NOHARA Keiko 野原恵子

… Alternative Names

野原惠子ノハラケイコ

野原恵子ノハラケイコ

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Researcher Number	50160271
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2020: 国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, フェロー 2015: 国立研究開発法人国立環境研究所, 環境健康研究センター, センター長 2015: 国立研究開発法人国立環境研究所, 環境健康研究センター, 研究センター長 2014: 独立行政法人国立環境研究所, 環境健康研究センター, センター長 2011 – 2014: 独立行政法人国立環境研究所, 環境健康研究センター, 室長 2007 – 2008: National Institute for Environmental Studies, 環境健康研究領域, 室長 1994 – 1995: 国立環境研究所, 環境健康部, 主任研究員
Review Section/Research Field	Principal Investigator Hygiene and public health / Hygiene / Medium-sized Section 63:Environmental analyses and evaluation and related fields / Functional biochemistry Except Principal Investigator Environmental and hygienic pharmacy / Risk sciences of radiation and chemicals
Keywords	Principal Investigator 無機ヒ素 / 妊娠期曝露 / DNAメチル化 / 精子 / 次世代影響 / 継世代影響 / 胎児期曝露 / miRNA / F2影響 / 肝腫瘍 … More / small RNA / tRNA fragment / piRNA / small RNA seq / 初期化 / 初期胚 / リプログラミング / 胚 / Monoclonal antibody / Activation / Thymocytes / T cell / Gangliosides / モノクローナル抗体 / ガングリオシド / 活性化 / 胸腺細胞 / T細胞 / miiRNA / 発がん / エピ変異 / DNAメチル基転移酵素 / 5-メチルシトシン / DNA損傷修復酵素 / Tet酵素 / グローバルDNAメチル化量 / 酸化的DNA損傷 / 低メチル食 / 能動的DNA脱メチル化 / 5ヒドロキシメチルシトシン / 5メチルシトシン / 能動的脱メチル化 / 突然変異 / メチル欠乏食 / エピジェネティクス / 酸化ストレス / 転写抑制複合体 / p130 / ポケットプロテイン / E2F / 転写因子 / 免疫細胞 … More Except Principal Investigator 酸化ストレス / 遺伝子 / 環境 / リスク評価 / 肝腫瘍 / 肝臓 / 妊娠期曝露 / Tgf-β / 細胞老化 / 多世代影響 / ヒ素 / 有害化学物質 / 癌 / 薬学 / 体内変異原性 / 発がん / 変異原物質 / 変異原性 / 規制効果 / 肺がん / in vivoアッセイ / 突然変異 / 環境変異原物質 / 大気汚染物質 Less

Inheritance of environmental impacts on DNA methylation through sperm to the next generation embryosPrincipal Investigator
- Principal Investigator
  
  NOHARA Keiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  National Institute for Environmental Studies
Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicalsPrincipal Investigator
- Principal Investigator
  
  NOHARA Keiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene and public health
- Research Institution
  National Institute for Environmental Studies
Characterization of mutation as a marker for carcinogenesis induced by oxidative stress: identification of mutation hotspot
- Principal Investigator
  
  AOKI Yasunobu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  National Institute for Environmental Studies
Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatin tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant micePrincipal Investigator
- Principal Investigator
  
  Nohara Keiko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene and public health
- Research Institution
  National Institute for Environmental Studies
The involvement of cellular senescence in hepatic tumors that increase through multiple generations by gestational arsenite exposure
- Principal Investigator
  
  Okamura Kazuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  National Institute for Environmental Studies
Studies on epimutations that are involved in multigenerational effects of environmental chemicals in micePrincipal Investigator
- Principal Investigator
  
  Nohara Keiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene and public health
- Research Institution
  National Institute for Environmental Studies
Assessment of current lung cancer and related health risk by past-exposure of particulates suspended in air
- Principal Investigator
  
  Aoki Yasunobu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  National Institute for Environmental Studies
Involvement of oxidative stress in the epigenetic changes induced by environmental chemicalsPrincipal Investigator
- Principal Investigator
  
  NOHARA Keiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  National Institute for Environmental Studies
Studies on the effect of arsenic on the transcription factors in immune cellsPrincipal Investigator
- Principal Investigator
  
