SHIMODA MINORU 下田実

… Alternative Names

下田実シモダミノル

SHIMODA Minoru 下田実

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Researcher Number	50154323
Affiliation (Current)	2025: 東京農工大学, (連合)農学研究科(研究院), 名誉教授
Affiliation (based on the past Project Information) *help	2018: 東京農工大学, (連合)農学研究科(研究院), 名誉教授 2016 – 2017: 東京農工大学, (連合)農学研究科(研究院), 教授 2007 – 2009: Tokyo University of Agriculture and Technology, Graduate School, Institute of Symbiotic Science and Technology, Professor 2006: 東京農工大学, 大学院共生科学技術研究院, 教授 2005: 東京農工大学, 大学院共生科学技術研究部, 教授 … More 2004: National University Corporation Tokyo University of Agriculture and Technology, Institute of Symbiotic Science and Technology, Associate Professor, 大学院・共生科学技術研究部, 助教授 1998 – 2003: 東京農工大学, 農学部, 助教授 1996: Tokyo University of Agriculture and Technology, Department of Veterinary Medicin, 農学部, 助教授 1988 – 1989: 東京農工大学, 農学部, 助手 1986: 東京農工大学, 農学部, 助手 Less
Review Section/Research Field	Principal Investigator Applied veterinary science / 動物臨床医学 / Clinical veterinary science Except Principal Investigator Basic veterinary science/Basic zootechnical science / 基礎獣医学 / Veterinary medical science / Clinical veterinary science
Keywords	Principal Investigator CYP3A / イヌ / CYP1A / ニフェジピン / キニジン / 酵素阻害 / dog / cimetidine / ketoconazole / erythromycin … More / fluoroquinolones / enzyme inhibition / ミダゾラム / ニューキノロン / CYP3A阻害 / CYP1A阻害 / テオフィリン / オフロキサシン / シメチジン / ケトコナゾール / エリスロマイシン / フルオロキノロン / cytochrome P450 / metabolism / acute phase response / dogs / テオフェリン / チトクロームP450 / シトクロームP450 / 薬物代謝 / 急性相反応 / 肝マイクロソーム / α_1酸性糖タンパク / ラット / CYP活性 / 血漿タンパク結合 / ヒドロコルチゾン / プレドニゾロン / 消炎ステロイド / 薬物間相互作用 / 薬物動態 / 治療 … More Except Principal Investigator reduced folate / oxidized folate / 還元型葉酸 / 音響キャビテーション / 取り込み / 超音波 / 抗癌剤 / 癌治療 / キャビテーション / drug database / drug residue / feed additive / animal drug / 医薬品データベース / 薬剤残留 / 動物用医薬品 / 医薬品デ-タベ-ス / 薬品残留 / 飼料添加物 / 動物用薬品 / gene / signal transduction / cancer / veterinary medicine / 突然変異 / イヌ / 分子標的 / 転写因子 / 肥満細胞腫 / 細胞周期 / 細胞増殖 / シグナル分子 / 遺伝子 / シグナル伝達 / 癌 / 獣医学 / folacin / conceptus growth / leucovorin / folate / litter size / sow reproductive performance / 胎子重量 / 排卵数 / 生存胎子数 / 菌体粉末 / 合成葉酸 / 胚生存率 / 胆汁中葉酸 / 発情再帰日数 / 恒常性維持機構 / 葉酸誘導体 / 妊娠母豚 / 活性葉酸 / ロイコボリン / 産子数増加 / 血漿中葉酸濃度 / 生産子数 / 母豚繁殖効率 / ビタミン葉酸 / rats / pigs / dihydrofolate reductase / アフィニティークロマトグラフ / 二水素葉酸還元酵素 / 四水素葉酸 / 葉酸 / ビタミン / ラット / 豚 / 葉酸還元酵素 / 酸化型葉酸 / スルファモノメトキシン / スルファジメトキシン / tissue cage / ブタ Less

Spatially selective anticancer drug uptake by ultrasonically induced cavitation
- Principal Investigator
  
  SASAKI KAZUAKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Tokyo University of Agriculture and Technology
Possible pharmacokinetic drug-drug interaction during corticosteroid therapy in dogsPrincipal Investigator
- Principal Investigator
  
  SHIMODA Minoru
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Tokyo University of Agriculture and Technology
An exhaustive study of tumorigenesis and development of a novel molecular targeting therapy for canine mastocytoma
- Principal Investigator
  
  MATSUDA Hiroshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Tokyo University of Agriculture and Technology
Possible pharmacokinetic drug-drug interaction by some drugs inhibiting cytochrome P450 activities in dogsPrincipal Investigator
- Principal Investigator
  
  SHIMODA Minoru
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  National University Corporation Tokyo University of Agriculture and Technology
Reproductive Performance and Conceptus Development in Sows in Response to Dietary Supplementation with Oxidized and Reduced Sources of Folic Acid
- Principal Investigator
  
  KOKUE Eiichi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Tokyo University of Agriculture and Technology
Effects of Acute Phase Response on Pharmacokinetics of Drugs in DogsPrincipal Investigator
- Principal Investigator
  
  SHIMODA Minoru
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  動物臨床医学
- Research Institution
  Tokyo University of Agriculture and Technology
Low activity of dihydrofolate reductase induces poor bioavailability of folic acid in pigs
- Principal Investigator
  
  KOKUE Eiichi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
Database System for Animal Drugs to Prevent Drug Residue
- Principal Investigator
  
  HAYAMA Toyoaki
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  基礎獣医学
- Research Institution
  Tokyo University of Agriculture and Technology
薬物の血漿アルブミンとの結合が薬物の組織分布に与える影響について
- Principal Investigator
  
