Saeki Toshiaki 佐伯俊昭

Researcher Number	50201512
Other IDs
Affiliation (Current)	2025: 埼玉医科大学, 医学部, 特任教授
Affiliation (based on the past Project Information) *help	2023: 埼玉医科大学, 医学部, 特任教授 2014 – 2022: 埼玉医科大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Tumor diagnostics Except Principal Investigator Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 52040:Radiological sciences-related / Radiation science / Medical systems
Keywords	Principal Investigator 放射線 / 生体分子 / 癌 / 近赤外光イメージング / 微小環境 / PET / PETCT / CT / 化学療法 / TRS … More / 薬物療法 / 散乱強度 / 脂肪 / 水 / 酸素飽和度 / ヘモグロビン / 拡散光スペクトロスコピー / 乳癌 … More Except Principal Investigator 乳癌 / 代謝 / ミトコンドリア / がん / PET / エストロゲン受容体PET / エストロゲン受容体 / 乳がん / 患者由来モデル / 患者由来がんモデル / 治療薬 / 呼吸鎖 / 三次元培養 / 子宮がん / 患者由来がん培養系 / パルボシクリブ / F-18-FES-PET / 内分泌療法 / CDK4/6阻害剤併用療法 / F-18-fluoroestradiol / 治療経過観察 / 乳癌多発転移 / エストロゲン受容体測定 / 乳癌多発転移再発 / CDK4/6阻害剤 / ホルモン治療 / 核医学 / 放射線 / F-18-FES / F-18-FMISO / 低酸素 / 新生血管増生 / サイトカイン / 低酸素PET / 拡散光イメージング / 画像診断システム Less

Elucidation and application of mechanisms of therapeutic resistance through mitochondrial metabolic alterations based on patient-derived cancer models
- Principal Investigator
  
  Ikeda Kazuhiro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Saitama Medical University
Study of the mechanism of acquired resistance to cancer therapy using patient-derived cancer models and focusing on mitochondrial metabolism
- Principal Investigator
  
  Ikeda Kazuhiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Saitama Medical University
A pilot study for early evaluation and estimation of prognosis of patients with advanced and/or relapsed breast cancer by endocrine and/or CDK4/6 inhibitor combined therapy using estrogen receptor PET
- Principal Investigator
  
  Ichiei Kuji
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Saitama Medical University
Multiparametric measurement using diffuse optical spectroscopy of breast cancer microenvironment in the setting of chemotherapyPrincipal Investigator
- Principal Investigator
  
  Saeki Toshiaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Saitama Medical University
Investigation of development of breast cancer treatment strategy with non-invasive estrogen receptors and hypoxic PET
- Principal Investigator
  
  Ichiei Kuji
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Saitama Medical University
Search for new biomarker of anti-cancer drug effect using near-infrared diffuse optical spectroscopy targeting vasculature and hypoxia
- Principal Investigator
  
  SAKAHARA Harumi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical systems
- Research Institution
  Hamamatsu University School of Medicine

All 2023 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Early Therapeutic Prediction Based on Tumor Hemodynamic Response Imaging: Clinical Studies in Breast Cancer with Time-Resolved Diffuse Optical Spectroscopy2019
- Author(s)
  Shigeto Ueda and Toshiaki Saeki
- Journal Title
  
  Appl. Sci.
  
  Volume: 9(1), 3; Issue: 1 Pages: 1-6
- DOI
  10.3390/app9010003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03591, KAKENHI-PROJECT-16K10293
[Journal Article] 生体機能イメージングによる癌微小環境の可視化と乳癌治療への新たな展望2018
- Author(s)
  上田重人、山根登茂彦、久慈一英、浅野彩、大崎昭彦、佐伯俊昭
- Journal Title
  
  乳癌の臨床
  
  Volume: 33 Pages: 83-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03591
[Journal Article] Intracellular hypoxia measured by 18F-fluoromisonidazole positron emission tomography has prognostic impact in patients with estrogen receptor-positive breast cancer2018
- Author(s)
  Asano A., Ueda S., Kuji I., Yamane T., Takeuchi H., Hirokawa E., Sugitani I., Shimada H., Hasebe T., Osaki A., Saeki T.
- Journal Title
  
