MORIYAMA Mitsuhiko 森山光彦

… Alternative Names

森山光彦モリヤマミツヒコ

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Researcher Number	50191060
Other IDs
Affiliation (Current)	2025: 日本大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2022: 日本大学, 医学部, 教授 2002 – 2003: Nihon University, School of Medicine, Assistant professor, 医学部, 助教授 2000 – 2001: 日本大学, 医学部, 講師 1996 – 1997: 日本大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Gastroenterology / Experimental pathology / Human pathology
Keywords	Principal Investigator mRNA / Genechip / DNA array / sequence / HDV RNA / recurrence / Gene expression / non cancerous liver / Cancerous foci / Hepatocellular carcinoma … More / DNA microarray / GeneChip / 肝硬変症 / 慢性C型肝炎 / 原発性肝細胞癌 / 肝細胞不規則再生 / Gene chip / 異所性再発 / 遺伝子発現 / 非癌部肝組織 / 癌部肝組織 / 肝細胞癌 / hepatitis delta / HDV antibody / 無症候性キャリア / B型慢性肝炎 / アミノ酸配列 / デルタ肝炎ウイルス / デルタ肝炎 / デルタ抗体 … More Except Principal Investigator HCV cloning / Chimpanzee / Hypervariable region-1 / Hepatitis C virus (HCV) / 肝細胞癌 / インテグリン / 細胞外マトリックス / TGFーβ1 / 肝線維化 / インテグリンβ１ / バイオマーカー / 肝癌 / 不規則再生肝細胞 / 膵癌細胞株 / 肝癌細胞株 / AR / GRP78 / ソラフェニブ / 進行肝細胞癌 / Toll-like receptor / 自然免疫 / Fos / レゴラフェニブ / レンバチニブ / AP-1 / c-Jun / c-Fos / TLR4 / ソラフェニブ耐性 / Anti-HCV antibody / Reinfection experiment / HCV genotype / chimpanzee / hepatitis C virus / HCV抗体 / 再感染実験 / RT-PCR / T7-based amplification / 肝臓 / 遺伝子発現 / マイクロダイセクション Less

Development of novel hepatocellular carcinoma biomarkers and drug targets focusing on irregularly regenerating hepatocytes.
- Principal Investigator
  
  YAMAZAKI Motomi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nihon University
The Role of Integrin-beta1 in Liver Fibrosis Progression
- Principal Investigator
  
  MASUZAKI Ryota
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nihon University
Sorafenib resistance and c-Jun in hepatocellular carcinoma
- Principal Investigator
  
  KANDA Tatsuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nihon University
Research of genetic analysis. of hepatitis C virus clones and immune response in reinfection experiment using chimpanzees.
- Principal Investigator
  
  SUGITANI Masahiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nihon University
Investigation by micro array of genes associated with hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  MORIYAMA Mitsuhiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nihon University
ジーンチップを用いたC型肝炎、肝癌特異的遺伝子発現プロファイルによる遺伝子診断
- Principal Investigator
  
  江角真理子
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Nihon University
Clinico-molecular characteristics of hepatitis D virus infection prevalent in a small island named Miyako island of JapanPrincipal Investigator
- Principal Investigator
  
  MORIYAMA Mitsuhiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nihon University School of Medicine

All 2022 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma2022
- Author(s)
  Moriyama Mitsuhiko、Kanda Tatsuo、Midorikawa Yutaka、Matsumura Hiroshi、Masuzaki Ryota、Nakamura Hitomi、Ogawa Masahiro、Matsuoka Shunichi、Shibata Toshikatu、Yamazaki Motomi、Kuroda Kazumichi、Nakayama Hisashi、Higaki Tokio、Kanemaru Kazunori、Miki Toshio、Sugitani Masahiko、Takayama Tadatoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 20508-20508
- DOI
  10.1038/s41598-022-25201-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-20K07706, KAKENHI-PROJECT-23K24398
[Journal Article] Noninvasive Assessment of Liver Fibrosis: Current and Future Clinical and Molecular Perspectives2020
- Author(s)
  Masuzaki Ryota、Kanda Tatsuo、Sasaki Reina、Matsumoto Naoki、Ogawa Masahiro、Matsuoka Shunichi、Karp Seth J.、Moriyama Mitsuhiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 14 Pages: 4906-4906
- DOI
  10.3390/ijms21144906
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08343
[Journal Article] Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma2020
- Author(s)
  Kanda Tatsuo、Goto Taichiro、Hirotsu Yosuke、Masuzaki Ryota、Moriyama Mitsuhiko、Omata Masao
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 4 Pages: 1525-1525
- DOI
  10.3390/ijms21041525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09404
[Journal Article] Follow-up Results of HCV GT2 Patients After Sofosbuvir/Ribavirin Therapy: Careful Attention to Occurrence of HCC2019
- Author(s)
  KANEKO TOMOHIRO、KANDA TATSUO、NIREI KAZUSHIGE、MATSUMOTO NAOKI、YAMAZAKI MOTOMI、SHIBATA TOSHIKATSU、TAMURA AKINORI、OGAWA MASAHIRO、NAKAJIMA NORIKO、MATSUOKA SHUNICHI、KURODA KAZUMICHI、KOMORIYA TOMOE、YAMAMOTO TATSUO、TAKAYAMA TADATOSHI、MORIYAMA MITSUHIKO
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 7 Pages: 3855-3862
- DOI
  10.21873/anticanres.13535
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09404
[Journal Article] Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review2019
- Author(s)
  Kanda Tatsuo、Goto Taichiro、Hirotsu Yosuke、Moriyama Mitsuhiko、Omata Masao
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 6 Pages: 1358-1358
- DOI
  10.3390/ijms20061358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09404
[Journal Article] Possible association of arrestin domain-containing protein 3 and progression of non-alcoholic fatty liver disease.2019
- Author(s)
  Ogawa M, Kanda T, Higuchi T, Takahashi H, Kaneko T, Matsumoto N, Nirei K, Yamagami H, Matsuoka S, Kuroda K, Moriyama M.
- Journal Title
  