  NOHARA Keiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  National Institute for Environmental Studies
Studies on the activation-associated ganglioside in rat T cellPrincipal Investigator
- Principal Investigator
  
  NOHARA Keiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Institute for Environmental Studies

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 2008 Other

All Journal Article Presentation Book

[Book] Chapter 3. Arsenic exposure and reproductive toxicity. In: Yamauchi H, Sun G editors. Arsenic contamination in Asia.2019
- Author(s)
  Udagawa O, Okamura bK, Siziki T, Nohara K.
- Total Pages
  14
- Publisher
  Springer
- ISBN
- Data Source
  KAKENHI-PROJECT-18K19860
[Book] Chapter 3. Arsenic Exposure and Reproductive Toxicity. In: Yamauchi H, Sun G editors. Arsenic contamination in Asia.2019
- Author(s)
  Udagawa O,Okamura K,Suzuki T,Nohara K
- Total Pages
  14
- Publisher
  Springer
- ISBN
- Data Source
  KAKENHI-PROJECT-17H04139
[Book] 毒性の科学2014
- Author(s)
  鈴木武博、野原恵子
- Total Pages
  200
- Publisher
  東大出版会
- Data Source
  KAKENHI-PROJECT-23390166
[Book] 2.6環境因子によるエピジェネティック制御毒性の科学2014
- Author(s)
  鈴木武博, 野原恵子
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-23390166
[Journal Article] Gestational arsenic exposure induces site-specific DNA hypomethylation in active retrotransposon subfamilies in offspring sperm in mice2020
- Author(s)
  Nohara Keiko、Nakabayashi Kazuhiko、Okamura Kazuyuki、Suzuki Takehiro、Suzuki Shigekatsu、Hata Kenichiro
- Journal Title
  
  Epigenetics & Chromatin
  
  Volume: 13 Issue: 1 Pages: 53-53
- DOI
  10.1186/s13072-020-00375-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03556, KAKENHI-PROJECT-17K08689, KAKENHI-PROJECT-18K19860
[Journal Article] Gestational arsenic exposure and paternal intergenerational epigenetic inheritance2020
- Author(s)
  Nohara Keiko、Suzuki Takehiro、Okamura Kazuyuki
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 409 Pages: 115319-115319
- DOI
  10.1016/j.taap.2020.115319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19860
[Journal Article] Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice.2017
- Author(s)
  Nohara K, Suzuki T, Okamura K, Matsushita J, Takumi S
- Journal Title
  
  Gene Env
  
  Volume: 39 Issue: 1
- DOI
  10.1186/s41021-016-0069-1
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293154, KAKENHI-PROJECT-15K15246
[Journal Article] Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F2 male offspring via the F1 male offspring2015
- Author(s)
  Nohara K, Okamura K, Suzuki T, Murai H, Ito T, Shinjo K, Takumi S, Michikawa T, Kondo Y, Hata K.
- Journal Title
  
  J Appl Toxicol
  
  Volume: 印刷中 Issue: 1 Pages: 105-112
- DOI
  10.1002/jat.3149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460831, KAKENHI-PROJECT-26293154, KAKENHI-PROJECT-26430136, KAKENHI-PROJECT-26860445, KAKENHI-PROJECT-25290048
[Journal Article] 妊娠期無機ヒ素曝露による子での癌遺伝子体細胞突然変異を介した発癌増加と多世代・継世代影響2014
- Author(s)
  野原恵子他
- Journal Title
  
  日本衛生学雑誌
  
  Volume: 69 Pages: 92-96
- NAID
  130004512932
- Data Source
  KAKENHI-PROJECT-26293154
[Journal Article] in vivo mutagenicity of arsenite in the livers of gpt delta transgenic mice2014
- Author(s)
  S. Takumi, Y. Aoki, T. Sano, T. Suzuki, T. Nohmi and K. Nohara
- Journal Title
  
  Mutat. Res.
  