  Breast Cancer Res
  
  Volume: 20 Issue: 1
- DOI
  10.1186/s13058-018-0970-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10361
[Journal Article] 生体機能イメージングによる癌微小環境の可視化と乳癌治療への新たな展望2018
- Author(s)
  上田重人, 山根　登茂彦, 久慈一英, 浅野彩, 大崎昭彦, 佐伯俊昭
- Journal Title
  
  乳癌の臨床
  
  Volume: 33 Pages: 83-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10361
[Journal Article] Assessing Oxygenation Response to Eribulin in a Patient with Recurrent Breast Cancer after Resistance to Endocrine Therapy.2017
- Author(s)
  Ueda S, Saeki T, Yamane T, Kuji I
- Journal Title
  
  OMICS J Radiol
  
  Volume: 6 Issue: 01 Pages: 250-250
- DOI
  10.4172/2167-7964.1000250
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26282144
[Journal Article] Bevacizumab induces acute hypoxia and cancer progression in patients with refractory breast cancer: Multimodal functional imaging and multiplex cytokine analysis.2017
- Author(s)
  Ueda S, Saeki T, Osaki A, Yamane T, Kuji I
- Journal Title
  
  Clin Cancer Res.
  
  Volume: 23(19) Issue: 19 Pages: 5769-5778
- DOI
  10.1158/1078-0432.ccr-17-0874
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10293, KAKENHI-PROJECT-16K10361, KAKENHI-PROJECT-26282144
[Journal Article] Bevacizumab Induces Acute Hypoxia and Cancer Progression in Patients with Refractory Breast Cancer: Multimodal Functional Imaging and Multiplex Cytokine Analysis.2017
- Author(s)
  Ueda S, Saeki T, Osaki A, Yamane T, Kuji I.
- Journal Title
  
  Clin Cancer Res.
  
  Volume: 23(19) Pages: 5769-5778
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03591
[Journal Article] In vivo imaging of eribulin-induced reoxygenation in advanced breast cancer patients: a comparison to bevacizumab.2016
- Author(s)
  Ueda S, Saeki T, Takeuchi H, Shigekawa T, Yamane T, Kuji I, Osaki A.
- Journal Title
  
  Br J Cancer
  
  Volume: 114 Issue: 11 Pages: 1212-1218
- DOI
  10.1038/bjc.2016.122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26282144
[Journal Article] Near-Infrared Diffuse Optical Imaging for Early Prediction of Breast Cancer Response to Neoadjuvant Chemotherapy: A Comparative Study Using 18F-FDG PET/CT.2016
- Author(s)
  Ueda S, Yoshizawa N, Shigekawa T, Takeuchi H, Ogura H, Osaki A, Saeki T, Ueda Y, Yamane T, Kuji I, Sakahara H.
- Journal Title
  
