKENHI-PROJECT-16K14578, KAKENHI-PROJECT-16H04671
[Journal Article] 痛みと鎮痛の歴史閑話3　ーフロイトと局所麻酔薬と催眠ー2016
- Author(s)
  小山なつ、等誠司
- Journal Title
  
  Practice of Pain Management
  
  Volume: 7(1) Pages: 30-37
- Data Source
  KAKENHI-PROJECT-15K08669
[Journal Article] 痛みと鎮痛の歴史閑話2　電気を使った痛みの治療の歴史　ーシビレエイとマラー、そしてマラーから2016
- Author(s)
  小山なつ、等誠司
- Journal Title
  
  Practice of Pain Management
  
  Volume: 6(4) Pages: 30-35
- Data Source
  KAKENHI-PROJECT-15K08669
[Journal Article] 痛みと鎮痛の歴史閑話2　電気を使った痛みの治療の歴史　ーシビレエイとマラー、そしてマラーから2016
- Author(s)
  小山なつ、等誠司
- Journal Title
  
  Practice of Pain Management
  
  Volume: ６
- Data Source
  KAKENHI-PROJECT-15K08669
[Journal Article] 痛みの伝導路　ー歴史から学ぶー2015
- Author(s)
  小山なつ、等誠司
- Journal Title
  
  脊髄外科
  
  Volume: 29(3) Pages: 32-37
- NAID
  130005142345
- Open Access
- Data Source
  KAKENHI-PROJECT-15K08669
[Journal Article] 痛みと鎮痛の歴史閑話1　聖アントニウスの火―St. Anthony's fire―2015
- Author(s)
  小山なつ、等誠司
- Journal Title
  
  Practice of Pain Management
  
  Volume: 6(3) Pages: 32-37
- Data Source
  KAKENHI-PROJECT-15K08669
[Journal Article] 痛みの概念を歴史から振り返る2015
- Author(s)
  小山なつ、等誠司
- Journal Title
  
  最新医学
  
  Volume: 70(8) Pages: 1690-1693
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] 条件付け恐怖の消去学習とWEBによる痛み関連学習に関する話題2021
- Author(s)
  小山なつ
- Organizer
  生理学研究所痛み研究会. 2020
- Invited
- Data Source
  KAKENHI-PROJECT-18K07390
[Presentation] Effects of voluntary wheel running on conditioned fear learning and extinction learning2020
- Author(s)
  Kitagawa H, Nakaji K, Daun K、Kuroda A, Koyama N, Hitoshi S
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-18K07390
[Presentation] 行性疼痛抑制を再考する2020
- Author(s)
  小山なつ
- Organizer
  日本ペインクリニック学会第54回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07390
[Presentation] MOOD STABILIZING DRUGS ACTIVATE ADULT NEURAL STEM CELLS-NEUROGENESIS SYSTEM2019
- Author(s)
  Keita Nakaji, Natsu Koyama, Takahiro Fuchigami, Seiji Hitoshi
- Organizer
  The International Society for Neurochemistry (ISN)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07390
[Presentation] 基礎からみた感覚障害2019
- Author(s)
  小山なつ
- Organizer
  第24回日本口腔顔面痛学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07390
[Presentation] Goshajinkigan, a Japanese traditional herbal medicine, prevents age-related allodynia in senescenc-eaccelerated mice.2019
- Author(s)
  M. NAKANISHI, N. KOYAMA, S. FUKUI, H. KITAGAWA.
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11107
[Presentation] Mood stabilizing drugs activate adult neural stem cell-neurogenesis system2019
- Author(s)
  Keita Nakaji, Natsu Koyama, Fuchigami, Seiji Hitoshi
- Organizer
  第9回アジア・オセアニア生理学会連合大会（FAOPS2019）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07390
[Presentation] The effects of environmental enrichment on the fear memory extinction2018
- Author(s)
  Natsu Koyama, Keita Kitagawa, Hiroaki Kitagawa, Kenny Daun
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] 痛みー恐怖記憶と消去促進に対する刺激豊かな環境の効果2018
- Author(s)
  小山なつ、中路景太、Kenny Daun、等誠司
- Organizer
  第40回日本疼痛学会
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] 痛みと鎮痛の基礎知識　ー再考2017
- Author(s)
  小山なつ
- Organizer
  日本超音波骨軟組織学会　第31回西日本支部学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] 急性痛と慢性痛の基礎知識2017
- Author(s)
  小山なつ
- Organizer
  第66回日本理学療法学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] 侵害刺激による恐怖情動記憶と消去学習に対する母子分離社会ストレスの効果2017
- Author(s)
  小山なつ、Daun Kenny、等誠司
- Organizer
  第39回日本疼痛学会
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] Mood stabilizing drugs activate adult neural stem cell-neurogenesis system2017
- Author(s)
  Keita Nakaji, Kenny Anak Daun, Natsu Koyama, and Seiji Hitoshi
- Organizer
  第94回日本生理学会
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] 疼痛学ことはじめ2017
- Author(s)
  小山なつ
- Organizer
  第39回日本疼痛学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] 実験動物と痛み2017
- Author(s)
  小山なつ
- Organizer
  第134回研究会関西実験動物研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] 教育のために効果的なWeb発信2017
- Author(s)
  小山なつ
- Organizer
  第94回日本生理学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] Effects of maternal separation on the corticosterone level and fear-related behavior in the adult mice2016
- Author(s)
  Daun K, Koyama N and Hitoshi S
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] 急性痛と慢性痛の基礎知識2016
- Author(s)
  小山なつ
- Organizer
  FTEXInstitute 第19回全体研修会
- Place of Presentation
  京都
- Year and Date
  2016-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] Maternal social separation during the stress hyporesponsive period attenuated the fear-related behavior2016
- Author(s)
  Koyama N, Daun K and Hitoshi S
- Organizer
  IASP 2016
- Place of Presentation
  横浜
- Year and Date
  2016-09-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] The effects of maternal separation during or after SHRP on the fear-related behavior in the adult mice2016
- Author(s)
  Koyama N, Haun K, Yamashita Y, Fuchigami T, Hitoshi S
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] 恐怖関連行動に対する幼若期ストレスの効果2015
- Author(s)
  小山なつ・李洪宇・等誠司
- Organizer
  第37回日本疼痛学会
- Place of Presentation
  市民会館崇城大学ホール
- Year and Date
  2015-07-03
- Data Source
  KAKENHI-PROJECT-15K08669
[Presentation] リウマチ医に知ってほしい痛みの基礎知識2015
- Author(s)
  小山なつ
- Organizer
  第59回日本リウマチ学会総会・学術大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-23
- Invited
- Data Source
  KAKENHI-PROJECT-15K08669