  Volume: 760 Pages: 42-47
- DOI
  10.1016/j.mrgentox.2013.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241016, KAKENHI-PROJECT-23390166, KAKENHI-PROJECT-24790600, KAKENHI-PROJECT-25293034, KAKENHI-PROJECT-25460831
[Journal Article] DOHaDとエピジェネティクス2013
- Author(s)
  野原恵子
- Journal Title
  
  産科と婦人科
  
  Volume: 80 Pages: 575-579
- Data Source
  KAKENHI-PROJECT-23390166
[Journal Article] 環境分野におけるDOHaD研究2013
- Author(s)
  野原恵子
- Journal Title
  
  公衆衛生
  
  Volume: 77 Pages: 1019-1021
- Data Source
  KAKENHI-PROJECT-23390166
[Journal Article] Long-term arsenic exposure induces histone H3 Lys9 dimethylation without altering DNA methylation in the promoter region of p16INK4a and down-regulates its expression in the liver of mice.2013
- Author(s)
  T. Suzuki and K. Nohara
- Journal Title
  
  J. Appl. Toxicol.
  
  Volume: 33 Issue: 9 Pages: 951-958
- DOI
  10.1002/jat.2765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390166, KAKENHI-PROJECT-23790680
[Journal Article] Late-onset increases in oxidative stress and other tumorigenic activities and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic.2012
- Author(s)
  Keiko Nohara
- Journal Title
  
  Toxicological Science
  
  Volume: 129 Issue: 2 Pages: 293-304
- DOI
  10.1093/toxsci/kfs203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310043, KAKENHI-PROJECT-23390166, KAKENHI-PROJECT-23790680, KAKENHI-PROJECT-24590307
[Journal Article] Late-onset increases in oxidative stress and other tumorigenic activities and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic2012
- Author(s)
  Nohara K. Tateishi Y. Suzuki T, Okamura K, Murai H, Takumi S, Maekawa F, Nishimura N, Kobori M, Ito T
- Journal Title
  
  Toxicol. Sci
  
  Volume: 129 Pages: 293-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390166
[Journal Article] Global DNA methylation in the mouse liver if affected by methy deficiency and arsenic in a sex-dependent manne2011
- Author(s)
  Nohara K, Baba T, Murai H, Kobayashi Y, Suzuki T, Tateishi Y, Matsumoto M, Nishimura N, Sano T
- Journal Title
  
  Arch. Toxicol
  
  Volume: 85 Pages: 653-661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390166
[Journal Article] Global DNA methylation in the mouse liver if affected by methyl deficiency and arsenic in a sex-dependent manner2011
- Author(s)
  Nohara, K., Baba, T, Murai, H., Kobayashi, Y., Suzuki, T., Tateishi, Y., Matsumoto, M., Nishimura, N., Sano, T.
- Journal Title
  
  Arch.Toxicol.
  
  Volume: 85 Pages: 653-661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390166
[Journal Article] Arsenite-induced thymus atrophy is mediated by cell cycle arrest :A characteristic down-regulation of E2F-related genes revealed by a microarray approach.2008
- Author(s)
  Nohara, K., Ao, K., Miyamoto, Y., Suzuki, T., Imaizumi, S., Tateishi, Y., Omura, S., Tohyama, C. and Kobayashi, T.
- Journal Title
  
  Toxicol. Sci. 101
  
  Pages: 226-238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590611
[Journal Article] Arsenite-induced thymus atrophy is mediated by ceH cycle arrest:A characteristic downregulation of E2F-related genes revealed by a microarray approach2008
- Author(s)
  K. Nohara, K. Ao, Y. Miyamoto, T. Suzuki, S. Imaizumi, Y. Tateishi, S. Omura, C. Tohyama, T. Kobayashi
- Journal Title
  