  International Journal of Medical Sciences
  
  Volume: 16 Issue: 7 Pages: 909-921
- DOI
  10.7150/ijms.34245
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09404
[Journal Article] APASL HCV guidelines of virus-eradicated patients by DAA on how to monitor HCC occurrence and HBV reactivation.2019
- Author(s)
  Kanda T, Lau GKK, Wei L, Moriyama M, Yu ML, Chuang WL, Ibrahim A, Lesmana CRA, Sollano J, Kumar M, Jindal A, Sharma BC, Hamid SS, Kadir Dokmeci A, Mamun-Al-Mahtab, McCaughan GW, Wasim J, Crawford DHG, Kao JH, Ooka Y, Yokosuka O, Sarin SK, Omata M.
- Journal Title
  
  Hepatology International
  
  Volume: 13 Issue: 6 Pages: 649-661
- DOI
  10.1007/s12072-019-09988-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09404
[Journal Article] Exosomes and Hepatocellular Carcinoma: From Bench to Bedside.2019
- Author(s)
  Reina Sasaki、Kanda Tatsuo、Yokosuka Osamu、Kato Naoya、Matsuoka Shunichi、Moriyama Mitsuhiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Pages: 2416-2416
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09404
[Journal Article] Exosomes and Hepatocellular Carcinoma: From Bench to Bedside2019
- Author(s)
  Sasaki Reina、Kanda Tatsuo、Yokosuka Osamu、Kato Naoya、Matsuoka Shunichi、Moriyama Mitsuhiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 6 Pages: 1406-1406
- DOI
  10.3390/ijms20061406
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09404
[Journal Article] Early occurrence and recurrence of hepatocellular carcinoma in hepatitis C virus-infected patients after sustained virological response2018
- Author(s)
  Kanda T, Matsuoka S, Moriyama M
- Journal Title
  
  Hepatology International
  
  Volume: 12 Issue: 2 Pages: 90-93
- DOI
  10.1007/s12072-018-9862-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09404
[Journal Article] Interferon-free treatment for patients with chronic hepatitis C and autoimmune liver disease: higher SVR rates with special precautions for deterioration of autoimmune hepatitis2018
- Author(s)
  Kanda T, Yasui S, Nakamura M, Nakamoto S, Takahashi K, Wu S, Sasaki R, Haga Y, Ogasawara S, Saito T, Kobayashi K, Kiyono S, Ooka Y, Suzuki E, Chiba T, Maruyama H, Imazeki F, Moriyama M, Kato N
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 14 Pages: 11631-11637
- DOI
  10.18632/oncotarget.24391
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09404
[Journal Article] Persistent Hepatic Inflammation Plays a Role in Hepatocellular Carcinoma After Sustained Virological Response in Patients with HCV Infection2018
- Author(s)
  Nirei K, Kanda T, Nakamura H, Matsuoka S, Takayama T, Sugitani M, Moriyama M
- Journal Title
  
  Int J Med Sci
  
  Volume: 15 Issue: 5 Pages: 466-474
- DOI
  10.7150/ijms.23147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09404
[Journal Article] Direct-acting antiviral agents against hepatitis C virus and lipid metabolism2017
- Author(s)
  Kanda T, Moriyama M
- Journal Title
  
  World J Gastroenterol
  
  Volume: 23 Issue: 31 Pages: 5645-5649
- DOI
  10.3748/wjg.v23.i31.5645
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09404
[Journal Article] Retreatment of patients with treatment failure of direct-acting antivirals: Focus on hepatitis C virus genotype 1b2017
- Author(s)
  Kanda T, Nirei K, Matsumoto N, Higuchi T, Nakamura H, Yamagami H, Matsuoka S, Moriyama M
- Journal Title
  