  KOKUE Eiichi
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  Tokyo University of Agriculture and Technology

All 2009 2008 2004 2002

All Journal Article Presentation

[Journal Article] Multiple oral dosing of ketoconazole influences pharmacokinetics of quinidine after intravenous and oral administration in beagle2004
- Author(s)
  M.Kuroha, Y.Shirai, M.Shimoda
- Journal Title
  
  J.Vet.Pharmacil.Therap. 27
  
  Pages: 355-359
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14560262
[Journal Article] Multiple oral dosing of ketoconazole influences pharmacokinetics of quinidine after intravenous and oral administration in beagle dogs.2004
- Author(s)
  M.Kuroha, Y.Shirai, M.Shimoda
- Journal Title
  
  J Vet Pharmacol Therap 27
  
  Pages: 355-369
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14560262
[Journal Article] Multiple oral dosing of ketokonazole influences pharmacokinetics of quinidine after intravenous and oral administration in beagle dogs.2004
- Author(s)
  M.Kuroha, M.Shimoda et al.
- Journal Title
  
  Journal of Veterinary Pharmacology and Therapeutucs 27
  
  Pages: 355-359
- Data Source
  KAKENHI-PROJECT-14560262
[Journal Article] Effect of multiple dosing of ketoconazole on pharmacokinetics of midazolam, a cytochrome P-450 3A substrate in beagle dogs2002
- Author(s)
  M.Kuroha, A.Azumano, Y.Kuze, M.Shimoda, E.Kokue
- Journal Title
  
  Drug Metab.Disp. 30
  
  Pages: 63-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14560262
[Journal Article] In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes.2002
- Author(s)
  M.Kuroha, Y.Kuze, M.Shimoda, E.Kokue
- Journal Title
  
  Am J Vet Res 63
  
  Pages: 900-905
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14560262
[Journal Article] Effect of multiple dosing of ketoconazole on pharmacokinetics of midazolam, a cytochrome P-450 3A substrate in beagle dogs.2002
- Author(s)
  M.Kuroha, A.Azumano, Y.Kuze, M.Shimoda, E.Kokue
- Journal Title
  
  Drug Metab Dispos 30
  
  Pages: 63-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14560262
[Journal Article] In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic2002
- Author(s)
  M.Kuroha, Y.Kuze, M.Shimoda, E.Kokue
- Journal Title
  
  Am.J.Vet.Res 63
  
  Pages: 900-905
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14560262
[Presentation] 犬におけるステロイド系抗炎症薬の投与が肝CYP酵素活性に及ぼす影響について2009
- Author(s)
  田中由衣、下田実, ら
- Organizer
  日本獣医学会
- Place of Presentation
  鳥取
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-19380176
[Presentation] ラットにおける消炎ステロイド投与の肝CYP酵素活性に対する影響2008
- Author(s)
  飯沼雄司, 下田実ら
- Organizer
  日本獣医学会
- Place of Presentation
  宮崎県シーガイヤ
- Data Source
  KAKENHI-PROJECT-19380176
[Presentation] 犬におけるステロイドのCYP活性に対する阻害作用2008
- Author(s)
  島田圭悟, 下田実ら
- Organizer
  日本獣医学会
- Place of Presentation
  宮崎県シーガイヤ
- Data Source
  KAKENHI-PROJECT-19380176

1. KOKUE Eiichi (50014965)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
2. IWASAKI Toshiro (50262754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KAMOMAE Hideo (60262226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SAITOH Toshiki (00162214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MATSUDA Hiroshi (80145820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TANAKA Akane (80418673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ARAI Katsuhiko (60175940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TSUJIMOTO Hajime (60163804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NISHIMURA Ryouhei (80172708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HAYAMA Toyoaki (80014893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SASAKI KAZUAKI (10421934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 臼井達哉 (80727652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TANIGAWA Manabu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TORIDE Yasuhiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 取手恭彦

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIMODA MINORU 下田 実

下田 実 シモダ ミノル

SHIMODA Minoru 下田 実

Research Projects

Research Products

Co-Researchers

Spatially selective anticancer drug uptake by ultrasonically induced cavitation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Possible pharmacokinetic drug-drug interaction during corticosteroid therapy in dogsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An exhaustive study of tumorigenesis and development of a novel molecular targeting therapy for canine mastocytoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Possible pharmacokinetic drug-drug interaction by some drugs inhibiting cytochrome P450 activities in dogsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reproductive Performance and Conceptus Development in Sows in Response to Dietary Supplementation with Oxidized and Reduced Sources of Folic Acid

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of Acute Phase Response on Pharmacokinetics of Drugs in DogsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Low activity of dihydrofolate reductase induces poor bioavailability of folic acid in pigs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Database System for Animal Drugs to Prevent Drug Residue

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

薬物の血漿アルブミンとの結合が薬物の組織分布に与える影響について

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Multiple oral dosing of ketoconazole influences pharmacokinetics of quinidine after intravenous and oral administration in beagle2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Multiple oral dosing of ketoconazole influences pharmacokinetics of quinidine after intravenous and oral administration in beagle dogs.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Multiple oral dosing of ketokonazole influences pharmacokinetics of quinidine after intravenous and oral administration in beagle dogs.2004

Author(s)

Journal Title

Data Source

[Journal Article] Effect of multiple dosing of ketoconazole on pharmacokinetics of midazolam, a cytochrome P-450 3A substrate in beagle dogs2002

Author(s)

Journal Title

Description

Data Source

[Journal Article] In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes.2002

SHIMODA MINORU 下田実

下田実シモダミノル

SHIMODA Minoru 下田実