  Toxicological Sciences 101
  
  Pages: 226-238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590611
[Presentation] 環境因子の妊娠期曝露による子の精子エピゲノム変化と次世代影響2020
- Author(s)
  野原恵子
- Organizer
  環境ホルモン学会第34回講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] マウス妊娠期ヒ素曝露によって誘導される仔精子のLINEおよびLTRレトロトランスポゾンのDNAメチル化変化2020
- Author(s)
  野原恵子,中林一彦,岡村和幸,鈴木武博,秦健一郎
- Organizer
  第14回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] マウス妊娠期ヒ素曝露による仔精子レトロトランスポゾン転写調節領域のメチル化低下2020
- Author(s)
  野原恵子、中林一彦、岡村和幸、鈴木武博、秦健一郎
- Organizer
  第90回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] 妊娠期ヒ素曝露を受けたF1精子由来のF2初期胚における遺伝子発現変化の検討2019
- Author(s)
  鈴木武博，岡村和幸，野原恵子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H04139
[Presentation] 妊娠期ヒ素曝露を受けたF1精子由来のF2初期胚における遺伝子発現変化の検討2019
- Author(s)
  鈴木武博，岡村和幸，野原恵子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] マウス妊娠期無機ヒ素曝露による仔精子レトロトランスポゾンのDNAメチル化低下2019
- Author(s)
  野原恵子，中林一彦，岡村和幸，鈴木武博，秦健一郎
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] Epigenetics and Environment2019
- Author(s)
  Keiko Nohara
- Organizer
  47th Myanmer Health Research Congress
- Invited
- Data Source
  KAKENHI-PROJECT-17H04139
[Presentation] 無機ヒ素の妊娠期曝露が仔の精子エピゲノム変化を介して次世代に影響を伝えるメカニズムの探索2019
- Author(s)
  野原恵子
- Organizer
  日本毒性学会生体金属部会主催メタルバイオサイエンス研究会2019
- Invited
- Data Source
  KAKENHI-PROJECT-17H04139
[Presentation] 妊娠期ヒ素曝露によるマウス精巣でのエピジェネティク変化の検討2019
- Author(s)
  鈴木武博, 野原恵子
- Organizer
  日本毒性学会生体金属部会主催メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-17H04139
[Presentation] Epigenetics and Environment.2019
- Author(s)
  Nohara K
- Organizer
  47th Myanmer Health Research Congress
- Invited
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] 無機ヒ素の妊娠期曝露が仔の精子エピゲノム変化を介して次世代に影響を伝えるメカニズムの探索2019
- Author(s)
  野原恵子
- Organizer
  日本毒性学会生体金属部会主催メタルバイオサイエンス研究会2019
- Invited
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] Small RNA sequencingを用いた妊娠期無機ヒ素曝露による子世代精子で変化するtRNA fragmentsの探索2019
- Author(s)
  岡村和幸，中林一彦，石渡啓介，鈴木武博，秦健一郎，野原恵子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H04139
[Presentation] マウス妊娠期無機ヒ素曝露による仔の精子DNAメチル化変化の解析2019
- Author(s)
  野原恵子, 中林一彦, 岡村和幸, 鈴木武博, 秦健一郎
- Organizer
  第8回日本DOHaD学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] 妊娠期無機ヒ素曝露の多世代影響とエピジェネティクス2018
- Author(s)
  野原恵子
- Organizer
  メタルバイオサイエンス研究会2018
- Data Source
  KAKENHI-PROJECT-17H04139
[Presentation] 妊娠期無機ヒ素曝露による孫世代（F2）の肝腫瘍増加に関与する仔世代（F1）精子のエピゲノム変化2018
- Author(s)
  野原恵子、岡村和幸、鈴木武博、中林一彦、秦健一郎
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] 妊娠期無機ヒ素曝露による孫世代（F2）の肝腫瘍増加に関与する仔世代（F1）精子のエピゲノム変化2018
- Author(s)
  野原恵子、岡村和幸、鈴木武博、中林一彦、秦健一郎
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H04139
[Presentation] 妊娠期化学物質曝露の多世代影響2018
- Author(s)
  野原恵子
- Organizer
  第45回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] 妊娠期化学物質曝露の多世代影響2018
- Author(s)
  野原恵子
- Organizer
  第45回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04139
[Presentation] 妊娠期無機ヒ素曝露の多世代影響とエピジェネティクス2018
- Author(s)
  野原恵子
- Organizer
  メタルバイオサイエンス研究会2018
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] F0マウス妊娠期ヒ素曝露がF1雄を介してF2世代で肝腫瘍を増加させる機序の探索：F1精子のDNAメチル化解析2018
- Author(s)
  野原恵子，岡村和幸，中林一彦，松下隼也，鈴木武博，市原学，秦健一郎
- Organizer
  第12回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-18K19860
[Presentation] 細胞老化に着目した妊娠期ヒ素曝露による孫世代肝腫瘍増加機序の解明2017
- Author(s)
  岡村和幸　野原恵子
- Organizer
  第36回生体と金属・化学物質に関する研究会
- Data Source
  KAKENHI-PROJECT-15K21611
[Presentation] 妊娠期ヒ素曝露による多世代影響の伝搬とフェノタイプ発現のメカニズムの探索2017
- Author(s)
  野原恵子,岡村和幸,鈴木武博