  J Nucl Med
  
  Volume: 57 Issue: 8 Pages: 1189-1195
- DOI
  10.2967/jnumed.115.167320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26282144, KAKENHI-PROJECT-15K19781
[Presentation] A pilot study of the use of positron emission tomography to evaluate early oestrogen receptor changes in patients with advanced and/or relapsed breast cancer administered endocrine therapy and CDK4/6 inhibitor combination therapy2023
- Author(s)
  I. Kuji, K. Matsuura, A. Osaki, T. Yamane, H. Ishiguro, T. Saeki
- Organizer
  EANM23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08207
[Presentation] A pilot study of the use of positron emission tomography to evaluate early oestrogen receptor changes in patients with advanced and/or relapsed breast cancer administered endocrine therapy and CDK4/6 inhibitor combination therapy2023
- Author(s)
  I. Kuji, K. Matsuura, A. Osaki, T. Yamane, H. Ishiguro, T. Saeki
- Organizer
  EANM2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08207
[Presentation] マルチパラメトリック拡散光スペクトロスコピーを用いた乳癌術前化学療法の治療効果モニターリング2019
- Author(s)
  上田重人、山根登茂彦、久慈一英、佐伯俊昭
- Organizer
  日本乳癌学会総会27回
- Data Source
  KAKENHI-PROJECT-17H03591
[Presentation] シンポジウム・乳癌PETの現状と将来の可能性: 低酸素PETと光イメージングの乳癌への応用2018
- Author(s)
  上田重人, 山根登茂彦, 久慈一英, 大崎昭彦, 佐伯俊昭
- Organizer
  第58回日本核医学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K10361
[Presentation] 初回導入ホルモン療法による治療層別化への機能イメージングの臨床応用：FDG-PETと拡散光イメージング2018
- Author(s)
  上田重人、島田浩子、杉谷郁子、杉山迪子、佐野弘、大崎明彦、高橋孝郎、佐伯俊昭
- Organizer
  第26回日本乳癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03591
[Presentation] [18F]-fluoromisonidazole PET/CTによる乳癌の細胞内低酸素の臨床的意義についてのサブタイプ別解析2018
- Author(s)
  浅野彩、上田重人、久慈一英、山根登茂彦、竹内英樹、廣川詠子、杉谷郁子、島田浩子、長谷部孝裕、大崎昭彦、佐伯俊昭
- Organizer
  日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10361
[Presentation] 低酸素イメージングFMISO-PET/CTの乳癌患者への臨床応用2017
- Author(s)
  浅野彩、上田重人、山根登茂彦、久慈一英、竹内英樹、廣川詠子、杉谷郁子、島田浩子、貫井麻未、一瀬友希、高橋孝郎、大崎昭彦、佐伯俊昭
- Organizer
  日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10361
[Presentation] ベバシズマブによる腫瘍低酸素の誘導と治療効果との関連についての核医学的考察2017
- Author(s)
  上田重人、佐伯俊昭、大崎昭彦、竹内英樹、廣川詠子、杉谷郁子、島田浩子、浅野彩、貫井麻未、一瀬友希、高橋孝郎、山根登茂彦、久慈一英
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-26282144
[Presentation] ベバシズマブによる腫瘍低酸素の誘導とがん進展との関連についての核医学的・分子生物学的考察2017
- Author(s)
  上田重人、佐伯俊昭、大崎昭彦、竹内英樹、杉谷郁子、廣川詠子、島田浩子、浅野彩、一瀬友希、高橋孝郎、山根登茂彦、久慈一英
- Organizer
  日本癌治療学会総会
- Data Source
  KAKENHI-PROJECT-17H03591
[Presentation] ベバシズマブによる急性低酸素の誘導とがん進展に関する核医学的・分子生物学的考察2017
- Author(s)
  上田重人, 佐伯俊昭, 大崎昭彦, 山根登茂彦, 久慈一英
- Organizer
  日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10361
[Presentation] Change in tumor hemoglobin concentration during neoadjuvant chemotherapy may predict pathological response in ER-negative breast cancer, but not in ER-positive breast cancer.2017
- Author(s)
  Ueda S, Yoshizawa N, Shigekawa T, Takeuchi H, Ogura H, Osaki A, Saeki T, Ueda Y, Yamane T, Kuji I, Sakahara H.
- Organizer
  SPIE Photonics West 2017
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2017-01-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26282144
[Presentation] エストロゲン受容体イメージング[18F]FES-PET/CTを施行した乳癌患者の症例報告2017
- Author(s)
  一瀬友希, 上田重人, 山根登茂彦, 大崎昭彦, 杉谷郁子, 廣川詠子, 島田浩子, 淺野彩, 久慈一英, 佐伯俊昭
- Organizer
  日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10361
[Presentation] ベバシズマブによる腫瘍低酸素の誘導と治療効果との関連についての核医学的考察2017
- Author(s)
  上田重人, 佐伯俊昭, 大崎昭彦, 竹内英樹, 廣川詠子, 杉谷郁子, 島田浩子, 浅野彩, 貫井麻未, 一瀬友希, 高橋孝郎, 山根登茂彦, 久慈一英
- Organizer
  日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10361
[Presentation] FMISO-PETと光イメージングの比較による乳癌における癌細胞低酸素状態とヘモグロビン状態変化の関係2015
- Author(s)
  久慈一英，上田重人，佐伯俊昭，山根登茂彦
- Organizer
  第55回日本核医学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-26282144
[Presentation] Near-infrared diffuse optical imaging for early prediction to neoadjuvant chemotherapy in patients with primary breast cancer2015
- Author(s)
  Ogura H, Yoshizawa N, Ueda S, Hosokawa Y, Matsunuma R, Tochikubo J, Nasu H, Shigekawa T, Takeuchi H, Osaki A, Saeki T, Yoshimoto K, Ohmae E, Suzuki T, Ueda Y, Yamashita Y, Sakahara H
- Organizer
  38th Annual San Antonio Breast Cancer Symposium
- Place of Presentation
  San Antonio, Texas, USA
- Year and Date
  2015-12-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26282144
[Presentation] 近赤外光イメージングによる術前化学療法の早期治療効果をFDG-PETと比較する臨床試験2015
- Author(s)
  上田重人，芳澤暢子，重川崇，竹内英樹，大崎昭彦，佐伯俊昭，小倉廣之，山根登茂彦，久慈一英，阪原晴海
- Organizer
  第53回日本癌治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-26282144
[Presentation] Correlation between intracellular hypoxia and ineffective neovascularization with increase of concentration of hemoglobin in breast cancer measured by 18F-fluoroimizadole PET/CT and diffusion optical spectroscopy2015
- Author(s)
  Kuji I, Ueda S, Yamane T, Shimano Y, Saeki T
- Organizer
  SNMMI 2015 Annual Meeting
- Place of Presentation
  Baltimoa, Maryland, USA
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26282144
[Presentation] A correlation between intracellular hypoxia and extracellular oxygen saturation in breast cancer measured by F-18-fluoroimizadole PET/CT and diffusion optical spectroscopy2015
- Author(s)
  Kuji I, Ueda S, Yamane T, Saeki T
- Organizer
  第74回日本医学放射線学会総会
- Place of Presentation
  横浜
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26282144