  World J Gastroenterol
  
  Volume: 23 Issue: 46 Pages: 8120-8127
- DOI
  10.3748/wjg.v23.i46.8120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09404
[Presentation] 細胞外マトリックスと肝細胞の接着分子に注目したアルコール性肝線維症の機序解明について2020
- Author(s)
  増崎亮太、Seth J. Karp、森山光彦
- Organizer
  第５６回　日本肝臓学会　ワークショップ
- Data Source
  KAKENHI-PROJECT-20K08343
[Presentation] レンバチニブを使用し著効した後, 再増悪をきたした肝細胞癌の2例.2019
- Author(s)
  有間修平, 高橋央, 金子朋弘, 本田真之, 石井大雄, 山名陽一郎, 水谷卓, 上村慎也, 松本直樹, 中村仁美, 山上裕晃, 神田達郎, 松岡俊一, 森山光彦.
- Organizer
  第55回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-17K09404
[Presentation] 各種分子標的薬が肝癌細胞株自然免疫シグナル伝達経路に与える影響に関する検討.2019
- Author(s)
  神田達郎, 松本直樹, 森山光彦.
- Organizer
  第23回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-17K09404
[Presentation] レゴラフェニブの肝癌細胞Toll-like receptor関連シグナルに対する影響.2019
- Author(s)
  神田達郎, 高橋央, 金子朋弘, 本田真之, 有間修平, 上村慎也, 金澤芯依,山名陽一郎, 水谷卓, 松本直樹, 中村仁美, 石井大雄, 楡井和重, 山上裕晃, 小川眞広, 松岡俊一, 森山光彦.
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09404
[Presentation] Different mechanism of action of regorafenib and lenvatinib on toll-like receptor-signaling pathways in human hepatoma cell lines.2019
- Author(s)
  Kanda T, Moriyama M.
- Organizer
  AASLD The Liver Meeting 2019, John B. Hynes Memorial Convention Center, Boston, MA, USA.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09404
[Presentation] レンバチニブが肝癌細胞Toll-like receptor関連シグナルに与える影響.2019
- Author(s)
  神田達郎, 松岡俊一, 小川眞広, 松本直樹, 上村慎也, 水谷卓, 有間修平, 本田真之, 金澤芯依, 金子朋弘, 高橋央, 山名陽一郎, 石井大雄, 樋口晃久, 山上裕晃, 中村仁美, 楡井和重, 森山光彦.
- Organizer
  第55回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-17K09404
[Presentation] Effects of regorafenib on the toll-like receptor signaling pathways in HCC.2019
- Author(s)
  Tatsuo Kanda, Naoki Matsumoto, Hiroaki Yamagami, Shunichi Matsuoka, Mitsuhiko Moriyama.
- Organizer
  APASL Single Topic Conference on Liver Immunology and Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09404

1. SUGITANI Masahiko (40187654)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KANDA Tatsuo (20345002)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
3. SUZUKI Koyu (00158974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ASAI Satoshi (80231108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHEIKH Aleemuzzaman (10277436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ABE Kenji (60130415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAZAKI Motomi (40376794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MASUZAKI Ryota (20866149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 江角真理子 (30167291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松岡俊一 (80307842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 山本敏樹 (50409009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 楡井和重 (70350014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 黒田和道 (50215109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 三木敏生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MORIYAMA Mitsuhiko 森山 光彦

森山 光彦 モリヤマ ミツヒコ

Research Projects

Research Products

Co-Researchers

Development of novel hepatocellular carcinoma biomarkers and drug targets focusing on irregularly regenerating hepatocytes.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Role of Integrin-beta1 in Liver Fibrosis Progression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Sorafenib resistance and c-Jun in hepatocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of genetic analysis. of hepatitis C virus clones and immune response in reinfection experiment using chimpanzees.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation by micro array of genes associated with hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ジーンチップを用いたC型肝炎、肝癌特異的遺伝子発現プロファイルによる遺伝子診断

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinico-molecular characteristics of hepatitis D virus infection prevalent in a small island named Miyako island of JapanPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Noninvasive Assessment of Liver Fibrosis: Current and Future Clinical and Molecular Perspectives2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Follow-up Results of HCV GT2 Patients After Sofosbuvir/Ribavirin Therapy: Careful Attention to Occurrence of HCC2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible association of arrestin domain-containing protein 3 and progression of non-alcoholic fatty liver disease.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] APASL HCV guidelines of virus-eradicated patients by DAA on how to monitor HCC occurrence and HBV reactivation.2019

Author(s)

Journal Title

MORIYAMA Mitsuhiko 森山光彦

森山光彦モリヤマミツヒコ