- Organizer
  第44回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04139
[Presentation] C3Hマウスの妊娠期ヒ素曝露による多世代影響へのmiRNAの関与2017
- Author(s)
  松下隼也、岡村和幸、宇田川理、鈴木武博、櫻井敏博、市原学、野原恵子
- Organizer
  第87回日本衛生学会学術総会
- Place of Presentation
  シーガイアコンベンションセンター（宮崎）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-26293154
[Presentation] 妊娠期ヒ素曝露により孫世代で増加する肝腫瘍への細胞老化の関与とその誘導因子2017
- Author(s)
  岡村和幸、鈴木武博、野原恵子
- Organizer
  第87回日本衛生学会学術総会
- Place of Presentation
  フェニックス・シーガイア・リゾート（宮崎県宮崎市）
- Year and Date
  2017-03-26
- Data Source
  KAKENHI-PROJECT-15K21611
[Presentation] 妊娠期ヒ素曝露により孫世代で増加する肝腫瘍への細胞老化の関与とその誘導因子2017
- Author(s)
  岡村和幸、鈴木武博、野原恵子
- Organizer
  第87回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-15K21611
[Presentation] 胎児期ヒ素曝露の仔・孫世代マウス肝細胞における網羅的遺伝子発現解析2017
- Author(s)
  鈴木武博、小堀真珠子、岡村和幸、野原恵子
- Organizer
  第87回日本衛生学会学術総会
- Place of Presentation
  シーガイアコンベンションセンター（宮崎）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-26293154
[Presentation] Novel DNA methylation changes induced by gestational arsenite exposure in hepatic tumors in F2 mice.2016
- Author(s)
  岡村和幸、中林一彦、堀部悠、河合智子、鈴木武博、秦健一郎、野原恵子
- Organizer
  第5回日本DOHaD研究会学術集会
- Place of Presentation
  国立成育医療研究センター（東京）
- Year and Date
  2016-07-23
- Data Source
  KAKENHI-PROJECT-26293154
[Presentation] 妊娠マウスへの無機ヒ素曝露による多世代影響2016
- Author(s)
  野原恵子、岡村和幸、鈴木武博
- Organizer
  第86回日本衛生学会学術総会
- Place of Presentation
  旭川市民文化会館（北海道）
- Year and Date
  2016-05-12
- Invited
- Data Source
  KAKENHI-PROJECT-26293154
[Presentation] C3HマウスにおいてDNAメチル化変化を介して肝腫瘍形成に関与する遺伝子の探索2016
- Author(s)
  松下隼也、岡村和幸、鈴木武博、中林一彦、堀部悠、河合智子、秦健一郎、桜井敏博、市原学、野原恵子
- Organizer
  第10回日本エピジェネティクス研究会
- Place of Presentation
  千里ライフサイエンスセンター（大阪）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26293154
[Presentation] 妊娠マウスへの無機ヒ素曝露による多世代影響2016
- Author(s)
  野原恵子、岡村和幸、鈴木武博
- Organizer
  第86回日本衛生学会学術総会
- Place of Presentation
  旭川市民文化会館（北海道）
- Year and Date
  2016-05-12
- Invited
- Data Source
  KAKENHI-PROJECT-15K15246
[Presentation] 妊娠期ヒ素曝露によるF2マウス肝臓の正常組織、腫瘍組織におけるDNAメチル化変化2016
- Author(s)
  岡村和幸、野原恵子
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26293154
[Presentation] 胎児期ヒ素曝露によるCH3マウスF2世代の肝細胞フェノタイプの検討2016
- Author(s)
  鈴木武博、野原恵子
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウインク愛知（愛知）
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-26293154
[Presentation] The Effects of Gestational Arsenite Exposure on the F2 Generation: Role of Epigenetics2015
- Author(s)
  Nohara K et al
- Organizer
  Society of Toxicology 54th Annual Meeting
- Place of Presentation
  San Diego (USA)
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-26293154
[Presentation] 無機ヒ素のエピジェネティック作用、変異原性、多世代・継世代影響2015
- Author(s)
  野原恵子　他
- Organizer
  日本環境変異原学会　第44回大会
- Place of Presentation
  九州大学（福岡県・福岡市）
- Year and Date
  2015-12-27
- Data Source
  KAKENHI-PROJECT-26293154
[Presentation] 妊娠期にヒ素曝露を受けたC3Hマウス雌のF2子孫における肝癌の遺伝子発現変化2014
- Author(s)
  野原恵子　岡村和幸
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜国際会議場（横浜）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26293154
[Presentation] In vivo mutagenicity assay of arsenite using gpt delta transgenic mice, Society of Toxicology2014
- Author(s)
  Takumi S, Aoki Y, Sano T, Suzuki T, Nohmi T, and Nohara K
- Organizer
  53rd Annual Meeting
- Place of Presentation
  Phoenix, USA
- Year and Date
  2014-03-26
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 妊娠期無機ヒ素曝露によるF2雄マウスでの肝腫瘍増加の機序の探索2014
- Author(s)
  野原恵子　他
- Organizer
  フォーラム2014 衛生薬学・環境トキシコロジー