1. Ichiei Kuji (90283142)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
2. 上田重人 (20646947)

# of Collaborated Projects: 4 results

# of Collaborated Products: 25 results
3. 山根登茂彦 (20526660)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
4. SAKAHARA Harumi (10187031)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. Ikeda Kazuhiro (30343461)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 芳澤暢子 (10402314)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. 小倉廣之 (50402285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. 井上聡 (40251251)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. YAMASHITA Yutaka (80393982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. UEDA Yukio (30393987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
11. 福島賢慈 (50408613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大崎昭彦 (90291484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 松浦一生 (90522954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Saeki Toshiaki 佐伯 俊昭

Research Projects

Research Products

Co-Researchers

Elucidation and application of mechanisms of therapeutic resistance through mitochondrial metabolic alterations based on patient-derived cancer models

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the mechanism of acquired resistance to cancer therapy using patient-derived cancer models and focusing on mitochondrial metabolism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A pilot study for early evaluation and estimation of prognosis of patients with advanced and/or relapsed breast cancer by endocrine and/or CDK4/6 inhibitor combined therapy using estrogen receptor PET

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multiparametric measurement using diffuse optical spectroscopy of breast cancer microenvironment in the setting of chemotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of development of breast cancer treatment strategy with non-invasive estrogen receptors and hypoxic PET

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for new biomarker of anti-cancer drug effect using near-infrared diffuse optical spectroscopy targeting vasculature and hypoxia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Early Therapeutic Prediction Based on Tumor Hemodynamic Response Imaging: Clinical Studies in Breast Cancer with Time-Resolved Diffuse Optical Spectroscopy2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 生体機能イメージングによる癌微小環境の可視化と乳癌治療への新たな展望2018

Author(s)

Journal Title

Data Source

[Journal Article] Intracellular hypoxia measured by 18F-fluoromisonidazole positron emission tomography has prognostic impact in patients with estrogen receptor-positive breast cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 生体機能イメージングによる癌微小環境の可視化と乳癌治療への新たな展望2018

Author(s)

Journal Title

Data Source

[Journal Article] Assessing Oxygenation Response to Eribulin in a Patient with Recurrent Breast Cancer after Resistance to Endocrine Therapy.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bevacizumab induces acute hypoxia and cancer progression in patients with refractory breast cancer: Multimodal functional imaging and multiplex cytokine analysis.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bevacizumab Induces Acute Hypoxia and Cancer Progression in Patients with Refractory Breast Cancer: Multimodal Functional Imaging and Multiplex Cytokine Analysis.2017

Author(s)

Journal Title

Data Source

[Journal Article] In vivo imaging of eribulin-induced reoxygenation in advanced breast cancer patients: a comparison to bevacizumab.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Near-Infrared Diffuse Optical Imaging for Early Prediction of Breast Cancer Response to Neoadjuvant Chemotherapy: A Comparative Study Using 18F-FDG PET/CT.2016

Author(s)

Journal Title

Saeki Toshiaki 佐伯俊昭