1. Nakanishi Miho (40382048)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
2. YOKOTA Toshikatsu (10001752)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. HIRATA Kazuhiko (30238357)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 吉岡芳親 (00174897)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 北川裕利 (50252391)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 福井聖 (80303783)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MINAMI Toshihede (60209830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NISHIKAWA Nozomu (10078595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 西尾健資 (70303790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 野村哲哉 (90218363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 高橋亨 (80206820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中江文 (60379170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 岸田友紀 (20423163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 萩原圭祐 (60423183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 犬伏俊郎 (20213142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

koyama Natsu 小山 なつ

Koyama Natsu 小山 なつ

KOYAMA Natsu 小山 なつ

Research Projects

Research Products

Co-Researchers

Elucidation and application of the mechanism of chronic pain from the perspective of taurine metabolism in the brain

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳のエネルギー代謝からみる慢性疼痛のメカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The involvement of neural stem cells in promoting elimination of pain-fear memory by lamotriginePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the analgesic mechanism of Japanese herbal medicine resulting from changes in brain plasticity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of the environmental enrichment causing neurogenesis for the pain-related fear extinctionPrincipal Investigator

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アロディニアにおける神経成長因子の役割Principal Investigator

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Algogenic auction of melittin ; bee venomPrincipal Investigator

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Role of GABA in activation and mechanism of antinociceptive system.Principal Investigator

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Studies on thalamic inhibitory mechanisms of nociception

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Examination of the shell theory of nociception

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Studies on pain transmission in the thalamus

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[Book] 痛みのバイオマーカーとしての機能的脳画像診断法2020

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[Book] 疼痛医学2020

Author(s)

koyama Natsu 小山なつ

Koyama Natsu 小山なつ

KOYAMA Natsu 小山なつ

[Book] 痛みと鎮痛の基礎知識.　増補改訂新版2016

[Book] ガイドライン準拠　NICUに入院している新生児の痛みのケア実践テキスト.2016

[Book] 痛みの集学的診療：痛みの教育コアカリキュラム2016

[Journal Article] 性の痛みはどのように考えられてきたのか？ : 慢性の痛み　－何によって生み出されているのか？2017

[Journal Article] 痛みと鎮痛の歴史閑話3　ーフロイトと局所麻酔薬と催眠ー2016

[Journal Article] 痛みと鎮痛の歴史閑話2　電気を使った痛みの治療の歴史　ーシビレエイとマラー、そしてマラーから2016

[Journal Article] 痛みと鎮痛の歴史閑話2　電気を使った痛みの治療の歴史　ーシビレエイとマラー、そしてマラーから2016