- Place of Presentation
  エポカルつくば（つくば市）
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-26293154
[Presentation] 無機ヒ素の胎児期曝露による後発的発癌増加の機序2013
- Author(s)
  野原恵子
- Organizer
  第83回日本衛生学会学術総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] メチオニン・コリン欠乏食投与によるDNA 低メチル化における能動的脱メチル化の関与2012
- Author(s)
  内匠正太, 佐野友春, 野原恵子
- Organizer
  第82回日本衛生学会学術総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] Late-onset gene expression changes in the livers of male C3H mice maternally exposed to arsenic : Implications for an increase in hepatic tumor incidence2012
- Author(s)
  Nohara, K., Tateishi, Y., Suzuki, T., Murai, H., Takumi, S., Okamura, K., Maekawa, F., Nishimura, N., Ito, T.
- Organizer
  51th Annual Meeting, Society of Toxicology
- Place of Presentation
  Moscone Convention Center(サンフランシスコ)
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 胎児期ヒ素曝露をうけたC3Hマウス雄肝臓におけるHa-ras変異をもった腫瘍の増加2012
- Author(s)
  野原恵子
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] Late increases in tumorigenic stress and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic2012
- Author(s)
  Keiko Nohara
- Organizer
  Prenatal Programming and Toxicity (PPTOX) III Meeting
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] gpt delta マウスを用いた無機ヒ素によるin vivo 突然変異解析2012
- Author(s)
  内匠正太, 青木康展, 佐野友春, 鈴木武博, 能美健彦, 野原恵子
- Organizer
  日本環境変異原学会第41回大会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] C3Hマウスへの胎児期無機ヒ素曝露によるF1およびF2世代でのHa-ras変異をもった腫瘍の増加2012
- Author(s)
  野原恵子
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] メチオニン・コリン欠乏食投与によるDNA低メチル化における能動的脱メチル化の関与2012
- Author(s)
  内匠正太、佐野友春、野原恵子
- Organizer
  第82回日本衛生学会学術総会
- Place of Presentation
  京都大学(京都府)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 無機ヒ素曝露によって増加したマウス肝臓癌において特異的にDNAメチル化が変化する領域の探索2011
- Author(s)
  鈴木武博、山下聡、立石幸代、牛島俊和、野原恵子
- Organizer
  日本環境変異原学会第40回大会
- Place of Presentation
  学術総合センター(東京都)
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] C3Hマウスの胎児期無機ヒ素曝露による成長後の肝癌増加と後発的遺伝子発現変化2011
- Author(s)
  野原恵子、立石幸代、鈴木武博、村井景、内匠正太、前川文彦、岡村和幸
- Organizer
  日本環境変異原学会第40回大会
- Place of Presentation
  学術総合センター(東京都)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] メチル欠乏食及びヒ素投与に伴うDNA低メチル化における酸化DNA損傷とDNAメチル基転移酵素の関与2011
- Author(s)
  内匠正太、佐野友春、野原恵子
- Organizer
  第5回日本エピジェネティクス研究会年会
- Place of Presentation
  KKRホテル熊本(熊本県)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] DNAメチル基転移酵素Dnmt3b発現の概日周期の制御機構2011
- Author(s)
  野原恵子、包金花、内匠正太、前川文彦
- Organizer
  第5回日本エピジェネティクス研究会年会
- Place of Presentation
  KKRホテル熊本(熊本県)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 環境応答に関わるDNAメチル基転移酵素の時計遺伝子による発現制御2011
- Author(s)
  前川文彦、榛葉繁紀、内匠正太、大和田美佳、包金花、野原恵子
- Organizer
  環境ホルモン学会第14回研究発表会
- Place of Presentation
  東京大学(東京都)
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 胎児期無機ヒ素曝露によるマウスの自然発癌増加とヘムオキシゲナーゼ遺伝子およびL1レトロトランスポゾンの発現増加2011
- Author(s)
  野原恵子、内匠正太、岡村和幸、前川文彦、鈴木武博、村井景、立石幸代
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] メチル欠乏食及びヒ素投与に伴うDNA 低メチル化における酸化DNA 損傷とDNA メチル基転移酵素の関与2011
- Author(s)
  内匠正太, 佐野友春, 野原恵子
- Organizer
  第5回日本エピジェネティクス研究会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 胎児期ヒ素曝露が導く成体C3Hマウスにおける血糖制御異常2011
- Author(s)
  前川文彦、村井景、野原恵子
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌市教育文化会館(北海道)
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 長期ヒ素曝露によるBリンパ球のセネッセンス誘導2011
- Author(s)
  岡村和幸、野原恵子
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 肝臓におけるDNAメチル基転移酵素遺伝子発現の概日周期:摂食と時計遺伝子の役割2011
- Author(s)
  前川文彦、榛葉繁則、内匠正太、大和田美佳、包金花、野原恵子
- Organizer
  第32回日本肥満学会
- Place of Presentation
  淡路夢舞台国際会議場(兵庫県)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 胎児期無期ヒ素曝露によって増加したマウス肝臓癌におけるゲノムワイドなDNAメチル化変化の解析2011
- Author(s)
  鈴木武博、山下聡、内匠正太、立石幸代、佐野友春、牛島俊和、野原恵子
- Organizer
  第17回ヒ素シンポジウム
- Place of Presentation
  つくば国際会議場(茨城県)
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] Transcriptional changes in immunotoxicology : Transcription factors, signal transduction, and epigenetics2009
- Author(s)
  Kerkvliet, N., Nohara. K
- Organizer
  Society of Toxicology : 2009 annual meeting
- Place of Presentation
  Baltimore
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-19590611
[Presentation] Transcriptional changes in immunotoxicology: Transcription factors, signal transduction, and epigenetics.2009
- Author(s)
  Kerkvliet, N., Nohara, K.
- Organizer
  Society of Toxicology: 2009 annual meeting
- Data Source
  KAKENHI-PROJECT-19590611
[Presentation] The E2F family is a sensitive target of arsenite in the thymus : A characteristic down-reguration of E2F-related genes revealed by immunotoxicogenomics2009
- Author(s)
  Nohara, K
- Organizer
  Society of Toxicology : 2009 annual meeting
- Place of Presentation
  Baltimore
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-19590611
[Presentation] 無機ヒ素によるp16INK4α発現調節へのエピジェネテクス作用の関与2009
- Author(s)
  鈴木武博, 村井景, 西村典子, 小林弥生, 野原恵子
- Organizer
  第8回分子予防環境医学研究会
- Place of Presentation
  東京
- Year and Date
  2009-01-23
- Data Source
  KAKENHI-PROJECT-19590611
[Presentation] ヒ素の毒性のゲノミクス・エピゲノミクス2009
- Author(s)
  野原恵子
- Organizer
  日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-19590611
[Presentation] The E2F family is a sensitive target of arsenite in the thymus: A characteristic down-reguration of E2F-related genes revealed by immunotoxicogenomics.2009
- Author(s)
  Nohara, K.
- Organizer
  Society of Toxicology: 2009 annual meeting
- Data Source
  KAKENHI-PROJECT-19590611
[Presentation] 無機ヒ素によるp16INK4α発現調節へのエピジェネテクス作用の関与2008
- Author(s)
  鈴木武博、村井景、西村典子、小林弥生、野原恵子
- Organizer
  第8回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-19590611
[Presentation] 環境化学物質のイムノトキシコゲノミクス2008
- Author(s)
  野原恵子
- Organizer
  第15回日本免疫毒性学会学術大会
- Data Source
  KAKENHI-PROJECT-19590611
[Presentation] ヒ素の癌抑制遺伝子の発現調節への影響2008
- Author(s)
  鈴木武博、村井景、松本みちよ、立石幸代、西村典子、小林弥生、野原恵子
- Organizer
  第8回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-19590611
[Presentation] ヒ素の癌抑制遺伝子の発現調節への影響2008
- Author(s)
  鈴木武博, 村井景, 松本みちよ, 立石幸代, 西村典子, 小林弥生, 野原恵子
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19590611
[Presentation] Maternal arsenic exposure of C3H mice increases hepatic tumor with an activating mutation in the oncogene Ha-ras in the F2 generation
- Author(s)
  K Nohara et al
- Organizer
  Society of Toxicology 53rd Annual Meeting
- Place of Presentation
  Phoenix, USA
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 胎児期ヒ素曝露によるC3Hマウス雄肝臓での脂質代謝変化とHa‐ras変異をもった腫瘍の増加
- Author(s)
  野原恵子
- Organizer
  第1回日本DOHaD研究会年会
- Place of Presentation
  和光
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 無機ヒ素による発癌への変異とエピ変異の関与
- Author(s)
  野原恵子
- Organizer
  第７回環境エピゲノミクス研究定例会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] マウス肝癌細胞株におけるFosb発現とDNAメチル化の関連
- Author(s)
  鈴木武博、野原恵子
- Organizer
  第13回分子予防環境医学研究会
- Place of Presentation
  和歌山
- Data Source
  KAKENHI-PROJECT-23390166
[Presentation] 環境化学物質の胎児期曝露による発癌に関する後発影響と継世代影響
- Author(s)
  野原恵子
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-23390166

1. SUZUKI Takehiro (60425494)

# of Collaborated Projects: 5 results

# of Collaborated Products: 29 results
2. Okamura Kazuyuki (50736064)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
3. AOKI Yasunobu (20159297)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. Nakabayashi Kazuhiko (10415557)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
5. 秦健一郎 (60360335)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
6. MATSUMOTO Michi (60132867)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. Matsushita Junya

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. SANO Tomoharu (10178808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
9. TAKUMI Shota (80570770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
10. NOHMI Takehiko (30150890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. NAKAJIMA Daisuke (10281411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MASUMURA Kenichi (40291116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YANAGISAWA Rie (70391167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. GOTO Sumio (30112890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Horii Takuro (00361387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Morita Sumiyo (40589264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Udagawa Osamu (50738466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 畑田出穂 (50212147)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 續輝久 (40155429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 大野みずき (70380524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 粟生佳奈

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 村井景

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
23. 三木大介

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 大井航

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. SAJI Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NOHARA Keiko 野原 恵子

野原 惠子 ノハラ ケイコ

野原 恵子 ノハラ ケイコ

Research Projects

Research Products

Co-Researchers

Inheritance of environmental impacts on DNA methylation through sperm to the next generation embryosPrincipal Investigator

Principal Investigator

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Research Institution

Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicalsPrincipal Investigator

Principal Investigator

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Research Institution

Characterization of mutation as a marker for carcinogenesis induced by oxidative stress: identification of mutation hotspot

Principal Investigator

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Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatin tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant micePrincipal Investigator

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The involvement of cellular senescence in hepatic tumors that increase through multiple generations by gestational arsenite exposure

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Studies on epimutations that are involved in multigenerational effects of environmental chemicals in micePrincipal Investigator

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Assessment of current lung cancer and related health risk by past-exposure of particulates suspended in air

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Involvement of oxidative stress in the epigenetic changes induced by environmental chemicalsPrincipal Investigator

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Studies on the effect of arsenic on the transcription factors in immune cellsPrincipal Investigator

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Studies on the activation-associated ganglioside in rat T cellPrincipal Investigator

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[Book] Chapter 3. Arsenic exposure and reproductive toxicity. In: Yamauchi H, Sun G editors. Arsenic contamination in Asia.2019

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[Book] Chapter 3. Arsenic Exposure and Reproductive Toxicity. In: Yamauchi H, Sun G editors. Arsenic contamination in Asia.2019

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[Book] 毒性の科学2014

Author(s)

NOHARA Keiko 野原恵子

野原惠子ノハラケイコ

野原恵子ノハラケイコ

[Book] 2.6環境因子によるエピジェネティック制御毒性の科学2014